Management of Ectopic Pregnancy in a Broad Ligament and Recurrent Tubal Pregnancy: A Case Report

Broad ligament pregnancy is a rare event and always delays in diagnosis. A pregnant woman in early twenties presented for our center. Routine ultra-sonography revealed a first trimester abdominal pregnancy. Broad ligament pregnancy was diagnosed intraoperation and treated with laparoscopic resection successfully. The patient has a history of right tubal pregnancy 2 years ago and terminated with Laparoscopic Salpingostomy. According to the long term followed-up for the patient, we found that she had recurrent right tubal pregnancy 5 months after the broad ligment ectopic pregnancy. She received the salpingectomy laparoscopically. We presented the case to discuss the clinical management of broad ligament ectopic pregnancy and options of surgical treatments of tubal pregnancy to reduce the risk of recurrent.

Incidental Serous Tubal Intraepithelial Carcinoma Detected by a Surgery for Ectopic Pregnancy

Serous tubal intraepithelial carcinoma is a putative precursor of high-grade serous carcinoma, which is the most common histological type of ovarian or pelvic peritoneal cancer. Serous tubal intraepithelial carcinoma is commonly found in patients with breast cancer susceptibility gene mutations who undergo risk-reducing salpingo-oophorectomy. Incidental serous tubal intraepithelial carcinoma found by a non-prophylactic surgery is rare. A 33-year-old woman referred to our hospital for a diagnosis of ectopic pregnancy. She underwent a laparoscopic right salpingectomy. Pathologically, ectopic pregnancy in the ampulla of the right fallopian tube was confirmed and serous tubal intraepithelial carcinoma was observed in the fallopian tube. Subsequently, she underwent a laparoscopic hysterectomy, bilateral oophorectomy, and left salpingectomy as additional treatment. She has experienced no recurrence thus far for 37 months since the surgery.

Uterine artery embolization in association with methotrexate infusion for the treatment of tubal ectopic pregnancy

Objective To investigate the safety, feasibility, and effectiveness of uterine artery embolization in association with methotrexate(MTX) infusion for the treatment of tubal ectopic pregnancy. Methods Fifty-one patients with tubal ectopic pregnancy were referred for interventional management. All patients received super-selective arteriography of the uterine artery, were infused with 50–100 mg methotrexate(MTX) through a catheter, and underwent embolization of the uterine artery with a gel-foam pledge. Clinical presentation, findings of physical examination, β-HCG values, and the size of the ectopic mass were documented for comparison. The concentration of MTX in blood was evaluated at 0.5, 6, 12, 24, 36, and 48 hours after the procedure. Results Forty-seven out of the 51 patients had clinical resolution of their tubal pregnancy(92.2%). The average time for the β-HCG value to decrease and come back to normal was 9.16 ± 2.54 days(mean +/-SD). MTX levels in peripheral blood could not be detected for patients who received 50 or 75 mg MTX at 36 hours after the procedure, while the MTX level was 0.01 μmol/L at 48 hours after the procedure for patients who received 100 mg. Out of the 4 cases whose ectopic mass size was ≥5 cm, 3 failed to respond to the treatment; however, those whose ectopic mass size was ≤5 cm responded positively to the treatment, regardless of the β-HCG concentration and abdominal bleeding, except for 1 patient who had to undergo laparoscopy for severe abdominal pain and who showed a reduction in her β-HCG level. Conclusion Uterine artery embolization in association with methotrexate infusion is safe and effective in the treatment of tubal ectopic pregnancy, especially for those women with mild to moderate bleeding, or for those at risk of a major hemorrhage. The selection criterion of mass size >5 cm should, therefore, be carefully considered.

Tubal pregnancy with molar degeneration in concurrent eutopic pregnancy. A case report

This research paper presents the infrequent case of a heterotopic pregnancy based on a tubal ectopic pregnancy with molar degeneration in concurrent eutopic pregnancy. Treatment with evacuation/suction curettage and perlaparoscopic salpingectomy was required. This case report confirms what is biologically valid in the statistically unlikely.

