Introduction: Ambulatory Blood Pressure Measurement (ABPM) is a non- invasive examination recommended for subjects at high cardiovascular risk, and those requiring a nocturnal drop in BP such as elderly and obese...Introduction: Ambulatory Blood Pressure Measurement (ABPM) is a non- invasive examination recommended for subjects at high cardiovascular risk, and those requiring a nocturnal drop in BP such as elderly and obese subjects, those with secondary hypertension or resistant, diabetics, subjects with metabolic syndrome or sleep apnea syndrome. The objective of this study was to evaluate the contribution of ABPM in the diagnosis and evaluation of the level of control of hypertension under treatment at the Bel Air international clinic. Materials and Methods: This is a retrospective, cross-sectional and descriptive study, carried out at the Bel Air International Clinic in Conakry (Guinea) between January 2019 and November 30, 2022. It included a consecutive series of 180 consenting patients recruited through an ambulatory measurement of 24-hour blood pressure from a FUGADA brand device. Results: We collected 180 patients, with a male predominance (sex-ratio M/F = 2.46). The mean age of the patients was 48.48 ± 14.23 years. The most represented age group was that of 32 to 42 years with 50 cases (27.8%) followed by that of 43 to 52 years with 42 cases or 23.3%. The indication was for diagnostic purposes in 106 cases 58.9%, the therapeutic evaluation in 58 patients (32.2%). The examination was prescribed by a cardiologist in 98 cases (54.4%), a general practitioner in 71 cases (39.4%), a neurologist in 11 cases (6.1%). In the therapeutic evaluation, high blood pressure was controlled in 24 patients (13.3%) and uncontrolled in 34 cases (18.9%). In the diagnostic indication, high blood pressure was confirmed in 79 cases (43.9%) with a statistically significant link (Chi2</sup> = 4.57 and p-value = 0.032). The nycthemeral mean was 187.27 ± 26.22 mmHg for systolic blood pressure (SBP) and 110.37 ± 19.06 mmHg for diastolic blood pressure (DBP), during the day, 151.64 ± 21.45 mmHg for SBP and 71.59 ± 8.67 mmHg for diastolic blood pressure. During the study 65 patients (36.1%) were identified as dippers and 115 patients (63.9%) were no-dipping. The antihypertensive protocol used was monotherapy in 68 cases (37.8%), dual therapy in 46 cases (25.6%), triple therapy in 17 cases (9.4%). However 39 patients or 21.7% were not taking any antihypertensive. Conclusion: This preliminary study, despite the modest sample size, showed the importance of ABPM as a tool for diagnosis, monitoring of hypertensive patients and therapeutic adaptation. A large-scale national study would be necessary for the rational use of ambulatory blood pressure measurement in our context in order to improve the management of hypertensive patients.展开更多
An inflatable cuff wrapped around the upper arm is widely used in noninvasive blood pressure measurement.However, the mechanical interaction between cuff and arm tissues, a factor that potentially affects the accuracy...An inflatable cuff wrapped around the upper arm is widely used in noninvasive blood pressure measurement.However, the mechanical interaction between cuff and arm tissues, a factor that potentially affects the accuracy of noninvasive blood pressure measurement, remains rarely addressed. In the present study, finite element(FE) models were constructed to quantify intra-arm stresses generated by cuff compression, aiming to provide some theoretical evidence for identifying factors of importance for blood pressure measurement or explaining clinical observations. Obtained results showed that the simulated tissue stresses were highly sensitive to the distribution of cuff pressure on the arm surface and the contact condition between muscle and bone. In contrast, the magnitude of cuff pressure and small variations in elastic properties of arm soft tissues had little influence on the efficiency of pressure transmission in arm tissues. In particular, it was found that a thickened subcutaneous fat layer in obese subjects significantly reduced the effective pressure transmitted to the brachial artery, which may explain why blood pressure overestimation occurs more frequently in obese subjects in noninvasive blood pressure measurement.展开更多
AIM: To train Tibetan monkey (Macaca thibetana) for intraocular pressure (IOP) measurement in conscious state and obtain normal IOP in conscious Tibetan Macaque. METHODS: The training was based on award-conditioned be...AIM: To train Tibetan monkey (Macaca thibetana) for intraocular pressure (IOP) measurement in conscious state and obtain normal IOP in conscious Tibetan Macaque. METHODS: The training was based on award-conditioned behavior. Food stimulation and human-animal interaction were used in this training. RESULTS: Trained Tibetan monkeys calmly accepted IOP measurement by the TonoVete (R) rebound tonometer without sedation or anesthesia and their IOP values were similar to other primates. CONCLUSION: Human-cultivated Thibetan monkeys are tamable, and can be used for biomedical research such as ophthalmic research without anesthesia.展开更多
Static cracking agent(SCA)is actively investigated as an alternative to explosive blasting for rock breakage due to its immense expansion property.SCA can eliminate the negative effects of shock,noise and harmful gase...Static cracking agent(SCA)is actively investigated as an alternative to explosive blasting for rock breakage due to its immense expansion property.SCA can eliminate the negative effects of shock,noise and harmful gases encountered in explosive blasting processes.Accurate measurement and deep understanding of the expansive properties of SCAs are important in their industrial application.An improved outer pipe method(OPM),termed the upper end surface method(UESM),is proposed in this paper to overcome the shortcomings of the OPM in the expansive pressure measurement of SCAs.Numerical simulation is used to proof the concept and a mathematical model established to relate the internal pressure and the radial strains at different positions in the upper end surface method test equipment.The new equipment is calibrated using oil pressure and strain measurements.The calibrated equipment is then used to measure the expansion pressure of SCA at three different water contents to proof its potential.The differences in the measurements with OPM and UESM at three different moisture contents are less than 4%.The experimental results confirm the accuracy and applicability of the more user friendly and less expensive UESM in the measurement of the expansive pressures of SCAs.展开更多
