High-grade serous carcinoma of the fallopian tube in a young woman with chromosomal 4q abnormality:A case report

BACKGROUND Few studies have reported an association between an increased risk of acquiring cancers and survival in patients with 4q deletion syndrome.This study presents a rare association between chromosome 4q abnormalities and fallopian tube highgrade serous carcinoma(HGSC)in a young woman.CASE SUMMARY A 35-year-old woman presented with acute dull abdominal pain and a known chromosomal abnormality involving 4q13.3 duplication and 4q23q24 deletion.Upon arrival at the emergency room,her abdomen appeared ovoid and distended with palpable shifting dullness.Ascites were identified through abdominal ultrasound,and computed tomography revealed an omentum cake and an enlarged bilateral adnexa.Blood tests showed elevated CA-125 levels.Paracentesis was conducted,and immunohistochemistry indicated that the cancer cells favored an ovarian origin,making us suspect ovarian cancer.The patient underwent debulking surgery,which led to a diagnosis of stage IIIC HGSC of the fallopian tube.Subsequently,the patient received adjuvant chemotherapy with carboplatin and paclitaxel,resulting in stable current condition.CONCLUSION This study demonstrates a rare correlation between a chromosome 4q abnormality and HGSC.UBE2D3 may affect crucial cancer-related pathways,including P53,BRCA,cyclin D,and tyrosine kinase receptors,thereby possibly contributing to cancer development.In addition,ADH1 and DDIT4 may be potential influencers of both carcinogenic and therapeutic responses.

Primary ovarian cancer combined with primary fallopian tube cancer:A case report

BACKGROUND Low grade serous carcinoma of the ovary(LGSOC)is a rare type of epithelial ovarian cancer with a low incidence rate.The origin of ovarian cancer has always been a hot topic in gynecological oncology research,and some scholars believe that the origin of ovarian malignant tumors is the fallopian tubes.Primary fallopian tube cancer is the lowest incidence of malignant tumors in the female reproductive system.There are only a few reports in the literature,but the mortality rate is very high.But in clinical practice,fallopian tube cancer is very common,but in most cases,it is classified as ovarian cancer.CASE SUMMARY We report a 54 years old postmenopausal woman who was hospitalized with a lower abdominal mass and underwent surgical treatment.The final pathological confirmation was low-grade serous carcinoma of the right ovary and low-grade serous carcinoma of the left fallopian tube.No special treatment was performed after the surgery,and the patient was instructed to undergo regular follow-up without any signs of disease progression.CONCLUSION The prognosis of LGSOC is relatively good,over 80%of patients still experience disease recurrence.

Primary Bilateral Adenocarcinoma of the Fallopian Tube: A Case Report

Primary fallopian tube carcinoma is an uncommon malignancy that accounts for 0.14% to 1.8% of gynecological cancers. The clinical symptom is not specific and preoperative diagnosis is easy to miss or delay because of a lack of specific symptoms. We reported a case of bilateral adenocarcinoma of the Fallopian tubes, was occurred in a 51-year-old postmenopausal woman and diagnosed with bilateral salpingectomy for suspicious of suppurative salpingitis. The diagnosis is not always suspected preoperatively. They are assimilated to salpingitis in the early stage, or to ovarian tumors in the advanced stage. The diagnosis is made postoperatively, after an anatomopathological examination. Its etiology is still poorly understood.

Primary Fallopian Tube Adenocarcinoma Discovered with the Vaginal Cytology: A Case Report with Pathological and Immunohistochemical Investigation

Background: Primary fallopian tube cancer is an extremely rare gynecological malignancy. Aim: To discuss, through a case report, the diagnostic process by means of cytology immunohistochemistry. Case Presentation: A 47-year-old Japanese woman, who also had lung cancer, presented with enlarged para-aortic lymph node without any symptoms. Based on the vaginal cytology report suggestive of gynecologic malignant tumor (possibly fallopian tube adenocarcinoma), primary surgery comprised of total abdominal hysterectomy and bilateral salpingo-oophorectomy was performed. Histopathology and immunohistochemistry examinations revealed primary fallopian tube carcinoma with metastasis of para-aortic lymph node. She is free from recurrence and metastases 9 months after the surgery and chemotherapy. Conclusion: Although primary fallopian tube cancer is a rare gynecologic malignancy, vaginal cytology may be useful for detecting fallopian tube carcinoma.