Intratubal Methotrexate Injection Combined with Chinese Herbal Medicine for Tubal Pregnancy and Following Pregnancy Prognosis

Objective: To compare the effects of treatment of tubal pregnancy (TP)and its following second pregnancy by intratubal methotrexate injection(IMI) alone and combination of IMI with Chinese herbal medicine. Methods: Thirty-five patients suffering from unruptured TP were divided into two groups at random, to the 19 patients in the treated group, the treatment of combined IMI with Ectopic Pregnancy decoction No. 2 (EP2, a traditional Chinese medical decoction) was applied, and to the other 16 patients in the control group, IMI alone was applied for control. Serum concentrations of human chorionic gonadotro-pinβ(β-HCG), size of the gestational sac, existent time of fetal cardiac beat and peritoneal fluid were measured before and after treatment. And hysterosalpingography were performed 6 months after ending the treatment to verify the presence of tubal obstruction and the condition of relapse.Results: The treatment of all the 35 women was successful. The recovery duration of serumβ-HCG, disappearance duration of TP sac and existent time of peritoneal fluid in the treated group were 20.0±7. 8 days, 1.2±0. 7 months and 10. 7±2. 9 days respectively, which were significantly different from those in the control group (24. 4 ±8.1 days, 3.6±1.7 months and 19.1±3. 2 days respectively(P<0. 05, P<0.01 and P<0. 05 respectively), but the existent time of fetal cardiac beat in the two groups (8.8±1. 9 days vs 9.0±1. 3 days) was not significantly different (P>0.05). The post-treatment oviduct obstructive rate in the two groups was 10.5% and 43.8% respectively, that in the treatment group was less significant (P<0.05). The relapse rate of EP in the treatment group was insignificantly different from that in the control group (5.3% vs 18.8%, P>0.05). Conclusion: The two therapies (IMI alone and IMI combined with EP2) could obtain e-qual efficacy in curing TP. Compared with IMI alone, the combined therapy appears to have the effects of accelerating the resorption of gestational sac and peritoneal fluid, improving the patency of fallopian tube and ameliorating the circumstance of pregnancy, which is favorable to improvement of the re-pregnancy rate and reduction of the re-occurrence of ectopic pregnancy as well as to the enhancement of the effect of IMI in killing trophocytes. But there is not enough proof to show the potency of EP2 in killing embryo.

Tubal Pregnancy with Acute Bleeding Treated by Laparoscopic Surgery: Tips and Case Presentation

Laparoscopic surgery is the standard surgical approach for ectopic pregnancy. However, some surgeons prefer laparotomy for patients with acute bleeding. We evaluated four cases of tubal pregnancy with massive hemoperitoneum (>800 ml) and performed laparoscopic surgery. The patient age ranged from 20 to 37 years, and the gestational age ranged from 5 to 8 weeks. All cases were hemodynamically unstable. Two cases had hemoperitoneum of >2000 mL, which was caused by the rupture of the left isthmus tube. In three cases, surgery could be started within approximately 30 min, and in one case, the start time extended owing to difficulty in anesthesia introduction. Moreover, in three cases, the target lesion was reached within 7 min, and the lesion was excised in approximately 20 min from the start of insufflation, and in one case with a lesion exceeding 7 cm, the time extended. All patients were safely treated via laparoscopic surgery. To initiate surgery without deterioration of the hemodynamic condition, blood transfusion can be started simultaneously with preparation for laparoscopic surgery. Lifting the lesion with a pair of forceps can help immediately stop bleeding, even if it is difficult to secure the visual field owing to massive bleeding. When there is difficulty in anesthesia or a large pregnancy lesion, care should be taken to avoid an increase in the amount of bleeding associated with extension of the perioperative period.

