Prevalence of Premature Ejaculation among Patients with Type 2 Diabetes in a Tertiary Health Institution: A Cross-Sectional Study

Background: Premature ejaculation (PE) is one of the sexual dysfunctions commonly present among patients with diabetes mellitus (DM), but rarely reported and not commonly investigated compared to erectile dysfunction. In this study, we aimed to investigate the prevalence of PE in a group of patients with type 2 DM and explore possible determinants of its occurrence and its association with erectile dysfunction. Methods: This was a cross-sectional study of subjects recruited from the Diabetes clinic and whose sexual function was assessed using the premature ejaculation diagnostic tool (PEDT) and erection hardness score (EHS), who were in heterosexuals relationship and resides together with their wives and had no major organ failure or acute infection within the last 1 month. Other socio-demographic history and diabetes-related questions were assessed. Results: A total of 69 subjects were recruited. The prevalence of PE was 27.5% in the study. There was a significant inverse relationship between the prevalence of premature ejaculation and frequency of sexual intercourse. Almost half 14/30 (46.7%) of those with erectile dysfunction had premature ejaculation. Diabetic patients with erectile dysfunction (ED) showed a significantly higher incidence of PE with significantly lower values of EHS. Higher level of fasting blood glucose was associated with higher prevalence of erectile dysfunction. Conclusions: The prevalence of PE was relatively high at 19/69 (27.5%) among our type 2 diabetic patients. Hence, health care giver should always endeavour to ask about it even when patients do not volunteer the information.

Current therapeutic strategies for premature ejaculation and future perspectives

早泄(PE ) 是在被骚乱在外部、中央的神经系统调停的人的普通性混乱。尽管为 PE 的所有药品的治疗是，当前使用 &#x02018； off-label' ，一些新奇口头的代理人和药管理的一些更新的方法现在提供重要地势给 PE 病人。然而，这个条件的原因论没被统一，首先因为为基本研究和为在有 PE 的病人的基于证据的临床的研究的一个广泛地接受的定义和评价工具的缺席的一个标准动物模型的缺乏。在这评论，我们为 PE 集中于当前的治疗学的策略和未来治疗观点。

Sexual function of premature ejaculation patients assayed with Chinese Index of Premature Ejaculation

Aim: To assess the psychometric properties of the Chinese Index of Premature Ejaculation (CIPE).Methods: The sexual function of 167 patients with and 114 normal controls without premature ejaculation (PE) were evaluated with CIPE. All subjects were married and had regular sexual activity. The CIPE has 10 questions, focusing on libido, erectile function, ejaculatory latency, sexual satisfaction and difficulty in delaying ejaculation, self-confidence and depression. Each question was responded to on a 5 point Likert-type scale. The individual question score and the total scale score were analyzed between the two groups. Results: There were no significant differences between the age, duration of marriage and educational level (P>0.05) of patients with and without PE and normal controls. The mean latency of patients with PE and normal controls were 1.6±1.2 and 10.2±9.5 minutes,respectively. Significant differences between patients with (26.7±4.6) PE and normal controls (41.9±4.0) were observed on the total score of CIPE (P<0.01). Using binary logistic regression analysis, PE was significantly related to five questions of the original measure. They are the so-called the CIPE-5 and include: ejaculatory latency, sexual satisfaction of patients and sexual partner, difficulty in delaying ejaculation, anxiety and depression. Receiver Operating Characteristic (ROC) curve analysis of CIPE-5 questionnaire indicated that the sensitivity and specificity of CIPEwere 97.60% and 94.74%, respectively. Employing the total score of CIPE-5, patients with PE could be divided intothree groups: mild (>15 point) 19.8%, moderate (10～14 point) 62.8% and severe (<9point) 16.7%. Conclusion:The CIPE-5 is a useful method for the evaluation of sexual function of patients with PE and can be used as a clinical endpoint for clinical trials studying the efficacy of pharmacological intervention.

