Background Right ventricular function plays an important role in the hemodynamic derangement during off-pump coronary artery bypass (OPCAB) surgery. Pressure-volume loops have been shown to provide load-independent ...Background Right ventricular function plays an important role in the hemodynamic derangement during off-pump coronary artery bypass (OPCAB) surgery. Pressure-volume loops have been shown to provide load-independent information of cardiac function. Therefore, the aim of this study was to investigate the feasibility of construction of right ventricular pressure-volume loops with pressure and volume data measured by a volumetric pulmonary artery catheter (PAC) and to evaluate right ventricular systolic and diastolic function by end-systolic elastance (EEs) and end-diastolic stiffness (EED) in OPCAB surgery. Methods Twenty-eight patients who underwent OPCAB surgery were included. After anesthesia induction, a volumetric PAC was placed via the right internal jugular vein. Data were recorded at: anesthesia steady-state before skin incision (T1); 5 minutes after the stabilizer device was placed for anastomosis on the heart's anterior wall (T2), lateral wall (T3), posterior wall (T4), respectively; after sternal closure (T5). Three sets of data were collected at each time point: first, hemodynamic variables were measured; second, right ventricular EEs and EED were calculated; third, right ventricular pressure-volume loops were constructed with pressure and volume data measured from end-diastole point, end-isovolumic systole point, peak-ejection point, end-systole point and end-isovolumic diastole point. Results Right ventricular pressure-volume loops generally shifted to the left during OPCAB surgery. Especially, the end-diastolic point shifted upward and to the left at T2--T5 compared with that at T1. Decrease in right ventricular ejection fraction, stroke volume index and end-diastolic volume index occurred (P 〈0.05) at T4 compared with values at TI. Pulmonary vascular resistance index at T4 increased relatively compared with that at T2 and T3. The change of EEs was not statistically significant during operation. Right atrial pressure increased only during coronary anastomoses (T2-- T4, P 〈0.05), whereas EED increased throughout OPCAB surgery (P 〈0.05). Conclusions Right ventricular pressure-volume loops can be constructed using a volumetric PAC. Right ventricular systolic dysfunction occurred during anastomoses on the heart's posterior wall not due to impaired myocardial contractility but as a result of reduced preload and a relative increase in afterload. Right ventricular diastolic function was impaired throughout OPCAB surgery.展开更多
Volumetric elastic modulus (VEM) is an important parameter in biophysics and biomechanics of plants for in particular understanding cell growth. This paper proposes a new relation that can be used for precisely dete...Volumetric elastic modulus (VEM) is an important parameter in biophysics and biomechanics of plants for in particular understanding cell growth. This paper proposes a new relation that can be used for precisely determining VEM. With the aid of this relation, it shows that the exponential approximation of the pressure-volume relationship adopted in most of the literatures in this field may lead to serious errors on VEM.展开更多
A frequency servo system-on-chip(FS-SoC)featuring output power stabilization technology is introduced in this study for high-precision and miniaturized cesium(Cs)atomic clocks.The proposed power stabilization loop(PSL...A frequency servo system-on-chip(FS-SoC)featuring output power stabilization technology is introduced in this study for high-precision and miniaturized cesium(Cs)atomic clocks.The proposed power stabilization loop(PSL)technique,incorporating an off-chip power detector(PD),ensures that the output power of the FS-SoC remains stable,mitigating the impact of power fluctuations on the atomic clock's stability.Additionally,a one-pulse-per-second(1PPS)is employed to syn-chronize the clock with GPS.Fabricated using 65 nm CMOS technology,the measured phase noise of the FS-SoC stands at-69.5 dBc/Hz@100 Hz offset and-83.9 dBc/Hz@1 kHz offset,accompanied by a power dissipation of 19.7 mW.The Cs atomic clock employing the proposed FS-SoC and PSL obtains an Allan deviation of 1.7×10^(-11) with 1-s averaging time.展开更多
The connective tissue fiber system and the surfactant system are essential and interdependent components of lung elasticity. Despite considerable efforts over the last decades, we are still far from understanding the ...The connective tissue fiber system and the surfactant system are essential and interdependent components of lung elasticity. Despite considerable efforts over the last decades, we are still far from understanding the quantitative roles of either the connective tissue fiber or the surfactant systems. Through thermo-statistic considerations of alveolar micromechanics, the author introduced a thermo-statistic state function “entropy” to analyze the elastic property of pulmonary parenchyma based on the origami model of alveolar polyhedron. By use of the entropy for alveolar micromechanics, from the logistic equation for the static pressure (<em>P</em>)-volume (<em>V</em>) curves including parameters <em>a</em>, <em>b</em>, <em>c</em>, and <em>k</em> (<em>V</em> - <em>a</em> = <em>b</em>/[1+ exp{-<em>k</em> (<em>P</em> - <em>c</em>)}]), a set of equations was obtained to define the internal energy of lungs (<em>U<sub>L</sub></em>) and its corresponding lung volume (<em>V<sub>L</sub></em>). Then, by use of parameters<em> a</em>, <em>b</em>, <em>c</em>, and <em>k</em>, an individual volume-internal energy (<em>V<sub>L</sub></em><sub> </sub>- <em>U<sub>L</sub></em>) diagram was constructed from reported data in patients on mechanical ventilation. Each <em>V<sub>L</sub></em> - <em>U<sub>L</sub></em> diagram constructed was discussed that its minimal value <em>U<sub>o</sub></em> = <em>c</em> (<em>a</em> + <em>b</em>/2) and its shape parameter <em>b</em>/<em>k</em> represent quantitatively the energy of tissue force and the energy of surface force. Furthermore, by use of the <em>V<sub>L</sub></em><sub> </sub>- <em>U<sub>L</sub></em> relationship, the hysteresis of lungs estimated by entropy production was discussed as dependent on the difference in the number of contributing pulmonary lobules. That is, entropy production might be a novel quantitative indicator to estimate the dynamics of the bronchial tree. These values obtained by combinations of parameters of the logistic P-V curve seem useful indicators to optimize setting a mechanical ventilator. Thus, it is necessary to develop easy tools for fitting the individual sigmoid pressure-volume curve measured in the intensive care unit to the logistic equation.展开更多