Recurrent tubal pregnancy following ipsilateral partial salpingectomy

A 34-year-old woman came into the Emergency Department of PUMCH with the complaint of sudden lower abdominal pain lasting 4 hours on May 1st, 2004. She had normal menstruation cycle with a period of 30 days. But her last menstruation was started 37 days ago. She experienced laparosalpingectomy for right tubal pregnancy on Jan. 23rd, 2003. During that operation, it was found that she had pelvic adhesions in the Douglas pouch.

Management and Results of Ectopic Pregnancy Adapted by Clinical Guidelines: Two Years Experience of University Hospital in Turkey

Ectopic pregnancy is defined as the fertilized ovum implants in a location outside the endometrial cavity, remains to be an important cause of maternal morbidity and mortality worldwide and is a health problem with incidence ranges between 0.25% and 2% of all pregnancies. In our study, in Izmir Katip Celebi University Ataturk Training and Research Hospital, Department of Obstetrics and Gynecology from 2011 to 2013, 96 cases with diagnosis of ectopic pregnancy managed by the adapted RCOG’s Guide were analyzed retrospectively. The data were analyzed as follows: age, the history of operation, smoking, the presence of intrauterine device, blood groups, hemoglobin, platelets, values of B-hCG, the diagnostic interval, intra-abdominal free fluid and/or acute abdomen, the method of treatment and the success of treatment.

Contralateral Tubal Ectopic Pregnancy after Ovulation of Another Side Ovary in Spontaneous Cycles:A Case Report and Review of the Literature

Pregnancies in the same side tube after the same side ovary ovulation are more common. We report an unusual case of contralateral tubal ectopic pregnancy after ovulation of another side ovary in spontaneous cycles. A 32-year-old woman underwent laparoscopic left fallopian tube conservative surgery because of left tubal pregnancy two years ago. She returned to our hospital with a positive pregnancy test and lower abdominal pain 28 d after the dominant follicle discharged in the right side ovary detected by transvaginal ultrasound in spontaneous cycles. Transvaginal ultrasonography revealed no intrauterine gestational sac but a left adnexal mass measuring 2.6 cm X2.5 cm. Videolaparoscopy was performed, and the diagnosis of an ectopic pregnancy in the let fallopian tube was confirmed by pathologic report. Tubal damage is the most important risk factor for tubal ectopic pregnancy. Embryos can be reversely migrated toward fallopian tubes, due to retrograde action of endometrial waves and uterine contractions, that is another necessary reason which contributes to such tubal pregnancy. Total salpingectomy or tubal sterilization is necessary for avoiding repeated tubal ectopic pregnancy.

Tubal Pregnancy Treated with Trichosanthin and Followed up by Hysterosalpingography

Twenty cases of unruptured tubal pregnancy were treated with trichosanthin intramuscularly.Only two cases were eventoally operated, so the effective rate was 90% . Hysterosalpingography was takenin 14 of 18 cases who was willing to accept the procedure at 0. 5- 1.5 year after the conservative treatment.Both tubes were patent in 10 of 14 cases, the rate of patency was 71.4% .

Factors associated with the incidence of ectopic pregnancy in women undergoing assisted reproductive treatment

