Addressing mucosal ulcers during orthodontic treatment:An urgent call for preventive strategies

Mucosal ulcers are a common yet often overlooked complication during orthodontic treatment,significantly impacting patient comfort and compliance.This letter aims to highlight the prevalence,potential causes,and management strategies for mucosal ulcers in orthodontic patients.By reviewing recent literature and clinical observations,we underscore the necessity for proactive measures and tailored interventions to mitigate the incidence and severity of these lesions.Emphasizing the role of patient education and the use of protective devices,we call for a multidisciplinary approach to enhance patient care and treatment outcomes.This discussion is particularly relevant in the context of evolving orthodontic techniques and materials,which necessitate continuous adaptation of clinical practices to ensure patient safety and well-being.

Prevention and Control Strategies of Nosocomial Infection and Effectiveness Evaluation in a Tertiary Teaching Hospital during the Epidemic of COVID-19

Objective: To evaluate the role of prevention and control strategies for nosocomial infection in a tertiary teaching hospital during the sudden outbreak of Corona Virus Disease 2019 (COVID-19). Methods: The hospital initiated an emergency plan involving multi-departmental defense and control. It adopted a series of nosocomial infection prevention and control measures, including strengthening pre-examination and triage, optimizing the consultation process, improving the hospital’s architectural composition, implementing graded risk management, enhancing personal protection, and implementing staff training and supervision. Descriptive research was used to evaluate the short-term effects of these in-hospital prevention and control strategies. The analysis compared changes in related evaluation indicators between January 24, 2020 and February 12, 2020 (Chinese Lunar New Year’s Eve 2020 to lunar January 19) and the corresponding lunar period of the previous year. Results: Compared to the same period last year, the outpatient fever rate increased by 1.85-fold (P P Conclusion: The nosocomial infection prevention and control strategies implemented during this specific period improved the detection and control abilities for the COVID-19 source of infection and enhanced the compliance with measures. This likely contributed significantly to avoiding the occurrence of nosocomial infection.

Hydrate Prevention Strategies and the Associated Cost in the Gulf of Mexico

With the petroleum industry endeavoring to develop promising oil and gas in deeper water, gas hydrates prevention is a serious concern for oil and gas producing companies producing at conditions in the hydrate region. This paper details lessons learned from the successful field deployment of AA LDHI and proper implementation strategies used for 3 different practical fields as case studies in the Gulf of Mexico. From the 3 field experiences, the AA LDHI has been used to replace the conventional thermodynamic hydrate inhibitor due to its numerous benefits during steady state operations and transition operations where AA LDHI is injected prior to extended shut in and restart for fields producing at low water cut. However, the strategy to develop a cost effective chemical management of hydrates for fields producing at high water cut is by pumping methanol or diesel to push down the wellbore fluid below the mud line during planned and unplanned shut-ins to delay water production, it also secures the riser with non hydrate fluids. This illustrates how the AA LDHIs are used in conjunction with more conventional hydrate management approaches to reach an optimal cost effective field hydrate management solution. However, this shows that the key to overall success of hydrate prevention is a full integration of a good front end design, a comprehensive deployment and an effective down hole monitoring system.

Comprehensive prevention strategies for retinopathy of prematurity:a literature review

Retinopathy of prematurity(ROP)is a kind of disease that can be seen in premature infants.It may cause a series of short-and longterm complications such as poor vision in premature infants,causing irreversible damage to them.Therefore,if we can prevent this disease,we can solve the above problems.This study summarized some factors that influence ROP,such as low gestational age,low birth weight,irrational oxygen use,anemia,blood transfusion,and thrombocytopenia;and also summarized a series of interventions that can prevent or delay the progression of ROP,such as reducing blood transfusion,the application of antenatal corticosteroids,and delaying clip umbilical cord,which can provide some reference for better clinical practice of preventing ROP.

