BACKGROUND Facial teratoma is a rare benign tumor that accounts for about 1.6%of all teratomas and can be diagnosed by prenatal ultrasound(US).The purpose of this report was to describe our experience with the diagnos...BACKGROUND Facial teratoma is a rare benign tumor that accounts for about 1.6%of all teratomas and can be diagnosed by prenatal ultrasound(US).The purpose of this report was to describe our experience with the diagnosis of fetal facial teratoma by prenatal US at second trimester to provide a reference for clinical diagnosis of fetal maxillofacial teratoma.CASE SUMMARY We present two cases of patients with abnormal fetal facial findings on US at second trimester of pregnancy in our department.Case 1 was a 31-year-old G3 P1+1 female,with US revealing a heterogeneous echogenicity of 32 mm×20 mm×31 mm on the fetal face,most of it located outside the oral cavity and filling the root of the oral cavity.Case 2 was a 29-year-old G1P0 female,with fetal head and neck US revealing a cystic-solid echo mass measuring 42 mm×33 mm×44 mm,the upper edge of the lesion reaching the palate and filling the oral cavity.The contours of the lesions were visualized using three-dimensional(3D)US imaging.Both patients decided to give up treatment.Biopsies of the lesions were performed after induction of labor,and diagnosed as maxillofacial teratoma.CONCLUSION Fetal maxillofacial teratomas can be diagnosed by US in early pregnancy,allowing parents to expedite treatment decisions.展开更多
BACKGROUND Congenital cytomegalovirus(CMV)infection represents a significant public health concern as the most prevalent viral infection in newborns,potentially leading to severe neurological and developmental complic...BACKGROUND Congenital cytomegalovirus(CMV)infection represents a significant public health concern as the most prevalent viral infection in newborns,potentially leading to severe neurological and developmental complications.The majority of cases are asymptomatic and remain undetected during pregnancy due to the absence of effective screening methods.CASE SUMMARY A 27-year-old primigravida presented for early pregnancy ultrasound,which revealed an atypical finding:A normal anechoic thalamus appearing hyperechoic on the mid-sagittal view of the fetal head.Subsequent ultrasound examinations during mid and late gestation demonstrated classic intracranial features sug-gestive of congenital CMV infection.Chromosomal karyotyping and microarray analysis of the fetus yielded no significant abnormalities.Following compre-hensive prenatal counseling regarding potential adverse fetal outcomes,the patient elected to continue her pregnancy.She ultimately underwent cesarean delivery at 42 weeks gestation at another facility,resulting in the birth of a female neonate.At five months of age,the infant presented with epilepsy and significant growth and developmental delays.CONCLUSION Congenital CMV infection occurs during the first trimester may manifest as hyperechoic thalamus which can be revealed by ultrasound in the mid-saggital view of the fetal head.Future research should investigate the correlation between echogenic thalamus and developmental outcomes,as well as explore early sc-reening techniques for suspected congenital CMV infection cases.展开更多
