This retrospective study aimed to investigate the clinical characteristics and neonatal outcomes of pregnant women with SARS-COV-2 in Wuhan Children's Hospital and further suggested a possible management strategy ...This retrospective study aimed to investigate the clinical characteristics and neonatal outcomes of pregnant women with SARS-COV-2 in Wuhan Children's Hospital and further suggested a possible management strategy for infected pregnant women under epidemic situation.In this study,8 pregnant women with SARS-COV-2 who were admitted into Wuhan Children's Hospital,China from February 1,2020 to March 30,2020 and the clinical features,laboratory data,maternal and neonatal outcomes were analyzed.The mean age of the women at the time of admission was 30.6 years.The mean gestational age of the women was 37 weeks±4 days,and one woman presented with dichorionic diamniotic(DCDA)twin pregnancy.Except for one woman who was febrile,others had no typical clinical symptoms.For all pregnant women,the count of white blood cells and lymphocytes appeared normal,but 6 had a lower percentage of lymphocytes.C-reactive protein(CRP)levels were normal for all the women.One neonate was tested positive for the coronavirus IgG and IgM antibodies.The clinical symptoms of the pregnant women with SARS-COV-2 were mild,and the laboratory data showed similar characteristics to those of non-infected pregnant women.Since one neonate was tested positive for coronavirus,there is a possibility of vertical transmission of SARS-CoV-2.Prompt and efficient screening,triage,and isolation of pregnant women are ffective management strategies to reduce nosocomial infection during the SARS-COV-2 epidemic.展开更多
More than 90% of HIV-positive children come from mother-to-child transmission, so mother-to-child interdiction is the main measure to prevent AIDS in children. Relevant data show that the incidence of mother-to-child ...More than 90% of HIV-positive children come from mother-to-child transmission, so mother-to-child interdiction is the main measure to prevent AIDS in children. Relevant data show that the incidence of mother-to-child transmission of HIV usually fluctuates between 15% and 50% without intervention. Standardized and effective comprehensive intervention can reduce the transmission rate of mother to child to less than 1%. At present, it is believed that mother-to-child transmission of AIDS can be blocked by comprehensive intervention, and its mechanism has been clearly studied. Combined with highly effective antiviral treatment, safe labor and artificial feeding, the mother to child transmission rate can be reduced to less than 1%. However, due to the effect of drugs on mother-to-child transmission of AIDS may lead to some changes in the main biochemical indicators of mother-to-child, there is no systematic analysis of the viral load, T lymphocyte subsets and major biochemical indicators of HIV/AIDS pregnant women before and after maternal-to-child transmission. In this study, the viral load, T lymphocyte subsets and major biochemical indicators of HIV/AIDS pregnant women before and after maternal-infant blockade were dynamically analyzed. It is hoped that this study will help to observe the basic physical fitness and disease development of pregnant women with HIV/AIDS during pregnancy, to provide a strong basis for the treatment and evaluation of maternal-infant blockade of HIV/AIDS pregnant women, and to establish a complete set of laboratory indicators to understand the body status of pregnant women at all stages to minimize the probability of fetal transmission, which will make good economic and social benefits.展开更多
