Changes in cognitive function in patients with primary insomnia

背景:原发性失眠患者是否存在认知功能损害,其神经心理学的证据仍不充分,需要作进一步研究。目的:探讨原发性失眠患者认知功能改变及其影响因素。方法:对40例失眠患者(失眠组)和48例正常睡眠者(对照组)进行匹兹堡睡眠质量指数(Pittsburgh SleepQ uality Index,PSQI)、情景记忆测试和蒙特利尔认知评估(Montreal cognitive assessment,MoC A)测验。结果:失眠者MoC A测试的总分(t=3.24,p=0.002)、命名(t=3.17,p=0.002)成绩较对照组差,即刻记忆(t=3.33,p=0.001)、延迟回忆(t=6.05,p=0.001)成绩较对照组差。不同失眠程度的被试在命名(F=7.56,p=0.001)、语言(F=3.22,p=0.045)、总分(F=6.72,p=0.002)、延迟记忆(F=8.41,p=0.001)、延迟回忆(F=22.67,p=0.001)差异显著。且原发性失眠患者的年龄与MoC A总分、即刻记忆、延迟回忆和延迟再认功能相关有统计学意义,受教育年限与MoC A总分、视空间与执行功能、命名、注意、语言、抽象等功能相关有统计学意义。结论:原发性失眠患者存在认知功能损害;且失眠程度越严重,认知功能损害范围越广,程度越重。

Chinese Guqin Music and Calligraphy for Treating Symptoms of Primary Insomnia

Purpose:To investigate the intervention effiects of using traditional Chinese Guqin music and Chinese Calligraphy handwriting(CCH)for patients with Primary Insomnia.Methods:A total of ninety patients were assigned to control group,Guqin group,and calligraphy group for 8 weeks.For 5 days a week,patients’heart rate variability(HRV)and frontal midline(FZ)electroencephalographic signals were recorded in a clinic during interventional period while either listening to Guqin music or writing calligraphy.Patients in the control group remained in rest condition.Results:For the Guqin group,the higher low-frequency-range HRV of coherence was found with marginal significance(P=0.055),and heart rate was significantly reduced(P<0.05)during Hie 4^th week in listening to Guqin music compared to the prerest period.For listening to Guqin music or calligraphy intervention,FZδ,FZθ,and FZα waves in the 8^th week compared to the 0^th week(Pre Intervention)showed a significantly enhanced effect(.P<0.05).Between the three groups,for heart rate and FZδ and FZθ waves,calligraphy group showed significantly increased heart rate than the Guqin group(P<0.001)and the control group(P=0.004);increased FZδ wave than die Guqin group(P<0.001)and the control group(P<0.001);and increased FZθ wave than the Guqin group(P=0.024)and the control group(P=0.008)respectively.Conclusion:Positive intervention effects on 11RV coherence of Guqin music;FZδ,FZθ,and FZα waves of Guqin music and calligraphy proved that Guqin music together with calligraphy training helping to promote physical and mental health,thereby it contributes to the clinical application of TCM Psychology for patients with insomnia syndrome.

Forkhead box protein O1(FoxO1)regulates lipids metabolism and cell proliferation mediated by insulin and PI3K-Akt-mTOR pathway in goose primary hepatocytes

In order to explore the role of forkhead box protein O1(FoxO1)in the lipid metabolism and cell proliferation,goose primary hepatocytes were isolated and incubated with insulin or PI3K-Akt-mTOR pathway dual inhibitor NVPBEZ235,and then transfected with FoxO1 interference plasmid.The related parameters of lipid metabolism and cell proliferation were measured.The results firstly showed that FoxO1 interference increased the intracellular TG and lipids concentration(P<0.05);and increased the proliferative index(PI),cell DNA synthesis,protein expression of Cyclin D1 in goose primary hepatocytes(P<0.05).Secondly,the co-treatment of insulin and FoxO1 interference increased the mRNA level and protein content of Cyclin D1(P<0.05);however,there was no significant difference between the insulin treatment and the co-treatment of insulin and miR-FoxO1 interference in the intracellular TG and lipids concentration and PI(P>0.05).Lastly,the decrease of intracellular TG and lipids concentration and PI induced by NVP-BEZ235 was up-regulated by FoxO1 interference significantly(P<0.05).In summary,FoxO1 could regulate the lipids metabolism and cell proliferation mediated by PI3K-Akt-mTOR signaling pathway in goose primary hepatocytes.Further investigations are required to highlight the potential role of FoxO1 in the lipid metabolism and cell proliferation mediated by insulin in goose primary hepatocyte.

