Thepathogenesisof prem ature ovarian failure (POF) rem ains unknow n. Accu- m ulated evidences indicate that abnorm ality in the im m une system m ay be one of the m ajor reasonsand theim balanceof Thelp typeI(Th1) ...Thepathogenesisof prem ature ovarian failure (POF) rem ains unknow n. Accu- m ulated evidences indicate that abnorm ality in the im m une system m ay be one of the m ajor reasonsand theim balanceof Thelp typeI(Th1) and Thelp typeII(Th2) m ay play an importantrolein theprocess. Study of thedistribution and functionalstatusof Th1/Th2 m ay behelpfulforevaluating thepathogenesisof POF.13 patientsw ith id- iopathic POFand 7 w om en of reproductiveagew ith norm alcyclew ereenrolled in this study.The percentage of Th1 and Th2 cellsfrom peripheralblood of thepatientsand the controls w as studied using FITC labelled CD4 m Ab to separate CD4+ cells by FACS, in com bination w ith in situ hybridization using Dig-labelled IL2, IL6 cDNA probes.Results:The patients w ith POF had significantly higher percentage of Th1 cellsascompared w ith the controls(49.76±9.22,20.06±7.10respectively, P< 0.001).The ratio of Th1/Th2 in thepatientsw ith POFw assignificantly higherthan thatof thecontrols(1.15±0.17, 0.63±0.09, P< 0.001). Conclusions: Thefindings of thisstudy suggestthatpatientsw ith POFhaveincreased Th1 cellactivation, w hich m ay be related to the pathogenesisof POF. Corresponding author: WANG Yi-li E-m ail: w yl@ irix. xam u. edu. cn展开更多
In this paper,we present observations of free oscillations of the Earth after major earthquakes in Chile(February 27,2010,Mw8.8)and Japan(March 11,2011,Mw9.1)using data from the dual-sphere superconducting gravimeter(...In this paper,we present observations of free oscillations of the Earth after major earthquakes in Chile(February 27,2010,Mw8.8)and Japan(March 11,2011,Mw9.1)using data from the dual-sphere superconducting gravimeter(SG-055),installed at Badargadh(23°0.47 N,70°0.62 E),Kutch,Gujarat,India in March 2009.To see the noise characteristics,we calculated the power spectral density of the gravity time series of 5 quiet days in the frequency band 0.05-20 mHz using the new low noise model(NLNM)as a reference.We compared the noise level of the Badargadh site to other SG sites around the world.This shows that the Badargadh SG is in a low noise state.We find that the noise increases at frequencies below 1 mHz.Such a characteristic is also observed in Djougou(Afrique,Benin)and Strasbourg(France).Using theoretical tides for Gujarat,we estimated a scale factor of about-814 nm/s~2/V for Gravl(lowersphere)and about-775 nm/s~2/V for Grav2(upper-sphere).We corrected the influence of atmospheric pressure from the one-second gravity data before switching to the frequency domain.We extracted a total of 53 Earth’s Free Oscillations(EFO)modes during the earthquake in Japan and about 47 EFO modes during the earthquake in Chile.We are able to extract the lowest0S2spheroidal mode(0.30945 mHz or54 min)and0S0radial mode(0.81439 mHz or 20 min).The longer time series shows individual0S2singlets and0S3(0.46855 mHz)singlets due to the Coriolis splitting effect.We cross-referenced the frequencies of these modes using the PREM model and previous global observations.The correlation coefficient between the observed and the PREM model for these two events are 0.999 for Japan earthquake and 0.993 for Chile earthquake.This validates the quality of the data useful for low-frequency studies in seismology.We also calculated the relative deviations of our observed fundamental modes with previously determined observed and theoretical values.We found that the relative deviations of our observed free oscillations do not exceed 0.5%,indicating good correlations.展开更多
文摘Thepathogenesisof prem ature ovarian failure (POF) rem ains unknow n. Accu- m ulated evidences indicate that abnorm ality in the im m une system m ay be one of the m ajor reasonsand theim balanceof Thelp typeI(Th1) and Thelp typeII(Th2) m ay play an importantrolein theprocess. Study of thedistribution and functionalstatusof Th1/Th2 m ay behelpfulforevaluating thepathogenesisof POF.13 patientsw ith id- iopathic POFand 7 w om en of reproductiveagew ith norm alcyclew ereenrolled in this study.The percentage of Th1 and Th2 cellsfrom peripheralblood of thepatientsand the controls w as studied using FITC labelled CD4 m Ab to separate CD4+ cells by FACS, in com bination w ith in situ hybridization using Dig-labelled IL2, IL6 cDNA probes.Results:The patients w ith POF had significantly higher percentage of Th1 cellsascompared w ith the controls(49.76±9.22,20.06±7.10respectively, P< 0.001).The ratio of Th1/Th2 in thepatientsw ith POFw assignificantly higherthan thatof thecontrols(1.15±0.17, 0.63±0.09, P< 0.001). Conclusions: Thefindings of thisstudy suggestthatpatientsw ith POFhaveincreased Th1 cellactivation, w hich m ay be related to the pathogenesisof POF. Corresponding author: WANG Yi-li E-m ail: w yl@ irix. xam u. edu. cn
基金the Department of Science and Technology,Government of Gujarat for providing the necessary funds for the study。
文摘In this paper,we present observations of free oscillations of the Earth after major earthquakes in Chile(February 27,2010,Mw8.8)and Japan(March 11,2011,Mw9.1)using data from the dual-sphere superconducting gravimeter(SG-055),installed at Badargadh(23°0.47 N,70°0.62 E),Kutch,Gujarat,India in March 2009.To see the noise characteristics,we calculated the power spectral density of the gravity time series of 5 quiet days in the frequency band 0.05-20 mHz using the new low noise model(NLNM)as a reference.We compared the noise level of the Badargadh site to other SG sites around the world.This shows that the Badargadh SG is in a low noise state.We find that the noise increases at frequencies below 1 mHz.Such a characteristic is also observed in Djougou(Afrique,Benin)and Strasbourg(France).Using theoretical tides for Gujarat,we estimated a scale factor of about-814 nm/s~2/V for Gravl(lowersphere)and about-775 nm/s~2/V for Grav2(upper-sphere).We corrected the influence of atmospheric pressure from the one-second gravity data before switching to the frequency domain.We extracted a total of 53 Earth’s Free Oscillations(EFO)modes during the earthquake in Japan and about 47 EFO modes during the earthquake in Chile.We are able to extract the lowest0S2spheroidal mode(0.30945 mHz or54 min)and0S0radial mode(0.81439 mHz or 20 min).The longer time series shows individual0S2singlets and0S3(0.46855 mHz)singlets due to the Coriolis splitting effect.We cross-referenced the frequencies of these modes using the PREM model and previous global observations.The correlation coefficient between the observed and the PREM model for these two events are 0.999 for Japan earthquake and 0.993 for Chile earthquake.This validates the quality of the data useful for low-frequency studies in seismology.We also calculated the relative deviations of our observed fundamental modes with previously determined observed and theoretical values.We found that the relative deviations of our observed free oscillations do not exceed 0.5%,indicating good correlations.
