Objective: To determine baseline iron and oxidative status in a cohort of pregnant women before iron supplementation in our setting. Background: Screening of iron deficiency before supplementation during pregnancy has...Objective: To determine baseline iron and oxidative status in a cohort of pregnant women before iron supplementation in our setting. Background: Screening of iron deficiency before supplementation during pregnancy has been scarce. Therefore, following routine iron supplementation confounding results might be found in outcomes of groups of patients considered. Taking in account that body/serum iron status is reportedly linked to maternal oxidative status, we aimed to associate assessment of baseline iron and oxidative status of women in need of oral supplementation during pregnancy. Methods: This is a cross-sectional study concerning 74 women attending antenatal care at the University Clinics of Kinshasa from September 2017 throughout June 2018, with a singleton pregnancy not exceeding 19 weeks, regardless of age and parity. Variables of the study included sociodemographic and anthropometric ones along with parameters of iron status (hemoglobin, hematocrit, ferritin, serum iron, transferrin and iron saturation capacity). Oxidative status was assessed using superoxide dismutase (SOD) and uric acid as antioxidants, while oxidant agents were oxidized LDL and blood glucose (beside serum iron and ferritin). According to local standards anemia was defined as hemoglobin 10 g/L and pathologic serum ferritin as 15 ng/ml. For statistical calculations we used t-test, chi-square test and Pearson’s correlation test, the significance being stated at p ≤ 0.05. Results: At recruitment (15.9 ± 1.7 9 week gestational age) mean hemoglobin value of the overall study group was 10.3 ± 1.5 g/dl. Anemia was diagnosed to 39 women that represented 52.2% of the study group, most of anemic women belonging to low socioeconomic sub-group (69.2% vs 29%;P < 0.001). The majority was para 2, with average weight of 70.2 ± 14.5 Kg (P not significant between sub-groups) and BMI of 26 ± 5.2 Kg/m2 (P < 0.01). The proportion of obeses was 18.9%. The proportion of intestinal parasitosis was significantly higher among anemic women (61.5% vs 34.3%;P < 0.02) that had lower alimentary iron intake (22.8 ± 4.9 gr/day vs 31.4 ± 9.5 gr;P < 0.001). Of markers of iron status serum ferritin and iron were lower in anemic women (7.5 ± 3.9 ng/ml vs 35.7 ± 17.1 ng/ml;P < 0.001 and 52.7 ± 38.9 μg/dl vs 96.2 ± 41.8 μg/dl, respectively. Both sub-groups were similar in serum transferrin. As of markers of oxidative stress anemic women had significantly higher superoxide dismutases (SOD) (1056.4 ± 762.1 UI/L vs 682.6 ± 543.9 UI/L (P < 0.02) and oxidizedd anti LDL Ac (439.6 ± 209.5 UI/L vs 192.8 ± 136.3 UI/L (P < 0.001). Serum iron, ferritin, SOD and oxidized LDL were more likely to assess iron and oxidative status in our setting. Conclusion: The rate of anemic mothers found in our study (52.2%) has been quite constant in our setting for years, meaning endemicity. Serum iron and ferritin were significantly lower in anemic women, which is supportive of routine iron supplementation during pregnancy. Significantly higher level of SOD and oxidized LDL in anemic women suggests that maternal anemia may count into oxidative stress likely to be found in these women.展开更多
The continence status and the most adequate form of delivery were assessed in pregnant women who had a suburethral band to treat stress urinary incontinence (SUI). A group of 57 women selected from different articles ...The continence status and the most adequate form of delivery were assessed in pregnant women who had a suburethral band to treat stress urinary incontinence (SUI). A group of 57 women selected from different articles published between 2000 and 2014 were reviewed. These women had become pregnant after having undergone a suburethral band procedure. Different aspects such as age, parity, type of band, time elapsed between the procedure and the pregnancy, SUI during pregnancy and after delivery, and the form of delivery were evaluated, as well as the possible relationship with the recurrence of SUI and the emergence of complications associated with the suburethral during pregnancy. A case of a complication related to a suburethral band was found in one patient who developed an episode of pyelonephritis and intermittent urethral obstruction which required a Foley catheter. Thirty patients had cesarean section while 27 had vaginal deliveries;12 patients had incontinence during pregnancy and 15 suffered from it after delivery. Postpartum SUI in relation with the delivery form did not show statistically relevant differences between the cesarean section group and the vaginal delivery group. It was observed that the emergence of SUI during pregnancy was a risk factor for the onset of postpartum SUI (OR = 6.47;p = 0.0137). The risk of developing postpartum SUI seems similar regardless the delivery form, thus it is plausible to recommend vaginal delivery to these patients. If there was a recurrence of SUI, a second suburethral band could be placed which would be as effective as the first one and would involve a lower risk surgery compared to a cesarean section.展开更多