Goiter is an enlargement of the thyroid gland which can be associated with a number of complications both for the mother and the fetus. A 34-year-old pregnant woman with normal thyroid function was referred to our Dep...Goiter is an enlargement of the thyroid gland which can be associated with a number of complications both for the mother and the fetus. A 34-year-old pregnant woman with normal thyroid function was referred to our Department of Obstetrics and Gynecology at Microcitemico Pediatric Hospital, Cagliari, for suspected fetal goiter at 32 gestational weeks. The case was monitored regularly by ultrasound and treated successfully with intra-amniotic levothyroxine (L-T4) administration. Fetal goiter was observed to decrease after this treatment and the thyroid ultrasound findings were also normal both at birth and in subsequent follow-ups. Our case report confirms the feasibility of conservative treatment with L-T4, which can effectively prevent complications related to fetal goiter.展开更多
目的:探究产前彩色多普勒超声评估胎儿生长受限(FGR)的价值,分析超声诊断假阴性的影响因素。方法:选择2019年10月至2023年7月于我院行产前彩色多普勒超声诊断为FGR并获得产后随访确诊的118例胎儿作为FGR真阳性组,60例产前彩色多普勒超...目的:探究产前彩色多普勒超声评估胎儿生长受限(FGR)的价值,分析超声诊断假阴性的影响因素。方法:选择2019年10月至2023年7月于我院行产前彩色多普勒超声诊断为FGR并获得产后随访确诊的118例胎儿作为FGR真阳性组,60例产前彩色多普勒超声诊断为FGR阴性而产后确诊为FGR的胎儿作为FGR假阴性组。比较首次检查时两组间不同孕周的超声参数;比较两组胎儿的临床资料,采用随机森林算法及多因素Logistic回归分析筛选影响超声诊断FGR假阴性的因素;构建多因素Logistic回归模型并评价其预测效能。结果:孕12~14周假阴性组胎儿的腹围、股骨长明显长于真阳性组,血流收缩末期峰值(S)/舒张末期峰值(D)明显低于真阳性组(P<0.05);孕15~27周假阴性组胎儿的腹围、股骨长明显长于真阳性组(P<0.05);孕28~37周假阴性组胎儿的腹围明显长于真阳性组(P<0.05);随机森林算法及多因素Logistic回归分析结果显示,孕期增重高于标准、妊娠糖尿病、胎方位为臀位、分娩胎龄>40周、胎儿性别为男性、腹围增加是影响超声诊断FGR假阴性的危险因素(P<0.05);当模型预测超声诊断FGR假阴性概率为0.85时,约登指数最大(74.46),敏感度为86.45%,特异度为88.01%,逻辑回归拟合优度检验结果显示模型Bootstrap验证前后的Nagelkerke R 2=0.602。结论:随着孕周的增加(12~37周),首次超声检查诊断FGR真阳性和假阴性胎儿间存在显著差异的指标数量逐渐减少,孕期增重、妊娠糖尿病、胎方位等是影响超声诊断FGR假阴性的危险因素。展开更多
目的探讨产前超声诊断胎儿迷走右锁骨下动脉(aberrant right subclavian artery,ARSA)的价值。方法选取2021年6月—2023年6月宜昌市妇幼保健院收治的80例孕妇为研究对象,所有孕妇均实施二维超声、四维超声检查。以临床综合诊断结果为金...目的探讨产前超声诊断胎儿迷走右锁骨下动脉(aberrant right subclavian artery,ARSA)的价值。方法选取2021年6月—2023年6月宜昌市妇幼保健院收治的80例孕妇为研究对象,所有孕妇均实施二维超声、四维超声检查。以临床综合诊断结果为金标准,分析各两种超声检查的疾病检出情况、诊断效能。结果二维超声检出阳性28例,阴性52例;四维超声检出阳性41例,阴性39例。四维超声检查灵敏度为95.24%(40/42)、特异度为97.37%(37/38)、准确度为96.25%(77/80),高于二维超声检查的52.38%(22/42)、84.21%(32/38)、67.50%(52/80),差异有统计学意义(χ^(2)=19.953、3.933、22.279,P均<0.05)。四维超声对食管后型、食管和气管之间型、气管前方型右锁骨下动脉迷走的诊断符合率高于二维超声检查,差异有统计学意义(P<0.05)。结论在胎儿ARSA诊断中,产前四维超声检查可明确具体畸形情况,为下一步医疗操作提供参考。展开更多
基金Supported by the Research Fund of the Anhui Medical University,No.2022xkj145.
文摘BACKGROUND Facial teratoma is a rare benign tumor that accounts for about 1.6%of all teratomas and can be diagnosed by prenatal ultrasound(US).The purpose of this report was to describe our experience with the diagnosis of fetal facial teratoma by prenatal US at second trimester to provide a reference for clinical diagnosis of fetal maxillofacial teratoma.CASE SUMMARY We present two cases of patients with abnormal fetal facial findings on US at second trimester of pregnancy in our department.Case 1 was a 31-year-old G3 P1+1 female,with US revealing a heterogeneous echogenicity of 32 mm×20 mm×31 mm on the fetal face,most of it located outside the oral cavity and filling the root of the oral cavity.Case 2 was a 29-year-old G1P0 female,with fetal head and neck US revealing a cystic-solid echo mass measuring 42 mm×33 mm×44 mm,the upper edge of the lesion reaching the palate and filling the oral cavity.The contours of the lesions were visualized using three-dimensional(3D)US imaging.Both patients decided to give up treatment.Biopsies of the lesions were performed after induction of labor,and diagnosed as maxillofacial teratoma.CONCLUSION Fetal maxillofacial teratomas can be diagnosed by US in early pregnancy,allowing parents to expedite treatment decisions.
