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去卵巢后痴呆大鼠模型β淀粉样蛋白及tau蛋白的变化及倍美力的干预作用 被引量:1
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作者 赵珩 于振香 +2 位作者 张海英 张昱 李晶 《中国老年学杂志》 CAS CSCD 北大核心 2007年第19期1853-1855,共3页
目的观察去卵巢后痴呆大鼠模型海马CA1区β淀粉样蛋白(Aβ)及tau蛋白阳性神经元的变化及倍美力(Premain)对其的影响,探讨倍美力的脑保护作用机制。方法采用穹窿海马伞切除术制备AD模型鼠,切除穹窿海马伞、双侧卵巢切除制备痴呆及雌激素... 目的观察去卵巢后痴呆大鼠模型海马CA1区β淀粉样蛋白(Aβ)及tau蛋白阳性神经元的变化及倍美力(Premain)对其的影响,探讨倍美力的脑保护作用机制。方法采用穹窿海马伞切除术制备AD模型鼠,切除穹窿海马伞、双侧卵巢切除制备痴呆及雌激素缺乏复合模型鼠,采用Morris水迷宫观察其行为学改变,利用免疫组织化学染色法测定大鼠海马CA1区Aβ及tau蛋白阳性神经元的表达。结果倍美力治疗组大鼠学习、记忆能力增强,海马CA1区Aβ及tau蛋白阳性神经元的表达低于正常组及模型组。结论倍美力有助于改善痴呆及雌激素缺乏复合模型鼠的学习及记忆能力。 展开更多
关键词 倍美力 老年性痴呆 β淀粉样蛋白(Aβ):tau蛋白
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去卵巢及穹窿海马伞切断复合模型大鼠不同脑区雌激素α受体mRNA的表达及倍美力的干预作用 被引量:1
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作者 赵珩 贾晓静 +1 位作者 张昱 李晶 《中风与神经疾病杂志》 CAS CSCD 北大核心 2007年第6期665-667,共3页
目的观察倍美力对去卵巢及穹窿海马伞切断后大鼠脑皮质、基底前脑及海马CA_1区雌激素α受体(estrogen receptor alpha,ERa)mRNA表达的干预作用,探讨其脑保护作用的机制。方法健康雌性Wister大鼠30只,随机分成对照组、模型组、倍美力组;... 目的观察倍美力对去卵巢及穹窿海马伞切断后大鼠脑皮质、基底前脑及海马CA_1区雌激素α受体(estrogen receptor alpha,ERa)mRNA表达的干预作用,探讨其脑保护作用的机制。方法健康雌性Wister大鼠30只,随机分成对照组、模型组、倍美力组;制备去卵巢及穹窿海马伞切断复合模型大鼠,采用Morris水迷宫观察其学习、记忆能力,利用RT-PCR及Western blotting法观察每组大鼠不问脑区雌激素α受体mRNA及蛋白的表达。结果模型组大鼠脑皮质、基底前脑、海马CA_1区雌激素α受体mRNA及蛋白的表达明显降低,学习、记忆能力下降,与对照组、倍美力组比较有显著差异(P<0.01);对照组与倍美力组比较无明显差异(P>0.05)。结论倍美力可上调大鼠脑皮质、基底前脑及海马CA_1区雌激素α受体mRNA及蛋白的表达,可能参与了学习、记忆能力的改善。 展开更多
关键词 倍美力 雌激素Α受体 去卵巢 阿尔茨海默病
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Kinematics of the high-excitation HH 890 jet in the Rosette Nebula
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作者 Jin-Zeng Li 《Chinese Journal of Astronomy and Astrophysics》 CSCD 2009年第5期577-584,共8页
Photoionized jets immersed in HII regions display special properties, which made them a distinctive category of Herbig-Haro (HH) flows. Detailed studies of such jet systems became one of the key issues in our unders... Photoionized jets immersed in HII regions display special properties, which made them a distinctive category of Herbig-Haro (HH) flows. Detailed studies of such jet systems became one of the key issues in our understanding of jet production and evolution. HH 890, initially called the Rosette HH2 jet, is the second photoionized jet discovered in the spectacular HII region of the Rosette Nebula. Contrary to conventional impressions of a jet, its discrete components are found to be unexpectedly broad and spatially detached from the proposed energy source. The jet displays additional unusual features which point to the disputable nature of the system. Here, we investigate the kinematics of the jet through high-quality echelle spectrograms. It is distinctively resolved into a fast component with a mean approaching velocity of-39 km s^-1 with respect to the systemic rest frame and a slow component with radial velocity centered at -9 km s^-1. The slow component indicates an apparently larger dispersion in radial velocity in various emission lines and is likely dissolving at roughly the speed of sound, which favors a photoevaporated origin. The [SII] doublet ratios indicate an electron density of -1.1×10^3 cm^-3 in the collimated jet and ,-9×10^2 cm^-3 in the HII region. This, along with the diffuse appearance of the extensive part of the jet, leads to a dissipation of the jet in the fully ionized medium of Rosette. In addition, time series of photometric observations provide evidence for remarkable light variations of the energy source. Its amplitudes of variation amount to 〉 1 mag in both R and I, which is commensurate with the young evolutionary status of the source as indicated by a red, late type optical spectrum. 展开更多
关键词 accretion disks -- ISM jets and outflows -- stars formation -- stars premain-sequence
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