Solar thermochemical energy storage based on calcium looping(CaL)process is a promising technology for next-generation concentrated solar power(CSP)systems.However,conventional calcium carbonate(CaCO_(3))pellets suffe...Solar thermochemical energy storage based on calcium looping(CaL)process is a promising technology for next-generation concentrated solar power(CSP)systems.However,conventional calcium carbonate(CaCO_(3))pellets suffer from slow reaction kinetics,poor stability,and low solar absorptance.Here,we successfully realized high power density and highly stable solar thermochemical energy storage/release by synergistically accelerating energy storage/release via binary sulfate and promoting cycle stability,mechanical strength,and solar absorptance via Al–Mn–Fe oxides.The energy storage density of proposed CaCO_(3)pellets is still as high as 1455 kJ kg^(-1)with only a slight decay rate of 4.91%over 100 cycles,which is higher than that of state-of-the-art pellets in the literature,in stark contrast to 69.9%of pure CaCO_(3)pellets over 35 cycles.Compared with pure CaCO_(3),the energy storage power density or decomposition rate is improved by 120%due to lower activation energy and promotion of Ca^(2+)diffusion by binary sulfate.The energy release or carbonation rate rises by 10%because of high O^(2-)transport ability of molten binary sulfate.Benefiting from fast energy storage/release rate and high solar absorptance,thermochemical energy storage efficiency is enhanced by more than 50%under direct solar irradiation.This work paves the way for application of direct solar thermochemical energy storage techniques via achieving fast energy storage/release rate,high energy density,good cyclic stability,and high solar absorptance simultaneously.展开更多
Objective: Ischemic conditioning (IC) limits myocyte necrosis after acute myocardial ischemia-reperfusion;however, controversy persists regarding its potential to attenuate LV contractile dysfunction. Pressure-volume ...Objective: Ischemic conditioning (IC) limits myocyte necrosis after acute myocardial ischemia-reperfusion;however, controversy persists regarding its potential to attenuate LV contractile dysfunction. Pressure-volume (P-V) loop analysis, via the load-insensitive conductance catheter method, was used to evaluate LV contractility, diastolic function, and ventriculo-arterial coupling. The goal of this study was to evaluate the ability of IC to improve post-ischemic recovery of LV contractile function. Methods: Twelve anesthetized dogs were randomly distributed to either the IC or the non-IC group;all dogs were subject to 60-min acute coronary occlusion followed by 180-min reperfusion. IC consisted of 4 repeated cycles of 5-min occlusion and 5-min reperfusion of the left main coronary artery. LV P-V relations were constructed under steady-state conditions (by inferior vena cava occlusion) at the beginning and end of the experiments;P-V loops were acquired at different time points before and during ischemia-reperfusion. Results: During ischemia and reperfusion, dP/dt<sub>max</sub> decreased significantly compared to baseline in both groups;dP/dt<sub>min</sub>, an indicator of the rate of LV relaxation rate was not affected for either group. Significant changes in several parameters of LV function including LVEF, SW, tPFR, ESV, and EDV caused by ischemia were also identified;none of these negative effects were resorbed, even in part, during reperfusion. Conclusions: Diminished LV contractile efficiency during systole and diastole produced by ischemia-reperfusion did not improve with IC pre-treatment despite significant endogenous protection against tissue necrosis.展开更多
The brain functions as a closed-loop system that continuously generates behavior in response to the external environment and adjusts actions based on the outcomes.Traditional research methodologies in neuroscience,esp...The brain functions as a closed-loop system that continuously generates behavior in response to the external environment and adjusts actions based on the outcomes.Traditional research methodologies in neuroscience,especially those employed in brain imaging experiments,have mainly adopted an open-loop paradigm(Grosenick et al.,2015).Functional neural circuits are analyzed offline and subsequently tested through manipulation of neuronal activities within specific regions or with genetic markers.By establishing a closed-loop research paradigm,functional ensembles can be detected and tested in real time with temporal sequences.These functional ensembles,rather than brain regions or genetically labeled neural populations,serve as fundamental units of neural networks,offering valuable insights into the dissection of neural circuits.The closed-loop research paradigm also enables the capture of high-dimensional activities of internal brain dynamics and precise elucidation of physiological processes such as learning,decision-making,and sleep.展开更多
Chemical looping oxidative dehydrogenation (CL-ODH) is an economically promising method for convertingethane into higher value-added ethylene utilizing lattice oxygen in redox catalysts, also known as oxygen carriers....Chemical looping oxidative dehydrogenation (CL-ODH) is an economically promising method for convertingethane into higher value-added ethylene utilizing lattice oxygen in redox catalysts, also known as oxygen carriers. Inthis study, perovskite-type oxide SrCoO_(3-δ) and B-site Mn ion-doped oxygen carriers (SrCo_(1-x)MnxO_(3-δ), x=0.1, 0.2, 0.3)were prepared and tested for the CL-ODH of ethane. The oxygen-deficient perovskite SrCoO_(3-δ) exhibited high ethyleneselectivity of up to 96.7% due to its unique oxygen vacancies and lattice oxygen migration rates. However, its low ethyleneyield limits its application in the CL-ODH of ethane. Mn doping promoted the reducibility of SrCoO_(3-δ) oxygen carriers,thereby improving ethane conversion and ethylene yield, as demonstrated by characterization and evaluation experiments.X-ray diffraction results confirmed the doping of Mn into the lattice of SrCoO_(3-δ), while X-ray photoelectron spectroscopy(XPS) indicated an increase in lattice oxygen ratio upon incorporation of Mn into the SrCoO_(3-δ) lattice. Additionally, H2temperature-programmed reduction (H2-TPR) tests revealed more peaks at lower temperature reduction zones and a declinein peak positions at higher temperatures. Among the four tested oxygen carriers, SrCo0.8Mn0.2O_(3-δ) exhibited satisfactoryperformance with an ethylene yield of 50% at 710 °C and good stability over 20 redox cycles. The synergistic effect of Mnplays a key role in increasing ethylene yields of SrCoO_(3-δ) oxygen carriers. Accordingly, SrCo0.8Mn0.2O_(3-δ) shows promisingpotential for the efficient production of ethylene from ethane via CL-ODH.展开更多
Raman lasers are essential in atomic physics,and the development of portable devices has posed requirements for time-division multiplexing of Raman lasers.We demonstrate an innovative gigahertz frequency hopping appro...Raman lasers are essential in atomic physics,and the development of portable devices has posed requirements for time-division multiplexing of Raman lasers.We demonstrate an innovative gigahertz frequency hopping approach of a slave Raman laser within an optical phase-locked loop(OPLL),which finds practical application in an atomic gravimeter,where the OPLL frequently switches between near-resonance lasers and significantly detuned Raman lasers.The method merges the advantages of rapid and extensive frequency hopping with the OPLL’s inherent low phase noise,and exhibits a versatile range of applications in compact laser systems,promising advancements in portable instruments.展开更多
