目的 探讨先天性心脏病（先心病）患者血浆NT-proBNP与肺动脉压之间的关系。方法 将在先心病门诊就诊筛选出的120例先心病患儿依据彩超检查结果分为对照组（肺动脉压正常组,n=60,PASP〈20 mm Hg）和实验组（肺动脉高压组,n=60）,肺动脉...目的 探讨先天性心脏病（先心病）患者血浆NT-proBNP与肺动脉压之间的关系。方法 将在先心病门诊就诊筛选出的120例先心病患儿依据彩超检查结果分为对照组（肺动脉压正常组,n=60,PASP〈20 mm Hg）和实验组（肺动脉高压组,n=60）,肺动脉高压组根据彩超检测脉动脉压结果分为A组（PASP 20-30 mm Hg）,B组（PASP 30-50 mm Hg）,C组（PASP〉50 mm Hg）,分别检测患者血浆NT-proBNP水平。结果 对照组血浆NT-proBNP含量明显小于实验组（t=25,P〈0.01）;先心病患者血浆NT-proBNP随着肺动脉压升高而明显升高,差异有统计学意义（组间比较t检验,P〈0.01）。结论 先心病合并肺动脉高压患者血浆NT-proBNP是升高的,NT-proBNP与肺动脉压存在相关性,NT-proBNP可作为先心病肺动脉高压评价的一个客观指标。展开更多
Background Although most patients with tetralogy of Fallot undergo radical repair during infancy and childhood,patients that remain undiagnosed and untreated until adulthood can still be treated.This study aimed to ev...Background Although most patients with tetralogy of Fallot undergo radical repair during infancy and childhood,patients that remain undiagnosed and untreated until adulthood can still be treated.This study aimed to evaluate longterm outcomes of adult patients with tetralogy of Fallot who were treated surgically,and to determine the predictors of postoperative pulmonary regurgitation.Methods Fifty-six adult patients underwent complete surgical repair.Forty-three patients （76.8%） required a transannular patch.Systolic,diastolic,and mean pressure in the main pulmonary artery were measured after repair.Results The early mortality rate was 3.6%.The 16-year survival rate was （84.4±11.5）%.Late echocardiography revealed 41 patients with transannular patch who had pulmonary regurgitation,consisting of mild pulmonary regurgitation in 28 patients,moderate in eight,and severe regurgitation in five patients.In addition,there was right ventricular outflow tract stenosis in nine patients,moderate/severe tricuspid valve regurgitation in seven,and residual ventricular septal defect in five.Logistic regression analysis demonstrated that the mean pulmonary pressure measured just after repair predicted late pulmonary regurgitation.Conclusions The long-term survival of surgically treated adult patients with tetralogy of Fallot is acceptable.The mean pressure 〉20 mmHg in the main pulmonary artery measured right after surgical repair may be a feasible reference to time the reconstruction of the pulmonary valve.展开更多
文摘目的 探讨先天性心脏病（先心病）患者血浆NT-proBNP与肺动脉压之间的关系。方法 将在先心病门诊就诊筛选出的120例先心病患儿依据彩超检查结果分为对照组（肺动脉压正常组,n=60,PASP〈20 mm Hg）和实验组（肺动脉高压组,n=60）,肺动脉高压组根据彩超检测脉动脉压结果分为A组（PASP 20-30 mm Hg）,B组（PASP 30-50 mm Hg）,C组（PASP〉50 mm Hg）,分别检测患者血浆NT-proBNP水平。结果 对照组血浆NT-proBNP含量明显小于实验组（t=25,P〈0.01）;先心病患者血浆NT-proBNP随着肺动脉压升高而明显升高,差异有统计学意义（组间比较t检验,P〈0.01）。结论 先心病合并肺动脉高压患者血浆NT-proBNP是升高的,NT-proBNP与肺动脉压存在相关性,NT-proBNP可作为先心病肺动脉高压评价的一个客观指标。
基金This study was supported by a grant from the Natural Science Foundation ofNingbo, Zhejiang （No. 2011A610036）.
文摘Background Although most patients with tetralogy of Fallot undergo radical repair during infancy and childhood,patients that remain undiagnosed and untreated until adulthood can still be treated.This study aimed to evaluate longterm outcomes of adult patients with tetralogy of Fallot who were treated surgically,and to determine the predictors of postoperative pulmonary regurgitation.Methods Fifty-six adult patients underwent complete surgical repair.Forty-three patients （76.8%） required a transannular patch.Systolic,diastolic,and mean pressure in the main pulmonary artery were measured after repair.Results The early mortality rate was 3.6%.The 16-year survival rate was （84.4±11.5）%.Late echocardiography revealed 41 patients with transannular patch who had pulmonary regurgitation,consisting of mild pulmonary regurgitation in 28 patients,moderate in eight,and severe regurgitation in five patients.In addition,there was right ventricular outflow tract stenosis in nine patients,moderate/severe tricuspid valve regurgitation in seven,and residual ventricular septal defect in five.Logistic regression analysis demonstrated that the mean pulmonary pressure measured just after repair predicted late pulmonary regurgitation.Conclusions The long-term survival of surgically treated adult patients with tetralogy of Fallot is acceptable.The mean pressure 〉20 mmHg in the main pulmonary artery measured right after surgical repair may be a feasible reference to time the reconstruction of the pulmonary valve.