A CLINICAL REPORT OF REFRACTOTY CARCINOMA OFOVARY AND FALLOPIAN TUBE TREATED WITH TAXOL

From September 1993 through March 1994, 30 cases of refractory carcinoma of the ovary and Fallopian tube were treated with Taxol. Complete response was seen in 4 and partial response in 8 cases with a response rate of 40 %. The average length of remission was 5 months in CR and 3.9 months in PR. The major toxic side effect was decrease in total white cell count and in neutrophil count. Apart from flushing of face during Taxol infusion in 6 patients, no other allergic reaction was observed. Gastrointestinal, neurologic, liver and renal toxicities were mild. Taxol is a drug of choice in the treatment of patients with cancer of the ovary and Fallopian tube who are resistant to conventional chemotherapy.

Fallopian tube:Its role in infertility and gynecological oncology

Disorders of the fallopian tube play a very important role in both infertility and gynaecological oncology. Tubal factor infertility is considered among the leading causes of female factor infertility. Many tubal disorders are related to infertility including congenital anomalies, acute and chronic inflammatory diseases, endometriosis and other pathologies that result in partial or total fallopian tube obstruction. In the field of gynaecological oncology, ovarian surface epithelial tumors remain one of the most fatal malignancies in women worldwide carrying the worst prognosis among female genital malignancies. For decades, the cell of origin of epithelial tumors has remained controversial and was largely believed to be surface ovarian epithelium. Recently several studies suggested that there is a major role of the fallopian tube in the development of ovarian surface epithelial tumors, mainly high grade serous carcinoma and other tumour types. In this article we review the role of the fallopian tube in both infertility and gynaecological oncology.

原发性输卵管癌的超声表现与诊断分析

目的:探讨原发性输卵管癌(primary fallopian tube carcinoma,PFTC)的超声声像图特征,分析漏诊、误诊原因,提高术前诊断准确度。方法:回顾并分析2017年1月—2022年12月上海市长宁区妇幼保健院收治并经术后病理学检查证实的13例PFTC患者的超声图像及临床资料。结果:术前超声提示输卵管来源7例(53.85%,7/13),误诊5例(38.46%,5/13),漏诊1例(7.69%,1/13)。依据术前超声表现,13例PFTC患者分为5类:Ⅰ类1例,附件区未见明显异常包块;Ⅱ类2例,为囊性包块,囊壁上见乳头样突起,乳头样结构内见血流信号;Ⅲ类5例,为“腊肠形”囊实性混合回声,边界清晰,实性区域内见血流信号;Ⅳ类2例,为“腊肠形”实性低回声包块,边界清晰;Ⅴ类3例,为不规则形实性低回声包块,单发或多发,边界欠清。术前超声诊断效能:Ⅰ类1例,术前100.0%(1/1)漏诊;Ⅱ、Ⅲ、Ⅳ类诊断准确度分别为100.0%(2/2)、80.0%(4/5)、50.0%(1/2);Ⅴ类误诊率100.0%(3/3)。结论:不同超声分类的PFTC术前诊断准确度具有一定的差异性,病灶太小容易漏诊,晚期患者误诊率高,但典型的PFTC术前超声诊断准确度值得肯定。此外,结合患者临床病史可为PFTC的鉴别诊断提供更为全面的参考。