Analysis of the Relationship between PI3K/Akt Signaling Pathway and Insomnia of Liver Depression Syndrome

Some studies have shown that the co-morbidity of insomnia and anxiety and depression is very prominent, among which 70% of anxiety patients are accompanied by sleep disorders, which is commonly referred to as insomnia of liver depression syndrome in traditional Chinese medicine. The etiology and pathogenesis of traditional Chinese medicine is liver-qi discomfort, and soothing liver and relieving depression should be taken as the basic treatment method and treatment principle. By sorting out the relevant literature on PI3K/Akt signaling pathway, the relationship between PI3K/Akt signaling pathway and depression and insomnia was sorted out, and the possible mechanism of Liver-soothing and Depression-Relieving therapy for insomnia of liver-depression syndrome was found.

Desired Dynamic Equation for Primary Frequency Modulation Control of Gas Turbines

Gas turbines play core roles in clean energy supply and the construction of comprehensive energy systems.The control performance of primary frequency modulation of gas turbines has a great impact on the frequency control of the power grid.However,there are some control difficulties in the primary frequency modulation control of gas turbines,such as the coupling effect of the fuel control loop and speed control loop,slow tracking speed,and so on.To relieve the abovementioned difficulties,a control strategy based on the desired dynamic equation proportional integral(DDE-PI)is proposed in this paper.Based on the parameter stability region,a parameter tuning procedure is summarized.Simulation is carried out to address the ease of use and simplicity of the proposed tuning method.Finally,DDE-PI is applied to the primary frequency modulation system of an MS6001B heavy-duty gas turbine.The simulation results indicate that the gas turbine with the proposed strategy can obtain the best control performance with a strong ability to deal with system uncertainties.The proposed method shows good engineering application potential.

Analysis of the Clinical Effect of Chinese Medicine Combined with Acupuncture and Moxibustion on Insomnia

Objective:To explore and analyze the clinical efficacy of Chinese medicine combined with acupuncture and moxibustion in the treatment of insomnia.Method:80 patients with primary insomnia were selected as the study sample,with 20 cases randomly selected as the control group and the rest as the observation group.The control group was treated with ordinary western medicine,while the observation group patients were treated with traditional Chinese medicine combined with acupuncture and moxibustion based on this syndrome differentiation.The comparison items were treatment effect,sleep quality,mental health,quality of life,specific sleep indicators,cerebral blood flow and neurotransmitters.Result:The treatment effectiveness showed that the observation group had a higher treatment effectiveness rate than the control group(P<0.05);The results of sleep quality showed that after treatment,the scores of the observation group were lower than those of the control group in seven dimensions:sleep quality,sleep time,sleep onset time,sleep efficiency,sleep disorders,hypnotic drugs,and daytime dysfunc‐tion score(P<0.05);The quality of life results showed that after treatment,the observa‐tion group had higher scores than the control group in eight dimensions:physiological function,physiological function,physical pain,health status,energy,social function,emotional function,and mental health(P<0.05);The results of slow wave sleep time and fast eye movement sleep time showed that after treatment,the HAMA and HAMD scores of the physiological mechanism in the observation group were lower than those in the control group(P<0.05);The results of cerebral blood flow and neurotransmitter indica‐tors show that after treatment,glutamateγ-The peak systolic blood flow velocity of ami‐nobutyric acid,vertebral artery,and basilar artery in the observation group was higher than that in the control group(P<0.05).Conclusion:The clinical treatment of Chinese medicine combined with acupuncture and moxibustion in the treatment of insomnia patients can significantly improve the clinical treatment effect,and improve the cerebral hemorrhage and neurotransmitter status of patients,promote the improvement of their physical and mental status,can more significantly improve the quality of sleep,reduce sleep difficulties,reduce the dosage of sleeping pills,which has important clinical application value.

