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Life-Cycle Bearing Capacity for Pre-Stressed T-beams Based on Full-Scale Destructive Test
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作者 Yushan Ye Tao Gao +4 位作者 Liankun Wang Junjie Ma Yingchun Cai Heng Liu Xiaoge Liu 《Structural Durability & Health Monitoring》 EI 2025年第1期145-166,共22页
To investigate the evolution of load-bearing characteristics of pre-stressed beams throughout their service life and to provide a basis for accurately assessing the actual working state of damaged pre-stressed concret... To investigate the evolution of load-bearing characteristics of pre-stressed beams throughout their service life and to provide a basis for accurately assessing the actual working state of damaged pre-stressed concrete T-beams,destructive tests were conducted on full-scale pre-stressed concrete beams.Based on the measurement and ana-lysis of beam deflection,strain,and crack development under various loading levels during the research tests,combined with the verification coefficient indicators specified in the codes,the verification coefficients of bridges at different stages of damage can be examined.The results indicate that the T-beams experience complete,incom-plete linear,and non-linear stages during the destructive test process.In the complete linear elastic stage,both the deflection and bottom strain verification coefficients comply with the specifications,indicating a good structural load-bearing capacity no longer adheres to the code’s requirements.In the non-linear stage,both coefficients exhi-bit a sharp increase,resulting in a further decrease in the structure’s load-bearing capacity.According to the pro-visions of the current code,the beam can be in the incomplete linear stage when both values fall within the code’s specified range.The strain verification coefficient sourced from the compression zone at the bottom of theflange is not recommended for assessing the bridge’s load-bearing capacity. 展开更多
关键词 pre-stressed T-beams whole process destructive test bearing capacity verification coefficient
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Mathematical framework of nonlinear elastic waves propagating in pre-stressed media
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作者 Jiangcheng CAI Mingxi DENG 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2024年第10期1705-1716,共12页
Acoustic nonlinearity holds potential as a method for assessing material stress.Analogous to the acoustoelastic effect,where the velocity of elastic waves is influenced by third-order elastic constants,the propagation... Acoustic nonlinearity holds potential as a method for assessing material stress.Analogous to the acoustoelastic effect,where the velocity of elastic waves is influenced by third-order elastic constants,the propagation of nonlinear acoustic waves in pre-stressed materials would be influenced by higher-order elastic constants.Despite this,there has been a notable absence of research exploring this phenomenon.Consequently,this paper aims to establish a theoretical framework for governing the propagation of nonlinear acoustic waves in pre-stressed materials.It delves into the impact of pre-stress on higher-order material parameters,and specifically examines the propagation of one-dimensional acoustic waves within the contexts of the uniaxial stress and the biaxial stress.This paper establishes a theoretical foundation for exploring the application of nonlinear ultrasonic techniques to measure pre-stress in materials. 展开更多
关键词 acoustoelastic effect nonlinear elastic wave pre-stress medium higher-order elastic constant
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PMF+双门限Tong检测的北斗B1I信号捕获算法 被引量:1
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作者 刁彦华 徐亚丽 +1 位作者 王晓君 刘昊昱 《通信与信息技术》 2024年第2期1-5,共5页
针对传统Tong检测算法检测时间长、漏警概率大的问题,提出将PMF+双门限Tong检测算法应用于北斗B1I信号的捕获中。首先,将射频前端模块处理得到的中频信号下变频至基带,对基带信号进行降速等预处理;然后,利用部分匹配滤波(PMF)算法计算... 针对传统Tong检测算法检测时间长、漏警概率大的问题,提出将PMF+双门限Tong检测算法应用于北斗B1I信号的捕获中。首先,将射频前端模块处理得到的中频信号下变频至基带,对基带信号进行降速等预处理;然后,利用部分匹配滤波(PMF)算法计算相关值,通过PMF算法将数据信号分成几个均等片段,对每一段信号都分别计算相关值,会出现三组具有同相位的相关结果;最后,利用双门限Tong检测算法对PMF算法计算得到的相关结果检测,达到捕获B1I信号的目的。仿真结果表明,利用该算法捕获北斗B1I信号,有效提高了捕获时的检测概率并缩短了检测时间,提高了捕获B1I信号的速度。 展开更多
关键词 B1I信号 匹配滤波 双门限tong检测 信号捕获