In this paper, a novel antenna is proposed for high-temperature testing, which can make the high-temperature pressure characteristics of a wireless passive ceramic pressure sensor demonstrated at up to a temperature o...In this paper, a novel antenna is proposed for high-temperature testing, which can make the high-temperature pressure characteristics of a wireless passive ceramic pressure sensor demonstrated at up to a temperature of 600℃. The design parameters of the antenna are similar to those of the sensor, which will increase the coupling strength between the sensor and testing antenna. The antenna is fabricated in thick film integrated technology, and the properties of the alumina ceramic and silver ensure the feasibility of the antenna in high-temperature environments. The sensor, coupled with the ceramic antenna, is investigated using a high-temperature pressure testing platform. The experimental measurement results show that the pressure signal in a harsh environment can be detected by the frequency diversity of the sensor.展开更多
This study proposed a measurement platform for continuous blood pressure estimation based on dual photoplethysmography(PPG)sensors and a deep learning(DL)that can be used for continuous and rapid measurement of blood ...This study proposed a measurement platform for continuous blood pressure estimation based on dual photoplethysmography(PPG)sensors and a deep learning(DL)that can be used for continuous and rapid measurement of blood pressure and analysis of cardiovascular-related indicators.The proposed platform measured the signal changes in PPG and converted them into physiological indicators,such as pulse transit time(PTT),pulse wave velocity(PWV),perfusion index(PI)and heart rate(HR);these indicators were then fed into the DL to calculate blood pressure.The hardware of the experiment comprised 2 PPG components(i.e.,Raspberry Pi 3 Model B and analog-todigital converter[MCP3008]),which were connected using a serial peripheral interface.The DL algorithm converted the stable dual PPG signals acquired from the strictly standardized experimental process into various physiological indicators as input parameters and finally obtained the systolic blood pressure(SBP),diastolic blood pressure(DBP)and mean arterial pressure(MAP).To increase the robustness of the DL model,this study input data of 100 Asian participants into the training database,including those with and without cardiovascular disease,each with a proportion of approximately 50%.The experimental results revealed that the mean absolute error and standard deviation of SBP was 0.17±0.46 mmHg.The mean absolute error and standard deviation of DBP was 0.27±0.52 mmHg.The mean absolute error and standard deviation of MAP was 0.16±0.40 mmHg.展开更多
AIM:To evaluate the precision of digital intraocular pressure(IOP)measurement in silicone oil(SO)filled eyes during vitrectomy.METHODS:This is a retrospective,single-blind study.Patients who were diagnosed with retina...AIM:To evaluate the precision of digital intraocular pressure(IOP)measurement in silicone oil(SO)filled eyes during vitrectomy.METHODS:This is a retrospective,single-blind study.Patients who were diagnosed with retinal detachment and scheduled for vitrectomy with SO injection were consecutively enrolled.During the vitrectomy,IOP was digitally measured and then by a rebound tonometer(Icare PRO).The rebound tonometer readings were masked to the surgeons.The digitally measured IOP and that of rebound tonometer were compared,and the inter-methods agreement was assessed.The absolute deviation in IOP values between these two methods(△IOP)was also calculated,and correlations between△IOP and refractive status,lens status and levels of surgeons’experience were analyzed.RESULTS:A total of 131 patients(131 eyes)were recruited,with a mean age of 51.0±16.1 y.There was no significant difference in IOPs between digital measurement and the rebound tonometer(15.6±4.3 vs 15.7±5.1 mm Hg;t=0.406,P=0.686).Intraclass correlation coefficients(ICC)analysis indicated a strong correlation between these two measurements(ICC=0.830,P<0.001).The mean△IOP was 2.0±1.9 mm Hg(range:0-12.8 mm Hg),with 98 eyes(74.8%)had the△IOP within 3 mm Hg.△IOP was found to be negatively correlated with levels of surgeons’experience(r=-0.183;P=0.037),but not with the refractive status or lens status of the patients(both P>0.05).CONCLUSION:For experienced surgeons,the digital IOP measurement may be an acceptable technique for IOP measurement in SO filled eyes during vitrectomy.However,its use by inexperienced surgeons should be taken with caution.展开更多
Blood pressure is an important physiological parameter to reflect human vital signs.In order to achieve the non-contact dynamic blood pressure acquisition based on ordinary optical camera,a theoretical understanding o...Blood pressure is an important physiological parameter to reflect human vital signs.In order to achieve the non-contact dynamic blood pressure acquisition based on ordinary optical camera,a theoretical understanding of the functional relationship between blood pressure and pulse wave signal conduction time.And through imaging photoelectric plethysmography(IPPG),pulse wave signal conduction time of forehead and hand was obtained with ordinary optical camera.First,the pulse wave conduction time was obtained by recording the video with an ordinary optical camera.Second,real-time blood pressure values were collected.Finally,based on the relationship between blood pressure and pulse wave conduction time,a non-contact blood pressure measurement prediction model was obtained through neural network fitting.So that non-contact blood pressure measurement with optical camera could be completed.The method in this paper has several advantages,such as low requirements on measuring equipment,low cost,and simple operation.It can let people get rid of the discomfort caused by measuring equipment such as cuff and can measure blood pressure at any time.The predicted blood pressure results were compared with an Omron wrist electronic sphygmomanometer.The calculated error of systolic blood pressure is-9.28%~3.16%,and the error of diastolic blood pressure is-9.84~4.35%.展开更多
