Effect of Health Management in Raising Awareness Rate of Disease Prevention and Treatment in Patients with Prehypertension

Objective: To analyze the effect of health management on improving the awareness rate of disease prevention and treatment in patients with prehypertension, so as to provide guidance for clinical management of patients with prehypertension. Methods: 108 patients diagnosed with prehypertension in our hospital were divided into a control group and an experimental group. The control group was not given management measures, while the experimental group was given health management. The incidence of hypertension and cognition level of hypertension knowledge were compared between the two groups after management. Results: The incidence of hypertension in the experimental group was 7.41% lower than that in the control group 29.63%. The cognitive level of hypertension in the patients (66.54 ± 1.25) was significantly higher than that in the patients without health management (41.45 ± 2.45), and P < 0.05;Conclusion: For patients with prehypertension, the implementation of health management is helpful to improve their cognition of hypertension, master related prevention knowledge, and reduce the incidence of hypertension.

Characteristics of 240 randomized controlled trials for adjusting constitution in preventive treatment of disease:A bibliometric analysis

Background:A growing number of randomized controlled trials(RCTs)have explored the significance of adjusting constitution for preventive treatment of disease in traditional Chinese medicine(TCM).In this study,we sought to comprehensively analyze the characteristics of these RCTs.Methods:All RCTs related to constitutional adjustment and preventive treatment of disease were included in the study.Literature was screened searching seven databases,including Pubmed,Web of Science,Embase,SinoMed,CNKI,Chongqing VIP,and Wangfang Database,from inception to December 2018.Data pertaining to bibliometrics,participants,and interventions were extracted and analyzed.Results:Two hundred and forty papers were published between 2007 and 2018,involving 240 RCTs with 55977 total participants.Sample size in these RCTs ranged from 30 to 7800.Among them,59 RCTs addressed disease prevention prior to onset involving 11 healthy states of participants,mainly for general health or sub-health population(40.68%)using health care and non-drug therapy.In control the development of existing disease(n Z 174),59 diseases were involved.Based on the number of RCTs and sample sizes,diseases including type 2 diabetes mellitus,primary hypertension,nonalcoholic fatty liver disease,and hyperlipoproteinemia accounted for 51.15%of the total patients studied.Drug therapy as an intervention was frequently used.In preventing recurrence after recovery(n Z 7),over 4 kinds of health status in participants were involved.Drug therapy combined with health care was mostly used.Most RCTs reported positive outcomes,with only one reporting negative findings(1/240).Conclusion:The number of RCTs of constitutional adjustment on preventive treatment of disease has gradually increased since 2012.Participants and intervention measures from the above-mentioned types of RCTs exhibit their own characteristics.Future systematic reviews or meta-analyses on constitutional adjustment for preventive treatment of disease are warranted.

Preventive online and offline health management intervention in polycystic ovary syndrome

BACKGROUND Polycystic ovary syndrome(PCOS) is characterized by hyperandrogenism, hyperinsulinemia, ovarian polycystic changes, and irregular ovulation, often occurring in women of childbearing age for whom it can be a cause of infertility. Hypothalamus-pituitary-ovarian axis dysregulation is important in the pathogenesis of PCOS and the associated chronic excess of sex hormones can lead to cardiovascular and cerebrovascular diseases, diabetes, and malignancies such as endometrial cancer, and breast cancer. At present, most scholars agree that lifestyle interventions in conjunction with drug treatment can help PCOS patients achieve their goals of successful pregnancy and childbirth.AIM To investigate the clinical effect of an online and offline(O2O) preventive health management model on PCOS with kidney deficiency and phlegm dampness.METHODS A total of 82 patients with PCOS of the kidney deficiency and phlegm dampness type who were admitted to Beijing Luhe Hospital Affiliated to Capital Medical University from April 2019 to June 2020 were randomly divided into two groups. The treatment group was treated with oral Diane-35 for 3 mo and received preventive O2O medical health management for 6 mo(including eating and living, exercise, drug management). The control group was treated with oral Diane-35 for 3 mo and completed outpatient health education. The traditional Chinese medicine(TCM) syndrome score, acne score, hair score, sex hormone level and clinical effects were compared between the two groups before and after the intervention. RESULTS After treatment, the TCM syndrome score, acne score, and serum luteinizing hormone/follicle stimulating hormone level were significantly lower in the treatment group than in the control group(P < 0.05). After 3 mo of treatment, the TCM syndrome curative effect index in the treatment group was 97.30% compared to 54.05% in the control group(P < 0.05), whereas the total treatment effect in the treatment group was 91.89%, compared to 54.05% in the control group(P < 0.05).CONCLUSION An integrated therapeutic approach incorporating medication, TCM methods and social media is more effective than standard treatment for PCOS.

Discussion on Relationship Between Meridians and Viscera of Decreased Ovarian Reserve from the Perspective of"Preventive Treatment of Disease"by Acupuncture

Based on extensive historical data,clinical experience,and modern scientific research,we discuss the relationship between meridians and viscera of decreased ovarian reserve(OR)from the perspective of"preventive treatment of disease"by acupuncture.It is believed that the endogenous protection mechanism of acupuncture in"preventive treatment of disease"lies in harmonizing Yin and Yang and dredging meridians;stimulating righteousness and rejecting the evil outside;preventing disease;co-cultivating body and spirit,and regulating emotions.The incidence ofOR dysfunction is closely related to the uterus-related meridians and viscera.The mechanism of acupuncture treatment of OR dysfunction may be related to reproductive endocrine hormone levels,ovarian tissue morphology,immune system,granulosa cell apoptosis,and related signal transduction pathways.The clinical effect of acupuncture treatment of diminished OR is reflected in improving menstruation and ovulation;improving OR function,promoting pregnancy;improving local ovarian microenvironment;improving negative emotions,improving quality of life,and thus affecting pregnancy outcomes.This article summarizes the mechanism of action and clinical effect of acupuncture in the treatment of decreased OR function based on recent findings,analyzes the advantages and disadvantages of acupuncture in the treatment of disease,and provides the rationale for the clinical application of acupuncture in the treatment of decreased OR function.

Risk assessment and management of hepatitis B reactivation from direct-acting antivirals for hepatitis C

Although hepatitis B virus(HBV)reactivation has been reported in hepatitis C patients who received interferon therapy,rare cases of HBV reactivation occur in the context of direct-acting antiviral(DAA)agent therapy for treatment of hepatitis C virus(HCV)infection.Recent studies observed that the reactivations were predominantly in hepatitis B surface antigen(HBsAg)positive patients,but reactivation can rarely occur in patients who are HBsAg negative and hepatitis B core antibody(HBcAb)positive.The severity of an HBV flare varies.In some cases,severe liver injury or fulminant hepatic failure may occur.HBV reactivation may occur regardless of HCV genotype and type of DAA regimens.The onset of HBV reactivation can range from 4 to 48 weeks after initiating DAA therapy.These patients may have undetectable levels of HBV deoxyribonucleic acid(DNA)prior to DAA treatment.Pre-emptive antiviral therapy for HBV should be considered in HBsAg-positive patients with high levels of viremia who are not receiving HBV treatment.If HBV DNA viral load is less than the guideline criteria for HBV treatment,one should consider pre-emptive HBV antiviral versus HBV DNA monitoring during DAA therapy.For patients who are HBsAg negative but HBcAb positive,close monitoring of serum alanine aminotransferase(ALT)levels during/post-treatment is highly recommended.The current review summarizes the recommendations of different society guidelines and discusses the appropriate management strategies in various patient profiles.