Premature ejaculation： current and future treatments

早泄(PE ) 被认出是最普通的男性混乱。因为有食物药品管理局(食物及药品管理局) 同意的既不一个普遍接受的定义也不药， PE 为对待这个条件的专业人员提供困难。尽管有这些缺点，医生们继续根据主要指南与 PE 诊断他们的病人并且与行为的治疗或离开标签药对待他们。这评论为 PE 集中于当前、新兴的治疗选择和药。每种治疗选择的优点和限制根据当前的出版考察同伴的文学被讨论。

New insights on premature ejaculation： a review of ：lefinition, classification, prevalence and treatmeni

关于早泄(PE ) 的定义，分类和流行有进行中的争论。PE 的第一个基于证据的定义与终生的 PE 被限制到异性爱的人从事阴道交际。不幸地，有 PE 的抱怨的许多病人不满足这些标准。然而，这些人能作为 PE 子类型，也就是获得的 PE，自然可变 PE 或象早熟一样之一被诊断射精的机能障碍。不过，这些子类型的有效性被证据还没支持了。一个普遍接受的 PE 定义的缺席和为数据获得的标准的缺乏导致了报导了冲突率的流行研究。20 &#x00025 的高流行； -30&#x00025；可能由于在如此的调查被进行的时间在定义使用的含糊的术语。尽管当为基于人口的流行研究询问了时，许多人可以抱怨 PE，仅仅他们的一些将活跃地为他们的抱怨寻求治疗，尽管大多数这些病人将定义与 PE 适合的症状。获得的 PE 病人的抱怨可能是更严重的，而经历象早熟一样的病人的抱怨射精的机能障碍与 PE 的各种各样的形式在人之中似乎最少严重。尽管众多的治疗形式为 PE 的管理被建议了，仅仅抗抑郁剂和热门麻木的乳脂当前被证明了有效。当任何一个都没被规章的机构同意了治疗形式，进一步的研究不管多么必须被带为 PE 开发有益的治疗策略。

Safety and efficacy of tramadol hydrochloride on treatment of premature ejaculation

早泄(PE ) 是最普通的性混乱。它影响 20 &#x00025； -30&#x00025；成年的人；这个条件的原因论还没被阐明了。这研究的目的是为 PE 的处理在不同剂量评估有性交的功效，安全， tolerability，不受欢迎的效果和对 tramadol hydrochloride 的改进满足。介绍了与的 300 个病人的一个总数终生(主要) PE 在这研究被包括。学习被执行 28 个星期，安慰剂(淀粉药片) 在被给 4 个星期，并且活跃成分(tramadol hydrochloride ) 在不同治疗学的剂量被管理 24 个星期。病人们被划分成三个相等的组，每由 100 个病人组成。第一组(A) 被给 tramadol hydrochloride 囊 25 &#x000a0； mg。第二组(B) 被给 tramadol hydrochloride 囊 50 &#x000a0； mg。第三组(C) 被给 tramadol hydrochloride 囊 100 &#x000a0； mg。所有自愿地包括的 300 个参加者完成了学习。病人的年龄从 25 ～ 50 年变化了。在治疗经期以后，记录数据为每个组被收集并且分析。结果在在所有的射精的潜伏时间(IELT ) 与基线数据相比组织的吝啬的 intravaginal 显示出高度重要的增加(P&#x0003c； 0.0001 ) 。我们断定在对 PE 的治疗的需求上的不同剂量的那使用的 tramadol hydrochloride 有效、安全、可容忍，与最小的不受欢迎的效果，并且为这个指示的赞同应该被寻求。

Possible association of the 5-HTTLPR serotonin transporter promoter gene polymorphism with premature ejaculation in a Turkish population