原发性失眠症患者人格发展异常过程分析——基于广安门忆溯性人格量表(GMPI)数据的分析

目的分析原发性失眠症患者人格发展异常过程。方法运用GMPI对原发性失眠症患者与健康人进行调查,分析2组人群差异及发现某些规律。结果失眠患者与健康人在三个年龄段存在的差异不同,其中童年期的差异尚小,仅仅表现于自主性发展水平弱于健康人群;随着年龄的增长,失眠症患者表现出越来越多的人格发展不足,重点表现在思维方式、社会恐惧感、自主性三个方面（P〈0.05或0.01）;不同年龄的患者在三个阶段表现出不同的发展特点。上小学之前,小于36岁的患者与大于50岁的患者表现出较明显的差异（P〈0.05或0.01）,但36~50岁之间的患者未发现与这2组患者的明显差异;在上小学至18岁这个年龄段的人格发展方面,继续保持这一趋势,但在这个阶段,在某些方面,小于36岁的患者组与36~50岁之间的患者组的差异也渐趋明显,尤其体现在不良教养方式以及社会自我、心理自我、独立性及自主性等方面。普遍的,小于36岁的患者组失眠症患者在自我分量表以及情绪情感分量表表现出的发展水平较低,而特殊的,在事业观维度,小于36岁的患者组表现出较高的发展水平。结论原发性失眠症患者与健康人的人格发展过程存在差异,而且具有时代烙印。

基于PI数据库的中压配网线路负荷分析软件的应用

为满足配网管理人员快速掌握中压配网负荷分布的要求,应用PI数据库提供的API函数库,进行PI客户端软件的二次开发,实现对中压配网10kV线路负荷的快速、准确、深入分析。

Obstructive sleep apnea: Screenings in primary, secondary and tertiary care settings

Insomnia is a major health problem affecting millions of people around the globe, particularly in the developed world, substantially impacting on individual work performance and raising disability costs. Insomnias can be broadly divided into primary and secondary types. Primary insomnias can further be divided into parasomnias and dyssomnias. Diagnostic approaches to insomnias can be challenging, thereby complicating the treatment process. Obstructive sleep apnea (OSA) falls under the category of primary insomnias and is a good example of frequently missed diagnoses. The goal of this paper is to document the development of a self-reporting sleep apnea scale based on graded percentage scores to correlate with primary, secondary and tertiary risks. Scores falling under fifty percent represent primary prevention risks of OSA and suggest possible interventions. A score of fifty percent highlights three core symptoms on the scale as described in detail below to represent early detection of OSA or secondary prevention. Finally, scores exceeding fifty percent will include associated risks of comorbidities as well as other factors contributing to OSA, or tertiary prevention, with separate scores assigned to individual risk factors. Analysis of final scores on the proposed scale would therefore, in our opinion help achieve the goal of grading the risk of OSA from a multidisciplinary preventive care aspect.

Integrative Therapy for Insomnia: A Pilot Study to Test an Extended CBT-I Program

Research background and Objectives: Cognitive Behavioral Therapy for Insomnia (CBT-I) is recognized as the preferred non-pharmaceutical treatment for Insomnia. This pilot study aims to test the efficacy of an extended version of CBT-I called Integrative Therapy for Insomnia (IT-I). The traditional CBT-I is complemented with exercises that are expected to enhance relearning to sleep by providing different stimuli, and access options for the retrieval and application of the acquired information, cognition, and skills. Method: The efficacy of the IT-I is measured by comparing the participants’ scores on the Insomnia Severity Index at baseline and post-treatment. In total 29 people, with a wide range of ages, participated in the 8 sessions’ treatment of one hour 45 minutes per session, in mixed groups of age, gender, and primary or comorbid insomnia. Results: Comparing the ISI baseline and post-treatment scores, results show a mean improvement of 7.2 points and a p r = −0.43. Conclusions: The integration of exercises that generate sensory-motor stimuli, and address the mirror neuron system fitting with the Mental Contrasting as a metacognitive strategy seems to facilitate re-learning to sleep in cases of primary insomnia as well as for comorbid insomnia. Further studies will be needed to arrive at more firm conclusions.

原发性失眠相关情绪障碍的低频振幅静息态fMRI研究

目的:探讨原发性失眠相关情绪障碍患者的脑内神经活动异常改变。方法:纳入18~60岁原发性失眠相关情绪障碍患者(失眠组)和正常受试者(对照组)各20例,对比2组低频振幅(ALFF)差异,并分析ALFF值与临床评估量表的相关性。结果:2组匹兹堡睡眠质量指数(PSQI)、焦虑自评量表(SAS)评分、抑郁自评量表(SDS)评分差异均有统计学意义(均P<0.05)。与对照组相比,失眠组ALFF值升高的脑区有左侧颞下回、右侧眶额皮质、右侧前扣带回、右侧颞中回、双侧额上回、右侧枕上回、左侧中央后回,ALFF值降低的脑区有左侧中扣带回、左侧额中回、右侧额上回(AlphaSim校正,P<0.01)。SDS评分与右侧眶额皮质的ALFF值呈正相关(r=0.528,P=0.024),SDS、SAS评分与左侧中扣带回ALFF值均呈正相关(r=0.641,0.494;均P<0.05)。结论:通过ALFF可发现原发性失眠相关情绪障碍患者的脑内异常神经活动,主要是情感、认知相关网络脑区(扣带回、眶额皮质等)存在脑自发活动异常,且部分脑区的自发活动与临床指标存在相关性。异常脑活动改变可能是原发性失眠相关情绪障碍患者的有效神经影像标志物,可为远期疾病严重性评估及疾病治疗提供影像学依据。