文摘BACKGROUND Congenital cytomegalovirus(CMV)infection represents a significant public health concern as the most prevalent viral infection in newborns,potentially leading to severe neurological and developmental complications.The majority of cases are asymptomatic and remain undetected during pregnancy due to the absence of effective screening methods.CASE SUMMARY A 27-year-old primigravida presented for early pregnancy ultrasound,which revealed an atypical finding:A normal anechoic thalamus appearing hyperechoic on the mid-sagittal view of the fetal head.Subsequent ultrasound examinations during mid and late gestation demonstrated classic intracranial features sug-gestive of congenital CMV infection.Chromosomal karyotyping and microarray analysis of the fetus yielded no significant abnormalities.Following compre-hensive prenatal counseling regarding potential adverse fetal outcomes,the patient elected to continue her pregnancy.She ultimately underwent cesarean delivery at 42 weeks gestation at another facility,resulting in the birth of a female neonate.At five months of age,the infant presented with epilepsy and significant growth and developmental delays.CONCLUSION Congenital CMV infection occurs during the first trimester may manifest as hyperechoic thalamus which can be revealed by ultrasound in the mid-saggital view of the fetal head.Future research should investigate the correlation between echogenic thalamus and developmental outcomes,as well as explore early sc-reening techniques for suspected congenital CMV infection cases.
文摘Goiter is an enlargement of the thyroid gland which can be associated with a number of complications both for the mother and the fetus. A 34-year-old pregnant woman with normal thyroid function was referred to our Department of Obstetrics and Gynecology at Microcitemico Pediatric Hospital, Cagliari, for suspected fetal goiter at 32 gestational weeks. The case was monitored regularly by ultrasound and treated successfully with intra-amniotic levothyroxine (L-T4) administration. Fetal goiter was observed to decrease after this treatment and the thyroid ultrasound findings were also normal both at birth and in subsequent follow-ups. Our case report confirms the feasibility of conservative treatment with L-T4, which can effectively prevent complications related to fetal goiter.
文摘目的:探究产前彩色多普勒超声评估胎儿生长受限(FGR)的价值,分析超声诊断假阴性的影响因素。方法:选择2019年10月至2023年7月于我院行产前彩色多普勒超声诊断为FGR并获得产后随访确诊的118例胎儿作为FGR真阳性组,60例产前彩色多普勒超声诊断为FGR阴性而产后确诊为FGR的胎儿作为FGR假阴性组。比较首次检查时两组间不同孕周的超声参数;比较两组胎儿的临床资料,采用随机森林算法及多因素Logistic回归分析筛选影响超声诊断FGR假阴性的因素;构建多因素Logistic回归模型并评价其预测效能。结果:孕12~14周假阴性组胎儿的腹围、股骨长明显长于真阳性组,血流收缩末期峰值(S)/舒张末期峰值(D)明显低于真阳性组(P<0.05);孕15~27周假阴性组胎儿的腹围、股骨长明显长于真阳性组(P<0.05);孕28~37周假阴性组胎儿的腹围明显长于真阳性组(P<0.05);随机森林算法及多因素Logistic回归分析结果显示,孕期增重高于标准、妊娠糖尿病、胎方位为臀位、分娩胎龄>40周、胎儿性别为男性、腹围增加是影响超声诊断FGR假阴性的危险因素(P<0.05);当模型预测超声诊断FGR假阴性概率为0.85时,约登指数最大(74.46),敏感度为86.45%,特异度为88.01%,逻辑回归拟合优度检验结果显示模型Bootstrap验证前后的Nagelkerke R 2=0.602。结论:随着孕周的增加(12~37周),首次超声检查诊断FGR真阳性和假阴性胎儿间存在显著差异的指标数量逐渐减少,孕期增重、妊娠糖尿病、胎方位等是影响超声诊断FGR假阴性的危险因素。
文摘目的探讨产前超声诊断胎儿迷走右锁骨下动脉(aberrant right subclavian artery,ARSA)的价值。方法选取2021年6月—2023年6月宜昌市妇幼保健院收治的80例孕妇为研究对象,所有孕妇均实施二维超声、四维超声检查。以临床综合诊断结果为金标准,分析各两种超声检查的疾病检出情况、诊断效能。结果二维超声检出阳性28例,阴性52例;四维超声检出阳性41例,阴性39例。四维超声检查灵敏度为95.24%(40/42)、特异度为97.37%(37/38)、准确度为96.25%(77/80),高于二维超声检查的52.38%(22/42)、84.21%(32/38)、67.50%(52/80),差异有统计学意义(χ^(2)=19.953、3.933、22.279,P均<0.05)。四维超声对食管后型、食管和气管之间型、气管前方型右锁骨下动脉迷走的诊断符合率高于二维超声检查,差异有统计学意义(P<0.05)。结论在胎儿ARSA诊断中,产前四维超声检查可明确具体畸形情况,为下一步医疗操作提供参考。