Background:Ectopic pregnancy(EP)is a common complication in women undergoing assisted reproductive treatment,but the underlying causes for this remain unclear.This study aimed to explore factors affecting the incidence of EP in in vitro fertilization(IVF)/intracytoplasmic sperm injection(ICSI).Methods:This was a retrospective study on the incidence of EP in IVF/ICSI cycles between January 1,2013 and December 31,2017.Patient age,infertility diagnosis(tubal factor or not),primary or secondary infertility,type of cycle(frozen-thawed or fresh),type of embryo(s)transferred(cleavage embryo or blastocyst),number of embryos transferred(one,two,or three),previous history of EP,and endometrial combined thickness were analyzed to explore their relationships with the incidence of EP.Based on clinical typing results,the patients were divided into an EP group or a non-EP group.Categorical variables were analyzed using Chi-squared test or Fisher exact test.Logistic regression analysis was performed to explore their associations with the incidence of EP.Results:The percentage of patients with primary infertility in EP group was significantly lower than that in non-EP group(31.3%vs.46.7%,χ^2=26.032,P<0.001).The percentage of patients with tubal infertility in EP group was also significantly higher than that in non-EP group(89.2%vs.63.6%,χ^2=77.410,P<0.001).The percentages of patients with transfer of cleavage-stage embryo or blastocyst(91.4%vs.84.4%,χ^2=10.132,P=0.001)and different endometrial combined thickness(ECT)(χ^2=18.373,P<0.001)differed significantly between EP and non-EP groups.For patients who had a previous history of one to four EPs,the percentage of patients undergoing transfer of a cleavage-stage embryo was significantly higher in EP group than that in non-EP group(92.2%vs.77.6%,χ^2=13.737,P<0.001).In multivariate logistic regression analysis,tubal infertility was strongly associated with EP(adjusted odds ratio:3.995,95%confidence interval:2.706-5.897,P<0.001).Conclusions:In IVF/ICSI cycles,transfer of a blastocyst-stage embryo,especially for patients with a previous history of EP,reduced the rate of EP.Tubal infertility was strongly associated with EP.

In vitro fertilization-embryo transfer in patients with unexplained recurrent pregnancy loss

Background:Empiric therapy for patients with unexplained recurrent pregnancy loss(URPL)is not precise.Some patients will ask for assisted reproductive technology due to secondary infertility or advanced maternal age.The clinical outcomes of URPL patients who have undergonein vitro fertilization-embryo transfer(IVF-ET)require elucidation.The IVF outcome and influencing factors of URPL patients need further study.Methods:A retrospective cohort study was designed,and 312 infertile patients with URPL who had been treated during January 2012 to December 2015 in the Reproduction Center of Peking University Third Hospital were included.By comparing clinical outcomes between these patients and those with tubal factor infertility(TFI),the factors affecting the clinical outcomes of URPL patients were analyzed.Results:The clinical pregnancy rate(35.18%vs.34.52%in fresh ET cycles,P=0.877;34.48%vs.40.27%in frozen-thawed ET cycles,P=0.283)and live birth rate(LBR)in fresh ET cycles(27.67%vs.26.59%,P=0.785)were not significantly different between URPL group and TFI group.URPL group had lower LBR in frozen-thawed ET cycles than that of TFI group(23.56%vs.33.56%,P=0.047),but the cumulative LBRs(34.69%vs.38.26%,P=0.368)were not significantly different between the two groups.The increased endometrial thickness(EMT)on the human chorionic gonadotropin day(odds ratio[OR]:0.848,95%confidence interval[CI]:0.748-0.962,P=0.010)and the increased number of eggs retrieved(OR:0.928,95%CI:0.887-0.970,P=0.001)were protective factors for clinical pregnancy in stimulated cycles.The increased number of eggs retrieved(OR:0.875,95%CI:0.846-0.906,P<0.001),the increased two-pronucleus rate(OR:0.151,95%CI:0.052-0.437,P<0.001),and increased EMT(OR:0.876,95%CI:0.770-0.997,P=0.045)in ET day were protective factors for the cumulative live birth outcome.Conclusion:After matching ages,no significant differences in clinical outcomes were found between the patients with URPL and the patients with TFI.A thicker endometrium and more retrieved oocytes increase the probability of pregnancy in fresh transfer cycles,but a better normal fertilization potential will increase the possibility of a live birth.

