In this study, the serum levels of the pregnancy zone protein (PZP) were determined by PZP-single radial immunodiffusion in 708 cases of normal pregnancy, 207 with abormal pregnancy and 188 with gynecological tumors. ...In this study, the serum levels of the pregnancy zone protein (PZP) were determined by PZP-single radial immunodiffusion in 708 cases of normal pregnancy, 207 with abormal pregnancy and 188 with gynecological tumors. The results indicated that serum PZP levels in the normal pregnancy was detectable 5 weeks after gestation. It increased with the advance of gestational weeks, and reached a peak level in week 40. The serum PZP levels in 81.7% of patients with threatened abortion but not aborted were within the normal range, and also mostly in those with pregnancy-nduced hypertension, intrauterine growth retardation (IUGR), anencepbalus and ectopic pregnancy; the serum PZP levels in 51.6% of patients with invasive moles and 80.0% with choriocarcinoma, respectively, were lower than in normal controls. In gynaecological tumors, the serum PZP levels were significantly higher in patients with ovarian carcinomas than in those with other ovarian tumors (P<0.01), and in those with endometrial or cervical carcinoma than in those with uterine myomas (P<0.01). These results suggest that measuring the serum PZP levels may be used as an important reference index to observe threatened abortion and to identify trophoblastic diseases and gynecological tumors.展开更多
妊娠区带蛋白(pregnancy zone protein,PZP)是一种高度依赖雌激素的免疫血浆蛋白,含有多个蛋白酶的识别位点,是一个较好的免疫抑制剂。PZP具有独特的结构和理化性质,在生物医学领域具有重要的应用潜力。近年来,随着ELISA技术和质谱技术...妊娠区带蛋白(pregnancy zone protein,PZP)是一种高度依赖雌激素的免疫血浆蛋白,含有多个蛋白酶的识别位点,是一个较好的免疫抑制剂。PZP具有独特的结构和理化性质,在生物医学领域具有重要的应用潜力。近年来,随着ELISA技术和质谱技术的发展,PZP水平在疾病中得到评估,其水平的升高已被报道与恶性疾病发生有关。该文综述了PZP在相关疾病中的研究进展,并重点阐述了其作为肿瘤的新型血清标志物的研究,以期为肿瘤的诊断提供新思路。展开更多
文摘In this study, the serum levels of the pregnancy zone protein (PZP) were determined by PZP-single radial immunodiffusion in 708 cases of normal pregnancy, 207 with abormal pregnancy and 188 with gynecological tumors. The results indicated that serum PZP levels in the normal pregnancy was detectable 5 weeks after gestation. It increased with the advance of gestational weeks, and reached a peak level in week 40. The serum PZP levels in 81.7% of patients with threatened abortion but not aborted were within the normal range, and also mostly in those with pregnancy-nduced hypertension, intrauterine growth retardation (IUGR), anencepbalus and ectopic pregnancy; the serum PZP levels in 51.6% of patients with invasive moles and 80.0% with choriocarcinoma, respectively, were lower than in normal controls. In gynaecological tumors, the serum PZP levels were significantly higher in patients with ovarian carcinomas than in those with other ovarian tumors (P<0.01), and in those with endometrial or cervical carcinoma than in those with uterine myomas (P<0.01). These results suggest that measuring the serum PZP levels may be used as an important reference index to observe threatened abortion and to identify trophoblastic diseases and gynecological tumors.
文摘妊娠区带蛋白(pregnancy zone protein,PZP)是一种高度依赖雌激素的免疫血浆蛋白,含有多个蛋白酶的识别位点,是一个较好的免疫抑制剂。PZP具有独特的结构和理化性质,在生物医学领域具有重要的应用潜力。近年来,随着ELISA技术和质谱技术的发展,PZP水平在疾病中得到评估,其水平的升高已被报道与恶性疾病发生有关。该文综述了PZP在相关疾病中的研究进展,并重点阐述了其作为肿瘤的新型血清标志物的研究,以期为肿瘤的诊断提供新思路。