我们与早泄(PE ) 在病人评估了血清素 transporter 基因(5-HTT ) 的遗传型在 PE 并且可能的 etiopathogenesis 决定基因因素的角色识别耐心的亚群。70 个 PE 病人和 70 控制的一个总数在这研究被包括。所有人是异性爱的，没有另外的混乱并且是结婚的任何一个或在一种稳定的关系中。PE 被定义为射精发生在阴道插入的 1 min 以内。从病人和控制的 Genomic DNA 用血清素 transporter 基因(5-HTTLPR ) 的倡导者区域的聚合酶链反应，和突变而产生之遗传的变化被分析被决定。5-HTTLPR (血清素 transporter 倡导者基因) 在 PE 病人对控制的遗传型如下被散布：L/L 16% 对 17% ， L/S 30% 对 53% 并且 S/S 54% 对 28% 。我们为 5-HTTLPR 基因的三多型性检验了 haplotype 分析：LL， LS 和 SS。在 5-HTTLPR 基因的等位基因频率的适当被 Hardy-Weinberg 平衡用 2 测试分析。5-HTTLPR 基因的短(S) 等位基因是显著地在 PE 病人更经常比在控制(P < 0.05 ) 。我们建议 5-HTTLPR 基因在所有主要 PE 盒子的 pathophysiology 起一个作用。进一步的研究被需要评估在 5-HTTLPR 基因多型性和耐心的亚群之间的关系(例如主要、第二等的 PE ) 对选择血清素举起禁止者以及种族差别的回答。

A new potential risk factor in patients with erectile dysfunction and premature ejaculation： folate deficiency

我们调查了酸(FA ) 与可勃起的机能障碍(编辑) 或早泄(PE ) 在病人铺平的浆液 folic。Fasting 浆液样品与编辑从 42 个病人被获得， 36 与 PE，有 PE 的 25 个编辑病人，和 30 个健康的人；吝啬的 intravaginal 射精潜伏时间(IELT ) 在 4 星期基线时期期间被测量。性荷尔蒙的层次(刺激滤泡的荷尔蒙， luteinizing 荷尔蒙，全部的睾丸激素) ， homocysteine (Hcys ) ，和 FA 用 chemiluminescent 免疫分析被测量。PE 病人和正常控制人的性函数用早泄(CIPE ) 的中国索引被评估。可勃起的 Function-5 (IIEF-5 ) 问询表的缩短的国际索引被用来为编辑病人并且为正常控制计量可勃起的质量。浆液 FA 集中在编辑是更低的(7.61 ±；3.97 ng ml −1), PE (9.37 ±；3.40 ng ml −1), 和 ED/PE (8.84 ±；4.28 个 ng ml −1) 病人比在健康的人(12.23 ±；5.76 ng ml −1, P <；0.05 ) 。在性荷尔蒙层次的重要差别都没与性机能障碍和健康控制在病人之间被发现(P >；0.05 ) 。在浆液 FA 集中和 CIPE 分数之间有积极关联(r = 0.530， P <；0.01 ) ， IIEF-5 得分(r = 0.589， P <；0.01 ) ，并且 IELT (r = 0.445， P <；0.01 ) ；与 Hcys 集中的否定关联(r =−； 0.487， P <；0.01 ) 在所有参加者被发现。这些调查结果显示出在浆液 FA 层次和性机能障碍之间的一种强壮的关系，可能由于氮的氧化物， Hcys，和 5-hydroxytryptamine 的新陈代谢上的 FA 的效果。

The 5-HT2c receptor gene Cys23Ser polymorphism influences the intravaginal ejaculation latency time in Dutch Caucasian men with lifelong premature ejaculation