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Mechanical properties and reinforcement effect of jointed rock mass with pre-stressed bolt 被引量:10
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作者 YANG Wen-dong LUO Guang-yu +4 位作者 BO Chun-jie WANG Ling Lü Xian-xian WANG Ying-nan WANG Xue-peng 《Journal of Central South University》 SCIE EI CAS CSCD 2020年第12期3513-3530,共18页
Pre-stressed bolt anchorage is the key technology for jointed rock masses in rock tunnelling,slope treatment and mining engineering.To investigate the mechanical properties and reinforcement effect of jointed rock mas... Pre-stressed bolt anchorage is the key technology for jointed rock masses in rock tunnelling,slope treatment and mining engineering.To investigate the mechanical properties and reinforcement effect of jointed rock masses with pre-stressed bolts,in this study,uniaxial compression tests were conducted on specimens with different anchoring types and flaw inclination angles.ABAQUS software was used to verify and supplement the laboratory tests.The laws of the uniaxial compressive strength(UCS)obtained from the numerical simulations and laboratory tests were consistent.The results showed that under the same flaw angle,both the UCS and elastic modulus of the bolted specimens were improved compared with those of the specimens without bolts and the improvements increased with an increase in the bolt pre-stress.Under the same anchoring type,the UCS and elastic modulus of the jointed specimens increased with an increase in the flaw angle.The pre-stressed bolt could not only restrain the slip of the specimens along the flaw surface but also change the propagation mode of the secondary cracks and limit the initiation of cracks.In addition,the plot contours of the maximum principal strain and the Tresca stress of the numerical models were influenced by the anchoring type,flaw angle,anchoring angle and bolt position. 展开更多
关键词 jointed rock mass pre-stressed bolt laboratory test numerical simulation
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Strength weakening effect of high static pre-stressed granite subjected to low-frequency dynamic disturbance under uniaxial compression 被引量:7
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作者 Wu-xing WU Feng-qiang GONG Quan JIANG 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2022年第7期2353-2369,共17页
This study aimed to elucidate the strength weakening effect of high static pre-stressed rocks subjected to low-frequency disturbances under uniaxial compression.Based on the uniaxial compressive strength(UCS)of granit... This study aimed to elucidate the strength weakening effect of high static pre-stressed rocks subjected to low-frequency disturbances under uniaxial compression.Based on the uniaxial compressive strength(UCS)of granite under static loading,70%,80%,and 90%of UCS were selected as the initial high static pre-stress(σ_(p)),and then the pre-stressed rock specimens were disturbed by sinusoidal stress with amplitudes of 30%,20%,and 10%of UCS under low-frequency frequencies(f)of 1,2,5,and 10 Hz,respectively.The results show that the rockburst failure of pre-stressed granite is caused by low-frequency disturbance,and the failure strength is much lower than UCS.When theσp or f is constant,the specimen strength gradually decreases as the f or σ_(p) increases.The experimental study illustrates the influence mechanism of the strength weakening effect of high static pre-stress rocks under low-frequency dynamic disturbance,that is,high static pre-stress is the premise and leading factor of rock strength weakening,while low-frequency dynamic disturbance induces rock failure and affects the strength weakening degree. 展开更多
关键词 deep rock high static pre-stress low-frequency dynamic disturbance strength weakening effect uniaxial compression ROCKBURST
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RC beam strengthened with pre-stressed CFP under the secondary load 被引量:5
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作者 LONG Bang-yun YUAN Guang-lin ZHU Dan-yu 《Journal of China University of Mining and Technology》 EI 2008年第4期618-622,共5页
