As a new choice for the treatment of degenerative lumbar disease, artificial lumbar disc replacement has been widely used in clinical surgery. The finite element is a very effective method to predict and simulate the ...As a new choice for the treatment of degenerative lumbar disease, artificial lumbar disc replacement has been widely used in clinical surgery. The finite element is a very effective method to predict and simulate the surgery effect. The purpose of this paper is to review the applications of finite element in artificial lumbar disc replacement, such as design of artificial lumbar disc prosthesis, risk and effect evaluation of artificial lumbar disc replacement, and assessment of operation methods. Lastly, we discuss the future development of finite element method applied in this field, including personalized design of the prosthesis, postoperative behavior guide, and artificial lumbar disc replacement combined with fusion surgery. In conclusion, as an invaluable complement to biomechanical experiments and clinical studies, the finite element method makes important contributions to our understanding of biomechanics of intervertebral disc, and plays an important role in the field of artificial lumbar disc replacement.展开更多
Nucleus Pulposus(NP)Replacement is a developing surgical methodology for the treatment of pathology related to degeneration of intervertebral discs(IVDs).This article provides necessary context regarding the patholo-g...Nucleus Pulposus(NP)Replacement is a developing surgical methodology for the treatment of pathology related to degeneration of intervertebral discs(IVDs).This article provides necessary context regarding the patholo-gies treated with this technology,the biomechanical structure and function of the IVD,and the procedures this technology aims to replace.Primarily,it provides an overview and discussion of commercial and experimental preformed and in situ curing prosthesis designs reported in the scientific literature and summarizes the results of biomechanical and clinical studies evaluating their efficacy.Contextual and updated information on the most recent research into NP replacement with novel hydrogel and tissue engineering(TE)strategies is described.Replacement of the NP allows for potential improvement in the treatment of degenerative spinal pathologies through minimally invasive surgical techniques.展开更多
Entangled Porous Titanium Alloy Metal Rubber(EPTA-MR)was used as a nucleus pulposus material in the design of non-fusion intervertebral disc prosthesis for the first time.A novel artificial lumbar intervertebral disc ...Entangled Porous Titanium Alloy Metal Rubber(EPTA-MR)was used as a nucleus pulposus material in the design of non-fusion intervertebral disc prosthesis for the first time.A novel artificial lumbar intervertebral disc prosthesis was designed by reconstructing the lumbar model with reverse engineering technology,and the biomechanical behavior of the prosthesis was simulated under varied working conditions.The nucleus pulposus size was determined by the actual size of human prosthesis.EPTA-MR samples with different densities were prepared by medical titanium alloy wire experimental studies were conducted on static stiffness,damping energy consumption,and fatigue life.The results indicated that the static stiffness of EPTA-MR could reach approximately 1500 N mm and its loss factor remained higher than 0.2,and the variation range was relatively small,with excellent vibration damping capacity and bearing capacity.Among them,the overall performance of EPTA-MR with a density of 2.5 g em 3 was closer to that of the physiologic intervertebral disc.A macro experiment of five million fatigue vibration tests combined with microstructure observation exhibited a wear rate of only 0.9396 g-MC with no noticeable change in the internal micro-morphology.Therefore,the EPTA-MR has a broad application prospect as the nucleus pulposus material of artificial intervertebral disc prosthesis.展开更多
文摘As a new choice for the treatment of degenerative lumbar disease, artificial lumbar disc replacement has been widely used in clinical surgery. The finite element is a very effective method to predict and simulate the surgery effect. The purpose of this paper is to review the applications of finite element in artificial lumbar disc replacement, such as design of artificial lumbar disc prosthesis, risk and effect evaluation of artificial lumbar disc replacement, and assessment of operation methods. Lastly, we discuss the future development of finite element method applied in this field, including personalized design of the prosthesis, postoperative behavior guide, and artificial lumbar disc replacement combined with fusion surgery. In conclusion, as an invaluable complement to biomechanical experiments and clinical studies, the finite element method makes important contributions to our understanding of biomechanics of intervertebral disc, and plays an important role in the field of artificial lumbar disc replacement.
文摘Nucleus Pulposus(NP)Replacement is a developing surgical methodology for the treatment of pathology related to degeneration of intervertebral discs(IVDs).This article provides necessary context regarding the patholo-gies treated with this technology,the biomechanical structure and function of the IVD,and the procedures this technology aims to replace.Primarily,it provides an overview and discussion of commercial and experimental preformed and in situ curing prosthesis designs reported in the scientific literature and summarizes the results of biomechanical and clinical studies evaluating their efficacy.Contextual and updated information on the most recent research into NP replacement with novel hydrogel and tissue engineering(TE)strategies is described.Replacement of the NP allows for potential improvement in the treatment of degenerative spinal pathologies through minimally invasive surgical techniques.
基金The authors thank the National Natural Science Foundation of China(Grant Nos.51805086 and 51975123)the Fujian Provincial Natural Science Foundation(Grant No.2019J01210)Fujian Province health education joint project(Grant No.2019-WJ-01).
文摘Entangled Porous Titanium Alloy Metal Rubber(EPTA-MR)was used as a nucleus pulposus material in the design of non-fusion intervertebral disc prosthesis for the first time.A novel artificial lumbar intervertebral disc prosthesis was designed by reconstructing the lumbar model with reverse engineering technology,and the biomechanical behavior of the prosthesis was simulated under varied working conditions.The nucleus pulposus size was determined by the actual size of human prosthesis.EPTA-MR samples with different densities were prepared by medical titanium alloy wire experimental studies were conducted on static stiffness,damping energy consumption,and fatigue life.The results indicated that the static stiffness of EPTA-MR could reach approximately 1500 N mm and its loss factor remained higher than 0.2,and the variation range was relatively small,with excellent vibration damping capacity and bearing capacity.Among them,the overall performance of EPTA-MR with a density of 2.5 g em 3 was closer to that of the physiologic intervertebral disc.A macro experiment of five million fatigue vibration tests combined with microstructure observation exhibited a wear rate of only 0.9396 g-MC with no noticeable change in the internal micro-morphology.Therefore,the EPTA-MR has a broad application prospect as the nucleus pulposus material of artificial intervertebral disc prosthesis.