老年女性原发性输卵管癌的MRI表现

目的分析老年女性原发性输卵管癌的MRI表现,提高其诊断准确率。方法回顾性分析2013年1月—2023年6月在复旦大学附属华东医院经病理证实的15例原发性输卵管癌MRI表现。测量病灶最大径,观察其信号强度、形态及增强后表现。测量其强化率、表观弥散系数(ADC)值,并与子宫肌层作统计学分析比较。结果15例输卵管癌病例共16个病灶。条管影伴结节5个,腊肠样病灶2个,肿块样9个。6个病灶见包膜强化。增强晚期病灶与子宫肌层强化率分别为(1.71±0.78)、(2.34±0.58),差异有统计学意义。病灶与子宫肌层ADC值分别为(0.788±0.133)×10^(-3)mm^(2)/s、(1.285±0.216)×10^(-3)mm^(2)/s,差异有统计学意义。输卵管积液5例,宫腔积液1例,未见正常卵巢。结论老年女性原发性输卵管癌MRI具特征性表现。正常卵巢在老年女性输卵管癌患者中不易显示,可能会增加诊断难度。

原发性输卵管浆液性癌的多参数MRI表现及临床病理对照分析

目的探讨原发性输卵管浆液性癌(primary fallopian tube carcinoma,PFTC)的MRI表现及与病理相关性。方法选取10例经手术病理证实的PFTC的MRI资料,分析MRI表现,包括病灶部位、形状、构成、大小、信号强度、强化情况、淋巴结转移、盆腔转移及典型征象。同时分析DWI和DCE特征以及临床病理特征。结果PFTC 10例患者,病灶11个,主要临床症状:阴道出血6例,腹部肿块6例。MRI肿瘤呈腊肠型7例,菜花型结节3例,分叶状1例。11个病灶肿瘤实性部分T_(1)WI呈低信号,T_(2)WI呈稍高信号,DWI呈明显高信号,5个病灶可见轻到中度强化,动态曲线呈II型,所有患者均可见“输卵管残余征”,5例增强扫描的患者可见“假包膜征”。结论PFTC表现为附件区肿块伴“输卵管残余征”及“假包膜征”;DWI及DCE对诊断原发性输卵管浆液性癌有一定的帮助。

Case Report:Liquid-based cytology aids in primary fallopian tube cancer diagnosis

Primary fallopian tube carcinoma(PFTC) is a rare malignant carcinoma among all genital tract malignancies.It occurs most commonly in postmenopausal women and is similar to ovarian malignancy historically and clinically.Because of its insidious onset and silent course,the diagnosis is made usually postoperatively.Liquid-based cytology(LBC) is a type of method for cervical cancer screening,but sometimes it may aid in making PFTC diagnosis.We report a 47-year-old woman with PFTC,whose diagnosis was made with the aid of LBC.

原发性输卵管癌25例临床分析

目的:探讨原发性输卵管癌的临床及病理特征、治疗。方法:回顾性分析我院收治的25例原发性输卵管癌病例。结果:患者平均年龄55岁。18例(72%)为绝经后妇女。最常见的临床表现依次为盆腔肿块23例(92%),异常阴道流血10例(40%),阴道排液9例(36%)和腹痛9例(36%)。组织学类型:浆液性腺癌20例(80%),混合性腺癌3例(12%),子宫内膜样腺癌2例(8%)。细胞分化:低分化17例(68%),中-低分化5例(20%),中分化3例(12%)。FIFO分期:Ⅰ期1例,Ⅱ期3例,Ⅲ期17例,Ⅳ期4例。结论:原发性输卵管癌临床表现多样且缺乏特异性,很少能在术前明确诊断。该病恶性程度高,临床多为晚期病例。手术及化疗是主要治疗手段。

原发性输卵管癌45例临床分析

目的:探讨原发性输卵管癌的临床表现及病理特征、诊治方法,以期提高对该病的认识。方法:回顾性分析我院2000～2010年收治的45例原发性输卵管癌患者的临床情况及诊治结果。结果:45例患者平均年龄56.9岁,30例(66.7%)为绝经后妇女。最常见的临床表现依次为盆腔肿块40例(88.9%),阴道排液13例(28.9%),腹胀10例(22.2%),腹痛9例(20.0%),异常阴道流血伴流液7例(15.6%),便秘2例(4.4%)。超声检查发现40例(88.9%)有盆腔肿块;32例行血清癌抗原125(CA125)水平测定,26例(81.3%)高于35U/ml。Ⅰ～Ⅳ期患者的5年生存比例分别为:Ⅰ期66.7%、Ⅱ期50.0%、Ⅲ期36.0%,Ⅳ期0。满意的肿瘤细胞减灭术患者较缩瘤术患者存活时间长。结论:原发性输卵管癌恶性程度高,临床表现多样且缺乏特异性,很少能在术前明确诊断。超声检查及CA125检测有助于诊断。手术是主要治疗手段。