Feasibility of using pre-stressed carbon fiber plates to strengthen reinforced concrete beams was studied. Based on the characteristics of carbon fiber plates, we developed a pre-stress clamp and a device for applying... Feasibility of using pre-stressed carbon fiber plates to strengthen reinforced concrete beams was studied. Based on the characteristics of carbon fiber plates, we developed a pre-stress clamp and a device for applying the pre-stress. Contrast tests were conducted between ordinary carbon fiber plates and a pre-stressed carbon fiber plate and between secondary loaded carbon fiber plates and a concrete beam strengthened with a secondary loaded carbon fiber plate. On this basis, we analyzed the failure pattern, the width of cracks and their distribution, the cracking load, the yield load, the limit load and the relation between load and deflec- tion. The results indicate that using pre-stressed carbon fiber plates to strengthen concrete beams is feasible and effective. 展开更多
关键词 pre-stress CFP secondary load strengthening RC beam
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Flexural Property of String Beam of Pre-Stressed Glulam Based on Influence of Regulation and Control 被引量:2
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作者 Nan Guo Wenbo Wang Hongliang Zuo 《Structural Durability & Health Monitoring》 EI 2019年第2期143-179,共37页
Applying pre-stress in glulam beam can reduce its deformation and make full use of the compressive strength of wood.However,when the glulam with low strength and the pre-stressed steel with high strength form combined... Applying pre-stress in glulam beam can reduce its deformation and make full use of the compressive strength of wood.However,when the glulam with low strength and the pre-stressed steel with high strength form combined members,materials of high strength can’t be fully utilized.Therefore,this study puts forward the idea of regulating and controlling string beam of pre-stressed glulam.By regulating and controlling the pre-stress,a part of the load borne by the wood is allocated to the pre-stressed tendon,which is equivalent to completing a redistribution of internal force,thus realizing the repeated utilization of the wood strength and the full utilization of the strength of the high-strength pre-stressed tendon.The bending experiments of 10 beams under 5 working conditions are carried out.The failure mode,bearing capacity and deformation of the beams are analyzed.The results show that 90%of beams are deformed under compression.The ultimate load of the regulated and controlled beam is obviously larger than that of the unregulated beam,and the ultimate load of the beam increases with the increase of the degree of regulation and control.Compared with that of the unregulated beams,the ultimate load of beams regulated by 7.5%-30%increases by 25.42%-65.08%,and the regulated and controlled effect is obvious.With the increase of the regulation and control amplitude of pre-stress,the stiffness of string beam of pre-stressed glulam increases.In addition,with the increase of the regulation and control amplitude,the compression height of the beam increases before the failure,and it reaches the state of full-section compression at the time of failure,giving full play to the compressive property of the glulam.At the end of the experiment,the constitutive relation which can reflect the anisotropy of the wood is established combined with the experimental data.The finite element analysis of the beam under 7 working conditions is carried out by using ABAQUS finite element program,and the influence of the regulation and control amplitude on the stress distribution and ultimate bearing capacity of the beam is discussed. 展开更多
关键词 STRING beam of GLULAM FLEXURAL PROPERTY experimental study pre-stress REGULATION and control
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Design and Preparation of High Elastic Modulus Self-compacting Concrete for Pre-stressed Mass Concrete Structures 被引量:2
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作者 祝雯 CHEN Yang +4 位作者 LI Fangxian ZHANG Tongsheng HU Jie 韦江雄 YU Qijun 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2016年第3期563-573,共11页