Analysis of Epidemic Prevention Strategies of Omicron Variant Abroad

Omicron variant was first found in Botswana, southern Africa, on November 9, 2021. The variant has many mutations and spreads quickly. It also has immune escape to existing COVID-19 vaccines, and the infection rate and repeated infection rate have increased worldwide. For such variant, at this stage, foreign countries mainly adopt three strategies to prevent and control the epidemic. First, big data is used to track the potential infection of the epidemic, trace the spread of the epidemic, screen close contacts, and control the scope of infection. The second is to maximum the coverage rate of vaccination, especially the coverage rate of the third injection, so as to reduce the infection level of Omicron variant. At last, they are developing a general coronavirus vaccine to prevent infection caused by SARS-CoV-2 variants, including the Omicron variant, so as to fundamentally eliminate the potential threat of variants to human beings. In this paper, three major epidemic prevention strategies of Omicron variant abroad were summarized in detail.

Determinants of overweight and obesity and preventive strategies in Pacific countries: a systematic review

Objective:This study aimed to explore more on contributing factors and prevention of overweight and obesity among Pacific islanders.Methods:Using Cochrane library guideline,four electronic databases,PubMed,Embase,Scopus and CINAHL,were systematically searched from 2010 to 2020.Search strategy included key concepts,free text terms,and database-controlled vocabulary terms to identify articles on determinants and preventative strategies of overweight and obesity in the Pacific countries.A data extraction sheet was developed to extract relevant information required for analysis and theme development for this study.Results:A total of 22 articles were summarized and categorized.Determinants of overweight and obesity identified two themes:environmental related factors 13.6%(3/22)and sociocultural related factors 27.3%(6/22).The preventative strategies of overweight and obesity was categorized into behavioural change 22.7%(5/22),school-related 18.2%(4/22),and policies 50%(11/22).The quality assessment of articles showed“Good”68.2%(15/22),and“Fair”31.8%(7/22).Conclusion:This study highlighted two contributing,non-medication factors affecting overweight and obesity are both environmental and socio-cultural issues.Overweight and obesity preventative strategies identified in the Pacific context considered behavioural change,knowledge enhancement,and policy development.Further research should aim at exploring the current preventative strategies in-depth,to appreciate the most feasible and recommended preventative approach within the Pacific society.

A Systematic Review of Contrast-Induced Acute Kidney Injury

Background: Contrast-induced acute kidney injury (CI-AKI) is the third most common cause of AKI in hospitalized patients. Contrast agents mainly cause acute kidney injury through hypoxic damage to renal parenchyma and toxic effects on renal capillaries and tubules. Patients with CI-AKI are more likely to experience adverse events, including longer hospital stay and costs, longer ICU stay, and higher mortality rates. This article elaborates on the definition, epidemiology, risk factors, pathogenesis, and prevention strategies of CI-AKI. Methods: We conducted an extensive literature search using contrast agents and AKI as keywords to identify relevant studies on CI-AKI. Conclusion: CI-AKI is a significant clinical challenge that requires a multifaceted approach to prevention and management. Understanding the risk factors, pathophysiology, and current best practices is essential for healthcare providers to optimize patient care and improve outcomes in those undergoing contrast-enhanced imaging procedures. Hydration therapy is currently the main prevention method, but antioxidants may also become a new strategy.

A Study of the Causes of In-Hospital Mortality in Patients with Acute Myocardial Infarction Complicated by Gastrointestinal Haemorrhage

Objective:To analyze the risk factors for death during hospitalization in patients with acute myocardial infarction(AMI)complicated by gastrointestinal bleeding(GIB).Methods:260 patients with AMI complicated by GIB who were admitted to the cardiology department of a hospital from January 2022 to December 2023 were retrospectively analyzed.27 patients who died during hospitalization were designated as the control group and the 233 patients who survived as the observation group.Baseline data and clinical indexes of patients in the two groups were compared,and multifactorial logistic regression was applied to analyze the risk factors for death during hospitalization in patients with AMI complicated by GIB.Results:Univariate analysis showed that the control group had higher proportions of patients with Killip classification III to IV on admission,new arrhythmias,and mechanical complications,as well as higher heart rates,white blood cell counts,urea nitrogen,and creatinine levels.The proportion of patients who received transfusion therapy during hospitalization was also higher in the control group.Conversely,the control group had lower systolic and left ventricular ejection fraction rates compared to the observation group,with statistically significant differences(P<0.05).Multifactorial logistic regression analysis revealed that new-onset arrhythmia(OR=2.724,95%CI 1.289-5.759),heart rate>100 beats/min(OR=3.824,95%CI 1.472-9.927),left ventricular ejection fraction<50%(OR=1.884,95%CI 0.893-3.968),BUN level(OR=1.029,95%CI 1.007-1.052),and blood transfusion(OR=3.774,95%CI 1.124-6.345)were independently associated with an increased risk of death during hospitalization in patients with AMI complicated by GIB.Conclusions:New arrhythmia,heart rate>100 beats/min,left ventricular ejection fraction<50%,elevated BUN levels,and blood transfusion are risk factors for death during hospitalization in patients with AMI complicated by GIB.