原发性输卵管癌15例临床分析

目的 探讨原发性输卵管癌的临床、病理特征,争取早期诊断、早期治疗、改善患者预后。方法 对1983年4月至2004年2月期间收治的15例原发性输卵管癌临床资料进行回顾性分析。结果 根据2000年FIGO标准分期,I期8例(占53. 33% );II期2例(占13. 33% );III期5例(占33. 33% )。该病多发生于绝经后妇女,以阴道排液、盆腔肿块及下腹痛为主要临床特征。以手术为主、化疗为辅的综合治疗可提高疗效。结论 临床期别及术后残存肿瘤的大小是影响预后的主要因素,早期诊断、早期治疗是改善患者预后的关键。

原发性输卵管癌22例诊断分析

背景与目的:原发性输卵管癌是少见的妇科恶性生殖道肿瘤,且该病症状极不典型,是最难确诊的恶性肿瘤之一。本文探讨了原发性输卵管癌的临床表现和诊断方法,分析术前未诊断原因,总结经验,以助于提高临床诊断率。方法:回顾性分析复旦大学附属妇产科医院2009年1月1日—2010年12月31日术前未诊断的22例原发性输卵管癌患者的临床表现、肿瘤标志物、以B超为主的影像学检查等。结果:22例患者中4例有阴道排液,8例有阴道流血,6例有腹痛,12例有腹水,5例感腹胀,3例感纳差恶心,3例感腰酸,2例有体质量下降,1例伴有性交痛,1例有腹泻。B超提示盆腔包块20例,盆腔包块伴发腹水12例。输卵管癌三联征(阴道排液、腹痛和附件包块)仅1例,输卵管癌二联征(附件包块合并阴道排液)2例。18例患者行血清CA125检测,升高者14例,1例术前铁蛋白检测异常升高。结论:原发性输卵管癌临床表现多不典型,不易早期诊断。通过分析本组患者的临床资料,认为综合患者病史、临床表现,并结合B超、CA125和铁蛋白检查,有阴道排液者应尽可能行细胞学检查,必要时行腹腔镜检查,有助于提高对原发性输卵管癌的诊断率。

输卵管肉瘤样癌形态学及免疫组化观察

目的探讨输卵管肉瘤样癌的病理形态学及免疫组织化学表型,提高对该病的认识和诊治水平。方法输卵管肉瘤样癌1例,光镜下观察其形态特征,应用免疫组化检测肉瘤样癌CK、EMA、S-100蛋白、Desmin、SMA、Leu-7、CD68、actin及Vimentin等的表达情况,并结合文献探讨该肿瘤的病理学表现及临床生物学行为。结果光镜下肉瘤样成分与癌成分共存,瘤体多以肉瘤样成分为主,肉瘤样组织中未见明确的骨、软骨、横纹肌肉瘤等异源成分。免疫组化检测表明:CK7、EMA和Vimentin表达均呈强阳性;S-100蛋白、SMA、Leu-7、CD68和actin表达呈部分阳性。结论该病临床表现缺乏特异性症状,术前诊断困难;B超、CT、MRI对分期有帮助,确诊依靠病理检查及免疫组化检测。输卵管肉瘤样癌极为少见,该肿瘤早期就可发生血行转移,预后极差,早期发现是改善预后的关键。