Requirements of self-compacting concrete (SCC) applied in pre-stressed mass concrete structures include high fluidity, high elastic modulus, low adiabatic temperature rise and low drying shrinkage, which cannot be s... Requirements of self-compacting concrete (SCC) applied in pre-stressed mass concrete structures include high fluidity, high elastic modulus, low adiabatic temperature rise and low drying shrinkage, which cannot be satisfied by ordinary SCC. In this study, in order to solve the problem, a few principles of SCC design were proposed and the effects of binder amount, fly ash (FA) substitution, aggregate content and gradation on the workability, temperature rise, drying shrinkage and elastic modulus of SCC were investigated. The results and analysis indicate that the primary factor influencing the fluidity was paste content, and the main methods improving the elastic modulusof SCC were a lower sand ratio and an optimized coarse aggregate gradation. Lower adiabatic temperature rise and drying shrinkage were beneficial for decreasing the cement content. Further, based on the optimization of mixture, a C50 grade SCC (with binder amount of only 480 kg/ m3, fly ash substitution of 40%, sand ratio of 51% and proper coarse aggregate gradation (Vs.~0 mm: V10-16 ram: V16.20 mm= 30%: 30%:40%)) with superior workability was successfully prepared. The temperature rise and drying shrinkage of the prepared SCC were significantly reduced, and the elastic modulus reached 37.6 GPa at 28 d. 展开更多
关键词 self-compacting concrete pre-stressed mass structure high elastic modulus adiabatic temperature rise drying shrinkage
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Pre-Stressed Rope Reinforced Anti-Sliding Pile 被引量:1
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作者 XU Jun WANG Chenghua 《Wuhan University Journal of Natural Sciences》 EI CAS 2006年第4期887-891,共5页
Pre-stressed rope reinforced anti-sliding pile is a composite anti-sliding structure. It is made up of pre-stressed rope and general anti-sliding pile. It can bring traditional anti-sliding pile's retaining performan... Pre-stressed rope reinforced anti-sliding pile is a composite anti-sliding structure. It is made up of pre-stressed rope and general anti-sliding pile. It can bring traditional anti-sliding pile's retaining performance into full play, and to treat with landslide fast and economically. The difference between them is that the pre-stressed rope will transfix the whole anti- sliding pile through a prearranged pipe in this structure. The working mechanics, the design method and economic benefit are studied. The results show that the pre-stressed rope reinforced anti-sliding pile can treat with the small and middle landslides or high slopes well and possess the notable advantage of technology and economic. 展开更多
关键词 pre-stressed rope anti-sliding pile composite anti-sliding structure
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Dynamic analysis of double-layer and pre-stressed multi-limb six-axis force sensor 被引量:1
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作者 Wang Zhijun He Jing +1 位作者 Cui Bingyan Li Zhanxian 《High Technology Letters》 EI CAS 2019年第2期189-196,共8页
In order to adapt to the specific task, the six-axis dynamic contact force between end-effectors of intelligent robots and working condition needs to be perceived. Therefore, the dynamic property of six-axis force sen... In order to adapt to the specific task, the six-axis dynamic contact force between end-effectors of intelligent robots and working condition needs to be perceived. Therefore, the dynamic property of six-axis force sensor which is installed on the end-effectors of intelligent robots will have influence on the veracity of detection and judgment to working environment contact force by intelligent robots directly. In this paper, dynamic analysis to double-layer and pre-stressed multi-limb six-axis force sensor is conducted. First, the structure of the sensor is introduced, and the limb number is confirmed by introducing the related definitions of convex analysis. Then, based on vibration of multiple-degree-of-freedom system, a mechanical vibration simplified model of double-layer and pre-stressed multiple limb six-axis force sensor is set up. After that, movement differential equations of sensor and the response of analytical expression are deduced, and the movement differential equations is solved. Finally, taking the double-layer and pre-stressed seven limb six-axis force sensor as an example, numerical calculation and simulation of deriving result is conducted, which verify the correctness and feasibility of the theoretical analysis. 展开更多
