AIM: To investigate the clinical features, treatment and prognosis of primary ocular adnexal mucosa-associated lymphoid tissue lymphoma(POAML).METHODS: A retrospective analysis was performed on 64 patients with POAML ...AIM: To investigate the clinical features, treatment and prognosis of primary ocular adnexal mucosa-associated lymphoid tissue lymphoma(POAML).METHODS: A retrospective analysis was performed on 64 patients with POAML who were admitted to the First Affiliated Hospital of Zhengzhou University from January 2006 to December 2018.RESULTS: With a median follow-up of 61 mo(range, 2-156 mo), estimated overall survival(OS) rate and progressionfree survival(PFS) rate at 10 y reached 94.5% and 61.5%, respectively. Median OS time and PFS time were not reached. During this period, only 3 patients died, but none of them died directly due to disease progression. One patient(1.6%) developed transformation to diffuse large B-cell lymphoma(DLBCL). Of the 56 patients achieved complete remission after first-line treatment, 5(8.9%) developed local and/or systemic relapse eventually. Patients ≥60 y had significantly shorter PFS than younger patients(P=0.01). For patients with early stages(Ann Arbor stage I and stage II), univariate analysis confirmed that radiotherapydose lower than 32 Gy were independently associated with shorter PFS(P=0.04). Other factors including gender, bone marrow involvement, the initial location of the disease, and the laterality were not associated with PFS.CONCLUSION: The data from our center indicate that POAML has a slow clinical progression and has an excellent clinical outcome. Patients with POAML harbor a continual risk of relaps and transformation to aggressive subtype of lymphoma.展开更多
为了探讨原发性胃恶性淋巴瘤(RGML)与幽门螺杆菌(Hp)感染的相关性,本文收集39例 PGML了以及22例淋巴性胃炎、32例 Hp 无关疾病的胃粘膜行对照研究。结果:PGML 组 Hp 检出率87.18%,显著高于对照的63.64、53.13%(P<0.005)。粘膜相关淋...为了探讨原发性胃恶性淋巴瘤(RGML)与幽门螺杆菌(Hp)感染的相关性,本文收集39例 PGML了以及22例淋巴性胃炎、32例 Hp 无关疾病的胃粘膜行对照研究。结果:PGML 组 Hp 检出率87.18%,显著高于对照的63.64、53.13%(P<0.005)。粘膜相关淋巴样组织(MALT)来源的淋巴瘤占92.31%。Hp 检出率达86.11%,瘤周慢性活动性胃炎及淋巴滤泡检出率分别为84.62、56.41%,且炎症活动程度与 Hp 分布密度相关。组织学研究提示胃 B 细胞 MALT 淋巴瘤与 Hp 感染相关。展开更多
基金Supported by the National Natural Science Foundation of China (Henan Joint Fund, No.U1404308)
文摘AIM: To investigate the clinical features, treatment and prognosis of primary ocular adnexal mucosa-associated lymphoid tissue lymphoma(POAML).METHODS: A retrospective analysis was performed on 64 patients with POAML who were admitted to the First Affiliated Hospital of Zhengzhou University from January 2006 to December 2018.RESULTS: With a median follow-up of 61 mo(range, 2-156 mo), estimated overall survival(OS) rate and progressionfree survival(PFS) rate at 10 y reached 94.5% and 61.5%, respectively. Median OS time and PFS time were not reached. During this period, only 3 patients died, but none of them died directly due to disease progression. One patient(1.6%) developed transformation to diffuse large B-cell lymphoma(DLBCL). Of the 56 patients achieved complete remission after first-line treatment, 5(8.9%) developed local and/or systemic relapse eventually. Patients ≥60 y had significantly shorter PFS than younger patients(P=0.01). For patients with early stages(Ann Arbor stage I and stage II), univariate analysis confirmed that radiotherapydose lower than 32 Gy were independently associated with shorter PFS(P=0.04). Other factors including gender, bone marrow involvement, the initial location of the disease, and the laterality were not associated with PFS.CONCLUSION: The data from our center indicate that POAML has a slow clinical progression and has an excellent clinical outcome. Patients with POAML harbor a continual risk of relaps and transformation to aggressive subtype of lymphoma.
文摘为了探讨原发性胃恶性淋巴瘤(RGML)与幽门螺杆菌(Hp)感染的相关性,本文收集39例 PGML了以及22例淋巴性胃炎、32例 Hp 无关疾病的胃粘膜行对照研究。结果:PGML 组 Hp 检出率87.18%,显著高于对照的63.64、53.13%(P<0.005)。粘膜相关淋巴样组织(MALT)来源的淋巴瘤占92.31%。Hp 检出率达86.11%,瘤周慢性活动性胃炎及淋巴滤泡检出率分别为84.62、56.41%,且炎症活动程度与 Hp 分布密度相关。组织学研究提示胃 B 细胞 MALT 淋巴瘤与 Hp 感染相关。