Gastric cancer: Epidemiology, risk factors and prevention strategies

Gastric cancer(GC) is a global health problem, with more than 1 million people newly diagnosed with GC worldwide each year. GC is more prevalent in less developed countries than in more developed countries. About half of all GC cases worldwide occur in East Asia, notably China. Globally, overall incidence rates of GC are declining, which is potentially attributed to a decrease in Helicobacter pylori(H. pylori) infection and the use of refrigeration to preserve foods rather than salt. GC is a multifactorial disease, and its occurrence and development were impacted by environmental and genetic factors. H. pylori infection is the primary risk factor for GC, especially for non-cardia. The prognosis of GC is poor due to stages at the first diagnosis. The 5-year survival rate is less than 10% when patients are diagnosed at an advanced stage, but the rate is as high as 85% if patients are detected at an earlier stage. Endoscopic screening can potentially prevent GC by early diagnosis and early treatment and has been widely adopted in screening programs in East Asian countries, such as Japan and Korea. This review summarizes updated epidemiological aspects, risk factors, and prevention strategies of GC in recent years to help researchers determine the most effective intervention strategies for reducing risk of GC.

Debris Flow Disaster Prevention and Mitigation of NonStructural Strategies in Taiwan

Taiwan has disadvantageous conditions for sediment-related disasters such as debris flows. The construction of engineering structures is an effective strategy for reducing debris flow disasters. However, it is impossible to construct engineering structures in all debris flow areas in a short period. Therefore, the government aims to gradually develop non-structural preventive strategies, including evacuation planning, debris flow disaster emergency action system, disaster resistant community program, recruitment of debris flow professional volunteers, debris flow warning systems, and land management strategies, to mitigate disasters and secure the safety of residents. This review describes the processes and effects of recent debris flow non-structural preventive strategies in Taiwan. The average number of casualties prior to the year 2000 was far higher than the corresponding number after 2000 because debris flow evacuation drills have been promoted since 2000 and the debris flow disaster emergency action system has been progressively improved since 2002. Furthermore, the changes in risks caused by debris flow disasters before and after the implementation of non-structural preventive strategies were used to explain the effectiveness of these strategies at the community level. The results showed that softwarebased non-structural preventive strategies can effectively reduce the casualties caused by debris flows at both the national and community levels.

Occurrence and Damage Characteristics of Sugarcane Catastrophic Diseases and Pests in Menglian Sugarcane Area and Their Prevention and Control Strategies

In recent years,the conditions of continuous warm winter,more rain and high humidity are very beneficial to the breeding and survival of sugarcane diseases and pests.Coupled with the degradation of single varieties,more attention on new plants and less on ratoon cane and the unscientific and unreasonable use of chemical pesticides,the types of sugarcane diseases and pests in the Menglian sugarcane area are increasing day by day,and the damage is increasing year by year,resulting in a substantial reduction in production and sugar,and a serious disaster threat to sugarcane production.Based on the field survey and the current sugarcane production practice in Menglian,this paper systematically reviewed the occurrence and damage dynamics and outbreak reasons of catastrophic diseases and pests that seriously influence sugarcane production,and proposed corresponding prevention and control strategies and integrated prevention and control technology according to the occurrence and damage characteristics of catastrophic diseases and pests.

