Objective: To investigate the effect of Xiaoaiping combined with neoadjuvant chemotherapy on the pro-proliferation molecule expression and immune function in patients with breast cancer. Methods: A total of 98 patient...Objective: To investigate the effect of Xiaoaiping combined with neoadjuvant chemotherapy on the pro-proliferation molecule expression and immune function in patients with breast cancer. Methods: A total of 98 patients with primary breast cancer who were diagnosed and treated in the hospital between December 2015 and February 2017 were collected and divided into control group and Xiaoaiping group by random number table, each with 49 cases. Control group received neoadjuvant chemotherapy + surgery + postoperative chemoradiotherapy, and Xiaoaiping group received Xiaoaiping + neoadjuvant chemotherapy + surgery + postoperative chemoradiotherapy. The differences in pro-proliferation gene expression in intraoperative breast cancer tissue as well as the differences in serum levels of Th1/Th2 cytokines and Th17/Treg cytokines before chemotherapy started (T0) and 1 week after neoadjuvant chemotherapy ended (T1) were compared between the two groups of patients. Results: MTA2, NRP-1, PKM2, TM4SF1 and ZIC1 mRNA expression in breast cancer tissue of Xiaoaiping group were lower than those of control group. At T1, serum IFN-γ and TNF-α levels of Xiaoaiping group were higher than those of control group whereas IL-4, IL-10, IL-17, IL-22, IL-35 and TGF-β levels were lower than those of control group. Conclusion: Xiaoaiping combined with neoadjuvant chemotherapy can effectively improve the curative effect of preoperative chemotherapy, and also significantly inhibit the proliferation activity of breast cancer cells and balance the immune function of the body.展开更多
文摘Objective: To investigate the effect of Xiaoaiping combined with neoadjuvant chemotherapy on the pro-proliferation molecule expression and immune function in patients with breast cancer. Methods: A total of 98 patients with primary breast cancer who were diagnosed and treated in the hospital between December 2015 and February 2017 were collected and divided into control group and Xiaoaiping group by random number table, each with 49 cases. Control group received neoadjuvant chemotherapy + surgery + postoperative chemoradiotherapy, and Xiaoaiping group received Xiaoaiping + neoadjuvant chemotherapy + surgery + postoperative chemoradiotherapy. The differences in pro-proliferation gene expression in intraoperative breast cancer tissue as well as the differences in serum levels of Th1/Th2 cytokines and Th17/Treg cytokines before chemotherapy started (T0) and 1 week after neoadjuvant chemotherapy ended (T1) were compared between the two groups of patients. Results: MTA2, NRP-1, PKM2, TM4SF1 and ZIC1 mRNA expression in breast cancer tissue of Xiaoaiping group were lower than those of control group. At T1, serum IFN-γ and TNF-α levels of Xiaoaiping group were higher than those of control group whereas IL-4, IL-10, IL-17, IL-22, IL-35 and TGF-β levels were lower than those of control group. Conclusion: Xiaoaiping combined with neoadjuvant chemotherapy can effectively improve the curative effect of preoperative chemotherapy, and also significantly inhibit the proliferation activity of breast cancer cells and balance the immune function of the body.