揿针联合耳穴压豆治疗原发性失眠临床研究

目的:探讨揿针联合耳穴压豆治疗原发性失眠的临床疗效及对患者睡眠效率、血清5-HT水平的影响。方法:选取原发性失眠患者112例,按照均等随机单盲分为对照组和试验组,各56例,两组均接受常规治疗,对照组在常规治疗基础上采用耳穴压豆法进行治疗,试验组在对照组基础上联合揿针治疗,比较两组治疗后临床疗效;治疗前后失眠严重程度[失眠严重程度指数(ISI)]、睡眠质量[匹兹堡睡眠指数(PSQI)]、心理状态[焦虑自评量表(SAS)、抑郁自评量表(SDS)评分]及神经内分泌指标[血清5-羟色胺(5-HT)、去甲肾上腺素(NE)]水平差异。结果:试验组临床疗效为94.64%,对照组为82.14%,两组比较差异有统计学意义(P<0.05);两组治疗后血清5-HT水平较治疗前显著升高,且试验组明显高于对照组(P<0.05);两组治疗后ISI、PSQI、SAS、SDS评分及血清NE水平较治疗前显著降低,且试验组明显低于对照组(P<0.05)。结论:揿针联合耳穴压豆治疗原发性失眠疗效确切,通过调节神经内分泌,能有效缓解失眠症状及心理状态,改善睡眠质量。

中药热奄包联合足底穴位敷贴治疗高原原发性失眠症疗效及对患者睡眠效率、生活质量的影响

目的:研究中药热奄包联合足底穴位敷贴治疗高原原发性失眠症(PI)的效果及其对患者睡眠效率和生活质量的影响。方法:选取62例高原PI患者,应用随机数字表法分为两组,观察组和对照组各31例。对照组接受艾司唑仑治疗,观察组在此基础上采用中药热奄包联合足底穴位敷贴,两组均治疗2个月。比较两组患者疗效、睡眠效率、睡眠质量及生活质量等。结果:观察组治疗总有效率高于对照组(P<0.05);治疗后,观察组睡眠总时间(TST)、睡眠维持率(SE)、快动眼睡眠相潜伏期(RL)均高于对照组,觉醒时间(AWT)、睡眠潜伏期(SL)、觉醒次数(AT)均小于对照组(P<0.05);治疗后,观察组匹兹堡睡眠质量指数(PSQI)各项评分和PSQI总评分低于对照组(P<0.05);治疗后,观察组世界卫生组织生存质量简表(WHOQOL-BREF)各项评分及总评分均高于对照组(P<0.05)。结论:中药热奄包联合足底穴位敷贴治疗高原原发性失眠症明显提高临床疗效,提升睡眠效率,改善PSQI评分,增加生活质量。

神经肽S受体基因多态性与原发性失眠的相关性研究

目的探讨神经肽S受体(neuropeptide S receptor,NPSR)基因单核苷酸多态性(single nucleotide polymorphism,SNP)位点(rs323917、rs323920、rs323922、rs2530547、rs324957)与原发性失眠(primary insomnia,PI)的相关性。方法选取2016年12月至2019年5月在甘肃省人民医院睡眠医学中心门诊就诊并确诊的PI患者157例作为PI组,选取同期133名健康体检者作为对照组。抽取受试者的静脉血标本,并提取DNA、聚合酶链反应(polymerase chain reaction,PCR)扩增、琼脂糖凝胶电泳,目标位点测序对rs323917、rs323920、rs323922、rs2530547、rs324957单核苷酸位点进行基因分型,同时行标准多导睡眠监测,分析基因多态性与PI的相关性。结果两组受试者的NPSR SNP位点(rs323917、rs323920、rs323922、rs2530547)基因型分布和等位基因频率及rs324957等位基因频率的差异均无统计学意义(P>0.05);rs324957位点基因型分布差异有统计学意义(P=0.034);两组受试者不同单倍型频率差异无统计学意义(P>0.05)。结论NPSR rs324957 SNP位点基因型表达或与PI相关,且以AG基因型为主。