有终生的早泄(LPE ) 的人的坚持的短 intravaginal 射精潜伏时间(IELT ) 与 5-hydroxytryptamine (HT ) 有关是 2C 受体工作，这被要求了。这研究的目的是与 LPE 在人调查 Cys23Ser 5-HT 2C 受体基因多型性和 IELT 的持续时间的关系。因此，未来的研究与 LPE 在 64 个荷兰的白种人人被进行。基线 IELT 被秒表在一个 1 月的时期上在性交期间估计。所有人是为 Cys23Ser 5-HT 2C 受体基因多型性的 genotyped。Cys 的等位基因频率和 5-HT 2C 受体基因多型性的重量的单位变体是坚定的。在 Cys/Cys 和重量的单位 / 重量的单位遗传型和在有 LPE 的人的 IELT 的自然对数之间的协会被调查。作为结果，几何吝啬、中部、自然的吝啬的 IELT 是 25.2， 27.0， 33.9 s 分别地。所有人， 20.0% ， 10.8% ， 23.1% 和 41.5% 在 10 以内射精，在阴道穿入以后的 10-20， 20-30 和 30-60 s。64 个人，为 5-HT 2C 受体基因的 Cys23Ser 多型性的 Cys/Cys 和重量的单位 / 重量的单位遗传型频率分别地是 81% 和 19% 。wildtypes (Cys/Cys ) 的几何吝啬的 IELT 显著地更低(22.6 s；95% CI 18.3-27.8 s ) 比在男同型结合的异种(重量的单位 / 重量的单位)(40.4 s；95% CI 20.3-80.4 s )(P = 0.03 ) 。Cys23Ser 5-HT 2C 受体基因多型性与 LPE 在人与 IELT 被联系，这被结束。有 Cys/Cys 遗传型的人与重量的单位 / 重量的单位遗传型比人有更短的 IELT。

Comparative study of on-demand and daily use of sertraline in treatment of premature ejaculation:A randomized clinical trial

Objective:The intravaginal ejaculatory latency time(IELT)may increase less in on-demand compared to daily intake,but may fulfill a suitable treatment for specific patients.We decided to compare the efficacy and safety of on-demand and daily use of sertraline in order to find the most effective and least complicated method in treatment of premature ejaculation(PE).Methods:This study was parallel or concurrent control randomized clinical trial.Two hundred and forty patients with PE diagnosed by urologist in the two groups of 120 from July 2017 to February 2019 enrolled in the study.In the first group,it is prescribed 50 mg sertraline each 12 h daily and the second group received 50 mg 4 h before coitus for 4 and 8 weeks.The IELT before treatment and during all coitus after treatment were recorded by the patient’s wife with a stopwatch.Results:Mean IELT before,4 and 8 weeks after treatment in two groups were:On-demand group 101.62±65.44 s,208.75±128.02 s and 265.87±145.70 s;daily use group 102.50-81.22 s,276.87±181.08 s and 353.75±176.45 s,respectively.The ejaculation time increased significantly in both groups(p<0.05).However,increase in ejaculation time in daily use group was significantly higher than the on-demand group in 4 weeks(p=0.036),especially in 8 weeks(p=0.009).The percent of side effects in daily use group(26.7%)was higher than on-demand group(20%)(p<0.05).Drowsiness,diarrhea and vertigo were significantly higher in the daily use than on-demand(p<0.05).Conclusions:On-demand and daily use of sertraline are effective and usually have no serious complications,but the on-demand method is considerably more tolerable.In patients who did not tolerate to daily use of this drug,on-demand could be used as a salvage therapy.

A Double-Blind, Placebo-Controlled Study of the Effectiveness of Mate Endurance TM Dietary Supplement on Sexual Satisfaction, Ejaculatory Control, and Distress in Men with Premature Ejaculation

Background: To assess the efficacy of the dietary supplement Mate Endurance on sexual satisfaction, ejaculatory control, and sexually related personal distress in patients with premature ejaculation. Methods: In a double-blind, randomized, placebo-controlled study, 68 patients between 21 and 60 years old with premature ejaculation were randomized to receive either Mate Endurance or placebo treatment for three months. The patients were provided a questionnaire at the start of the study and again three months post commencement of the study. The questionnaires were comprised of the Index of Premature Ejaculation (IPE) and the PE Diagnostic Tool (PEDT). Results: Participants in the treatment group experienced a significant improvement in symptoms often associated with premature ejaculation versus those in the placebo group. The treatment was widely used with limited adverse effects. Conclusions: The results of the study demonstrate the effectiveness of the dietary supplement Mate Endurance in improving symptoms associated with premature ejaculation, including general sexual satisfaction and distress associated with sexual encounters.