Precise and low-latency information transmission through communication systems is essential in the Industrial Internet of Things(IIoT).However,in an industrial system,there is always a coupling relationship between th...Precise and low-latency information transmission through communication systems is essential in the Industrial Internet of Things(IIoT).However,in an industrial system,there is always a coupling relationship between the control and communication components.To improve the system's overall performance,exploring the co-design of communication and control systems is crucial.In this work,we propose a new metric±Age of Loop Information with Flexible Transmission(AoLI-FT),which dynamically adjusts the maximum number of uplink(UL)and downlink(DL)transmission rounds,thus enhancing reliability while ensuring timeliness.Our goal is to explore the relationship between AoLI-FT,reliability,and control convergence rate,and to design optimal blocklengths for UL and DL that achieve the desired control convergence rate.To address this issue,we first derive a closed-form expression for the upper bound of AoLI-FT.Subsequently,we establish a relationship between communication reliability and control convergence rates using a Lyapunov-like function.Finally,we introduce an iterative alternating algorithm to determine the optimal communication and control parameters.The numerical results demonstrate the significant performance advantages of our proposed communication and control co-design strategy in terms of latency and control cost.展开更多
Perovskite oxides has been attracted much attention as high-performance oxygen carriers for chemical looping reforming of methane,but they are easily inactivated by the presence of trace H_(2)S.Here,we propose to modu...Perovskite oxides has been attracted much attention as high-performance oxygen carriers for chemical looping reforming of methane,but they are easily inactivated by the presence of trace H_(2)S.Here,we propose to modulate both the activity and resistance to sulfur poisoning by dual substitution of Mo and Ni ions with the Fe-sites of LaFeO_(3)perovskite.It is found that partial substitution of Ni for Fe substantially improves the activity of LaFeO_(3)perovskite,while Ni particles prefer to grow and react with H_(2)S during the long-term successive redox process,resulting in the deactivation of oxygen carriers.With the presence of Mo in LaNi_(0.05)Fe_(0.95)O_(3−σ)perovskite,H_(2)S preferentially reacts with Mo to generate MoS_(2),and then the CO_(2)oxidation can regenerate Mo via removing sulfur.In addition,Mo can inhibit the accumulation and growth of Ni,which helps to improve the redox stability of oxygen carriers.The LaNi_(0.05)Mo_(0.07)Fe_(0.88)O_(3−σ)oxygen carrier exhibits stable and excellent performance,with the CH_(4)conversion higher than 90%during the 50 redox cycles in the presence of 50 ppm H_(2)S at 800℃.This work highlights a synergistic effect in the perovskite oxides induced by dual substitution of different cations for the development of high-performance oxygen carriers with excellent sulfur tolerance.展开更多
The evolution of dislocation loops in austenitic steels irradiated with Fe^(+)is investigated using cluster dynamics(CD)simulations by developing a CD model.The CD predictions are compared with experimental results in...The evolution of dislocation loops in austenitic steels irradiated with Fe^(+)is investigated using cluster dynamics(CD)simulations by developing a CD model.The CD predictions are compared with experimental results in the literature.The number density and average diameter of the dislocation loops obtained from the CD simulations are in good agreement with the experimental data obtained from transmission electron microscopy(TEM)observations of Fe~+-irradiated Solution Annealed 304,Cold Worked 316,and HR3 austenitic steels in the literature.The CD simulation results demonstrate that the diffusion of in-cascade interstitial clusters plays a major role in the dislocation loop density and dislocation loop growth;in particular,for the HR3 austenitic steel,the CD model has verified the effect of temperature on the density and size of the dislocation loops.展开更多
To solve the problems of low gasification efficiency and high tar content caused by solid–solid contact between biomass and oxygen carrier in traditional biomass chemical looping gasification process.The decoupling s...To solve the problems of low gasification efficiency and high tar content caused by solid–solid contact between biomass and oxygen carrier in traditional biomass chemical looping gasification process.The decoupling strategy was adopted to decouple the biomass gasification process,and the composite oxygen carrier was prepared by embedding Fe_(2)O_(3) in molecular sieve SBA-16 for the chemical looping reforming process of pyrolysis micromolecular model compound methane,which was expected to realize the directional reforming of pyrolysis volatiles to prepare hydrogen-rich syngas.Thermodynamic analysis of the reaction system was carried out based on the Gibbs free energy minimization method,and the reforming performance was evaluated by a fixed bed reactor,and the kinetic parameters were solved based on the gas–solid reaction model.Thermodynamic analysis verified the feasibility of the reaction and provided theoretical guidance for experimental design.The experimental results showed that the reaction performance of Fe_(2)O_(3)@SBA-16 was compared with that of pure Fe_(2)O_(3) and Fe_(2)O_(3)@SBA-15,and the syngas yield was increased by 55.3%and 20.7%respectively,and it had good cycle stability.Kinetic analysis showed that the kinetic model changed from three-dimensional diffusion to first-order reaction with the increase of temperature.The activation energy was 192.79 kJ/mol by fitting.This paper provides basic data for the directional preparation of hydrogen-rich syngas from biomass and the design of oxygen carriers for pyrolysis of all-component chemical looping reforming.展开更多
Ethane chemical looping oxidative dehydrogenation(CL-ODH)to ethylene is a new technology for converting ethane to ethylene.In the current study MeO/LaCoO_(3)(MeO=Fe_(2)O_(3),NiO or Co_(2)O_(3))composite metal oxides w...Ethane chemical looping oxidative dehydrogenation(CL-ODH)to ethylene is a new technology for converting ethane to ethylene.In the current study MeO/LaCoO_(3)(MeO=Fe_(2)O_(3),NiO or Co_(2)O_(3))composite metal oxides were prepared via citrate gel and impregnation methods,and used as oxygen carriers for CL-ODH.X-ray diffraction results indicated that all oxygen carriers had a perovskite structure even after eight redox cycles.Under a reaction temperature of 650°C,a reaction pressure of 0.1 MPa,and a weight hourly space velocity(WHSV)of 7500 mL/(g·h),ethane conversion over Co_(2)O_(3)/LaCoO_(3) reached 100%and ethylene selectivity reached 60%,both of which were better than corresponding values attained over Fe_(2)O_(3)/LaCoO_(3) and NiO/LaCoO_(3).Ethylene selectivity remained stable for 80 cycles over Co_(2)O_(3)/LaCoO_(3),then decreased gradually after 80 cycles.X-ray photoelectron spectroscopy results and evaluation results indicated that lattice oxygen and O_(2)2-had a direct relationship with ethane conversion and ethylene selectivity.Co_(2)O_(3)/LaCoO_(3) exhibited a strong capacity to release and absorb oxygen,mainly due to interaction between Co_(2)O_(3) and LaCoO_(3).展开更多