输卵管部分切除术联合端端吻合术影响患者输卵管通畅性和妊娠的相关因素分析

目的:探讨输卵管部分切除术联合端端吻合术后影响患者输卵管通畅性和妊娠的风险因素。方法:选取2020年1月至2023年4月郑州市妇幼保健院300例输卵管妊娠患者,所有患者均行输卵管部分切除术联合端端吻合术,并于术后行子宫输卵管造影检查。对患者术后输卵管的通畅性进行统计分析,并采用Lasso-Logistic回归分析术后输卵管通畅性的风险因素,Spearman相关性分析法分析各风险因素与术后妊娠的关系。结果:300例患者中输卵管通畅225例(通畅组),输卵管通而不畅54例及输卵管堵塞21例(不通畅组)。单因素分析结果显示,年龄、输卵管孕囊直径、输卵管妊娠部位、手术时机、盆腔粘连、吻合术方式、剩余输卵管长度、盆腔手术史、术中电凝输卵管部位的次数(以下简称术中电凝次数)、术中出血量、手术医生工作年限是术后输卵管通畅性的影响因素(均P<0.01);Lasso回归分析进一步筛选出7个影响因素:输卵管妊娠部位、盆腔粘连、吻合术方式、剩余输卵管长度、盆腔手术史、术中电凝次数、手术医生工作年限;Logistic回归分析结果显示,输卵管峡部妊娠、盆腔粘连、开腹吻合术、盆腔手术史、术中电凝次数是术后输卵管通畅性的独立危险因素,剩余输卵管长度、手术医生工作年限是术后输卵管通畅性的独立保护因素(均P<0.01)。研究随访1年,失访5例。295例患者中,术后1年妊娠192例(65.08%),其中宫内妊娠172例(89.58%),异位妊娠20例(10.42%)。Spearman相关性分析结果显示,输卵管峡部妊娠、盆腔粘连、开腹吻合术、盆腔手术史、术中电凝次数与术后妊娠呈负相关,剩余输卵管长度、手术医生工作年限与术后妊娠呈正相关(均P<0.01)。结论:输卵管峡部妊娠、盆腔粘连、开腹吻合术、盆腔手术史、术中电凝次数是影响输卵管部分切除术联合端端吻合术后患者输卵管通畅性的独立危险因素,且与术后妊娠呈负相关;剩余输卵管长度、手术医生工作年限是影响输卵管部分切除术联合端端吻合术后患者输卵管通畅性的独立保护因素,且与术后妊娠呈正相关。

腹腔镜下输卵管开窗取胚术配合甲氨蝶呤对输卵管妊娠患者宫内妊娠率的影响

目的探讨腹腔镜下输卵管开窗取胚术配合甲氨蝶呤治疗输卵管妊娠的效果。方法120例输卵管妊娠患者分为两组,对照组给予甲氨蝶呤治疗,实验组给予腹腔镜下输卵管开窗取胚术配合甲氨蝶呤治疗,比较两组的治疗效果。结果治疗后,实验组的总有效率高于对照组,月经恢复时间、包块消失时间、腹痛消失时间及住院时间均短于对照组,宫内妊娠率高于对照组(P<0.05)。结论腹腔镜下输卵管开窗取胚术配合甲氨蝶呤治疗输卵管妊娠患者可以提高宫内妊娠率,安全性高。

输卵管异位妊娠史及其治疗方式对IVF/ICSI助孕结局的影响

目的探讨输卵管异位妊娠(TEP)史及其治疗方式对体外受精/卵胞浆内单精子注射(IVF/ICSI)助孕结局的影响。方法选取2019年1月至2021年12月在南京大学医学院附属鼓楼医院生殖医学科首次行IVF/ICSI新鲜周期移植的患者资料,根据有无TEP史分为TEP组和对照组,TEP组再按照输卵管保留与否分为3个亚组:亚组1(双侧输卵管均切除,n=137)、亚组2(单侧输卵管切除,n=410)和亚组3(双侧输卵管均保留,n=100)。分别比较TEP组和对照组,以及TEP不同治疗亚组的一般情况和妊娠结局,包括活产率、临床妊娠率、自然流产率、异位妊娠率等。结果本研究共纳入1294个周期,其中TEP组647个周期,对照组647个周期,两组的不孕年限有显著差异(P<0.05),其余基础资料均无显著差异(P>0.05)。TEP组移植囊胚的周期占比显著高于对照组(P<0.05),但两组的临床妊娠率、活产率、异位妊娠率、自然流产率均无显著差异(P>0.05)。TEP各亚组之间的窦卵泡数(AFC)、基础FSH水平、雌激素水平和异位妊娠率均无显著差异(P>0.05),亚组1的不孕年限最短(P<0.05)、临床妊娠率和活产率最高。结论TEP史对首次行IVF/ICSI助孕患者的妊娠率和活产率没有影响,也不增加再次异位妊娠的风险;接受了双侧输卵管切除术的TEP患者行IVF/ICSI,可以获得更好的妊娠结局。