原发性输卵管癌46例分析

目的 :研究原发性输卵管癌的临床特点 ,提高临床医生对原发性输卵管癌的认识。方法 :分析 4 6例原发性输卵管癌的发病情况及临床病理特点。结果 :1980～ 1998年 18年间共收治原发性输卵管癌 2 1例 ,而 1999～ 2 0 0 2年 4年间共收治 2 5例 ,1999年后早中期病例较 1999年前明显增多。 4 6例中术前误诊 4 2例 ,误诊率达 91 3%。结论 :原发性输卵管癌发病率有逐渐增高的趋势 ,误诊率高。

原发性输卵管癌的磁共振征象分析

目的:探讨原发性输卵管癌(PFTC)的MRI影像特征。方法:回顾性分析15例经手术及病理证实的原发性输卵管癌的临床资料和MRI表现,总结其MRI影像特征。结果:病灶表现为附件区肿块,单侧14例,双侧1例。9例为囊实性肿块,其中6例肿块呈腊肠形,3例呈不规则形;5例伴不同程度输卵管积水;8例囊性成分于T1WI呈低信号、T2WI呈高信号;1例囊性成分于T1WI、T2WI均呈高信号;实性成分均呈T1WI等或低信号、T2WI不均匀高信号。4例为实性肿块,其中2例呈腊肠形,1例呈卵圆形,1例呈不规则形;呈T1WI低信号、T2WI稍高信号。2例为管状囊性肿块伴管壁乳头状软组织结节,囊液呈T1WI低信号、T2WI高信号,管壁结节呈T1WI稍低信号、T2WI稍高信号。增强后各种实性成分呈明显不均匀强化。伴腹水5例、直肠转移性肿块1例。结论:附件区腊肠形囊实性肿块伴输卵管积水或腊肠形实性肿块是输卵管癌较具特征性的MRI征象。

CD47在输卵管癌中的表达及临床意义

目的:检测CD47在输卵管癌和正常输卵管组织中的表达,并探讨其临床意义。方法:应用免疫组织化学法检测输卵管癌患者标本73例和正常输卵管标本31例中CD47的表达情况,分析其与输卵管癌患者临床病理参数的关系及其表达对患者预后的影响。结果:CD47以胞膜着色为主,亦有胞浆着色,CD47在输卵管癌高表达率为42.5%,明显低于正常输卵管组织的83.9%(P<0.01)。生存曲线分析显示CD47阴性表达的输卵管癌患者死亡率增高(P<0.05)。结论:CD47表达的减低可指导临床诊断原发性输卵管癌,且其表达减低与输卵管癌预后不良有关。

输卵管癌复发和生存影响因素的多因素分析

目的:总结输卵管癌的临床特征,探讨影响输卵管癌复发与生存的因素。方法:回顾分析2001年1月至2011年5月黑龙江省肿瘤医院收治的52例原发性输卵管癌患者的临床资料,采用Cox风险比例回归模型进行生存分析。结果:52例患者的复发率为59.6%(31/52),生存率为42.3%(22/52)。单因素分析显示,FIGO分期、CA125值、组织分级、残余病灶大小与输卵管癌的复发和生存预后有关。多因素分析显示,FIGO分期、CA125值、组织分级、残余病灶大小是影响输卵管癌复发的重要因素,FIGO分期、CA125值、残余病灶大小是影响患者生存预后的重要因素。结论:FIGO分期晚、术前CA125高、组织分化差、残余病灶大的患者复发的风险大;FIGO分期晚、术前CA125高、残余病灶大的患者预后差。对于有上述危险因素的患者应加强随访,及时给予干预治疗,从而提高患者术后生存期,改善患者生存质量。

原发性输卵管癌研究现状与进展

原发性输卵管癌发病率低,主要发生于绝经后的妇女,目前病因尚不明确,临床表现为阴道排液、阴道流血、腹痛及盆腔肿块等,影像学上易被误诊为卵巢肿瘤,临床分期类似于卵巢癌,治疗以手术为主,术后辅以化疗和放疗。早期即易发生淋巴结转移,与相同分期的卵巢癌比较有生存优势,诊断时分期、术后残余病灶直径与预后有关。现从病因、临床表现、术前影像学及其它检查手段、组织学分型、分化程度、病理诊断标准、治疗与预后方面进行综述。