The sensitivity difference between the glans penis and penile shaft in primary premature ejaculation

The penis is a vital organ of perception that transmits perceived signals to ejaculation-related centers.The penis consists of the glans penis and penile shaft,which differ considerably in both histology and innervation.This paper aims to investigate whether the glans penis or the penile shaft is the main source of sensory signals from the penis and whether penile hypersensitivity affects the whole organ or only part of it.The thresholds,latencies,and amplitudes of somatosensory evoked potentials(SSEPs)were recorded in 290 individuals with primary premature ejaculation using the glans penis and penile shaft as the sensory areas.The thresholds,latencies,and amplitudes of SSEPs from the glans penis and penile shaft in patients were significantly different(all P<0.0001).The latency of the glans penis or penile shaft was shorter than average(indicating hypersensitivity)in 141(48.6%)cases,of which 50(35.5%)cases were sensitive in both the glans penis and penile shaft,14(9.9%)cases were sensitive in the glans penis only,and 77(54.6%)cases were sensitive in the penile shaft only(P<0.0001).There are statistical differences in the signals perceived through the glans penis and the penile shaft.Penile hypersensitivity does not necessarily mean that the whole penis is hypersensitive.We classify penile hypersensitivity into three categories,namely,glans penis,penile shaft,and whole-penis hypersensitivity,and we propose the new concept of penile hypersensitive zone.

The application of intraoperative neurophysiological monitoring in selective dorsal neurotomy for primary premature ejaculation:a prospective single-center study

Selective dorsal neurotomy(SDN)is a surgical treatment for primary premature ejaculation(PE),but there is still no standard surgical procedure for selecting the branches of the dorsal penile nerves to be removed.We performed this study to explore the value of intraoperative neurophysiological monitoring(IONM)of the penile sensory-evoked potential(PSEP)for standard surgical procedures in SDN.One hundred and twenty primary PE patients undergoing SDN were selected as the PE group and 120 non-PE patients were selected as the normal group.The PSEP was monitored and compared between the two groups under both natural and general anesthesia(GA)states.In addition,patients in the PE group were randomly divided into the IONM group and the non-IONM group.During SDN surgery,PSEP parameters of the IONM group were recorded and analyzed.The differences in PE-related outcome measurements between the perioperative period and 3 months'postoperation were compared for the PE patients,and the differences in effectiveness and complications between the IONM group and the non-IONM group were compared.The results showed that the average latency of the PSEP in the PE group was shorter than that in the normal group under both natural and GA states(P<0.001).Three months after surgery,the significant effective rates in the IONM and non-IONM groups were 63.6%and 34.0%,respectively(P<0.01),and the difference in complications between the two groups was significant(P<0.05).IONM might be useful in improving the short-term therapeutic effectiveness and reducing the complications of SDN.

Abnormal cortical surface-based spontaneous and functional connectivity in the whole brain in lifelong premature ejaculation patients

