Medical and surgical approach to ocular surface reconstruction

Ocular surface disease(OSD)can have a severe impact on patients as it can lead to visual impairment and persistent discomfort.Ocular surface reconstruction(OSR)is an approach to the management of ocular diseases that cause structural damage to the ocular surface.OSR encompasses both medical and surgical treatment options.In this review,we discuss the medical and surgical strategies used in OSR.Medical management often aims to treat tear insufficiency,inflammation,and keratinization.Surgical treatments may be employed for a variety of reasons,including failure of medical management.This may include improving the oculo-palpebral structures in order to improve lid positioning and tear film.Additional therapies focus on improving tear production,such as through salivary gland transplantation.In situations where the ocular surface is so severely damaged that there is loss of limbal stem cells,limbal stem cell transplant(LSCT)may be indicated.Other surgeries such as amniotic membrane transplant(AMT)and conjunctival flaps(CFs)can help promote corneal healing.Finally,in severe situations where the cornea is beyond salvage,corneal transplantation,such as a penetrating keratoplasty(PKP),can be considered.OSR often requires a combination of medical and surgical approaches targeted to each specific patient’s presentation in order to achieve optimal outcomes.

保存人羊膜移植治疗眼表疾病的临床观察

目的 观察羊膜移植治疗眼表疾病的临床疗效。方法 将严重眼表疾病患者 1 3例 1 4眼的眼表组织清除后用保存的健康人羊膜移植到表层剖切面。结果 随访 9.3± 5 .9个月 ,1 2例 1 3眼手术成功 (92 .86 % ) ,眼表重建 ,其中 1例 2眼成功重建了中央角膜上皮 ,视力提高到 0 .3 ,复明并脱残。 1例角膜穿孔患者移植的羊膜溶解 ,手术失败。结论 羊膜移植治疗眼表疾病有良好的效果 ,具有取材方便 ,无排斥反应 ,手术成功率高 ,是治疗眼表面疾病的一种有效方法。