文摘Objective: To determine baseline iron and oxidative status in a cohort of pregnant women before iron supplementation in our setting. Background: Screening of iron deficiency before supplementation during pregnancy has been scarce. Therefore, following routine iron supplementation confounding results might be found in outcomes of groups of patients considered. Taking in account that body/serum iron status is reportedly linked to maternal oxidative status, we aimed to associate assessment of baseline iron and oxidative status of women in need of oral supplementation during pregnancy. Methods: This is a cross-sectional study concerning 74 women attending antenatal care at the University Clinics of Kinshasa from September 2017 throughout June 2018, with a singleton pregnancy not exceeding 19 weeks, regardless of age and parity. Variables of the study included sociodemographic and anthropometric ones along with parameters of iron status (hemoglobin, hematocrit, ferritin, serum iron, transferrin and iron saturation capacity). Oxidative status was assessed using superoxide dismutase (SOD) and uric acid as antioxidants, while oxidant agents were oxidized LDL and blood glucose (beside serum iron and ferritin). According to local standards anemia was defined as hemoglobin 10 g/L and pathologic serum ferritin as 15 ng/ml. For statistical calculations we used t-test, chi-square test and Pearson’s correlation test, the significance being stated at p ≤ 0.05. Results: At recruitment (15.9 ± 1.7 9 week gestational age) mean hemoglobin value of the overall study group was 10.3 ± 1.5 g/dl. Anemia was diagnosed to 39 women that represented 52.2% of the study group, most of anemic women belonging to low socioeconomic sub-group (69.2% vs 29%;P < 0.001). The majority was para 2, with average weight of 70.2 ± 14.5 Kg (P not significant between sub-groups) and BMI of 26 ± 5.2 Kg/m2 (P < 0.01). The proportion of obeses was 18.9%. The proportion of intestinal parasitosis was significantly higher among anemic women (61.5% vs 34.3%;P < 0.02) that had lower alimentary iron intake (22.8 ± 4.9 gr/day vs 31.4 ± 9.5 gr;P < 0.001). Of markers of iron status serum ferritin and iron were lower in anemic women (7.5 ± 3.9 ng/ml vs 35.7 ± 17.1 ng/ml;P < 0.001 and 52.7 ± 38.9 μg/dl vs 96.2 ± 41.8 μg/dl, respectively. Both sub-groups were similar in serum transferrin. As of markers of oxidative stress anemic women had significantly higher superoxide dismutases (SOD) (1056.4 ± 762.1 UI/L vs 682.6 ± 543.9 UI/L (P < 0.02) and oxidizedd anti LDL Ac (439.6 ± 209.5 UI/L vs 192.8 ± 136.3 UI/L (P < 0.001). Serum iron, ferritin, SOD and oxidized LDL were more likely to assess iron and oxidative status in our setting. Conclusion: The rate of anemic mothers found in our study (52.2%) has been quite constant in our setting for years, meaning endemicity. Serum iron and ferritin were significantly lower in anemic women, which is supportive of routine iron supplementation during pregnancy. Significantly higher level of SOD and oxidized LDL in anemic women suggests that maternal anemia may count into oxidative stress likely to be found in these women.
文摘The continence status and the most adequate form of delivery were assessed in pregnant women who had a suburethral band to treat stress urinary incontinence (SUI). A group of 57 women selected from different articles published between 2000 and 2014 were reviewed. These women had become pregnant after having undergone a suburethral band procedure. Different aspects such as age, parity, type of band, time elapsed between the procedure and the pregnancy, SUI during pregnancy and after delivery, and the form of delivery were evaluated, as well as the possible relationship with the recurrence of SUI and the emergence of complications associated with the suburethral during pregnancy. A case of a complication related to a suburethral band was found in one patient who developed an episode of pyelonephritis and intermittent urethral obstruction which required a Foley catheter. Thirty patients had cesarean section while 27 had vaginal deliveries;12 patients had incontinence during pregnancy and 15 suffered from it after delivery. Postpartum SUI in relation with the delivery form did not show statistically relevant differences between the cesarean section group and the vaginal delivery group. It was observed that the emergence of SUI during pregnancy was a risk factor for the onset of postpartum SUI (OR = 6.47;p = 0.0137). The risk of developing postpartum SUI seems similar regardless the delivery form, thus it is plausible to recommend vaginal delivery to these patients. If there was a recurrence of SUI, a second suburethral band could be placed which would be as effective as the first one and would involve a lower risk surgery compared to a cesarean section.
文摘【目的】研究连翘叶提取物(Forsythia suspensa leaves extract,FSLE)对孕马血清促性腺激素(pregnant mare serum gonadotropin,PMSG)在肝脏中代谢的影响,改善在畜牧生产中因PMSG代谢缓慢而造成的氧化应激。【方法】采用半仿生酶醇法提取连翘叶有效成分,给予昆明雌鼠不同含量的FSLE进行动物体内试验;收集小鼠血清,进行酶联免疫吸附试验,检测各组小鼠血清中PMSG的质量浓度;采集小鼠肝脏组织,检测氧化应激指标谷胱甘肽、超氧化物歧化酶、丙二醛和过氧化氢的水平;采用Western-blot检测小鼠肝脏组织孕烷X受体(pregnane X receptor,PXR)和细胞色素酶P45017A1(cytochrome P45017A1,CYP17A1)蛋白的表达水平。【结果】FSLE可显著降低小鼠血清中PMSG的质量浓度,且可以减缓PMSG代谢引起的氧化应激。Western-blot结果显示:FSLE可显著下调小鼠肝组织中PXR和CYP17A1蛋白的表达。【结论】连翘叶提取物可能是通过下调肝脏中PXR和CYP17A1的表达减缓PMSG代谢引起的氧化应激。