In this paper, we present a method based on self-mixing interferometry combing extreme learning machine for real-time human blood pressure measurement. A signal processing method based on wavelet transform is applied ...In this paper, we present a method based on self-mixing interferometry combing extreme learning machine for real-time human blood pressure measurement. A signal processing method based on wavelet transform is applied to extract reversion point in the self-mixing interference signal, thus the pulse wave profile is successfully reconstructed. Considering the blood pressure values are intrinsically related to characteristic parameters of the pulse wave, 80 samples from the MIMIC-II database are used to train the extreme learning machine blood pressure model. In the experiment, 15 measured samples of pulse wave signal are used as the prediction sets. The results show that the errors of systolic and diastolic blood pressure are both within 5 mm Hg compared with that by the Coriolis method.展开更多
This paper presents a micro packaged MEMS pressure sensor for intracranial pressure measurement which belongs to BioMEMS. It can be used in lumbar puncture surgery to measure intracranial pressure. Minia- turization i...This paper presents a micro packaged MEMS pressure sensor for intracranial pressure measurement which belongs to BioMEMS. It can be used in lumbar puncture surgery to measure intracranial pressure. Minia- turization is key for lumbar puncture surgery because the sensor must be small enough to allow it be placed in the reagent chamber of the lumbar puncture needle. The size of the sensor is decided by the size of the sensor chip and package. Our sensor chip is based on silicon piezoresistive effect and the size is 400 × 400 μm2. It is much smaller than the reported polymer intracranial pressure sensors such as liquid crystal polymer sensors. In terms of package, the traditional dual in-line package obviously could not match the size need, the minimal size of recently reported MEMS-based intracranial pressure sensors after packaging is 10 × 10 mm2. In this work, we are the first to introduce a quad flat no-lead package as the package form of piezoresistive intracranial pressure sensors, the whole size of the sensor is minimized to only 3 × 3 mm2. Considering the liquid measurement environment, the sensor is gummed and waterproof performance is tested; the sensitivity of the sensor is 0.9 × 10-2 mV/kPa.展开更多
The axial flow structure in a high-density CFB riser having a height of 18 m is investigated on the basis of pressure measurements.Solids circulation rates reach 1400 kg/(m2 s)at superficial gas velocities of 5-9 m/s ...The axial flow structure in a high-density CFB riser having a height of 18 m is investigated on the basis of pressure measurements.Solids circulation rates reach 1400 kg/(m2 s)at superficial gas velocities of 5-9 m/s and the apparent solids holdup exceeds 0.2,indicating high-density operations have been achieved.The apparent solids holdup increases with the solids circulation rate increasing and/or superficial gas velocity decreasing.Axial distributions of the apparent solids holdup have exponential shapes with denser regions at the bottom and more dilute regions in the upper part.The apparent slip velocity increases with the increasing solids holdup and reaches 14 m/s,showing that there are more opportunities of cluster formation in high-density operation.Furthermore,the apparent slip velocity has a power relation with the apparent solids holdup under a wide range of operating conditions.展开更多
The monitoring of increased intracranial pressure(ICP) is necessary in the diagnosis and treatment of patients with neurological disease because it can provide an insight into the mechanism of the head injury. In th...The monitoring of increased intracranial pressure(ICP) is necessary in the diagnosis and treatment of patients with neurological disease because it can provide an insight into the mechanism of the head injury. In this letter, we develop a novel miniature Fabry–Perot(F-P) sensor for ICP measurement. The proposed sensor is fabricated by using a commercially available fusion splicer and a fiber cleaver, by which many difficult art problems involved in fabrication are solved and the online monitoring of the F-P cavity is actualized. The sensor exhibits a linear response to the applied pressure over the range of 0–25 k Pa(ample for ICP measurement), with a sensitivity of 10.18 nm/k Pa, a resolution of 0.1 k Pa, and a reduced thermal sensitivity of 0.068 nm/°C, which shows it can meet the requirements of ICP measurement.展开更多
Two measurement systems are developed for in-situ dielectric property measurement under high pressure in a wide-temperature range from 77K to 1273 K. The high-temperature system ranging from room temperature up to 127...Two measurement systems are developed for in-situ dielectric property measurement under high pressure in a wide-temperature range from 77K to 1273 K. The high-temperature system ranging from room temperature up to 1273K is equipped with a hexahedron anvils press, while the low-temperature system ranging from liquid nitrogen temperature to normal condition is equipped using the piston cylinder setup with a specially designed sample chamber. Using these configurations, the dielectric property measurement of ferroelectrie BaTiO3 and multiferroie Tm0.5Gd0.5MnO3 compounds are demonstrated, which proves the validity of the systems through the tuning of the polarization and phase transition boundary by high pressure. These two systems will be equally applicable to a wide variety of electronic and transport property measurements of insulators, semiconductors, as well as battery materials.展开更多
A digital camera measuring system has been used successfully to measure the space fluctuation behaviors of Induced Dielectric Barrier Discharge (IDBD) plasma at atmospheric pres- sure. The experimental results showed ...A digital camera measuring system has been used successfully to measure the space fluctuation behaviors of Induced Dielectric Barrier Discharge (IDBD) plasma at atmospheric pres- sure. The experimental results showed that: (1) The uniformity of electron temperature in space depends on discharge condition and structure of web electrode. For a certain web electrode the higher the discharge voltage is, the more uniform distribution of electron temperature in space will be. For a certain discharge the finer and denser the holes on web electrode are, the more uniform distribution of electron temperature in space will be (2). Digital camera is an available equipment to measure some behaviors of the plasma working at atmospheric pressure.展开更多