四维超声子宫输卵管造影术对输卵管性不孕症患者术后妊娠影响

目的:探讨输卵管性不孕症患者行四维超声子宫输卵管造影(4D HyCoSy)结果及与术后自然妊娠关系。方法:收集2021年11月-2023年7月于本院生殖中心门诊疑为输卵管性不孕症,行4D-HyCoS检查显示至少有一侧输卵管通畅或双侧输卵管轻度通而不畅、年龄22~40岁并检查后积极备孕患者120例临床资料。收集患者一般临床资料及造影结果,随访患者造影术后6个月内自然妊娠情况并分为自然妊娠组(n=32)以及非自然妊娠组(n=88)。对比两组一般资料、输卵管通畅情况以及自然妊娠情况,采用多因素分析各因素对造影术后自然妊娠的影响。结果:术后6个月累计妊娠32例(26.7%),妊娠组年龄及不孕年限均小于非妊娠组,输卵管通畅度优于非妊娠组;logistic回归分析显示,年龄大、不孕时间长、输卵管通畅性不佳是和4D HyCoSy后6个月内自然妊娠的不利因素(均P<0.05)。结论:4D-HyCoSy技术能够在检查后短期内提升输卵管不孕症女性的自然妊娠几率;患者年龄大、不孕时间长及输卵管通畅度不佳影响4D-HyCoSy检查后自然妊娠。

超声引导下甲氨蝶呤局部注射联合米非司酮治疗未破裂型输卵管妊娠的临床效果

目的观察超声引导下甲氨蝶呤局部注射联合米非司酮治疗未破裂型输卵管妊娠的临床效果。方法选取2022年9月至2023年12月内蒙古科技大学包头医学院第一附属医院收治的60例未破裂型输卵管妊娠患者作为研究对象,采用随机数字表法分为对照组与观察组,每组30例。对照组采用口服米非司酮治疗,观察组采用超声引导下向未破裂输卵管妊娠囊内注射甲氨蝶呤+口服米非司酮治疗。比较两组β-人绒毛膜促性腺激素(β-HCG)水平、治疗总有效率及不良反应总发生率。结果观察组治疗后3、6d的β-HCG水平低于对照组(P<0.05);观察组治疗总有效率高于对照组(P<0.05);观察组不良反应总发生率为6.67%,低于对照组的30.00%(P<0.05)。结论超声引导下甲氨蝶呤局部注射联合米非司酮治疗未破裂型输卵管妊娠的临床效果显著,能够促进β-HCG水平的恢复,减少不良反应,值得推广。

输卵管妊娠葡萄胎合并腹腔内出血一例

输卵管妊娠葡萄胎在临床上极为罕见,术前诊断大多存在困难,确诊主要依靠术后组织病理学诊断。报告1例38岁女性因右侧输卵管妊娠破裂致腹腔内出血急诊行腹腔镜右侧输卵管切除术,术后病理提示完全性葡萄胎的病例。该患者术后恢复良好,随访期间血清人绒毛膜促性腺激素(human chorionic gonadotropin,hCG)下降满意,无阴道出血、咳嗽和咳血等相关病灶转移症状。输卵管妊娠葡萄胎多表现为急腹症,因此对于急腹症患者临床上应警惕葡萄胎的可能性,其治疗多以手术为主,必要时行化疗,术后需严密随访,注意病变侵蚀及恶变可能。