Objective:Colorectal cancer(CRC)is a prevalent malignant tumor with a high fatality rate.CircPDIA4 has been shown to have a vital role in cancer development by acting as a facilitator.Nevertheless,the impact of the ci...Objective:Colorectal cancer(CRC)is a prevalent malignant tumor with a high fatality rate.CircPDIA4 has been shown to have a vital role in cancer development by acting as a facilitator.Nevertheless,the impact of the circPDIA4/miR-9-5p/SP1 axis on development of CRC has not been studied.Methods:Western blot,immunohistochemistry,and reverse transcription-quantitative polymerase chain reaction assays were used to analyze gene expression.The CCK-8 assay was used to assess cell growth.The Transwell assay was used to detect invasion and migration of cells.The luciferase reporter and RNA immunoprecipitation tests were used to determine if miR-9-5p and circPDIA4(or SP1)bind to one another.An in vivo assay was used to measure tumor growth.Results:It was shown that circPDIA4 expression was greater in CRC cell lines and tissues than healthy cell lines and tissues.CircPDIA4 knockdown prevented the invasion,migration,and proliferation of cells in CRC.Additionally,the combination of circPDIA4 and miR-9-5p was confirmed,as well as miR-9-5p binding to SP1.Rescue experiments also showed that the circPDIA4/miR-9-5p/SP1 axis accelerated the development of CRC.In addition,SP1 combined with the promoter region of circPDIA4 and induced circPDIA4 transcription.CircPDIA4 was shown to facilitate tumor growth in an in vivo assay.Conclusions:The circPDIA4/miR-9-5p/SP1 feedback loop was shown to aggravate CRC progression.This finding suggests that the ceRNA axis may be a promising biomarker for CRC patient treatment.展开更多
With the development of wireless communication technology,an urgent problem to be solved is co-site broadband interference on independent communication platforms such as satellites,space stations,aircrafts and ships.A...With the development of wireless communication technology,an urgent problem to be solved is co-site broadband interference on independent communication platforms such as satellites,space stations,aircrafts and ships.Also,the problem of strong selfinterference rejection should be solved in the co-time co-frequency full duplex mode which realizes spectrum multiplication in 5G communication technology.In the research of such interference rejection,interference cancellation technology has been applied.In order to reject multipath interference,multitap double LMS(Least Mean Square)loop interference cancellation system is often used for cancelling RF(Radio Frequency)domain interference cancelling.However,more taps will lead to a more complex structure of the cancellation system.A novel tap single LMS loop adaptive interference cancellation system was proposed to improve the system compactness and reduce the cost.In addition,a mathematical model was built for the proposed cancellation system,the correlation function of CP2FSK(Continuous Phase Binary Frequency Shift Keying)signal was derived,and the quantitative relationship was established between the correlation function and the interference signal bandwidth and tap delay differential.The steadystate weights and the expression of the average interference cancellation ratio(ICR)were deduced in the scenes of LOS(Line of Sight)interference with antenna swaying on an independent communication platform and indoor multipath interference.The quantitative relationship was deeply analyzed between the interference cancellation performance and the parameters such as antenna swing,LMS loop gain,and interference signal bandwidth,which was verified by simulation experiment.And the performance of the proposed interference cancellation system was compared with that of the traditional double LMS loop cancellation system.The results showed that the compact single LMS loop cancellation system can achieve an average interference rejection capability comparable to the double LMS loop cancellation system.展开更多
In this paper,a generalized nth-order perturbation method based on the isogeometric boundary element method is proposed for the uncertainty analysis of broadband structural acoustic scattering problems.The Burton-Mill...In this paper,a generalized nth-order perturbation method based on the isogeometric boundary element method is proposed for the uncertainty analysis of broadband structural acoustic scattering problems.The Burton-Miller method is employed to solve the problem of non-unique solutions that may be encountered in the external acoustic field,and the nth-order discretization formulation of the boundary integral equation is derived.In addition,the computation of loop subdivision surfaces and the subdivision rules are introduced.In order to confirm the effectiveness of the algorithm,the computed results are contrasted and analyzed with the results under Monte Carlo simulations(MCs)through several numerical examples.展开更多
文摘Background Right ventricular function plays an important role in the hemodynamic derangement during off-pump coronary artery bypass (OPCAB) surgery. Pressure-volume loops have been shown to provide load-independent information of cardiac function. Therefore, the aim of this study was to investigate the feasibility of construction of right ventricular pressure-volume loops with pressure and volume data measured by a volumetric pulmonary artery catheter (PAC) and to evaluate right ventricular systolic and diastolic function by end-systolic elastance (EEs) and end-diastolic stiffness (EED) in OPCAB surgery. Methods Twenty-eight patients who underwent OPCAB surgery were included. After anesthesia induction, a volumetric PAC was placed via the right internal jugular vein. Data were recorded at: anesthesia steady-state before skin incision (T1); 5 minutes after the stabilizer device was placed for anastomosis on the heart's anterior wall (T2), lateral wall (T3), posterior wall (T4), respectively; after sternal closure (T5). Three sets of data were collected at each time point: first, hemodynamic variables were measured; second, right ventricular EEs and EED were calculated; third, right ventricular pressure-volume loops were constructed with pressure and volume data measured from end-diastole point, end-isovolumic systole point, peak-ejection point, end-systole point and end-isovolumic diastole point. Results Right ventricular pressure-volume loops generally shifted to the left during OPCAB surgery. Especially, the end-diastolic point shifted upward and to the left at T2--T5 compared with that at T1. Decrease in right ventricular ejection fraction, stroke volume index and end-diastolic volume index occurred (P 〈0.05) at T4 compared with values at TI. Pulmonary vascular resistance index at T4 increased relatively compared with that at T2 and T3. The change of EEs was not statistically significant during operation. Right atrial pressure increased only during coronary anastomoses (T2-- T4, P 〈0.05), whereas EED increased throughout OPCAB surgery (P 〈0.05). Conclusions Right ventricular pressure-volume loops can be constructed using a volumetric PAC. Right ventricular systolic dysfunction occurred during anastomoses on the heart's posterior wall not due to impaired myocardial contractility but as a result of reduced preload and a relative increase in afterload. Right ventricular diastolic function was impaired throughout OPCAB surgery.