醒脑安神针法治疗原发性失眠的临床疗效观察

目的 观察醒脑安神针法治疗原发性失眠的临床疗效。方法 选取2023年6月-2024年2月本院收治的66原发性失眠患者为研究对象,分为治疗组和对照组,各33例。治疗组以醒脑安神针法针刺治疗,对照组以口服艾司唑仑片治疗。比较2组匹兹堡睡眠质量指数(PSQI)、焦虑自评量表(SAS)、抑郁自评量表(SDS)及临床疗效。结果 治疗后,2组的PSQI量表评分、SAS评分及SDS评分均较治疗前降低(P<0.05),且治疗组的评分降低的更显著(P<0.05);治疗组总有效率(90.6%)明显高于对照组(74.2%)(P<0.05)。结论 醒脑安神针法能有效改善原发性失眠患者的睡眠状况,缓解患者焦虑、抑郁状态,具有良好的临床疗效。

基于PSG探析针刺联合耳穴压豆治疗肝脾不和型原发性失眠临床疗效

目的应用多导睡眠监测仪探析针刺联合耳穴压豆治疗肝脾不和型失眠的临床疗效。方法将216例肝脾不和型失眠的患者随机分为针刺组、耳穴压豆组、联合组,每组各72例。针刺组选神门、安眠、百会等穴针刺,耳穴压豆组选心、交感、神门、皮质下等耳穴压豆,联合组为针刺及耳穴压豆方法联合使用。4周后,观察3组治疗前后在临床疗效、中医证候评分、匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)评分、焦虑自评量表(selfrating anxiety scale,SAS)评分、抑郁自评量表(self-rating depression scale,SDS)评分、多导睡眠监测结果等方面的变化。结果(1)治疗后,3组患者中医证候评分较治疗前均明显改善,且联合组优于针刺组和耳穴压豆组,差异有统计学意义(P<0.05)。(2)治疗后,3组患者PSQI评分较治疗前均明显改善,差异有统计学意义(P<0.05),且联合组优于针刺组和耳穴压豆组,差异有统计学意义(P<0.05)。(3)治疗后,3组患者SAS评分、SDS评分较治疗前均明显改善,差异有统计学意义(P<0.05),且联合组改善优于针刺组和耳穴压豆组,差异有统计学意义(P<0.05)。(4)治疗后,3组患者多导睡眠监测结果中总睡眠时间(TST)、睡眠潜伏期(RL)及N1、N3期较治疗前均明显改善,且联合组明显优于针刺组和耳穴压豆组,差异具有统计学意义(P<0.05)。(5)针刺组总有效率77.78%(56/72),耳穴压豆组总有效率79.17%(57/72),联合组总有效率95.83%(69/72),联合组分别与针刺组、耳穴压豆组相比,差异均有统计学意义(P<0.05)。结论针刺联合耳穴压豆能显著提高患者睡眠质量,缓解焦虑、抑郁等情绪,同时又能改善患者肝脾不和的临床症状,为临床治疗肝脾不和型失眠的非药物治疗提供客观、可量化依据。

Efficacy of Chinese Medicine Treatment Based on Syndrome Differentiation for Primary Insomnia:A Randomized Placebo Controlled Triple-Blinded Trial

Objective:To assess efficacy of Chinese medicine(CM)on insomnia considering characteristics of treatment based on syndrome differentiation.Methods:A total of 116 participants aged 18 to 65 years with moderate and severe primary insomnia were randomized to the placebo(n=20)or the CM group(n=96)for a 4-week treatment and a 4-week follow-up.Three CM clinicians independently prescribed treatments for each patient based on syndromes differentiation.The primary outcome was change in total sleep time(TST)from baseline.Secondary endpoints included sleep onset latency(SOL),wake time after sleep onset(WASO),sleep efficiency,Pittsburgh Sleep Quality Index(PSQI)and CM symptoms.Results:The CM group had an average 0.6 h more(95%confidence interval(CI):0.3–0.9,P<0.001)TST and 34.1%(10.3%–58.0%,P=0.005)more patients beyond 0.5 h TST increment than that of the placebo group.PSQI was changed–3.3(–3.8 to–2.7)in the CM group,a–2.0(–3.2 to–0.8,P<0.001)difference from the placebo group.The CM symptom score in the CM group decreased–2.0(–3.3 to–0.7,P=0.003)more than the placebo group.SOL and WASO changes were not significantly different between groups.The analysis of prescriptions by these clinicians revealed blood deficiency and Liver stagnation as the most common syndromes.Prescriptions for these clinicians displayed relative stability,while the herbs varied.All adverse events were mild and were not related to study treatment.Conclusions:CM treatment based on syndrome differentiation can increase TST and improve sleep quality of primary insomnia.It is effective and safe for primary insomnia.In future studies,the long-term efficacy validation and the exploratory of eutherapeutic clinicians'fixed herb formulas should be addressed.(Registration No.NCT01613183).