BACKGROUND Spastic pelvic floor syndrome(SPFS)is a refractory pelvic floor disease characterized by abnormal(uncoordinated)contractions of the external anal sphincter and puborectalis muscle during defecation,resultin...BACKGROUND Spastic pelvic floor syndrome(SPFS)is a refractory pelvic floor disease characterized by abnormal(uncoordinated)contractions of the external anal sphincter and puborectalis muscle during defecation,resulting in rectal emptation and obstructive constipation.The clinical manifestations of SPFS are mainly characterized by difficult defecation,often accompanied by a sense of anal blockage and drooping.Manual defecation is usually needed during defecation.From physical examination,it is commonly observed that the patient's anal muscle tension is high,and it is difficult or even impossible to enter with his fingers.AIM To investigate the characteristics of anorectal pressure and botulinum toxin A injection combined with biofeedback in treating pelvic floor muscle spasm syndrome.METHODS Retrospective analysis of 50 patients diagnosed with pelvic floor spasm syndrome.All patients underwent pelvic floor surface electromyography assessment,anorectal dynamics examination,botulinum toxin type A injection 100 U intramuscular injection,and two cycles of biofeedback therapy.RESULTS After the botulinum toxin A injection combined with two cycles of biofeedback therapy,the patient's postoperative resting and systolic blood pressure were significantly lower than before surgery(P<0.05).Moreover,the electromyography index of the patients in the resting stage and post-resting stages was significantly lower than before surgery(P<0.05).CONCLUSION Botulinum toxin A injection combined with biofeedback can significantly reduce pelvic floor muscle tension in treating pelvic floor muscle spasm syndrome.Anorectal manometry is an effective method to evaluate the efficacy of treatment objectively.However,randomized controlled trials are needed.展开更多
Sub-harmonic component generated from microbubbles is proven to be potentially used in noninvasive blood pressure measurement. Both theoretical and experimental studies are performed in the present work to investigate...Sub-harmonic component generated from microbubbles is proven to be potentially used in noninvasive blood pressure measurement. Both theoretical and experimental studies are performed in the present work to investigate the dependence of the sub-harmonic generation on the overpressure with different excitation pressure amplitudes and pulse lengths. With 4-MHz ultrasound excitation at an applied acoustic pressure amplitude of 0.24 MPa, the measured sub-harmonic amplitude exhibits a decreasing change as overpressure increases; while non-monotonic change is observed for the applied acoustic pressures of 0.36 MPa and 0.48 MPa, and the peak position in the curve of the sub-harmonic response versus the overpres- sure shifts toward higher overpressure as the excitation pressure amplitude increases. Furthermore, the exciting pulse with long duration could lead to a better sensitivity of the sub-harmonic response to overpressure. The measured results are ex- plained by the numerical simulations based on the Marmottant model. The numerical simulations qualitatively accord with the measured results. This work might provide a preliminary proof for the optimization of the noninvasive blood pressure measurement through using sub-harmonic generation from microbubbles.展开更多
The purpose of this study was to clarify grid convergence property of three-dimensional measurement-integrated (3D-MI) simulation for a flow behind a square cylinder with Karman vortex street. Measurement-integrated (...The purpose of this study was to clarify grid convergence property of three-dimensional measurement-integrated (3D-MI) simulation for a flow behind a square cylinder with Karman vortex street. Measurement-integrated (MI) simulation is a kind of the observer in the dynamical system theory by using CFD scheme as a mathematical model of the system. In a former study, two-dimensional MI (2D-MI) simulation with a coarse grid system showed a fairly good result in comparison with a 2D ordinary (2D-O) simulation, but the results were degraded with grid refinement. In this study, 3D-MI simulation and three-dimensional ordinary (3D-O) simulation were performed with three grid systems of different grid resolutions, and their grid convergence properties were compared. As a result, all 3D-MI simulations reproduced the vortex shedding frequency identical to that of the experiment, and the flow fields obtained were very close, within 5% difference between the results, while the results of the 3D-O simulations showed variation of the solution under convergence. It is shown that the grid convergence property of 3D-MI simulation is monotonic and better than that of 3D-O simulation, whereas those of 2D-O and 2D-MI simulations for streamwise velocity fluctuation are divergent. The solution of 3D-MI simulation with a relatively coarse grid system properly reproduces the basic three-dimensional structure of the wake flow as well as the drag and lift coefficients.展开更多
In this paper,we study the pressure of C^(1)-smooth partially hyperbolic diffeomorphisms with sup-additive potentials.We give several definitions of the so called unstable(measure theoretic)pressure in terms of Bowen...In this paper,we study the pressure of C^(1)-smooth partially hyperbolic diffeomorphisms with sup-additive potentials.We give several definitions of the so called unstable(measure theoretic)pressure in terms of Bowen’s picture and the capacity picture.We show that all such unstable metric pressures of a given ergodic measure equals the corresponding unstable measure theoretic entropy plus the Lyapunov exponent of the potentials with respect to the ergodic measure.展开更多
To obtain thermal contact resistance(TCR) between the vertical double-diffused metal-oxide-semiconductor(VDMOS) and the heat sink, we derived the relationship between the total thermal resistance and the contact f...To obtain thermal contact resistance(TCR) between the vertical double-diffused metal-oxide-semiconductor(VDMOS) and the heat sink, we derived the relationship between the total thermal resistance and the contact force imposed on the VDMOS. The total thermal resistance from the chip to the heat sink is measured under different contact forces, and the TCR can be extracted nondestructively from the derived relationship. Finally, the experimental results are compared with the simulation results.展开更多