Clinical Characteristics and Prevention Strategies of Falls in Hospitalized Patients with Chronic Kidney Disease

Objectives: To analyze the clinical features of falls in hospitalized patients with chronic kidney disease (CKD), and to provide basis for preventing the occurrence of falls in hospitalized patients with CKD. Method: A retrospective study was conducted to analyze the 27 adverse events of falls in hospitalized patients from the department of nephrology in Peking University Shenzhen Hospital during May 2009 and May 2019. Results: Among the 27 patients with falls, people over 65 years old accounted for 55.56%;74.07% of the patients had caregivers;the peak period of falls was from June to August, accounting for 40.74%, mainly occurring from 7:00 to 8:00, 12:00 to 13:30 and 19:00 to 21:00;the locations of falls were mostly near the bed and in the bathroom, accounting for 33.33% and 22.22%, respectively;suffering from anemia, hypoproteinemia, abnormal serum potassium, calcium-phosphorus metabolism disorders accompanied by abnormal parathyroid hormone and hypertension accounted for 88.89%, 85.19%, 29.63%, 96.30% and 81.48% respectively. The inpatients on dialysis therapy accounted for 66.67%. Conclusion: The occurrence of falls in hospitalized patients with CKD was not only related to age, caregivers, time, months, locations or other conventional factors, but also the complications and dialysis therapies. To effectively reduce the occurrence of falls, it’s necessary to enhance the sense of safety and responsibility of caregivers. Besides, nurses should strengthen the inspection of wards for inpatients engaging in some intensive activities, and nurses should also pay more attention to the inpatients with anemia, hypoproteinemia, calcium-phosphorus metabolism disorders and those on dialysis therapies.

基于风险评估和参展流程的大型展会疫情风险防控管理实践:以中国国际进口博览会为例

大型展会易发生传染病暴发等公共卫生风险,尤其是新冠疫情暴发后,平衡疫情防控的要求和展会办展体验度是展会行业高质量发展面临的主要难题,相关先进实践经验须进一步总结与推广。通过对5届中国国际进口博览会疫情风险防控成功经验的探索,从展会的参展流程出发,明确各流程中潜在的疫情风险。基于风险评估理论,提出“风险对象分离原则”“疫情防控和展会服务保障组织体系、运行方案和健康促进措施相结合原则”“基于参展参会流程的多点触发监测和实验室检测原则”。同时,基于对不同疫情形势下大型展会疫情防控目标和重点措施的剖析,提出健全组织体系、加强内外联动、风险分级管理、联动开展应急处置等保障模式,相关经验可为今后大型展会疫情风险防控提供参考。

上海市应对新型冠状病毒肺炎疫情综合防控策略

面对新型冠状病毒肺炎疫情,上海市坚决贯彻中央部署要求,采取了最严格、最全面、最积极的防控措施,在短时间内有效地遏制疫情蔓延势头。在疫情防控过程中,准确把握疫情形势变化,因时因势调整防控策略和措施,在严防境外疫情输入、有效处置本土疫情、统筹推动疫情防控和经济社会发展方面形成了行之有效的防控举措,构建起超大城市科学精准防控工作模式。

上海市新型冠状病毒肺炎防控策略探讨

根据政府公开发布的数据和相关的媒体报道,分析归纳上海市新型冠状病毒肺炎疫情防控方略,探讨超大城市应对突发传染病的防控经验和策略。上海市通过居家隔离、联防联控、群防群治、信息公开和分级复工等防控措施,成功将新型冠状病毒肺炎患者人数控制在1641人(截至2021年1月24日),占全国累计确诊病例数的1.64%,防控效果显著。上海市有效地控制了疫情蔓延,为超大城市应对突发急性传染病等公共卫生事件提供了极有价值的经验和策略。

基于风险评估和流程再造的口岸疫情风险防控管理实践

借助机场疫情防控专班的实际经验,从机场业务流程视角出发,明确各流程中口岸防疫风险,制定详细的空港口岸风险要素评估方案,构建基于风险分级的口岸疫情风险要素管理方法,系统性地将风险阻断和防疫措施集成到机场现有的各项业务中,为我国口岸疫情防控体系建设提供实证依据与理论参考。

面向入境货运业务的口岸疫情防控实践:以浦东国际机场为例

新型冠状病毒肺炎疫情发生以来,在“保供保生产”的防疫需求下,我国空港口岸的入境货运量不降反增,入境货运业务成为当前口岸疫情防控的重点内容之一,各口岸机场的先进实践经验需进一步总结与推广。基于浦东国际机场国际入境货运业务的探索实践,总结出以风险评估与流程再造为主的空港口岸货运疫情管控理论:包括“人、物、环境”同防策略下的货运要素风险评估方法、“风险对象分离原则”和“风险单元最小化原则”;明确基于风险分级的货运流程分类管理策略,提出货物动线设计、货物分离和拆装存运的方案;总结基于风险评估的货运人员动态管理方法与风险单元最小化的实践案例,涵盖机组边检、登记进出、健康监测、就医管理、住宿通勤等方面,为我国口岸货运业务疫情防控的精细化管理提供经验参考。