腹腔镜下输卵管开窗术与切除术对输卵管妊娠患者生育功能及远期预后影响

目的:分析比较腹腔镜下输卵管开窗术与切除术对输卵管妊娠患者生育功能和远期预后的影响.方法:纳入2019年1月-2022年8月本院妇科收治的输卵管妊娠患者100例,按照入院时间顺序编号分为开窗术组和切除术组各50例,分别给予腹腔镜下输卵管开窗术或输卵管切除术.分析两组手术相关指标,术后并发症发生情况,输卵管通畅情况,卵巢储备功能指标以及术后3年内妊娠情况.结果:两组血绒毛膜促性腺激素恢复时间和住院时间无差异(均P>0.05),切除术组手术用时(30.64±3.71min)、术中出血量(59.77±7.50ml)均大于开窗术组(21.38±3.04 min、43.98±6.01ml)(均P0.05).两组术后并发症发生率(32.0%、30.8%)无差异(P>0.05).开窗术组至少一侧输卵管通畅比例(96.0%)大于切除术组(80.0%),术后6个月时血清卵泡刺激素(FSH mIU/ml)(6.71±2.35)及FSH/(黄体生成素)LH(1.49±0.37)均低于切除术组(8.41±3.79mIU/ml、2.19±0.44),雌二醇(78.39±14.90pg/ml)、抗缪勒管激素(4.36±1.96μg/L)水平高于切除术组(50.74±19.02pg/ml、3.61±1.75μg/L),术后3年内宫内妊娠比例(80.0%)及再次异位妊娠比例(18.0%)均高于切除术组(54.0%、6.0%)(均P<0.05)结论:相较于腹腔镜下输卵管切除术,腹腔镜下输卵管开窗术治疗输卵管异位妊娠对患者生育功能影响更小.

The Expression and Change of the β_3 Integrin Subunit and Fibronectin in Normal Human Oviductal Tissue and Tubal Ectopic Pregnant Tissue

Objective To investigate the expression and change of the β3 integrin subunit and fibronectin in normal human oviductal tissue during various phases of the menstrual cycle and tubal ectopic pregnant tissueMethods Samples of normal ( n=29 ) and pregnant fallopian tube ( n=22 ) tissues were obtained from women who had normal cycle and history of normal pregnancy. Normal oviductal tissue samples were divided into 4 groups based on their menstrual cycle. Both expression and distribution of the β3 subunit and fibronectin were determined with the immunohistochemical method and the image analysis.Results The β3 subunit was expressed in the cytoplasm of ciliated cells. The expression level of the β3 subunit was higher after ovulation than that before ovulation in isthmus epithelium (P<0.001), and declined significantly after ovulation in ampullae epithelium (P<0.001). In umbrella epithelium within 4 days after ovulation, the expression level of the β3 subunit was observed at rather higher level among other phases (P <0.001). The ciliated and secretory cells of the epithelium except for where the pregnancy occurred in tubal pregnancy expressed the β3 subunit, and no significant relationship was found between the normal tubal tissue of the secretory phase and tubal ectopic pregnant tissue (P>0.05). Fibronectin was expressed in the basement membrane of human oviductal epithelium and matrix. The expression level of fibronectin was higher in the hyperplastic phase than that in the secretory one (P<0.001). And it was lower in normal tubal tissue of the secretory phase than that in tubal ectopic pregnant tissue (P<0.001).Conclusion Theβ3 integrin subunit was expressed in the ciliated cells of human oviductal epithelium, and fibronectin was expressed in the basement membrane of human oviductal epithelium and matrix. Their expression and change in oviductal tissue is based on different phases of menstrual cycle. The β3 subunit could not related to the occurrence of tubal ectopic pregnancy. Fibronectin could be the potential molecular basis for the tubal ectopic pregnancy.