The primary issue regarding the plasma synthetic jet actuator(PSJA)is its performance attenuation at high frequencies.To solve this issue,a self-supplementing,dual-cavity,plasma synthetic jet actuator(SD-PSJA)is desig...The primary issue regarding the plasma synthetic jet actuator(PSJA)is its performance attenuation at high frequencies.To solve this issue,a self-supplementing,dual-cavity,plasma synthetic jet actuator(SD-PSJA)is designed,and the static properties of the SD-PSJA are investigated through experiments and numerical simulations.The pressure measurement shows that the SD-PSJA has two saturation frequencies(1200 Hz and 2100 Hz),and the experimental results show that both the saturation frequencies decrease as the volume of the bottom cavity of the SD-PSJA increases.As the size of the supplement hole increases,the first saturation frequency increases continuously,while the second saturation frequency shows a trend of first decreasing and then increasing.Numerical simulations show that the working process of the SD-PSJA is similar to that of the PSJA,but the volume of the cavity in the SD-PSJA is smaller than that of the PSJA;the SD-PSJA can supplement air to the top cavity through two holes,thus reducing the refresh time and effectively improving the jet intensity of the actuator at high frequencies.展开更多
文摘Introduction: Ambulatory Blood Pressure Measurement (ABPM) is a non- invasive examination recommended for subjects at high cardiovascular risk, and those requiring a nocturnal drop in BP such as elderly and obese subjects, those with secondary hypertension or resistant, diabetics, subjects with metabolic syndrome or sleep apnea syndrome. The objective of this study was to evaluate the contribution of ABPM in the diagnosis and evaluation of the level of control of hypertension under treatment at the Bel Air international clinic. Materials and Methods: This is a retrospective, cross-sectional and descriptive study, carried out at the Bel Air International Clinic in Conakry (Guinea) between January 2019 and November 30, 2022. It included a consecutive series of 180 consenting patients recruited through an ambulatory measurement of 24-hour blood pressure from a FUGADA brand device. Results: We collected 180 patients, with a male predominance (sex-ratio M/F = 2.46). The mean age of the patients was 48.48 ± 14.23 years. The most represented age group was that of 32 to 42 years with 50 cases (27.8%) followed by that of 43 to 52 years with 42 cases or 23.3%. The indication was for diagnostic purposes in 106 cases 58.9%, the therapeutic evaluation in 58 patients (32.2%). The examination was prescribed by a cardiologist in 98 cases (54.4%), a general practitioner in 71 cases (39.4%), a neurologist in 11 cases (6.1%). In the therapeutic evaluation, high blood pressure was controlled in 24 patients (13.3%) and uncontrolled in 34 cases (18.9%). In the diagnostic indication, high blood pressure was confirmed in 79 cases (43.9%) with a statistically significant link (Chi2</sup> = 4.57 and p-value = 0.032). The nycthemeral mean was 187.27 ± 26.22 mmHg for systolic blood pressure (SBP) and 110.37 ± 19.06 mmHg for diastolic blood pressure (DBP), during the day, 151.64 ± 21.45 mmHg for SBP and 71.59 ± 8.67 mmHg for diastolic blood pressure. During the study 65 patients (36.1%) were identified as dippers and 115 patients (63.9%) were no-dipping. The antihypertensive protocol used was monotherapy in 68 cases (37.8%), dual therapy in 46 cases (25.6%), triple therapy in 17 cases (9.4%). However 39 patients or 21.7% were not taking any antihypertensive. Conclusion: This preliminary study, despite the modest sample size, showed the importance of ABPM as a tool for diagnosis, monitoring of hypertensive patients and therapeutic adaptation. A large-scale national study would be necessary for the rational use of ambulatory blood pressure measurement in our context in order to improve the management of hypertensive patients.
基金supported in part by the National Natural Science Foundation of China (Grant 81370438)the SJTU Medical-Engineering Cross-cutting Research Project (Grant YG2015MS53)supported by the Hui-Chun Chin and Tsung-Dao Lee Chinese Undergraduate Research Program Endowment
文摘An inflatable cuff wrapped around the upper arm is widely used in noninvasive blood pressure measurement.However, the mechanical interaction between cuff and arm tissues, a factor that potentially affects the accuracy of noninvasive blood pressure measurement, remains rarely addressed. In the present study, finite element(FE) models were constructed to quantify intra-arm stresses generated by cuff compression, aiming to provide some theoretical evidence for identifying factors of importance for blood pressure measurement or explaining clinical observations. Obtained results showed that the simulated tissue stresses were highly sensitive to the distribution of cuff pressure on the arm surface and the contact condition between muscle and bone. In contrast, the magnitude of cuff pressure and small variations in elastic properties of arm soft tissues had little influence on the efficiency of pressure transmission in arm tissues. In particular, it was found that a thickened subcutaneous fat layer in obese subjects significantly reduced the effective pressure transmitted to the brachial artery, which may explain why blood pressure overestimation occurs more frequently in obese subjects in noninvasive blood pressure measurement.
基金National Natural Science Foundation of China (No.81170851)Capital Project of the Transfer of Scientific and Technological Achievements in Research Institutes of Sichuan Province, China (2009 Chuan fiscal teach [2009] No.36)Sichuan Provincial Health Department Scientific Research Project, China (No.100474)
文摘AIM: To train Tibetan monkey (Macaca thibetana) for intraocular pressure (IOP) measurement in conscious state and obtain normal IOP in conscious Tibetan Macaque. METHODS: The training was based on award-conditioned behavior. Food stimulation and human-animal interaction were used in this training. RESULTS: Trained Tibetan monkeys calmly accepted IOP measurement by the TonoVete (R) rebound tonometer without sedation or anesthesia and their IOP values were similar to other primates. CONCLUSION: Human-cultivated Thibetan monkeys are tamable, and can be used for biomedical research such as ophthalmic research without anesthesia.
基金funded by the State Key Research Development Program of China(No.2018YFC0604400)the National Science Foundation of China(Nos.51874068,52074062)+2 种基金the Fundamental Research Funds for the Central Universities(Nos.N2001003,N160107001,N180701016,N182608003,N2001001)the 111 Project(No.B17009)The authors also acknowledge Nazarbayev University for funding the research through its Collaborative Research Program(No.OPCRP2020014).
