Mechanism prediction analysis of an epidemic prevention sachet in preventing new coronavirus pneumonia

Objective:To explore the prevention mechanism of an anti-epidemic sachet on the new coronavirus pneumonia(COVID-19)based on the network pharmacology and molecular docking method.Methods:The chemical constituents and action targets of wormwood leaves,white peony,borneol,Rhizoma atracylodis,and Herba pogostemonis in the epidemic-preventive sachet were retrieved in TCMSP database.Query the genes of targets through the Uniprot database,and then use Cytoscape 3.7.2 software to build a medicinal drugs-active ingredients-targets(genes)network for visualization.Then we used DAVID to perform gene ontology(GO)function enrichment analysis and genome encyclopedia(KEGG)pathway analysis to predict the mechanisms of action.Draw histograms and bubble charts for visualization with Excel software and Omicshare database.The crystal structure of ACE2 was searched in the RCSB PDB database,and the compounds and proteins were molecularly docked with the help of PyMOL,AutoDockTool,and Vina software.Results:Sixty-seven effective chemical components in the anti-epidemic sachet were screened and a drugs-chemical components-targets network was constructed to obtain 948 targets,and 18 core targets and 28 core target pathways were predicted.6 compounds in Folium artemisiae argyi,13 compounds in Radix angelicae dahuricae,3 compounds in Rhizoma atracylodis,4 compounds in Fructus tsaoko,8 compounds in Herba pogostemonis,and 3 compounds in Rhizoma acori talarinowii have less binding energy with 1R42 than the ligand.Conclusion:It is predicted that the anti-epidemic sachet has prevention effects on new coronavirus pneumonia.

Overview of research on prevention and control of novel coronavirus pneumonia based on traditional Chinese medicine theories and methods

From ancient times to the present,the plague has had a huge impact on human life.Traditional Chinese medicine has also accumulated valuable epidemic prevention theories and methods from the practice of anti-epidemic,and formed a unique epidemic prevention thinking.Chinese medicine is good at using the thinking of the three talents of heaven,earth and human beings to adjust the epidemic situation according to the time and place,and uses the thinking of five transports and six qi to predict the development trend of the epidemic and guide the clinical treatment rules.Physicians of later generations summed up the characteristics of epidemics and put forward many theories and ideas of traditional Chinese medicine for epidemic prevention,including Wu Youxing's theory of suffocating qi and the thinking of dialectical treatment of Jiu Chuan,the differentiation and treatment method of Wei qi and nourishing blood of rotten throat Dansha,and the essence of grasping the essence of Lingnan famous Chinese medicine.Deng Tietao's thoughts on the diagnosis and treatment of SARS in the fight against SARS,etc.This article will summarize the thinking theories of traditional Chinese medicine for epidemic prevention and control and China's traditional epidemic prevention measures,and give an overview and explanation in combination with the current domestic new coronavirus prevention and control work.

Clinical Research of Pre-Hospital Emergency Care, Nursing, Infection Prevention and Control for Senile Osteoporotic Vertebral Compression Fracture during Epidemic Period

Background: Novel coronavirus pneumonia (NCP) and osteoporotic vertebral compression fractures (OVCF) are the high incidences of diseases in the elderly. During the epidemic period, if not treated in time, the complications are high and the mortality is high. If we do not pay attention to infection prevention and control in pre-hospital emergency care, it will lead to the first time infection of medical staff and in-hospital cross infection in emergency outpatient receiving area. The correct consideration of both and the establishment of perfect pre-hospital emergency treatment and infection prevention and control synchronous strategy is an important premise to ensure the stable, orderly and safe medical treatment. Objective: To explore the effect of synchronous implementation of pre-hospital emergency care, nursing and infection pre-vention and control for senile OVCF during the epidemic. In order to improve the efficiency of pre-hospital emergency care and prevent the spread of infection. Method: A total of 92 elderly patients with OVCF who received pre-hospital treatment in 18 hospitals in Zhangjiakou City during the epidemic prevention and control period from January 2020 to November 2022 and met the inclusion criteria were selected as research objects, including 24 males and 68 females, aged 65 - 82 (74.2 ± 2.2) years. All patients were associated with concomitant injuries and underlying diseases. All patients in this group underwent predictive pre-hospital rescue and infection prevention and control procedures. Results: All the 92 elderly patients with OVCF received timely pre-hospital treatment during the epidemic period, and no aggravation occurred of the 92 patients, 35 were in the high risk area, 10 were in the medium risk area, and 47 were in the low risk area. Exclude OVCF for NCP Patients were treated according to the conventional diagnosis and treatment principles. Suspected and confirmed cases are transferred to designated surgical hospitals for treatment. All patients were followed up 3 months, 6 months and 12 months after treatment. There was no death rate, high satisfaction of pre-hospital first aid, high diagnostic accuracy, and good curative effect. None of the rescue personnel had any infection rate, and no hospital infection transmission and nosocomial cross infection occurred. Conclusion: It is the first step to safely treat patients and prevent cross infection to establish a perfect synchronous strategy of pre-hospital first aid and infection prevention and control.