基金supported by the National Natural Science Foundation of China(10772100)
文摘Volumetric elastic modulus (VEM) is an important parameter in biophysics and biomechanics of plants for in particular understanding cell growth. This paper proposes a new relation that can be used for precisely determining VEM. With the aid of this relation, it shows that the exponential approximation of the pressure-volume relationship adopted in most of the literatures in this field may lead to serious errors on VEM.
基金supported by the National Natural Science Foundation of China under Grant 62034002 and 62374026.
文摘A frequency servo system-on-chip(FS-SoC)featuring output power stabilization technology is introduced in this study for high-precision and miniaturized cesium(Cs)atomic clocks.The proposed power stabilization loop(PSL)technique,incorporating an off-chip power detector(PD),ensures that the output power of the FS-SoC remains stable,mitigating the impact of power fluctuations on the atomic clock's stability.Additionally,a one-pulse-per-second(1PPS)is employed to syn-chronize the clock with GPS.Fabricated using 65 nm CMOS technology,the measured phase noise of the FS-SoC stands at-69.5 dBc/Hz@100 Hz offset and-83.9 dBc/Hz@1 kHz offset,accompanied by a power dissipation of 19.7 mW.The Cs atomic clock employing the proposed FS-SoC and PSL obtains an Allan deviation of 1.7×10^(-11) with 1-s averaging time.
文摘The connective tissue fiber system and the surfactant system are essential and interdependent components of lung elasticity. Despite considerable efforts over the last decades, we are still far from understanding the quantitative roles of either the connective tissue fiber or the surfactant systems. Through thermo-statistic considerations of alveolar micromechanics, the author introduced a thermo-statistic state function “entropy” to analyze the elastic property of pulmonary parenchyma based on the origami model of alveolar polyhedron. By use of the entropy for alveolar micromechanics, from the logistic equation for the static pressure (<em>P</em>)-volume (<em>V</em>) curves including parameters <em>a</em>, <em>b</em>, <em>c</em>, and <em>k</em> (<em>V</em> - <em>a</em> = <em>b</em>/[1+ exp{-<em>k</em> (<em>P</em> - <em>c</em>)}]), a set of equations was obtained to define the internal energy of lungs (<em>U<sub>L</sub></em>) and its corresponding lung volume (<em>V<sub>L</sub></em>). Then, by use of parameters<em> a</em>, <em>b</em>, <em>c</em>, and <em>k</em>, an individual volume-internal energy (<em>V<sub>L</sub></em><sub> </sub>- <em>U<sub>L</sub></em>) diagram was constructed from reported data in patients on mechanical ventilation. Each <em>V<sub>L</sub></em> - <em>U<sub>L</sub></em> diagram constructed was discussed that its minimal value <em>U<sub>o</sub></em> = <em>c</em> (<em>a</em> + <em>b</em>/2) and its shape parameter <em>b</em>/<em>k</em> represent quantitatively the energy of tissue force and the energy of surface force. Furthermore, by use of the <em>V<sub>L</sub></em><sub> </sub>- <em>U<sub>L</sub></em> relationship, the hysteresis of lungs estimated by entropy production was discussed as dependent on the difference in the number of contributing pulmonary lobules. That is, entropy production might be a novel quantitative indicator to estimate the dynamics of the bronchial tree. These values obtained by combinations of parameters of the logistic P-V curve seem useful indicators to optimize setting a mechanical ventilator. Thus, it is necessary to develop easy tools for fitting the individual sigmoid pressure-volume curve measured in the intensive care unit to the logistic equation.
基金supported by the National Natural Science Foundation of China[No.51820105010 and 51888103]support from Jiangsu Province(No.BK20202008,BE2022024,BE2022602,BK20220001,BK20220009,and BK20220077).
文摘Solar thermochemical energy storage based on calcium looping(CaL)process is a promising technology for next-generation concentrated solar power(CSP)systems.However,conventional calcium carbonate(CaCO_(3))pellets suffer from slow reaction kinetics,poor stability,and low solar absorptance.Here,we successfully realized high power density and highly stable solar thermochemical energy storage/release by synergistically accelerating energy storage/release via binary sulfate and promoting cycle stability,mechanical strength,and solar absorptance via Al–Mn–Fe oxides.The energy storage density of proposed CaCO_(3)pellets is still as high as 1455 kJ kg^(-1)with only a slight decay rate of 4.91%over 100 cycles,which is higher than that of state-of-the-art pellets in the literature,in stark contrast to 69.9%of pure CaCO_(3)pellets over 35 cycles.Compared with pure CaCO_(3),the energy storage power density or decomposition rate is improved by 120%due to lower activation energy and promotion of Ca^(2+)diffusion by binary sulfate.The energy release or carbonation rate rises by 10%because of high O^(2-)transport ability of molten binary sulfate.Benefiting from fast energy storage/release rate and high solar absorptance,thermochemical energy storage efficiency is enhanced by more than 50%under direct solar irradiation.This work paves the way for application of direct solar thermochemical energy storage techniques via achieving fast energy storage/release rate,high energy density,good cyclic stability,and high solar absorptance simultaneously.