文摘Static cracking agent(SCA)is actively investigated as an alternative to explosive blasting for rock breakage due to its immense expansion property.SCA can eliminate the negative effects of shock,noise and harmful gases encountered in explosive blasting processes.Accurate measurement and deep understanding of the expansive properties of SCAs are important in their industrial application.An improved outer pipe method(OPM),termed the upper end surface method(UESM),is proposed in this paper to overcome the shortcomings of the OPM in the expansive pressure measurement of SCAs.Numerical simulation is used to proof the concept and a mathematical model established to relate the internal pressure and the radial strains at different positions in the upper end surface method test equipment.The new equipment is calibrated using oil pressure and strain measurements.The calibrated equipment is then used to measure the expansion pressure of SCA at three different water contents to proof its potential.The differences in the measurements with OPM and UESM at three different moisture contents are less than 4%.The experimental results confirm the accuracy and applicability of the more user friendly and less expensive UESM in the measurement of the expansive pressures of SCAs.
基金Project supported by the National Natural Science Foundation for Distinguished Young Scholars,China(Grant No.51425505)the National Natural Science Foundation of China(Grant No.61471324)+1 种基金the Program for the Outstanding Innovative Teams of Higher Learning Institutions of Shanxi Province,China(Grant No.2013-077)the Graduate Students Outstanding Innovation Project of Shanxi Province,China(Grant No.20143020)
文摘In this paper, a novel antenna is proposed for high-temperature testing, which can make the high-temperature pressure characteristics of a wireless passive ceramic pressure sensor demonstrated at up to a temperature of 600℃. The design parameters of the antenna are similar to those of the sensor, which will increase the coupling strength between the sensor and testing antenna. The antenna is fabricated in thick film integrated technology, and the properties of the alumina ceramic and silver ensure the feasibility of the antenna in high-temperature environments. The sensor, coupled with the ceramic antenna, is investigated using a high-temperature pressure testing platform. The experimental measurement results show that the pressure signal in a harsh environment can be detected by the frequency diversity of the sensor.
基金This study was supported in part by the Ministry of Science and Technology MOST 108-2221-E-150-022-MY3 and Taiwan Ocean University.
文摘This study proposed a measurement platform for continuous blood pressure estimation based on dual photoplethysmography(PPG)sensors and a deep learning(DL)that can be used for continuous and rapid measurement of blood pressure and analysis of cardiovascular-related indicators.The proposed platform measured the signal changes in PPG and converted them into physiological indicators,such as pulse transit time(PTT),pulse wave velocity(PWV),perfusion index(PI)and heart rate(HR);these indicators were then fed into the DL to calculate blood pressure.The hardware of the experiment comprised 2 PPG components(i.e.,Raspberry Pi 3 Model B and analog-todigital converter[MCP3008]),which were connected using a serial peripheral interface.The DL algorithm converted the stable dual PPG signals acquired from the strictly standardized experimental process into various physiological indicators as input parameters and finally obtained the systolic blood pressure(SBP),diastolic blood pressure(DBP)and mean arterial pressure(MAP).To increase the robustness of the DL model,this study input data of 100 Asian participants into the training database,including those with and without cardiovascular disease,each with a proportion of approximately 50%.The experimental results revealed that the mean absolute error and standard deviation of SBP was 0.17±0.46 mmHg.The mean absolute error and standard deviation of DBP was 0.27±0.52 mmHg.The mean absolute error and standard deviation of MAP was 0.16±0.40 mmHg.
基金Supported by the National Natural Science Foundation of China(No.81670851)。
文摘AIM:To evaluate the precision of digital intraocular pressure(IOP)measurement in silicone oil(SO)filled eyes during vitrectomy.METHODS:This is a retrospective,single-blind study.Patients who were diagnosed with retinal detachment and scheduled for vitrectomy with SO injection were consecutively enrolled.During the vitrectomy,IOP was digitally measured and then by a rebound tonometer(Icare PRO).The rebound tonometer readings were masked to the surgeons.The digitally measured IOP and that of rebound tonometer were compared,and the inter-methods agreement was assessed.The absolute deviation in IOP values between these two methods(△IOP)was also calculated,and correlations between△IOP and refractive status,lens status and levels of surgeons’experience were analyzed.RESULTS:A total of 131 patients(131 eyes)were recruited,with a mean age of 51.0±16.1 y.There was no significant difference in IOPs between digital measurement and the rebound tonometer(15.6±4.3 vs 15.7±5.1 mm Hg;t=0.406,P=0.686).Intraclass correlation coefficients(ICC)analysis indicated a strong correlation between these two measurements(ICC=0.830,P<0.001).The mean△IOP was 2.0±1.9 mm Hg(range:0-12.8 mm Hg),with 98 eyes(74.8%)had the△IOP within 3 mm Hg.△IOP was found to be negatively correlated with levels of surgeons’experience(r=-0.183;P=0.037),but not with the refractive status or lens status of the patients(both P>0.05).CONCLUSION:For experienced surgeons,the digital IOP measurement may be an acceptable technique for IOP measurement in SO filled eyes during vitrectomy.However,its use by inexperienced surgeons should be taken with caution.
基金The work of this paper is supported by the National Natural Science Foundation of China under Grant No.61572038,the Innovation Project Foundation NCUT.
文摘Blood pressure is an important physiological parameter to reflect human vital signs.In order to achieve the non-contact dynamic blood pressure acquisition based on ordinary optical camera,a theoretical understanding of the functional relationship between blood pressure and pulse wave signal conduction time.And through imaging photoelectric plethysmography(IPPG),pulse wave signal conduction time of forehead and hand was obtained with ordinary optical camera.First,the pulse wave conduction time was obtained by recording the video with an ordinary optical camera.Second,real-time blood pressure values were collected.Finally,based on the relationship between blood pressure and pulse wave conduction time,a non-contact blood pressure measurement prediction model was obtained through neural network fitting.So that non-contact blood pressure measurement with optical camera could be completed.The method in this paper has several advantages,such as low requirements on measuring equipment,low cost,and simple operation.It can let people get rid of the discomfort caused by measuring equipment such as cuff and can measure blood pressure at any time.The predicted blood pressure results were compared with an Omron wrist electronic sphygmomanometer.The calculated error of systolic blood pressure is-9.28%~3.16%,and the error of diastolic blood pressure is-9.84~4.35%.