关键词 six-axis force sensor multi-limb pre-stressed mechanical vibration dynamic analysis
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Experimental study on seismic behavior of circular RC columns strengthened with pre-stressed FRP strips 被引量:1
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作者 Zhou Changdong Lu Xilin +1 位作者 Li Hui Tian Teng 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2013年第4期625-642,共18页
Bonding fiber reinforced polymer (FRP) has been commonly used to improve the seismic behavior of circular reinforced concrete (RC) columns in engineering practice. However, FRP jackets have a significant stress hy... Bonding fiber reinforced polymer (FRP) has been commonly used to improve the seismic behavior of circular reinforced concrete (RC) columns in engineering practice. However, FRP jackets have a significant stress hysteresis effect in this strengthening method, and pre-tensioning the FRP can overcome this problem. This paper presents test results of 25 circular RC columns strengthened with pre-stressed FRP strips under low cyclic loading. The pre-stressing of the FRP strips, types of FRP strips and longitudinal reinforcement, axial load ratio, pre-damage degree and surface treatments of the specimens are considered as the primary factors in the tests. According to the failure modes and hysteresis curves of the specimens, these factors are analyzed to investigate their effect on bearing capacity, ductility, hysteretic behavior, energy dissipation capacity and other important seismic behaviors. The results show that the initial lateral confined stress provided by pre-stressed FRP strips can effectively inhibit the emergence and development of diagonal shear cracks, and change the failure modes of specimens from brittle shear failure to bending or bending-shear failure with better ductility. As a result, the bearing capacity, ductility, energy dissipation capacity and deformation capacity of the strengthened specimens are all significantly improved. 展开更多
关键词 experimental study circular reinforced concrete column pre-stress fiber reinforced polymer axial loadratio seismic behavior active confinement
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A Statistical Analysis of the Modulus of Elasticity and Compressive Strength of Concrete C45/55 for Pre-stressed Precast Beams 被引量:2
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作者 Jiri Kolisko Petr Hunka Karel Jung 《Journal of Civil Engineering and Architecture》 2012年第11期1571-1576,共6页
Random behavior of concrete C45/55 XF2 used for prefabricated pre-stressed bridge beams is described on the basis of evaluating a vast set of measurements. A detailed statistical analysis is carried out on 133 test re... Random behavior of concrete C45/55 XF2 used for prefabricated pre-stressed bridge beams is described on the basis of evaluating a vast set of measurements. A detailed statistical analysis is carried out on 133 test results of cylinders 150 ~ 300 mm in size. The tests have been running in laboratories of the Klokner Institute. A single worker took all specimens throughout the period, and the subsequent measurements of the static modulus of elasticity and the compressive strength of the concrete were performed. The measurements were made at the age of 28 days after specimens casting, and only one testing machine with the same capping method was used. Suitable theoretical models of division are determined on the basis of tests in good congruence, with the use of Z2 and the Bernstein criterion. A set of concrete compressive strength (carried out on 133 test results of cylinders 150 ~ 300 mm after test of static modulus of elasticity) shows relatively high skewness in this specific case. This cause that limited beta distribution is better than generally recommended theoretical distribution for strength the normal or lognormal. The modulus of elasticity is not significantly affected due to skewness because the design value is based on mean value. 展开更多
关键词 Concrete compression strength modulus of elasticity prefabricated pre-stressed bridge beams goodness-of-fit test statistical assessment.