Preventive Effect of Xiangsha Yangwei Pills on the Novel Coronavirus Pneumonia from"Genuine Qi Exists,Illness Never"

The preventive effect of traditional Chinese medicine on the novel coronavirus(COVID-19)pneumonia is embodied in the"prevention before disease onset"of"treatment of disease"theory of thought,and it is considered that the key to the success or failure of prevention is whether the healthy qi is abundant or not.This article discusses and understands the"genuine qi"from the The Medical Classic of the Yellow Emperor,and describes its meaning comprehensively and systematically,combining with the expansion and supplement of many doctors in later generations.The"genuine qi"includes healthy qi,pulse qi,congenital qi,personal qi,Jing qi primordial qi and food energy,all of which are closely related to spleen-stomach.The function of spleen-stomach is normal,water and grain are transported properly,and the rise and fall of qi is appropriate,then the human body's qi is abundant,the anti-evil force is strong,and people are not easy to cause disease;even if the disease,the prognosis is better.This the novel coronavirus pneumonia comprehensive analysis,belongs to the traditional Chinese medicine science"damp-toxin epidemic",therefore the prevention should pay more attention to strengthen spleen and stomach,eliminate dampness,and Xiangsha Yangwei Pills is the appropriate choice.

Comparison and Enlightenment of Emergency Response Measures between Costa Serena and Diamond Princess in Response to New Coronavirus Pneumonia

This article analyzes the basic situation of the cruise ship Costa Serena and Princess Diamond and the emergency treatment and control measures in response to the novel coronavirus epidemic,investigates the management differences between the two cruise ships and puts forward relevant suggestions.

疫毒为本,热重兼湿——广东地区新型冠状病毒肺炎临证救治探讨

目的探讨广东地区新型冠状病毒肺炎病机特点及救治要点。方法收集自2019年12月份新冠肺炎爆发以来在本单位确诊的患者四诊资料,结合既往疫病救治经验及相关文献总结。结果广东地区新冠肺炎病理因素以疫毒为本,属热毒疫范畴,热重兼湿,虚、瘀征象不明显;病情演变五脏相关,但初期病情多处于卫气分阶段,病位在肺脾,以实证为主,及早将病情控制在卫气分阶段可防止其传变;应树立现代中医思维,重视截断疗法及解毒透邪、清热化湿法的运用;发挥中药汤剂配合中成药静脉滴注、成药口服等方式,在严格掌握抗生素及抗病毒药物的使用指征前提下辅以相应治疗,多途径用药,力挽病势;注意食疗与生活起居、心理调摄。结论疫毒为本,热重兼湿是广东新冠肺炎的核心病机,在临床救治中应结合本地区特殊的时令、气候及人群特点,在"三因制宜"的理论指导下进行临证辨治。

高校图书馆信息资源应急保障体系

《普通高等学校图书馆规程》未对高校图书馆所应提供应急服务作出具体规定。面对重大传染病疫情如何建立高校图书馆信息资源应急保障体系,国内外缺乏相应研究成果。高校图书馆亟须对2019-2020年新冠肺炎疫情期间的危机管理措施进行思考研究,建立有效的信息资源应急保障体系,以应对今后更为多变的信息服务环境。利用文献调研和网站调研,并结合教育部高等学校图书情报工作指导委员会网站上发布的全国各省市高校图书馆疫情期间的服务报告,从应急管理保障、资源服务保障、网络技术保障、服务平台保障和馆员能力保障五个方面,阐述高校信息资源应急保障体系主要内容及存在问题。针对目前现状并结合疫情期间出现的相关案例,建议高校图书馆从五个方面加强信息资源应急保障:建立应急机制,提升资源保障能力;规范服务标准,助推线上服务拓展;整合教学资源,嵌入智慧教学平台;创新共享理念,增强应急服务力度;凝聚行业力量,打造专业服务团队。