Recent research has highlighted structural and functional abnormalities in the cerebral cortex of patients with premature ejaculation(PE).These anomalies could play a pivotal role in the physiological mechanisms underlying PE.This study leveraged functional magnetic resonance imaging(fMRI),a noninvasive technique,to explore these neural mechanisms.We conducted resting-state fMRI scans on 36 PE patients and 22 healthy controls(HC),and collected data on Premature Ejaculation Diagnostic Tool(PEDT)scores and intravaginal ejaculation latency time(IELT).Employing a surface-based regional homogeneity(ReHo)approach,we analyzed local neural synchronous spontaneous activity,diverging from previous studies that utilized a volume-based ReHo method.Areas with significant ReHo differences between PE and HC groups underwent surface-based functional connectivity(FC)analysis.Significant discrepancies in ReHo and FC across the cortical surface were observed in the PE cohort.Notably,PE patients exhibited decreased ReHo in the left triangular inferior frontal gyrus and enhanced ReHo in the right middle frontal gyrus.The latter showed heightened connectivity with the left lingual gyrus and the right orbital superior frontal gyrus.Furthermore,a correlation between ReHo and FC values with PEDT scores and IELT was found in the PE group.Our findings,derived from surface-based fMRI data,underscore specific brain regions linked to the neurobiological underpinnings of PE.

Short‐term effect of the prone masturbation training on premature ejaculation

Background:Whether conventional behavioral therapies for premature ejaculation can significantly improve the intravaginal ejaculatory latency time is still controversial.Prone masturbation is rare and observed in some patients with delayed ejaculation.Therefore,we tried to verify whether the regular prone masturbation training method had a therapeutic effect on premature ejaculation.Methods:From July to December 2018,a total of 21 patients met the enrollment criteria and volunteered to participate.Participants were diagnosed with premature ejaculation with an intravaginal ejaculatory latency time of less than 3min and a Premature Ejaculation Diagnostic Tool score greater than 9.Participants performed 12‐week prone masturbation training.Results:Ten patients completed the entire treatment regimen.The mean age of the 10 participants was 30.4±6.1 years,the mean frequency of sexual intercourse was 1.9±0.83 times a week,and the median duration of premature ejaculation was 1.5 years.After 3 months of prone masturbation training,the median self‐reported intravaginal ejaculatory latency time significantly increased from 60 to 105 s(p=0.011),and the mean Premature Ejaculation Diagnostic Tool scores decreased from15.0±3.7 to 12.7±3.7 points(p=0.119).Conclusions:The regular prone masturbation training method,as a novel behavioral therapy,probably has a therapeutic effect on premature ejaculation.

Dorsal penile nerves and primary premature ejaculation

基于我们的临床的经验的背景，在有主要早泄(PPE ) 的病人的背面的阴茎神经的数字不与平均数字(2 个分支) 一致。在这研究，我们与 PPE.Methods 在健康中国成年人和病人之中评估了背面的阴茎神经的数字和分发阴茎的背面的神经，阴茎的深背面的静脉，并且在阴茎的深扁带之间的阴茎和 albuginea 阴茎的背面的动脉小心地被引出，在 38 个成年尸体标本观察了，并且数。在有 PPE 的 128 个外科的病人的背面的阴茎神经的数字和分发是坚定的。38 个盒子的背面的阴茎神经的数字作为在 1 种情况中的 follows:7 分支的结果；6 在 1 种情况中分叉；5 在 6 种情况中分叉；4 在 9 种情况中分叉；3 在 14 种情况中分叉；并且 2 在 7 种情况中分叉。大多数背面的神经与对方并且在阴茎的背平行。在仅仅 8 个盒子中，分支被一些交流分支连接。在 4 种情况中， 1 或 2 根薄背面的神经在阴茎的腹的方面上继续他们的小径。在有 PPE 的病人的背面的阴茎神经的分支的平均数字是 7.16。基于 38 个盒子的学习的结论，背面的阴茎神经的平均数字是 3.55 个分支，有 PPE 的病人的更大。这些初步的结果建议过多的背面的阴茎神经可以经由增加的敏感影响 PPE 并且为 PPE 的可能的治疗提供地志的数据。

Pelvic muscle floor rehabilitation as a therapeutic option in lifelong premature ejaculation： long-term outcomes