文摘Objective: Ischemic conditioning (IC) limits myocyte necrosis after acute myocardial ischemia-reperfusion;however, controversy persists regarding its potential to attenuate LV contractile dysfunction. Pressure-volume (P-V) loop analysis, via the load-insensitive conductance catheter method, was used to evaluate LV contractility, diastolic function, and ventriculo-arterial coupling. The goal of this study was to evaluate the ability of IC to improve post-ischemic recovery of LV contractile function. Methods: Twelve anesthetized dogs were randomly distributed to either the IC or the non-IC group;all dogs were subject to 60-min acute coronary occlusion followed by 180-min reperfusion. IC consisted of 4 repeated cycles of 5-min occlusion and 5-min reperfusion of the left main coronary artery. LV P-V relations were constructed under steady-state conditions (by inferior vena cava occlusion) at the beginning and end of the experiments;P-V loops were acquired at different time points before and during ischemia-reperfusion. Results: During ischemia and reperfusion, dP/dt<sub>max</sub> decreased significantly compared to baseline in both groups;dP/dt<sub>min</sub>, an indicator of the rate of LV relaxation rate was not affected for either group. Significant changes in several parameters of LV function including LVEF, SW, tPFR, ESV, and EDV caused by ischemia were also identified;none of these negative effects were resorbed, even in part, during reperfusion. Conclusions: Diminished LV contractile efficiency during systole and diastole produced by ischemia-reperfusion did not improve with IC pre-treatment despite significant endogenous protection against tissue necrosis.
文摘The brain functions as a closed-loop system that continuously generates behavior in response to the external environment and adjusts actions based on the outcomes.Traditional research methodologies in neuroscience,especially those employed in brain imaging experiments,have mainly adopted an open-loop paradigm(Grosenick et al.,2015).Functional neural circuits are analyzed offline and subsequently tested through manipulation of neuronal activities within specific regions or with genetic markers.By establishing a closed-loop research paradigm,functional ensembles can be detected and tested in real time with temporal sequences.These functional ensembles,rather than brain regions or genetically labeled neural populations,serve as fundamental units of neural networks,offering valuable insights into the dissection of neural circuits.The closed-loop research paradigm also enables the capture of high-dimensional activities of internal brain dynamics and precise elucidation of physiological processes such as learning,decision-making,and sleep.
文摘[目的]研究庆阳驴养殖群体的遗传多样性与母系起源,了解其遗传信息,为保护庆阳驴种质资源、选育和遗传改良工作提供理论依据。[方法]随机选取133头庆阳驴,对其线粒体DNA(mitochondrial DNA,mtDNA)D-loop区序列进行PCR扩增、测序及比对,并探讨庆阳驴的遗传多样性与母系起源。[结果]在获得的520 bp D-loop碱基序列中,AT含量(57.3%)高于GC含量(42.8%),表现出碱基的偏倚性;检测到38个变异位点,包含8个碱基对的转换;其核苷酸多样性(Pi)、单倍型多样性(Hd)、平均核苷酸差异(K)分别为0.01591、0.895和8.274,与欧洲家驴和中国家驴研究的平均值相比较低,说明该驴品种核苷酸变异较为贫乏。庆阳驴mtDNA D-loop区存在35个单倍型,单倍型之间的遗传距离为0.002~0.042。系统进化结果显示,庆阳驴存在2个线粒体支系,表明其具有2个母系起源,且遗传距离表明,庆阳驴与克罗地亚家驴之间的遗传距离较近。[结论]本研究从分子水平初步揭示庆阳驴核苷酸变异比较贫乏,杂交程度高,mtDNA遗传多态性正逐步丧失,应加强庆阳驴品种的遗传资源保护工作。
基金the SINOPEC Research and Development Project(No.JR22094).
文摘Chemical looping oxidative dehydrogenation (CL-ODH) is an economically promising method for convertingethane into higher value-added ethylene utilizing lattice oxygen in redox catalysts, also known as oxygen carriers. Inthis study, perovskite-type oxide SrCoO_(3-δ) and B-site Mn ion-doped oxygen carriers (SrCo_(1-x)MnxO_(3-δ), x=0.1, 0.2, 0.3)were prepared and tested for the CL-ODH of ethane. The oxygen-deficient perovskite SrCoO_(3-δ) exhibited high ethyleneselectivity of up to 96.7% due to its unique oxygen vacancies and lattice oxygen migration rates. However, its low ethyleneyield limits its application in the CL-ODH of ethane. Mn doping promoted the reducibility of SrCoO_(3-δ) oxygen carriers,thereby improving ethane conversion and ethylene yield, as demonstrated by characterization and evaluation experiments.X-ray diffraction results confirmed the doping of Mn into the lattice of SrCoO_(3-δ), while X-ray photoelectron spectroscopy(XPS) indicated an increase in lattice oxygen ratio upon incorporation of Mn into the SrCoO_(3-δ) lattice. Additionally, H2temperature-programmed reduction (H2-TPR) tests revealed more peaks at lower temperature reduction zones and a declinein peak positions at higher temperatures. Among the four tested oxygen carriers, SrCo0.8Mn0.2O_(3-δ) exhibited satisfactoryperformance with an ethylene yield of 50% at 710 °C and good stability over 20 redox cycles. The synergistic effect of Mnplays a key role in increasing ethylene yields of SrCoO_(3-δ) oxygen carriers. Accordingly, SrCo0.8Mn0.2O_(3-δ) shows promisingpotential for the efficient production of ethylene from ethane via CL-ODH.