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Stress Analysis of New Type Pre-Stressed Anchor Bearing Plate Combining Stamping with Welding Forming and Its Anchorage Zone
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作者 Daosen Chen Nianchun Deng +1 位作者 Zanzhi Wang Haining Zuo 《World Journal of Engineering and Technology》 2017年第4期33-41,共9页
An anchor bearing plate transfers the anchoring force from anchor plate to the concrete and the pre-stress is formed in the concrete structure. Currently, the main type of anchor bearing plate is cast iron. It is brit... An anchor bearing plate transfers the anchoring force from anchor plate to the concrete and the pre-stress is formed in the concrete structure. Currently, the main type of anchor bearing plate is cast iron. It is brittle during transportation and tension process. This paper presents a new type of anchor bearing plate combined stamping with welding forming. The structure of the new type anchor bearing plate is introduced. The stress states of the anchor bearing plate and anchorage zone under work are studied. Various specifications of anchor bearing plate are studied by ANSYS finite element analysis software following the AASHTO specification. The analysis results are compared with the results of the same type of OVM round-shaped anchor plate. The study results show that the new pre-stressed anchor plates combined stamping with welding forming are feasible and more sturdy which can meet the engineering demand. 展开更多
关键词 pre-stressed Concrete Structure Finite Element Analysis ANCHOR BEARING Plate Stress of ANCHORAGE Zone
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Pre-stressed anchoring beam technique applicable in the reinforcement of high-steep slopes
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作者 Zhifa YANG Luqing ZHANG Jiewang ZHU 《Global Geology》 2006年第2期213-216,共4页
During the construction of some large-scale rock engineering,high-steep slopes and insufficient slope stability induced by unloading fissures are often encountered.For the reinforcement of these slopes,some techniques... During the construction of some large-scale rock engineering,high-steep slopes and insufficient slope stability induced by unloading fissures are often encountered.For the reinforcement of these slopes,some techniques(including conventional pre-stressed anchoring cable and unconventional anchoring hole)are usually utilized,however,having several obvious defects.Thus,it is very difficult for a designer to design an efficient reinforcement scheme for the high-steep slopes.For this reason,the authors develop the pre-stressed anchoring beam technique,in which tensile capacity of pre-stressed structures are fully utilized.It is analyzed that the new technique is characterized by multi-functions,including engineering investigation,efficient reinforcement,drainage,monitoring and urgent strength supplement,and hoped to be extensively applicable in the reinforcement of high-steep slopes. 展开更多
