Background The survival rate of preterm infants with critical congenital heart disease （P-CCHD） has been improved by medicine advances. The aims of this study were to investigate the contemporary treatments for shor...Background The survival rate of preterm infants with critical congenital heart disease （P-CCHD） has been improved by medicine advances. The aims of this study were to investigate the contemporary treatments for short-term outcomes of P-CCHD and to evaluate risk factors associated with the outcomes. Methods Sixty-four P-CCHD patients admitted to Guangdong General Hospital between 2011 and 2015 were included in this study. De-mographic characteristics and patient records were reviewed. Logistic regression was used to analyze the risk fac-tors of P-CCHD outcome. Results Thirty-six patients underwent surgical treatments for cardiac anomalies. Moreover, 31.25% of the P-CCHD infants did not receive surgery because these parents refused further treat-ment. The in-hospital mortality rate was 8.3% for the patients who underwent surgeries. During a median follow-up of 1.2 years, the survivors were basically healthy. However, mental and physical growth retardation remained. Conclusions Compared to infants in developed Western countries, the treatments and short-term outcomes of P-CCHD infants were satisfactory. However, the long-term outcomes remain to be determined.展开更多
【目的】探讨早产低出生体重对6～24月龄儿童智力和运动发育的影响及随年龄而变化的趋势。【方法】观察组:早产低出生体重儿86例;正常对照组115例,采用纵向随访方法,在儿童6月、12月、18月和24月龄时,应用Bayley婴幼儿发育量表进行评估...【目的】探讨早产低出生体重对6～24月龄儿童智力和运动发育的影响及随年龄而变化的趋势。【方法】观察组:早产低出生体重儿86例;正常对照组115例,采用纵向随访方法,在儿童6月、12月、18月和24月龄时,应用Bayley婴幼儿发育量表进行评估,结果用智力发育指数(mental development index,MDI)和运动发育指数(psychomotordevelopment index,PDI)、以及校正年龄后的智力和运动发育指数(MDIJ和PDIJ)表示。【结果】早产组在6月、12月、18月及24月龄时MDI及PDI均低于正常对照组,差异有统计学意义(P<0.05)。经校正年龄后,与对照组相比,早产组6月龄MDIJ略高(P=0.017),差异有统计学意义,其余年龄段差异无统计学意义;校正后的PDIJ在多数年龄段仍然落后于对照组,差异有统计学意义。24月龄时早产组MDI、PDI仍<85者各有9例(10.5%)、10例(11.6%)。早产组24月龄MDI与父母亲文化水平、MDIJ6、PDIJ6和PDIJ12呈显著相关(r=0.387～0.664,P<0.05),运动发育与母亲年龄、父亲文化、MDIJ6、PDIJ6、MDIJ12和PDIJ12呈显著相关(r=0.473～0.672,P<0.05)。【结论】早产低出生体重对婴幼儿的智力和运动发育有明显的不利影响,但随年龄的增长智力发育指数与正常儿童的差距缩小。展开更多
基金supported by the National Natural Science Foundation of China(No.8167060825)
文摘Background The survival rate of preterm infants with critical congenital heart disease （P-CCHD） has been improved by medicine advances. The aims of this study were to investigate the contemporary treatments for short-term outcomes of P-CCHD and to evaluate risk factors associated with the outcomes. Methods Sixty-four P-CCHD patients admitted to Guangdong General Hospital between 2011 and 2015 were included in this study. De-mographic characteristics and patient records were reviewed. Logistic regression was used to analyze the risk fac-tors of P-CCHD outcome. Results Thirty-six patients underwent surgical treatments for cardiac anomalies. Moreover, 31.25% of the P-CCHD infants did not receive surgery because these parents refused further treat-ment. The in-hospital mortality rate was 8.3% for the patients who underwent surgeries. During a median follow-up of 1.2 years, the survivors were basically healthy. However, mental and physical growth retardation remained. Conclusions Compared to infants in developed Western countries, the treatments and short-term outcomes of P-CCHD infants were satisfactory. However, the long-term outcomes remain to be determined.
文摘【目的】探讨早产低出生体重对6～24月龄儿童智力和运动发育的影响及随年龄而变化的趋势。【方法】观察组:早产低出生体重儿86例;正常对照组115例,采用纵向随访方法,在儿童6月、12月、18月和24月龄时,应用Bayley婴幼儿发育量表进行评估,结果用智力发育指数(mental development index,MDI)和运动发育指数(psychomotordevelopment index,PDI)、以及校正年龄后的智力和运动发育指数(MDIJ和PDIJ)表示。【结果】早产组在6月、12月、18月及24月龄时MDI及PDI均低于正常对照组,差异有统计学意义(P<0.05)。经校正年龄后,与对照组相比,早产组6月龄MDIJ略高(P=0.017),差异有统计学意义,其余年龄段差异无统计学意义;校正后的PDIJ在多数年龄段仍然落后于对照组,差异有统计学意义。24月龄时早产组MDI、PDI仍<85者各有9例(10.5%)、10例(11.6%)。早产组24月龄MDI与父母亲文化水平、MDIJ6、PDIJ6和PDIJ12呈显著相关(r=0.387～0.664,P<0.05),运动发育与母亲年龄、父亲文化、MDIJ6、PDIJ6、MDIJ12和PDIJ12呈显著相关(r=0.473～0.672,P<0.05)。【结论】早产低出生体重对婴幼儿的智力和运动发育有明显的不利影响,但随年龄的增长智力发育指数与正常儿童的差距缩小。