Peripherally inserted central catheters in critically ill patients-complications and its prevention:A review

Peripherally inserted central catheter(PICC)is extensively used in critical care settings,because it plays a vital role in providing safe central venous entry.However,PICC is associated with several complications,which should be detected to shorten the duration of patients'improvement,reduce health care cost,and lessen the incidence of various PICC-related complications.Therefore,this study aimed to outline current literature on PICC procedures,potential complications,and measures for prevention.Understanding evidence-based guidelines regarding insertion technique,early detection of complications,and care bundle of PICC is significant in complication prevention.Implementation of education,training,and appropriate multidisciplinary approaches on PICC care among nurses and caregivers is the key to preventing complications.Thus,the strict care of indwelling PICC lines,the targeted and reasonable PICCassociated complication prevention,and nursing care have a major clinical significance in reducing the occurrence of potential PICC complications.

Aging men-Challenges ahead

The prolongation of life expectancy and the drastic reduction of fertility rate are the primary cause of an agingworld. It is projected that the elderly (above 65) will increase within the next 25 years by 82% , whereas the new bornonly by 3% . Despite the enormous medical progress during the past few decades, the last years of life are still accom-panied by increasing ill health and disability. The ability to maintain active and independent living for as long as possi-ble is a crucial factor for aging in health and dignity. Therefore, the promotion of healthy aging and the prevention ofdisability in men, must assume a central role in medical research and medical practice as well as in the formulation ofnational health and social policies. Effective programs promoting health and aging will ensure a more efficient use ofhealth and social services and improve the quality of life in older persons by enabling them to remain independent andproductive. The most important and drastic gender differences in aging are related to organs and or systems dependantor influenced by reproductive hormones. In distinction to the course of reproductive aging in women, with the rapid de-cline in sex hormones and expressed by the cessation of menses, aging men experience a slow and continuous decline ofhormones. This decline in endocrine function involves; A decrease of testosterone, dehydroepiandrosterone (DHEA),oestrogens, thyroid stimulating hormone (TSH), growth hormone (GH), insulin-like growth factor-1 (IGF-1), andmelatonin. This decrease is concomitant with an increase of LH and FSH. In addition sex hormone binding globulin's(SHBG) increase with age resulting in further lowering the concentrations of free biologically active androgens. Inter-ventions such as hormone replacement therapy may prevent, delay or alleviate the debilitating conditions which may re-sult from secondary partial endocrine deficiency. Primary and secondary preventive strategies such as the promotion of asafe environment, healthy lifestyle including proper nutrition, appropriate exercise, avoidance of smoking, avoidanceof drug and alcohol abuses, if done effectively, should result in a significant reduction of the health and social costs,reduce pain and suffering, increase the quality of life of the elderly and enable them to remain productive and contributeto the well-being of society. In light of this, public awareness of medical knowledge needs to be increased and basic,clinical, socio-economic and epidemiological research intensified. (Asian J Androl 2001 Sep; 3; 161 - 168)

Dimethylacetamide-induced Hepatic Injury in Vitro: Mechanism and Potential Preventive Strategy

N,N-Dimethylacetamide （DMAc） is a widely used organic solvent in modern chemical industry with low to moderate hepatotoxicity to occupational health of employees. But so far, there are fewer and less conclusive data concerning its pathogenic mechanism in detail. In current study, the toxicity of DMAc was firstly investigated on human normal hepatocytes （LO-2）, using a series of molecular biology measurements to ananlyze the effect and mechanism of DMAc-induced hepatic cell injury and explore effective prophylactic measures. We found that DMAc triggered LO-2 apoptosis in a obviously dose-dependent manner, caused by increased ROS generation and activation of Bcl-2 pathway. Significantly, glutathione （GSH） rather than vitamin C （Vit C） could partially inhibit DMAc-induced apoptosis thus showing potential as a effective precaution for workers.