目的:分析乙肝孕妇乙型肝炎病毒(hepatitis B virus,HBV)脱氧核糖核酸(Deoxyribonucleic acid,DNA)载量检测在母婴传播筛查中的应用效果评估。方法:选取2021年1月至2022年1月乙肝孕妇100例进入研究,根据孕妇乙肝两对半定性检测结果分为...目的:分析乙肝孕妇乙型肝炎病毒(hepatitis B virus,HBV)脱氧核糖核酸(Deoxyribonucleic acid,DNA)载量检测在母婴传播筛查中的应用效果评估。方法:选取2021年1月至2022年1月乙肝孕妇100例进入研究,根据孕妇乙肝两对半定性检测结果分为大三阳组,小三阳组和其他组,比较各组间孕妇新生儿脐带血HBV-DNA载量检测结果及1年后新生儿HBV DNA阳性率;比较不同HBV-DNA载量孕妇新生儿脐带血HBV-DNA载量检测结果。结果:100例孕妇中大三阳46例(46.00%),小三阳32例(32.00%),其他22例(22.00%)。100例孕妇中新生儿脐带血HBV-DNA阳性共14例,宫内感染发生率14.00%。大三阳组新生儿脐带血HBV-DNA阳性率显著高于小三阳组和其他组(P<0.05);三组间1年后新生儿HBV DNA阳性率无显著性差异(P>0.05);100例孕妇中HBV-DNA载量≥10^(5)37例(37.00%),10^(3)~10^(5)44例(44.00%)和<10^(3)19例(19.00%)。HBV-DNA载量≥10^(5)中新生儿脐带血HBV-DNA阳性率显著高于10^(3)~10^(5)和<10^(3)(P<0.05);HBV-DNA载量≥10^(5)中平均新生儿脐带血HBV-DNA log病毒载量显著高于10^(3)~10^(5)(P<0.05)。结论:乙肝孕妇HBV-DNA载量检测对母婴传播具有重要意义,该检测有助于评估孕妇感染程度、预测婴儿感染风险,并监测治疗效果,值得推广应用。展开更多
Objective:To evaluate efficiency of HAART in the prevention of mother to child HIV transmission.Methods:A longitudinal study was conducted on 1 300 women attending the antenatal service at Saint Camille Medical Centre...Objective:To evaluate efficiency of HAART in the prevention of mother to child HIV transmission.Methods:A longitudinal study was conducted on 1 300 women attending the antenatal service at Saint Camille Medical Centre from September 2010 to July 2011.The HIV status of mothers was determined by rapid tests and EUSA.Discordant results were confirmed by real-time PCR.PCR was used to determine HIV status of children born from HIV-positive mothers.Results:Among 1 300 pregnant women tested for HIV,378 were seropositive.Mothers were predominantly housewives(69.7%),and their mean age was(28.32±0.15) years.The overall prevalence of HIV transmission from mother to child was 4.8%(18/378).This prevalence differed significantly from 0.0%(0/114) to 6.8%(18/264) in children born from mothers under HAART and those with mothers under New Prophylactic Protocol(ACT + 3TC + NVP),respectively(P【 0.01).Children’s mortality rate during the medical follow up was 1.3%(5/378).Among 16 women with HIV dubious status by ELISA,the Real Time PCR confirmed 2/16(12.5%) as HIV positive. Conclusions:The protocol of prevention of mother to children HIV transmission(PMTCT) is effective.The rate of HIV vertical transmission is significantly reduced.Early diagnosis determined by PCR of children born from HIV- positive mother is necessary and recommended in the context of PMTCT in Burkina Faso.We also found that PCR is an effective tool to confirm HIV status in pregnant women.展开更多
目的系统评价孕产妇配偶参与围产期保健体验的质性研究,为更好地开展护理实践提供依据。方法系统检索Cochrane Library、PubMed、Web of Science、CINAHL、Embase、Scopus、中国知网、万方数据库、中国生物医学文献数据库、维普数据库,...目的系统评价孕产妇配偶参与围产期保健体验的质性研究,为更好地开展护理实践提供依据。方法系统检索Cochrane Library、PubMed、Web of Science、CINAHL、Embase、Scopus、中国知网、万方数据库、中国生物医学文献数据库、维普数据库,检索关于孕产妇配偶参与围产期保健体验质性研究,检索时限从建库至2022年10月11日。本研究使用2016版JBI循证卫生保健中心质性研究质量评价标准对纳入文献进行质量评价,运用Meta整合方法对研究结果进行整合。结果共纳入13篇研究,质量等级均为B级。提炼出44个研究结果,将相似结果归纳组合形成6个新的类别,并整合为3个结果:孕产妇配偶积极参与体验;孕产妇配偶消极参与体验;孕产妇配偶感觉参与围产期保健外界阻力重重。结论孕产妇配偶参与围产期母婴保健存在复杂情绪体验,需要结合我国国情及不同地区的卫生保健环境,深入探讨促进该群体参与母婴保健的系统策略,以确保其参与围产期保健的实施效果。展开更多
目的探讨妇幼健康信息化在高危孕产妇管理工作中的应用效果。方法选取2019年1—12月深圳市南山区妇幼保健院实施常规管理的100例高危孕产妇作为对照组,选取2020年1—12月深圳市南山区妇幼保健院实施妇幼健康信息化管理的100例高危孕产...目的探讨妇幼健康信息化在高危孕产妇管理工作中的应用效果。方法选取2019年1—12月深圳市南山区妇幼保健院实施常规管理的100例高危孕产妇作为对照组,选取2020年1—12月深圳市南山区妇幼保健院实施妇幼健康信息化管理的100例高危孕产妇中作为研究组。对比2组管理效果。结果研究组登记建档率、产检次数高于对照组,胎儿宫内窘迫、新生儿窒息发生率低于对照组(P<0.05)。研究组产妇急性事件总发生率为4.00%,低于对照组的15.00%(P<0.05)。管理后,研究组遵医嘱依从性(遵医嘱服药、科学运动、合理饮食、规律作息、自我管理)评分高于对照组,焦虑自评量表评分(self-rating anxiety scale,SAS)低于对照组(P<0.05)。出院时,研究组满意度(主动服务、健康宣教、交流能力、操作水平、环境评估)评分高于对照组(P<0.05)。管理后,研究组健康调查简表(the MOS item short fromhealth survey,SF-36)评分高于对照组(P<0.05)。结论高危孕产妇管理中使用妇幼健康信息化技术有利于提高管理效果,预防产妇急性事件的发生,改善产妇不良情绪,提高其遵医嘱依从性和生活质量,提高产妇对护理服务的满意度。展开更多