基金supported by the National Natural Science Foundation of China (No.61675174)the Natural Science Foundation of Fujian Province (No.2020J01705)。
文摘In this paper, we present a method based on self-mixing interferometry combing extreme learning machine for real-time human blood pressure measurement. A signal processing method based on wavelet transform is applied to extract reversion point in the self-mixing interference signal, thus the pulse wave profile is successfully reconstructed. Considering the blood pressure values are intrinsically related to characteristic parameters of the pulse wave, 80 samples from the MIMIC-II database are used to train the extreme learning machine blood pressure model. In the experiment, 15 measured samples of pulse wave signal are used as the prediction sets. The results show that the errors of systolic and diastolic blood pressure are both within 5 mm Hg compared with that by the Coriolis method.
基金Project supported by the National Natural Science Foundation of China(Nos.61025021,61434001)the ‘Thousands Talents’ Program for Pioneer Researchers and Its Innovation Team,China
文摘This paper presents a micro packaged MEMS pressure sensor for intracranial pressure measurement which belongs to BioMEMS. It can be used in lumbar puncture surgery to measure intracranial pressure. Minia- turization is key for lumbar puncture surgery because the sensor must be small enough to allow it be placed in the reagent chamber of the lumbar puncture needle. The size of the sensor is decided by the size of the sensor chip and package. Our sensor chip is based on silicon piezoresistive effect and the size is 400 × 400 μm2. It is much smaller than the reported polymer intracranial pressure sensors such as liquid crystal polymer sensors. In terms of package, the traditional dual in-line package obviously could not match the size need, the minimal size of recently reported MEMS-based intracranial pressure sensors after packaging is 10 × 10 mm2. In this work, we are the first to introduce a quad flat no-lead package as the package form of piezoresistive intracranial pressure sensors, the whole size of the sensor is minimized to only 3 × 3 mm2. Considering the liquid measurement environment, the sensor is gummed and waterproof performance is tested; the sensitivity of the sensor is 0.9 × 10-2 mV/kPa.
基金The authors acknowledge the support of the National Natural Science Foundation of China(Grant No.91534204,21622609,and 91834302)Science Foundation of China University of Petroleum,Beijing(Grant No.2462018BJC003)。
文摘The axial flow structure in a high-density CFB riser having a height of 18 m is investigated on the basis of pressure measurements.Solids circulation rates reach 1400 kg/(m2 s)at superficial gas velocities of 5-9 m/s and the apparent solids holdup exceeds 0.2,indicating high-density operations have been achieved.The apparent solids holdup increases with the solids circulation rate increasing and/or superficial gas velocity decreasing.Axial distributions of the apparent solids holdup have exponential shapes with denser regions at the bottom and more dilute regions in the upper part.The apparent slip velocity increases with the increasing solids holdup and reaches 14 m/s,showing that there are more opportunities of cluster formation in high-density operation.Furthermore,the apparent slip velocity has a power relation with the apparent solids holdup under a wide range of operating conditions.
基金supported by Beijing Nova Program under Grant No.Z121101002512111
文摘The monitoring of increased intracranial pressure(ICP) is necessary in the diagnosis and treatment of patients with neurological disease because it can provide an insight into the mechanism of the head injury. In this letter, we develop a novel miniature Fabry–Perot(F-P) sensor for ICP measurement. The proposed sensor is fabricated by using a commercially available fusion splicer and a fiber cleaver, by which many difficult art problems involved in fabrication are solved and the online monitoring of the F-P cavity is actualized. The sensor exhibits a linear response to the applied pressure over the range of 0–25 k Pa(ample for ICP measurement), with a sensitivity of 10.18 nm/k Pa, a resolution of 0.1 k Pa, and a reduced thermal sensitivity of 0.068 nm/°C, which shows it can meet the requirements of ICP measurement.
基金Supported by the National Basic Research Program of China under Grant No 2009CB623301
文摘Two measurement systems are developed for in-situ dielectric property measurement under high pressure in a wide-temperature range from 77K to 1273 K. The high-temperature system ranging from room temperature up to 1273K is equipped with a hexahedron anvils press, while the low-temperature system ranging from liquid nitrogen temperature to normal condition is equipped using the piston cylinder setup with a specially designed sample chamber. Using these configurations, the dielectric property measurement of ferroelectrie BaTiO3 and multiferroie Tm0.5Gd0.5MnO3 compounds are demonstrated, which proves the validity of the systems through the tuning of the polarization and phase transition boundary by high pressure. These two systems will be equally applicable to a wide variety of electronic and transport property measurements of insulators, semiconductors, as well as battery materials.
基金This work was supported by National Natural Science Foundation of China No.19775010.
文摘A digital camera measuring system has been used successfully to measure the space fluctuation behaviors of Induced Dielectric Barrier Discharge (IDBD) plasma at atmospheric pres- sure. The experimental results showed that: (1) The uniformity of electron temperature in space depends on discharge condition and structure of web electrode. For a certain web electrode the higher the discharge voltage is, the more uniform distribution of electron temperature in space will be. For a certain discharge the finer and denser the holes on web electrode are, the more uniform distribution of electron temperature in space will be (2). Digital camera is an available equipment to measure some behaviors of the plasma working at atmospheric pressure.