基于区块链技术的我国传染病监测预警系统的优化研究

为了用区块链技术改进和优化我国传染病监测预警系统,将现行传染病自动预警系统、网络直报系统、公共卫生数据交换系统、医院信息管理系统整合成一条疫情监测预警的协同链;将疾控中心、医院、药店、社区等整合成一条医疗信息安全共享的数据链;将传染病报告卡、传染病风险特征标签、电子健康档案、电子病历等疫情哨点数据整合成一条能及时发现疫情爆发的证据链。充分利用区块链技术的分布式加密存储、数字身份认证、智能合约的自动化执行和数据防篡改、数据安全共享等技术优势,建立兼顾实时性和准确性的传染病早期联合预警监测平台。

基于五运六气理论对新型冠状病毒感染肺炎的几点思考

基于五运六气理论,尤其是三年化疫理论,对当前正在流行的新型冠状病毒感染的肺炎进行病因病机分析及分期诊疗指导。

新型冠状病毒患者机械通气中的感染防控措施

目的探索新型冠状病毒肺炎(COVID-19)患者机械通气中的感染防控措施,为安全应用机械通气技术提供借鉴。方法计算机检索Pub Med、Ovid、万方、维普等数据库,并结合机械通气应用经验,探讨COVID-19患者机械通气中的感染防控措施。结果提出呼吸机外部回路、内部回路、外表面、过滤网及特殊部件的感染防控方法;归纳总结出人工气道的吸痰操作和雾化治疗的感染防控措施。结论成功完成COVID-19患者机械通气中感染防控方案,为机械通气应用及维护提供参考建议。

新型冠状病毒肺炎对心血管系统影响的中医认识与防治策略

新型冠状病毒肺炎可能会造成心脏损伤,且具有心血管基础疾病的新型冠状病毒肺炎患者预后明显较差。针对新型冠状病毒肺炎对心血管系统所造成的影响,通过阐述其与心血管疾病之间的关系及中医对其病理机制的认识,为新型冠状病毒肺炎中医药防治系统化提供指导。

《长春中医药大学附属医院新型冠状病毒肺炎防治方案》试行第一版至第四版的演变思考

2020年1月22日-2月17日,王檀团队制定了共4版《长春中医药大学附属医院新型冠状病毒肺炎防治方案》,该方案认为新型冠状病毒肺炎归属于中医"疫毒"范畴,病机特点为寒、湿、虚、瘀、痹。第一版将本病分为外感早期,外感迁延期,寒湿痹肺期,肺肾虚冷、肺络痹阻期;经二版、三版修订,第四版方案将本病分为卫表期、伤肺期、恢复期,并将各期进一步分层。第一版将本病分为风寒外束、寒湿内盛,邪郁肌腠、痰热郁肺,寒湿痹肺,肺肾虚冷、肺络痹阻4个证型,至三版、四版,则修订为疫毒外袭、寒湿内盛,邪郁肌腠、痰热郁肺,疫毒寒湿痹肺,气阴两伤、热毒聚肺,脾肾虚冷、疫毒化火,伤阴耗液、心阳浮动,肺肾虚冷、肺络痹阻,气阴两伤,心神不宁等8个证型,并增加了指导用药等内容。该方案还提出了预防措施。

国医大师防治新型冠状病毒肺炎处方分析

目的分析目前公布的国医大师预防或治疗新型冠状病毒肺炎(COVID-19)的处方,解读其辨证思路及用药规律。方法检索国医大师公布的关于预防或治疗COVID-19的处方,检索期限自2020年1月1日至2020年2月12日。结果共9位国医大师公布了22个处方。周仲瑛、孙光荣、唐祖宣、李佃贵、金世元、王琦、熊继柏、刘祖贻共8位国医大师开具了9个预防用方,涉及中药32味,处方以益气、化湿、清热解毒为主,辅以养阴清热、疏风解表、宣肺化痰。唐祖宣、杨春波、李佃贵、孙光荣4位国医大师开具了10个治疗类处方,涉及中药61味,处方以化湿、清热、解毒为基本法则,唐老按湿邪与寒、热、毒邪分型证治,杨老依湿邪在体内的传变为辨证依据,李老专攻"湿热浊毒",孙老强调"疏风清热"。李佃贵、周仲瑛、王琦3位国医大师开具了3个香囊处方,涉及中药14味,均选用了藿香芳香化湿。结论多位国医大师积极参与防治COVID-19,对本病的病因病机认识基本一致,不论是治疗处方或是预防处方皆以益气、化湿、清热、解毒为主,结合用药频次统计,使用药物最多的是黄芪、藿香、金银花,具体证治方面则不尽相同。