基金supported by Wuhan Health Commission Fund,China(No.WX14A08).
文摘This retrospective study aimed to investigate the clinical characteristics and neonatal outcomes of pregnant women with SARS-COV-2 in Wuhan Children's Hospital and further suggested a possible management strategy for infected pregnant women under epidemic situation.In this study,8 pregnant women with SARS-COV-2 who were admitted into Wuhan Children's Hospital,China from February 1,2020 to March 30,2020 and the clinical features,laboratory data,maternal and neonatal outcomes were analyzed.The mean age of the women at the time of admission was 30.6 years.The mean gestational age of the women was 37 weeks±4 days,and one woman presented with dichorionic diamniotic(DCDA)twin pregnancy.Except for one woman who was febrile,others had no typical clinical symptoms.For all pregnant women,the count of white blood cells and lymphocytes appeared normal,but 6 had a lower percentage of lymphocytes.C-reactive protein(CRP)levels were normal for all the women.One neonate was tested positive for the coronavirus IgG and IgM antibodies.The clinical symptoms of the pregnant women with SARS-COV-2 were mild,and the laboratory data showed similar characteristics to those of non-infected pregnant women.Since one neonate was tested positive for coronavirus,there is a possibility of vertical transmission of SARS-CoV-2.Prompt and efficient screening,triage,and isolation of pregnant women are ffective management strategies to reduce nosocomial infection during the SARS-COV-2 epidemic.
文摘More than 90% of HIV-positive children come from mother-to-child transmission, so mother-to-child interdiction is the main measure to prevent AIDS in children. Relevant data show that the incidence of mother-to-child transmission of HIV usually fluctuates between 15% and 50% without intervention. Standardized and effective comprehensive intervention can reduce the transmission rate of mother to child to less than 1%. At present, it is believed that mother-to-child transmission of AIDS can be blocked by comprehensive intervention, and its mechanism has been clearly studied. Combined with highly effective antiviral treatment, safe labor and artificial feeding, the mother to child transmission rate can be reduced to less than 1%. However, due to the effect of drugs on mother-to-child transmission of AIDS may lead to some changes in the main biochemical indicators of mother-to-child, there is no systematic analysis of the viral load, T lymphocyte subsets and major biochemical indicators of HIV/AIDS pregnant women before and after maternal-to-child transmission. In this study, the viral load, T lymphocyte subsets and major biochemical indicators of HIV/AIDS pregnant women before and after maternal-infant blockade were dynamically analyzed. It is hoped that this study will help to observe the basic physical fitness and disease development of pregnant women with HIV/AIDS during pregnancy, to provide a strong basis for the treatment and evaluation of maternal-infant blockade of HIV/AIDS pregnant women, and to establish a complete set of laboratory indicators to understand the body status of pregnant women at all stages to minimize the probability of fetal transmission, which will make good economic and social benefits.