关键词 large-scale rock engineering pre-stressed anchoring beam slope reinforcement
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Tong检测算法性能分析及参数设置 被引量:6
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作者 朱云龙 丑武胜 杨东凯 《北京航空航天大学学报》 EI CAS CSCD 北大核心 2015年第3期418-423,共6页
Tong检测算法是常用的信号检测算法,但在其统计性能以及算法参数设置等方面仍缺少全面的结论.针对这些问题,运用统计和递推分析方法对信号搜索单元滞留次数的均值及方差进行了较为详细的理论分析,给出了相应表达式,根据3西格玛原则,提... Tong检测算法是常用的信号检测算法,但在其统计性能以及算法参数设置等方面仍缺少全面的结论.针对这些问题,运用统计和递推分析方法对信号搜索单元滞留次数的均值及方差进行了较为详细的理论分析,给出了相应表达式,根据3西格玛原则,提出了一种最大滞留次数限定方法.分析了检测概率、噪声搜索单元和信号搜索单元平均滞留次数与算法中计数器初值和最大值以及预检测信噪比之间的关系.分析结果表明Tong检测算法参数的设置需依据信号强弱和搜索方式,并折衷考虑对检测概率与噪声搜索单元或信号搜索单元平均滞留次数的影响. 展开更多
关键词 卫星导航 接收机 捕获 检测 tong检测算法
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高动态条件下Tong检测技术应用研究 被引量:3
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作者 孙晓锋 刘云飞 王西夺 《无线电工程》 2012年第4期34-36,43,共4页
针对Tong检测技术对高动态条件下的检测性能进行了分析。基于高动态大多普勒条件下的应用,进行了Tong检测技术改进研究,提出了改进后检测搜索策略,详细论述了策略改进依据。对搜索单元检测次数及检测概率进行了仿真,从仿真结果可以看出... 针对Tong检测技术对高动态条件下的检测性能进行了分析。基于高动态大多普勒条件下的应用,进行了Tong检测技术改进研究,提出了改进后检测搜索策略,详细论述了策略改进依据。对搜索单元检测次数及检测概率进行了仿真,从仿真结果可以看出,对有信号搜索单元的驻留检测次数明显减少,总检测时间随之变小,有信号单元的总检测概率得到提高,满足高动态条件下的检测要求。 展开更多
关键词 高动态 tong检测 驻留次数 多普勒
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敦煌吐蕃文书中的“色通(Se tong)”考 被引量:16
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作者 陆离 《敦煌研究》 CSSCI 北大核心 2012年第2期66-72,共7页
敦煌吐蕃文文书中出现地名色通(se tong),应该是敦煌汉文文书中的西同,即今甘肃省阿克塞哈萨克族自治县境内的苏干湖及其附近地区。吐蕃统治时期在该地设有敦煌通颊色通巴(tmhong kyab se tong phavi)军事部落,由吐蕃、吐谷浑、党项、... 敦煌吐蕃文文书中出现地名色通(se tong),应该是敦煌汉文文书中的西同,即今甘肃省阿克塞哈萨克族自治县境内的苏干湖及其附近地区。吐蕃统治时期在该地设有敦煌通颊色通巴(tmhong kyab se tong phavi)军事部落,由吐蕃、吐谷浑、党项、汉等部族成员组成,西同(se tong)亦即敦煌吐鲁番文书中记载的墨离川、墨离海地区。 展开更多
关键词 SE tong 西同 苏干湖 墨离川 墨离海
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Analysis on the Origin and Phylogenetic Status of Tong Sheep Using 12 Blood Protein and Nonprotein Markers
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作者 孙伟 常洪 +5 位作者 杨章平 耿荣庆 角田健司 任战军 陈宏宇 Musa H.Hussein 《Journal of Genetics and Genomics》 SCIE CAS CSCD 北大核心 2007年第12期1097-1105,共9页
This study is based on the Tong sheep obtained by the random sampling method of typical colonies in the central area of Baishui County in Shaanxi Province, China. An investigation was undertaken to clarify the gene co... This study is based on the Tong sheep obtained by the random sampling method of typical colonies in the central area of Baishui County in Shaanxi Province, China. An investigation was undertaken to clarify the gene constitution of blood protein and nonprotein types of Tong sheep. Twelve genetic markers were examined by starch-gel electrophoresis and cellulose acetate electrophoresis. Polymorphism in Tong sheep was found at the following 10 loci, transferrin (Tf), alkaline phosphatase (Alp), leucine aminopeptidase (Lap), arylesterase (Ary-Es), hemoglobin-β (Hb-β), X-protein (X-p), carbonic anhydrase (CA), catalase (Cat), malate dehydrogenase (MDH), and lysine (Ly), whereas, albumin (A1) and postalbumin (Po) loci were monomorphic. Genetic approach degree method and phylogenetic relationship clustering method