Objective: This study was to investigate the invasiveness of pregnancy-induced hypertension (PIH) trophoblast cells and evaluate the effects of IGF-Ⅱand TGF-β1 on cytotrophoblast invasion.Methods: Cytotrophoblast ce...Objective: This study was to investigate the invasiveness of pregnancy-induced hypertension (PIH) trophoblast cells and evaluate the effects of IGF-Ⅱand TGF-β1 on cytotrophoblast invasion.Methods: Cytotrophoblast cells from normal and PIH placenta were separated and purified. Cytotrophoblast invasiveness of normal and PIH placenta was measured by in vitro invasion assay. Effects of IGF-Ⅱand TGF-β1 on cytotrophoblast invasion were also studied.Results: In PIH group, cytotrophoblast invasiveness was dramatically decreased. In normal group, trophoblast invasiveness was significantly enhanced by IGF-Ⅱ but inhibited by TGF-β1. Neither IGF-Ⅱ nor TGF-β1 had statistically significant effects on PIH trophoblast invasion.Conclusions: PIH cytotrophoblast invasiveness dramatically decreases as compared to the normal level. IGF-Ⅱand TGF-β1 may play an important role in shallow trophoblast invasion on PIH.展开更多
Objective: The purpose of this article is to review the literature assessing foetal and maternal pregnancy outcomes in women with PCOS who used metformin during pregnancy. Study Design: A literature search was conduct...Objective: The purpose of this article is to review the literature assessing foetal and maternal pregnancy outcomes in women with PCOS who used metformin during pregnancy. Study Design: A literature search was conducted using MEDLINE, with analysis of 25 studies that recorded neonatal and maternal outcomes in women who used metformin during pregnancy. The outcomes assessed in this review include congenital deformities, miscarriages, preterm labour, gestational diabetes (GDM) and pregnancy induced hypertension (PIH). Results: We found that the use of metformin throughout pregnancy correlated with decreased rates of preterm labour, GDM and PIH. Conflicting evidence exists over whether metformin use during pregnancy reduced miscarriage rates. The use of metformin during pregnancy did not increase teratogenicity risks. Conclusion: The use of metformin throughout pregnancy is associated with decreased rates of preterm labour, GDM, and PIH. However, more randomised controls involving larger numbers of participants are required for more definitive results.展开更多
目的:分析凝血功能、纤溶指标在妊娠高血压中的表达及给予联合用药后的变化。方法:选择本院2021年8月至2022年8月收治的妊娠期高血压患者84例为观察组,在同一时期选择于本院就诊的健康孕妇84例为对照组,检测并对比观察组及对照组的凝血...目的:分析凝血功能、纤溶指标在妊娠高血压中的表达及给予联合用药后的变化。方法:选择本院2021年8月至2022年8月收治的妊娠期高血压患者84例为观察组,在同一时期选择于本院就诊的健康孕妇84例为对照组,检测并对比观察组及对照组的凝血功能、纤溶指标,之后根据患者高血压严重程度将观察组划分为轻度高血压(n=28)、中度高血压(n=28)以及子痫前期(n=28),对比不同高血压严重程度患者的凝血功能以及纤溶指标,最后给予观察组药物治疗,对比联合用药前、后观察组患者凝血功能、纤溶指标变化情况,借助受试者工作(receiver operating characteristic,ROC)曲线评估诊断效能。结果:两组受试者凝血功能、纤溶指标对比差异有统计学意义(P<0.05)。与治疗前相比,治疗后三组高血压患者的凝血功能、纤溶指标均有所下降,三组高血压患者凝血功能以及纤溶指标对比差异有统计学意义(P<0.05)。ROC曲线分析结果显示,PT的曲线下面积(area under curve,AUC)为1.000,其灵敏度以及特异度分别为100.00%、100.00%,高于其他指标检测的水平。结论:凝血、纤溶指标与妊娠期高血压发病之间存在密切关系,能够为早期妊娠期高血压患者的诊断、治疗提供数据参考,并在治疗后期起到评估预后的作用。展开更多
文摘Objective: This study was to investigate the invasiveness of pregnancy-induced hypertension (PIH) trophoblast cells and evaluate the effects of IGF-Ⅱand TGF-β1 on cytotrophoblast invasion.Methods: Cytotrophoblast cells from normal and PIH placenta were separated and purified. Cytotrophoblast invasiveness of normal and PIH placenta was measured by in vitro invasion assay. Effects of IGF-Ⅱand TGF-β1 on cytotrophoblast invasion were also studied.Results: In PIH group, cytotrophoblast invasiveness was dramatically decreased. In normal group, trophoblast invasiveness was significantly enhanced by IGF-Ⅱ but inhibited by TGF-β1. Neither IGF-Ⅱ nor TGF-β1 had statistically significant effects on PIH trophoblast invasion.Conclusions: PIH cytotrophoblast invasiveness dramatically decreases as compared to the normal level. IGF-Ⅱand TGF-β1 may play an important role in shallow trophoblast invasion on PIH.
文摘Objective: The purpose of this article is to review the literature assessing foetal and maternal pregnancy outcomes in women with PCOS who used metformin during pregnancy. Study Design: A literature search was conducted using MEDLINE, with analysis of 25 studies that recorded neonatal and maternal outcomes in women who used metformin during pregnancy. The outcomes assessed in this review include congenital deformities, miscarriages, preterm labour, gestational diabetes (GDM) and pregnancy induced hypertension (PIH). Results: We found that the use of metformin throughout pregnancy correlated with decreased rates of preterm labour, GDM and PIH. Conflicting evidence exists over whether metformin use during pregnancy reduced miscarriage rates. The use of metformin during pregnancy did not increase teratogenicity risks. Conclusion: The use of metformin throughout pregnancy is associated with decreased rates of preterm labour, GDM, and PIH. However, more randomised controls involving larger numbers of participants are required for more definitive results.
文摘目的:分析凝血功能、纤溶指标在妊娠高血压中的表达及给予联合用药后的变化。方法:选择本院2021年8月至2022年8月收治的妊娠期高血压患者84例为观察组,在同一时期选择于本院就诊的健康孕妇84例为对照组,检测并对比观察组及对照组的凝血功能、纤溶指标,之后根据患者高血压严重程度将观察组划分为轻度高血压(n=28)、中度高血压(n=28)以及子痫前期(n=28),对比不同高血压严重程度患者的凝血功能以及纤溶指标,最后给予观察组药物治疗,对比联合用药前、后观察组患者凝血功能、纤溶指标变化情况,借助受试者工作(receiver operating characteristic,ROC)曲线评估诊断效能。结果:两组受试者凝血功能、纤溶指标对比差异有统计学意义(P<0.05)。与治疗前相比,治疗后三组高血压患者的凝血功能、纤溶指标均有所下降,三组高血压患者凝血功能以及纤溶指标对比差异有统计学意义(P<0.05)。ROC曲线分析结果显示,PT的曲线下面积(area under curve,AUC)为1.000,其灵敏度以及特异度分别为100.00%、100.00%,高于其他指标检测的水平。结论:凝血、纤溶指标与妊娠期高血压发病之间存在密切关系,能够为早期妊娠期高血压患者的诊断、治疗提供数据参考,并在治疗后期起到评估预后的作用。