学习的目的是评估骨盆的地板肌肉(PFM ) 的长期的结果在有终生的早泄(PE ) 的男性的康复，用 intravaginal 射精的潜伏时间(IELT ) 和自我报告早泄诊断工具(PEDT ) 同样主要的结果。154 个参加者的一个总数回顾地在这研究被考察，与 122 完成训练协议。在基线，所有参加者有一个 IELT 60 s 和 PEDT 分数 > 11。参加者完成了 PFM 康复的一个 12 星期的节目，包括 physio-kinesiotherapy 处理， electrostimulation，和生物反馈，与每星期的三个会议，与为在每个会议完成的每个部件的 20 min。干预的有效性被在 IELT 和 PEDT 价值的几何平均数比较变化评估，从基线，在在干预期间的 3 ， 6 ，和 12 个月，并且在 24 和 36 月 postintervention ，用配对的样品2尾巴t测试，包括联系了95%信心间隔。 122 个参加者完成了 PFM 康复， 111 获得了他们的射精反射的控制与 161.6 s 的吝啬的 IELT 和在干预的12星期的端点的 2.3 的 PEDT 分数，分别地，从 40.4 s 和 17.0 个分数的基线代表增加为 IELT 和 PEDT ( P < 0.0001 )。95 个参加者完成了 36 月的后续，在 24 和 36 月 postintervention 的 64% 和 56% 维持的令人满意的射精控制分别地。

Penile sensory thresholds in subtypes of premature ejaculation： implications of comorbid erectile dysfunction

阴茎超敏性在早泄(PE ) 起一个重要作用，但是在在 PE 的子类型之中的阴茎敏感的差别是未知的。因此，我们在终生、获得的 PE 的 PE 子类型比较了阴茎感觉阀值，有或没有可勃起的机能障碍(编辑) 的 PE，有一 intravaginal 射精潜伏时间的 PE 1 min 并且 > 有或没有高潮的快乐的 1 min，和 PE 感性的机能障碍。在到 2016 年 1 月的 2014 年 8 月期间，有 PE 的 136 个病人被包括。阴茎温暖、冷、振动的阀值被测量。临床的特征，性生活，早泄诊断工具(PEDT ) 分数，和可勃起的功能(IIEF-5 ) 分数的国际索引的 5 条款版本的数据是镇定的。与编辑组一起的 PE 的振动阀值在正确花冠 sulcus 是更高的(中部的振幅：4.92 对 3.65 m， P = 0.02 ) 并且恰好阴茎的柄(中部的振幅：3.87 对 3.30 m， P = 0.03 ) ，当在在另外的子类型之间的阴茎感觉阀值的差别不是重要的时。没有编辑组，中部的 PEDT 分数在 PE 是更低的(12 对 14， P < 0.001 ) 。IIEF-5 和 PEDT 分数否定地被相关(r = 0.29， P < 0.001 ) 。有高潮的快乐的病人感性的机能障碍让更低的中部的 IIEF-5 得分(20 对 21， P = 0.02 ) 。有 PE 和编辑的病人有更低的阴茎敏感，并且编辑与更严重的症状和更弱的高潮的快乐感觉被联系。在有 PE 的人， comorbid 编辑的管理是必要的。在在可勃起的功能的副作用的情况下，热门麻药应该小心地与 PE 和编辑在人被使用。

基于“核心病机观”探讨男科疾病的诊疗模式

男科疾病多具有病因复杂、共病普遍等特点,中医证候以复合证型为主,加上医师对疾病的认识受限及着眼点不同,容易导致同一病证得出不同的结论。如此错综复杂的情况使得部分男科疾病难以通过传统手段准确辨证,在一定程度上制约了中医男科学疗效的突破。核心病机是疾病的本质性病机,有其固定的病理基础,能够反映疾病发展演变规律。因此,在诊治部分难以准确辨证的男科疾病时,可从疾病的核心病机论治,以此避免单纯辨证的时限性和主观性局限,从而提高临床疗效。