新型冠状病毒肺炎:问题与困惑

在武汉及周边地区爆发的新型冠状病毒肺炎(COVID-19)给我国整个社会带来巨大的挑战。作为一种新发的传染性疾病,无论是对其流行病学,还是临床救治等方面,均存在诸多问题和困惑。如何做到有效防控、提高救治成功率和进行科学管理是当务之急。

新型冠状病毒肺炎中医病因与辨治的思考

新型冠状病毒肺炎是感受新型冠状病毒所致,属于中医学“疫病”的范畴,其病因为吴又可提出的“异气”,与六淫不同,具有生物学属性;侵袭人体主要造成气阴损伤,气化失常,湿饮停聚;治疗当以“逐邪为第一要义”,恢复机体平衡状态。

冠状病毒的致病性及防控

近50年来,新的冠状病毒不断出现,引起人类及动物的各种疾病。近期,在武汉肺炎患者中分离到新的冠状病毒。世界卫生组织(World Health Organization,WHO)认为,中国在短期内即初步鉴定出新病原,且采取了有效管控措施,显示了科学家的科技实力及政府对突发新现传染病的处置能力。本文简要介绍了近年来新出现的冠状病毒并提出防控建议。

疫情防控中大数据应用的逻辑及其规制路径——以新冠肺炎疫情为例

政府应急管理需要充分应用大数据技术,在这次新冠肺炎疫情中,大数据填补了突发疫情相关信息的认知缺口,回应了政府疫情研判、应急管理、保障民生的需要,发挥了重要价值。为了应对疫情防控中大数据应用面临的数据共享、数据整合和个人隐私保护等方面的障碍,需要在理论和实践层面解决好数据信息共享与个人隐私保护的张力、真实信息和虚假信息的争锋、数据整合与数据碎片的矛盾等突出问题。未来可以通过搭建规范的疫情防控大数据平台、整合疫情防控大数据使用规范和完善疫情防控大数据法律体系,从而充分发挥大数据应用在疫情防控中的重要支撑作用。

中医药防治新型冠状病毒肺炎优势分析

在几千年抗疫防病的实践中中医学已经积累了丰富的经验,对急性传染病的常态化预防和治疗形成了独特的理论体系,在指导中医药防治疫病方面起到非常重要的作用,该文重在中医药防治疫病新型冠状病毒感染肺炎的优势与特色方面进行阐述,将从调摄精神、增强机体免疫力、中药防治、针灸疗法、中医香疗等多个方面进行分析,旨在挖掘中医药在抗击新冠病毒感染肺炎的战役中发挥出的优势与特色。

浅论《瘟疫论》对新型冠状病毒肺炎防治的指导意义

新型冠状病毒于2019年末席卷华夏大地,其传播迅速,来势凶猛,给中国乃至全世界造成了不可估量的损失。目前,针对新型冠状病毒肺炎的治疗,西医尚未发现特效治疗药物,在对抗新型冠状病毒肺炎的过程中,中医发挥了不可磨灭的作用。本研究运用吴又可编著的《瘟疫论》,对新冠肺炎的病因、临床症状、中医治疗、治疗之后的护理以及预防等方面进行解析,为中医预防以及治疗新冠肺炎提供理论依据。

曲靖地区13例新型冠状病毒肺炎的中西医结合诊治初探

目的:分析曲靖地区13例新型冠状病毒肺炎确诊患者的临床资料及中西医结合治疗情况,总结中西医结合治疗方案,并形成曲靖地区的新型冠状病毒肺炎中医辨治方案。方法:收集2020年1月23日至2月27日在曲靖市第一人民医院出院的13例新型冠状病毒肺炎患者资料,对患者的基本信息、中医证候、治疗方法等进行分析。结果:13例患者平均年龄(28±11.83)岁,男性46.15%,女性53.85%;病情轻型1例(8%),普通型10例(77%),重型2例(15%);首发症状:咳嗽3例(23%),发热1例(8%),发热伴咳嗽6例(46%),发热伴咽痛1例(8%),无症状2例(15%);中医证候肺脾气虚6例(46%),湿热郁肺5例(39%),疫毒闭肺2例(15%)。采用中西医结合治疗后患者的咳嗽、胸闷、咽痛等症状消失,临床治愈12例(92.3%)。结论:中西医结合诊疗新冠肺炎可发挥中医药的独特优势。