Efficacy of press needle on immune function and quality of life in female breast cancer patients after radical mastectomy:study protocol for a randomized controlled trial

Radical mastectomy may lead to suppression of cellular immune function in patients with malignant tumors,and affect the quality of life(QOL)of patients.Immune suppression is a common cause of complications and adverse reactions in adjuvant therapy after radical mastectomy of breast cancer.Currently,there are few proven effective treatments for immune suppression.Therefore,it’s necessary to develop a new treatment method.Press needle is widely used in clinical practice.However,there have been relatively few studies that evaluate the effects of press needle on postoperative immune function.The aim of the present study is to assess the effects of press needle on immune function and QOL in female breast cancer patients undergoing radical mastectomy.This study will be a single-center,randomized and single-blinded trial.Totally 78 eligible patients will be randomized in a ratio of 1:1 to the press needle group or the sham press needle group.During the treatment phase,patients will undergo five times weekly of verum press needle or sham press needle for 2 weeks.The primary outcome measures will be the peripheral blood levels of CD8^(+),CD4^(+),CD3^(+),and CD4^(+)/CD8^(+)T cells.The secondary outcome measures will be the changes of patients’QOL,evaluated by the Karnofsky Performance Scale score and the EORTC core quality of life questionnaire(EORTC QLQ-C30).Furthermore,5-year survival rate and recurrence rate will be evaluated.Safety and adverse events will be assessed at each visit.The results of this on-going study will provide clinical evidence for the effects and safety of press needle on immune function and QOL in patients after breast cancer resection compared with sham press needle.

Postoperative pain of mixed hemorrhoid treated by embedding needles in rbái(二白 EX-UE 2)

Objective To explore the effectiveness of treating postoperative pain of mixed hemorrhoid by embedding needles in Erbai （二白EX-UE 2） and find possible ways for relieving postoperative pain of mixed hemorrhoids. Methods press needle （SEIRIN pyonexes） were embedded in EX-UE 2 of patients with postoperative pain of mixed hemorrhoid, once a day and totally 7 treatments. Visual analogue scale （VAS） values were adopted for evaluation. Results Complete remission of clinical pain was observed in 34 cases, accounting for 50.00%; significantly effective in 19 cases, accounting for 27.94%; effective in 13 cases, accounting for 19.12%; and ineffective in 2 cases, accounting for 2.94%; the total effective rate was 97.06%. Conclusion The therapy of treating postoperative pain of mixed hemorrhoid by embedding press needle in EX-UE2 is effectively satisfactory.