基于经络知热感度测定法探究原穴在失眠证型辨识中的应用

目的:运用经络知热感度测定法测量十二正经原穴在各证型失眠患者中的热敏状态及经络虚实变化,探究原穴在失眠证型辨识中的应用。方法:对符合原发性失眠标准的72例患者进行中医辨证分型,运用经络知热感度测定法测定其十二经原穴的测量值、中位数、热敏系数及不均衡点出现率,归纳总结其阳性穴位点,探究不同证型经络虚实的改变情况。结果:本研究纳入的失眠患者中证型分布以心脾两虚为主,肝火扰心次之。测量值方面,心脾两虚证与肝火扰心证患者的原穴在合谷、神门、大陵、太溪、京骨及冲阳穴差异有统计学意义(P<0.05),心脾两虚型测量值的平均水平均高于肝火扰心型;热敏系数方面,两组的热敏系数在合谷、神门、大陵、太溪、太冲及冲阳穴差异有统计学意义(P<0.05),心脾两虚证失眠患者合谷、神门、大陵、太溪及冲阳穴热敏系数的平均水平高于肝火扰心证,肝火扰心证失眠患者在太冲穴的热敏系数高于心脾两虚证;不均衡点出现率方面,两证型在腕骨、阳池、神门及冲阳穴的不均衡穴点出现率差异存在统计学意义(P<0.05);在经络的虚实改变上,心脾两虚证经络改变以虚寒为主,肝火扰心证以实热为主。结论:原穴的热敏状态可为探察经络虚实改变、辨别失眠证型及指导治疗选穴提供参考依据。

基于脏气法时论辨治大脑默认网络功能损害

通过探讨大脑默认网络功能损害的病理机制与脏藏精功能受损的相关性,揭示脏藏精功能受损是原发性失眠的病机核心,并基于《素问·脏气法时论》“病-脏-药”三位一体的“气味合和”理论,以心、肝、脾三脏功能失衡为内核,探究大脑默认网络功能损害的中医证治,以期为临床防治原发性失眠大脑默认网络功能损害探索新思路。

针刺联合中药治疗原发性失眠的疗效和安全性

目的观察针刺联合中药治疗原发性失眠的疗效和安全性。方法将72例原发性失眠患者按照随机数字表法分为2组,对照组36例予针刺治疗,观察组36例在对照组治疗基础上辅以中药治疗,2组均治疗4周。治疗结束后,比较2组治疗前后睡眠觉醒时间、总睡眠时间和睡眠效率,采用酶联免疫吸附法检测血清脑源性神经营养因子(BDNF)、5-羟色胺(5-HT)水平,比较失眠严重程度指数(ISI)评分和匹兹堡睡眠质量指数(PSQI)评分,治疗结束后统计2组的不良反应发生率。结果2组治疗后睡眠觉醒时间均较本组治疗前降低(P<0.05),总睡眠时间和睡眠效率均升高(P<0.05);且观察组治疗后睡眠觉醒时间低于对照组(P<0.05),总睡眠时间和睡眠效率均高于对照组(P<0.05)。2组治疗后血清BDNF、5-HT水平均较本组治疗前升高,且观察组治疗后均高于对照组(P<0.05)。2组治疗后ISI、PSQI评分均较本组治疗前降低,且观察组治疗后均低于对照组(P<0.05)。观察组不良反应发生率低于对照组(P<0.05)。结论针刺联合中药治疗原发性失眠可显著降低减少患者的睡眠觉醒时间,增加睡眠总时间,提高患者的睡眠效率,提高患者血清BDNF、5-HT水平,有效改善失眠症状,增加治疗安全性,值得临床治疗推广。