文摘BACKGROUND Spastic pelvic floor syndrome(SPFS)is a refractory pelvic floor disease characterized by abnormal(uncoordinated)contractions of the external anal sphincter and puborectalis muscle during defecation,resulting in rectal emptation and obstructive constipation.The clinical manifestations of SPFS are mainly characterized by difficult defecation,often accompanied by a sense of anal blockage and drooping.Manual defecation is usually needed during defecation.From physical examination,it is commonly observed that the patient's anal muscle tension is high,and it is difficult or even impossible to enter with his fingers.AIM To investigate the characteristics of anorectal pressure and botulinum toxin A injection combined with biofeedback in treating pelvic floor muscle spasm syndrome.METHODS Retrospective analysis of 50 patients diagnosed with pelvic floor spasm syndrome.All patients underwent pelvic floor surface electromyography assessment,anorectal dynamics examination,botulinum toxin type A injection 100 U intramuscular injection,and two cycles of biofeedback therapy.RESULTS After the botulinum toxin A injection combined with two cycles of biofeedback therapy,the patient's postoperative resting and systolic blood pressure were significantly lower than before surgery(P<0.05).Moreover,the electromyography index of the patients in the resting stage and post-resting stages was significantly lower than before surgery(P<0.05).CONCLUSION Botulinum toxin A injection combined with biofeedback can significantly reduce pelvic floor muscle tension in treating pelvic floor muscle spasm syndrome.Anorectal manometry is an effective method to evaluate the efficacy of treatment objectively.However,randomized controlled trials are needed.
基金Project supported by the National Basic Research Program from Ministry of Science and Technology,China(Grant No.2011CB707900)the National Natural Science Foundation of China(Grant Nos.81271589,81227004,11174141,11374155,11612032,and 81301616)the Natural Science Foundation of Jiangsu Province,China(Grant Nos.BE2011110 and BK20131017)
文摘Sub-harmonic component generated from microbubbles is proven to be potentially used in noninvasive blood pressure measurement. Both theoretical and experimental studies are performed in the present work to investigate the dependence of the sub-harmonic generation on the overpressure with different excitation pressure amplitudes and pulse lengths. With 4-MHz ultrasound excitation at an applied acoustic pressure amplitude of 0.24 MPa, the measured sub-harmonic amplitude exhibits a decreasing change as overpressure increases; while non-monotonic change is observed for the applied acoustic pressures of 0.36 MPa and 0.48 MPa, and the peak position in the curve of the sub-harmonic response versus the overpres- sure shifts toward higher overpressure as the excitation pressure amplitude increases. Furthermore, the exciting pulse with long duration could lead to a better sensitivity of the sub-harmonic response to overpressure. The measured results are ex- plained by the numerical simulations based on the Marmottant model. The numerical simulations qualitatively accord with the measured results. This work might provide a preliminary proof for the optimization of the noninvasive blood pressure measurement through using sub-harmonic generation from microbubbles.
文摘The purpose of this study was to clarify grid convergence property of three-dimensional measurement-integrated (3D-MI) simulation for a flow behind a square cylinder with Karman vortex street. Measurement-integrated (MI) simulation is a kind of the observer in the dynamical system theory by using CFD scheme as a mathematical model of the system. In a former study, two-dimensional MI (2D-MI) simulation with a coarse grid system showed a fairly good result in comparison with a 2D ordinary (2D-O) simulation, but the results were degraded with grid refinement. In this study, 3D-MI simulation and three-dimensional ordinary (3D-O) simulation were performed with three grid systems of different grid resolutions, and their grid convergence properties were compared. As a result, all 3D-MI simulations reproduced the vortex shedding frequency identical to that of the experiment, and the flow fields obtained were very close, within 5% difference between the results, while the results of the 3D-O simulations showed variation of the solution under convergence. It is shown that the grid convergence property of 3D-MI simulation is monotonic and better than that of 3D-O simulation, whereas those of 2D-O and 2D-MI simulations for streamwise velocity fluctuation are divergent. The solution of 3D-MI simulation with a relatively coarse grid system properly reproduces the basic three-dimensional structure of the wake flow as well as the drag and lift coefficients.
基金supported by a NSFC grant(11501066)the Department of Education in Chongqing City(KJQN201900724 and KJQN202100722)in Chongqing Jiaotong Universitysupported by the Chongqing Key Laboratory of Analytic Mathematics and Applications。
文摘In this paper,we study the pressure of C^(1)-smooth partially hyperbolic diffeomorphisms with sup-additive potentials.We give several definitions of the so called unstable(measure theoretic)pressure in terms of Bowen’s picture and the capacity picture.We show that all such unstable metric pressures of a given ergodic measure equals the corresponding unstable measure theoretic entropy plus the Lyapunov exponent of the potentials with respect to the ergodic measure.
基金Project supported by the National Natural Science Foundation of China(Grant No.61204081)
文摘To obtain thermal contact resistance(TCR) between the vertical double-diffused metal-oxide-semiconductor(VDMOS) and the heat sink, we derived the relationship between the total thermal resistance and the contact force imposed on the VDMOS. The total thermal resistance from the chip to the heat sink is measured under different contact forces, and the TCR can be extracted nondestructively from the derived relationship. Finally, the experimental results are compared with the simulation results.
基金National Natural Science Foundation of China(No.61971345)the Foundation for Key Laboratories of National Defense Science and Technology of China(No.614220120030810).
文摘The primary issue regarding the plasma synthetic jet actuator(PSJA)is its performance attenuation at high frequencies.To solve this issue,a self-supplementing,dual-cavity,plasma synthetic jet actuator(SD-PSJA)is designed,and the static properties of the SD-PSJA are investigated through experiments and numerical simulations.The pressure measurement shows that the SD-PSJA has two saturation frequencies(1200 Hz and 2100 Hz),and the experimental results show that both the saturation frequencies decrease as the volume of the bottom cavity of the SD-PSJA increases.As the size of the supplement hole increases,the first saturation frequency increases continuously,while the second saturation frequency shows a trend of first decreasing and then increasing.Numerical simulations show that the working process of the SD-PSJA is similar to that of the PSJA,but the volume of the cavity in the SD-PSJA is smaller than that of the PSJA;the SD-PSJA can supplement air to the top cavity through two holes,thus reducing the refresh time and effectively improving the jet intensity of the actuator at high frequencies.