基金Project supported by the National Key Research and Development Program of China(Grant Nos.2021YFA0718300 and 2021YFA1400900)the National Natural Science Foundation of China(Grant Nos.11920101004,11934002,and 92365208)+1 种基金Science and Technology Major Project of Shanxi(Grant No.202101030201022)Space Application System of China Manned Space Program.
文摘Raman lasers are essential in atomic physics,and the development of portable devices has posed requirements for time-division multiplexing of Raman lasers.We demonstrate an innovative gigahertz frequency hopping approach of a slave Raman laser within an optical phase-locked loop(OPLL),which finds practical application in an atomic gravimeter,where the OPLL frequently switches between near-resonance lasers and significantly detuned Raman lasers.The method merges the advantages of rapid and extensive frequency hopping with the OPLL’s inherent low phase noise,and exhibits a versatile range of applications in compact laser systems,promising advancements in portable instruments.
基金supported in part by the National Key R&D Program of China under Grant 2024YFE0200500in part by the Guangdong Basic and Applied Basic Research Foundation under Grant 2024A1515012615in part by the Department of Science and Technology of Guangdong Province under Grant 2021QN02X491。
文摘Precise and low-latency information transmission through communication systems is essential in the Industrial Internet of Things(IIoT).However,in an industrial system,there is always a coupling relationship between the control and communication components.To improve the system's overall performance,exploring the co-design of communication and control systems is crucial.In this work,we propose a new metric±Age of Loop Information with Flexible Transmission(AoLI-FT),which dynamically adjusts the maximum number of uplink(UL)and downlink(DL)transmission rounds,thus enhancing reliability while ensuring timeliness.Our goal is to explore the relationship between AoLI-FT,reliability,and control convergence rate,and to design optimal blocklengths for UL and DL that achieve the desired control convergence rate.To address this issue,we first derive a closed-form expression for the upper bound of AoLI-FT.Subsequently,we establish a relationship between communication reliability and control convergence rates using a Lyapunov-like function.Finally,we introduce an iterative alternating algorithm to determine the optimal communication and control parameters.The numerical results demonstrate the significant performance advantages of our proposed communication and control co-design strategy in terms of latency and control cost.
基金financially supported by the National Natural Science Foundation of China (Nos. 52174279, U2202251, and 52266008)Applied Basic Research Program of Yunnan Province for Distinguished Young Scholars (No. 202201AV070004)+1 种基金Central Guiding Local Science and Technology Development Fund (No. 202207AA110001)the Yunnan Fundamental Research Projects (No. 202301AU070027, 202401AT070388)
文摘Perovskite oxides has been attracted much attention as high-performance oxygen carriers for chemical looping reforming of methane,but they are easily inactivated by the presence of trace H_(2)S.Here,we propose to modulate both the activity and resistance to sulfur poisoning by dual substitution of Mo and Ni ions with the Fe-sites of LaFeO_(3)perovskite.It is found that partial substitution of Ni for Fe substantially improves the activity of LaFeO_(3)perovskite,while Ni particles prefer to grow and react with H_(2)S during the long-term successive redox process,resulting in the deactivation of oxygen carriers.With the presence of Mo in LaNi_(0.05)Fe_(0.95)O_(3−σ)perovskite,H_(2)S preferentially reacts with Mo to generate MoS_(2),and then the CO_(2)oxidation can regenerate Mo via removing sulfur.In addition,Mo can inhibit the accumulation and growth of Ni,which helps to improve the redox stability of oxygen carriers.The LaNi_(0.05)Mo_(0.07)Fe_(0.88)O_(3−σ)oxygen carrier exhibits stable and excellent performance,with the CH_(4)conversion higher than 90%during the 50 redox cycles in the presence of 50 ppm H_(2)S at 800℃.This work highlights a synergistic effect in the perovskite oxides induced by dual substitution of different cations for the development of high-performance oxygen carriers with excellent sulfur tolerance.
基金supported by the National Natural Science Foundation of China(No.U1967212)the Fundamental Research Funds for the Central Universities(No.2021MS032)the Nuclear Materials Innovation Foundation(No.WDZC-2023-AW-0305)。
文摘The evolution of dislocation loops in austenitic steels irradiated with Fe^(+)is investigated using cluster dynamics(CD)simulations by developing a CD model.The CD predictions are compared with experimental results in the literature.The number density and average diameter of the dislocation loops obtained from the CD simulations are in good agreement with the experimental data obtained from transmission electron microscopy(TEM)observations of Fe~+-irradiated Solution Annealed 304,Cold Worked 316,and HR3 austenitic steels in the literature.The CD simulation results demonstrate that the diffusion of in-cascade interstitial clusters plays a major role in the dislocation loop density and dislocation loop growth;in particular,for the HR3 austenitic steel,the CD model has verified the effect of temperature on the density and size of the dislocation loops.
基金National Natural Science Foundation of China(Grant Nos:22038011,51976168)K.C.Wong Education Foundation,the Natural Science Basic Research Program of Shaanxi(Program No.2021JLM-17)+1 种基金Programme of Introducing Talents of Discipline to Universities(B23025)Innovation Capability Support Program of Shaanxi(Program Nos:2023KJXX-004,2023-CX-TD-26,2022KXJ-126).
文摘To solve the problems of low gasification efficiency and high tar content caused by solid–solid contact between biomass and oxygen carrier in traditional biomass chemical looping gasification process.The decoupling strategy was adopted to decouple the biomass gasification process,and the composite oxygen carrier was prepared by embedding Fe_(2)O_(3) in molecular sieve SBA-16 for the chemical looping reforming process of pyrolysis micromolecular model compound methane,which was expected to realize the directional reforming of pyrolysis volatiles to prepare hydrogen-rich syngas.Thermodynamic analysis of the reaction system was carried out based on the Gibbs free energy minimization method,and the reforming performance was evaluated by a fixed bed reactor,and the kinetic parameters were solved based on the gas–solid reaction model.Thermodynamic analysis verified the feasibility of the reaction and provided theoretical guidance for experimental design.The experimental results showed that the reaction performance of Fe_(2)O_(3)@SBA-16 was compared with that of pure Fe_(2)O_(3) and Fe_(2)O_(3)@SBA-15,and the syngas yield was increased by 55.3%and 20.7%respectively,and it had good cycle stability.Kinetic analysis showed that the kinetic model changed from three-dimensional diffusion to first-order reaction with the increase of temperature.The activation energy was 192.79 kJ/mol by fitting.This paper provides basic data for the directional preparation of hydrogen-rich syngas from biomass and the design of oxygen carriers for pyrolysis of all-component chemical looping reforming.
