Impact of Revascularization on the Distal to Proximal Pressure Ratio in Case of Multiple Coronary Stenoses

Objective: In order to take a decision about the revascularization approach to be adopted, it is of fundamental importance to determine whether coronary artery stenoses induce ischemia or not. An index, named (Fractional Flow Reserve), based on pressure measurements has been proposed to this aim and is usually interpreted in terms of flows. The objective of this work is to compute simultaneously pressures and flow rates in the coronary network of patients with three-vessel disease, in order to study more precisely the relationship between these two quantities. Approach: 22 patients have been included in the study. Some pressure and flow rate measurements were collected during by-pass surgery. These clinical data allow determining parameters for a patient’s specific model, based on the electric/hydraulic analogy. Collateral pathways are included in the model, as well as the severity of the disease and the impact of revascularization. Main Results: For patients with stenoses on LAD, LCx, LMCA and occlusion of the RCA, the flow rate delivered to the right territory is of course a function of the aortic pressure, the left stenoses severity, and the pressure distal to the thrombosis. But it mainly depends on the capillary and collateral resistances, and on the proportion between them. Abnormal microvascular hemodynamics, may be present in patients with non-hemodynamic significant lesions as assessed by the pressure ratio. Complete revascularization with the 3 grafts is demonstrated to be fully justified. The direction of collateral flows may be reversed, depending on the pressure gradient. In any case, they remain low and become negligible when the 3 grafts are operating. Significance: Surgical decision based only on pressure measurements may miss some real hemodynamic problems due to the considered stenosis. This risk is even greater in case of serial stenoses.

Dynamic simulation and safety evaluation of high-speed trains meeting in open air

Dynamic responses of a carriage under excitation with the German high-speed low-interference track spectrum together with the air pressure pulse generated as high-speed trains passing each other are investigated with a multi-body dynamics method.The variations of degrees of freedom（DOFs：horizontal movement,roll angle,and yaw angle）,the lateral wheel-rail force,the derailment coefficient and the rate of wheel load reduction with time when two carriages meet in open air are obtained and compared with the results of a single train travelling at specifie speeds.Results show that the rate of wheel load reduction increases with the increase of train speed and meets some safety standard at a certain speed,but exceeding the value of the rate of wheel load reduction does not necessarily mean derailment.The evaluation standard of the rate of wheel load reduction is somewhat conservative and may be loosened.The pressure pulse has significan effects on the train DOFs,and the evaluations of these safety indexes are strongly suggested in practice.The pressure pulse has a limited effect on the derailment coefficien and the lateral wheel-rail force,and,thus,their further evaluations may be not necessary.

THEORETICAL AND EXPERIMENTAL STUDY ON THE PRESSURE AND VACUUM CONTINUOUS CONTROL SYSTEM BASED ON HYBRID PUMP

A novel pressure and vacuum continuous control system, which adopts a hybrid pump as pressure and vacuum source, is presented. The mathematical model of the system is developed. The theoretical simulation and analysis on the system are implemented in order to study the relationships among the characteristics, parameters and working points of the system. The experimental investigations on the system characteristics are presented with the adoption ofa fuzzy-PID controller. The simulation and experimental results indicate that the pressure and vacuum continuous control system based on hybrid pump has good dynamic and static performance, strong robustness and satisfactory adaptability to various system parameters. According to the results, system can successfully gain high accuracy and fast response signal. Also, the mathematical model of system is also testified by the experimental results.

Wind tunnel simulation of wind loading on a solid structure of revolution

The wind tunnel simulations of wind loading on a solid structure of revolution with one smooth and five rough surfaces were conducted using wind tunnel tests. Timemean and fluctuating pressure distributions on the surface were obtained, and the relationships between the roughness Reynolds number and pressure distributions were analyzed and discussed. The results show that increasing the surface roughness can significantly affect the pressure distribution, and the roughness Reynolds numbers play an important role in the change of flow patterns. The three flow patterns of subcritical, critical and supercritical flows can be classified based on the changing patterns of both the mean and the fluctuating pressure distributions. The present study suggests that the wind tunnel results obtained in the supercritical pattern reflect more closely those of full-scale solid structure of revolution at the designed wind speed.

Suppression effect of jet flow on pulsating pressure of cavity using scale-adaptive simulation model

The suppression of the aerodynamic noise in the cavity has a great significance to solve relevant puzzles of weapon bays. Acoustic field of the standard cavity model is simulated by using the computational fluid dynamics technology based on scale-adaptive simulation （SAS） model. The results obtained by the proposed method in this paper show reasonable agreement with experiments. On the basis of this, effect of different jet flow rates on the time-averaged variables, turbulent kinetic energy, root mean square （RMS） of sound pressure, sound sources distribution and the pulsating pressure distribution in the cavity is studied. The analysis shows that the jet flow has great influence on the cavity flow field and the distribution of pulsating pressure RMS by changing the morphology of the shear layer. The most obvious of these measures is spout4 configuration, the influence mainly in the form of reducing the pulsating pressure of the whole cavity and changing the sound pressure level in the far field. The results show that different jet flow rates have different control effects on pulsating pressure in the cavity and sound pressure level in the far field. Furthermore, the jet flow rates and the suppression effect on the pulsating pressure have no linear relation.

Near-wall behaviors of oblique-shock-wave/turbulent-boundary-layer interactions

A direct numerical simulation （DNS） on an oblique shock wave with an incident angle of 33.2° impinging on a Mach 2.25 supersonic turbulent boundary layer is performed. The numerical results are confirmed to be of high accuracy by comparison with the reference data. Particular efforts have been made on the investigation of the near-wall behaviors in the interaction region, where the pressure gradient is so significant that a certain separation zone emerges. It is found that, the traditional linear and loga- rithmic laws, which describe the mean-velocity profiles in the viscous and meso sublayers, respectively, cease to be valid in the neighborhood of the interaction region, and two new laws of the wall are proposed by elevating the pressure gradient to the leading order. The new laws are inspired by the analysis on the incompressible separation flows, while the compressibility is additionally taken into account. It is verified by the DNS results that the new laws are adequate to reproduce the mean-velocity profiles both inside and outside the interaction region. Moreover, the normalization adopted in the new laws is able to regularize the Reynolds stress into an almost universal distribution even with a salient adverse pressure gradient （APG）.