were used to judge the origin and phylogenetic status of Tong sheep. Results from both methods maintained that Tong sheep belonged to the "Mongolia group", and Mongolia sheep was the origin of Tong sheep. This was also supported by the history of Tong sheep breeding. Compared to the phylogenetic relationship clustering method, the genetic approach degree method was more reliable for the extraction from East and South of Central Asia, and was more effective in reflecting the breeding course of Tong sheep. 展开更多
关键词 tong sheep ORIGIN phylogenetic status genetic approach degree phylogenetic relationship clustering
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温肾通督方促进小鼠脊髓损伤的修复
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作者 赵瑞华 陈思娴 +6 位作者 郭杨 石磊 吴承杰 吴毛 杨光露 张昊恒 马勇 《中国组织工程研究》 CAS 北大核心 2025年第6期1118-1126,共9页
背景:前期研究证实,温肾通督方可通过抑制脾脏B细胞焦亡、促进微血管内皮细胞吞噬髓鞘碎片、影响小胶质细胞迁移和浸润、促进受损神经元恢复、降低脊髓损伤后神经元凋亡等促进脊髓损伤恢复,但其机制尚不明确。目的:探讨温肾通督方对脊... 背景:前期研究证实,温肾通督方可通过抑制脾脏B细胞焦亡、促进微血管内皮细胞吞噬髓鞘碎片、影响小胶质细胞迁移和浸润、促进受损神经元恢复、降低脊髓损伤后神经元凋亡等促进脊髓损伤恢复,但其机制尚不明确。目的:探讨温肾通督方对脊髓损伤小鼠髓系细胞触发受体2(triggering receptor expressed on myeloid cells 2,TREM2)及PI3K/Akt信号通路的影响。方法:取36只C57BL/6小鼠,采用随机数字表法分为假手术组、模型组、温肾通督方组,每组12只。模型组与温肾通督方组采用改良Allen’s法制备小鼠T10脊髓损伤模型,造模后第1天,温肾通督方组灌胃给予温肾通督方,假手术组、模型组灌胃给予生理盐水,每天1次,连续给药28 d。给药期间,通过BMS评分和斜板实验评价各组小鼠运动功能;造模后第7,28天,采用苏木精-伊红染色观察各组小鼠脊髓组织病理变化,免疫荧光染色双标法检测脊髓组织离子化钙结合适配分子1(ionized calcium binding adaptor molecule 1,IBA1)、TREM2蛋白表达,Western blot检测脊髓组织TREM2、PI3K、p-PI3K、Akt、p-Akt、Bcl2、Bax、Caspase3蛋白表达。结果与结论:①BMS评分和斜板实验结果表明,脊髓损伤造模后小鼠后肢运动功能下降,而经过温肾通督方治疗后,脊髓损伤小鼠后肢运动功能明显提升。②苏木精-伊红染色结果显示,与模型组比较,温肾通督方小鼠脊髓组织病理结构明显改善,表现为背侧白质和神经元萎缩程度、细胞质空泡化降低及炎性细胞浸润减少等。③免疫荧光染色结果显示,造模后第7天,模型组IBA1、TREM2蛋白表达均低于假手术组(P<0.05),温肾通督方组IBA1、TREM2蛋白表达均高于模型组(P<0.05);造模后第28天,模型组TREM2蛋白表达低于假手术组(P<0.05),温肾通督方组小鼠脊髓组织中的TREM2蛋白表达高于模型组(P<0.05)。④Western blot检测结果表明,造模后第7天,与假手术组相比,模型组TREM2、Akt蛋白表达及Bcl2/Bax比值降低(P<0.05),p-Akt、Bax蛋白表达及p-Akt/Akt比值升高(P<0.05);与模型组相比,温肾通督方组TREM2、PI3K、p-PI3K、Akt、p-Akt、Bcl2蛋白表达及p-PI3K/PI3K、p-Akt/Ak、Bcl2/Bax比值升高(P<0.05),Bax、Caspase3蛋白表达降低(P<0.05)。造模后第28天,与假手术组相比,模型组TREM2、PI3K、p-PI3K、Akt、p-Akt、Bcl2蛋白表达及Bcl2/Bax比值降低(P<0.05),Bax蛋白表达升高(P<0.05);与模型组相比,温肾通督方组TREM2、PI3K、Akt、p-Akt、Bcl2蛋白表达及Bcl2/Bax比值升高(P<0.05),Bax蛋白表达降低(P<0.05)。⑤结果表明,温肾通督方可能通过上调小胶质细胞TREM2激活PI3K/Akt信号通路,抑制神经元凋亡发挥神经保护作用,进而促进脊髓损伤的修复。 展开更多
关键词 脊髓损伤 温肾通督方 小胶质细胞 髓系细胞触发受体2 PI3K/AKT信号通路
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Introduction to "Ma Shi Wen Tong"
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作者 张楠 《科教导刊》 2015年第10X期23-24,共2页
As the first works of Chinese grammar, "Ma Shi Wen Tong" has epoch-making significance in the history of Chinese grammar. It marks that Chinese grammar study has become an independent science. This research ... As the first works of Chinese grammar, "Ma Shi Wen Tong" has epoch-making significance in the history of Chinese grammar. It marks that Chinese grammar study has become an independent science. This research intends to generalize "Wen Tong". 展开更多
关键词 GRAMMAR MA SHI WEN tong
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