文摘Ethane chemical looping oxidative dehydrogenation(CL-ODH)to ethylene is a new technology for converting ethane to ethylene.In the current study MeO/LaCoO_(3)(MeO=Fe_(2)O_(3),NiO or Co_(2)O_(3))composite metal oxides were prepared via citrate gel and impregnation methods,and used as oxygen carriers for CL-ODH.X-ray diffraction results indicated that all oxygen carriers had a perovskite structure even after eight redox cycles.Under a reaction temperature of 650°C,a reaction pressure of 0.1 MPa,and a weight hourly space velocity(WHSV)of 7500 mL/(g·h),ethane conversion over Co_(2)O_(3)/LaCoO_(3) reached 100%and ethylene selectivity reached 60%,both of which were better than corresponding values attained over Fe_(2)O_(3)/LaCoO_(3) and NiO/LaCoO_(3).Ethylene selectivity remained stable for 80 cycles over Co_(2)O_(3)/LaCoO_(3),then decreased gradually after 80 cycles.X-ray photoelectron spectroscopy results and evaluation results indicated that lattice oxygen and O_(2)2-had a direct relationship with ethane conversion and ethylene selectivity.Co_(2)O_(3)/LaCoO_(3) exhibited a strong capacity to release and absorb oxygen,mainly due to interaction between Co_(2)O_(3) and LaCoO_(3).
基金supported by the National Natural Science Foundation of China(Grant Nos.82073276 and 82273100)Science and Technology Project of Tianjin Binhai New Area Health Commission(Grant No.2022BWKY016)the China Digestive Tumor Clinical Scientific Research Public Welfare Project(Grant No.P014-058).
文摘Objective:Colorectal cancer(CRC)is a prevalent malignant tumor with a high fatality rate.CircPDIA4 has been shown to have a vital role in cancer development by acting as a facilitator.Nevertheless,the impact of the circPDIA4/miR-9-5p/SP1 axis on development of CRC has not been studied.Methods:Western blot,immunohistochemistry,and reverse transcription-quantitative polymerase chain reaction assays were used to analyze gene expression.The CCK-8 assay was used to assess cell growth.The Transwell assay was used to detect invasion and migration of cells.The luciferase reporter and RNA immunoprecipitation tests were used to determine if miR-9-5p and circPDIA4(or SP1)bind to one another.An in vivo assay was used to measure tumor growth.Results:It was shown that circPDIA4 expression was greater in CRC cell lines and tissues than healthy cell lines and tissues.CircPDIA4 knockdown prevented the invasion,migration,and proliferation of cells in CRC.Additionally,the combination of circPDIA4 and miR-9-5p was confirmed,as well as miR-9-5p binding to SP1.Rescue experiments also showed that the circPDIA4/miR-9-5p/SP1 axis accelerated the development of CRC.In addition,SP1 combined with the promoter region of circPDIA4 and induced circPDIA4 transcription.CircPDIA4 was shown to facilitate tumor growth in an in vivo assay.Conclusions:The circPDIA4/miR-9-5p/SP1 feedback loop was shown to aggravate CRC progression.This finding suggests that the ceRNA axis may be a promising biomarker for CRC patient treatment.
基金supported by the National Natural Science Foundation of China[Grant No.61771187]the Natural Science Foundation of Hubei Province[Grant No.2016CFB396]+1 种基金the Hubei Provincial Technology Innovation Special Major Project[Grant No.2019AAA018]the Major Project of Hubei Collaborative Innovation Center for High-efficiency Utilization of Solar Energy[HBSKFZD2015002]。
文摘With the development of wireless communication technology,an urgent problem to be solved is co-site broadband interference on independent communication platforms such as satellites,space stations,aircrafts and ships.Also,the problem of strong selfinterference rejection should be solved in the co-time co-frequency full duplex mode which realizes spectrum multiplication in 5G communication technology.In the research of such interference rejection,interference cancellation technology has been applied.In order to reject multipath interference,multitap double LMS(Least Mean Square)loop interference cancellation system is often used for cancelling RF(Radio Frequency)domain interference cancelling.However,more taps will lead to a more complex structure of the cancellation system.A novel tap single LMS loop adaptive interference cancellation system was proposed to improve the system compactness and reduce the cost.In addition,a mathematical model was built for the proposed cancellation system,the correlation function of CP2FSK(Continuous Phase Binary Frequency Shift Keying)signal was derived,and the quantitative relationship was established between the correlation function and the interference signal bandwidth and tap delay differential.The steadystate weights and the expression of the average interference cancellation ratio(ICR)were deduced in the scenes of LOS(Line of Sight)interference with antenna swaying on an independent communication platform and indoor multipath interference.The quantitative relationship was deeply analyzed between the interference cancellation performance and the parameters such as antenna swing,LMS loop gain,and interference signal bandwidth,which was verified by simulation experiment.And the performance of the proposed interference cancellation system was compared with that of the traditional double LMS loop cancellation system.The results showed that the compact single LMS loop cancellation system can achieve an average interference rejection capability comparable to the double LMS loop cancellation system.
基金sponsored by the Graduate Student Research and Innovation Fund of Xinyang Normal University under No.2024KYJJ012.
文摘In this paper,a generalized nth-order perturbation method based on the isogeometric boundary element method is proposed for the uncertainty analysis of broadband structural acoustic scattering problems.The Burton-Miller method is employed to solve the problem of non-unique solutions that may be encountered in the external acoustic field,and the nth-order discretization formulation of the boundary integral equation is derived.In addition,the computation of loop subdivision surfaces and the subdivision rules are introduced.In order to confirm the effectiveness of the algorithm,the computed results are contrasted and analyzed with the results under Monte Carlo simulations(MCs)through several numerical examples.