基金the Episcopal Italian Conference in Roma,Italy,for the financial support
文摘Objective:To evaluate efficiency of HAART in the prevention of mother to child HIV transmission.Methods:A longitudinal study was conducted on 1 300 women attending the antenatal service at Saint Camille Medical Centre from September 2010 to July 2011.The HIV status of mothers was determined by rapid tests and EUSA.Discordant results were confirmed by real-time PCR.PCR was used to determine HIV status of children born from HIV-positive mothers.Results:Among 1 300 pregnant women tested for HIV,378 were seropositive.Mothers were predominantly housewives(69.7%),and their mean age was(28.32±0.15) years.The overall prevalence of HIV transmission from mother to child was 4.8%(18/378).This prevalence differed significantly from 0.0%(0/114) to 6.8%(18/264) in children born from mothers under HAART and those with mothers under New Prophylactic Protocol(ACT + 3TC + NVP),respectively(P【 0.01).Children’s mortality rate during the medical follow up was 1.3%(5/378).Among 16 women with HIV dubious status by ELISA,the Real Time PCR confirmed 2/16(12.5%) as HIV positive. Conclusions:The protocol of prevention of mother to children HIV transmission(PMTCT) is effective.The rate of HIV vertical transmission is significantly reduced.Early diagnosis determined by PCR of children born from HIV- positive mother is necessary and recommended in the context of PMTCT in Burkina Faso.We also found that PCR is an effective tool to confirm HIV status in pregnant women.
文摘目的系统评价孕产妇配偶参与围产期保健体验的质性研究,为更好地开展护理实践提供依据。方法系统检索Cochrane Library、PubMed、Web of Science、CINAHL、Embase、Scopus、中国知网、万方数据库、中国生物医学文献数据库、维普数据库,检索关于孕产妇配偶参与围产期保健体验质性研究,检索时限从建库至2022年10月11日。本研究使用2016版JBI循证卫生保健中心质性研究质量评价标准对纳入文献进行质量评价,运用Meta整合方法对研究结果进行整合。结果共纳入13篇研究,质量等级均为B级。提炼出44个研究结果,将相似结果归纳组合形成6个新的类别,并整合为3个结果:孕产妇配偶积极参与体验;孕产妇配偶消极参与体验;孕产妇配偶感觉参与围产期保健外界阻力重重。结论孕产妇配偶参与围产期母婴保健存在复杂情绪体验,需要结合我国国情及不同地区的卫生保健环境,深入探讨促进该群体参与母婴保健的系统策略,以确保其参与围产期保健的实施效果。
文摘目的探讨妇幼健康信息化在高危孕产妇管理工作中的应用效果。方法选取2019年1—12月深圳市南山区妇幼保健院实施常规管理的100例高危孕产妇作为对照组,选取2020年1—12月深圳市南山区妇幼保健院实施妇幼健康信息化管理的100例高危孕产妇中作为研究组。对比2组管理效果。结果研究组登记建档率、产检次数高于对照组,胎儿宫内窘迫、新生儿窒息发生率低于对照组(P<0.05)。研究组产妇急性事件总发生率为4.00%,低于对照组的15.00%(P<0.05)。管理后,研究组遵医嘱依从性(遵医嘱服药、科学运动、合理饮食、规律作息、自我管理)评分高于对照组,焦虑自评量表评分(self-rating anxiety scale,SAS)低于对照组(P<0.05)。出院时,研究组满意度(主动服务、健康宣教、交流能力、操作水平、环境评估)评分高于对照组(P<0.05)。管理后,研究组健康调查简表(the MOS item short fromhealth survey,SF-36)评分高于对照组(P<0.05)。结论高危孕产妇管理中使用妇幼健康信息化技术有利于提高管理效果,预防产妇急性事件的发生,改善产妇不良情绪,提高其遵医嘱依从性和生活质量,提高产妇对护理服务的满意度。
