Bicanalicular versus monocanalicular intubation after failed probing in congenital nasolacrimal duct obstruction

AIM：To investigate the clinical outcomes of different intubation techniques in the cases of failed primary probing.METHODS： This retrospective study was performed on338 patients with the diagnosis of congenital nasolacrimal duct obstruction with age 1-4y that had failed primary probing.Intubation was performed under light sedation in operating room and the stent was left 3mo in place.Clinical outcome was investigated 3mo after tube removal.RESULTS： Bicanalicular intubation method had higher complete and relative success rates compared to monocanalicular intubation（P =0.00）.In addition,Monoka intubation had better outcomes compared to Masterka technique（P =0.046）.No difference was found between genders but the higher the age,the better the outcomes with bicanalicular technique rather than monocanalicular.CONCLUSION： Overall success rate of bicanalicular intubation is superior to monocanalicular technique especially in older ages.Also,based upon our clinical outcomes,Masterka intubation is not recommended in cases of failed probing.

Nasal flap preservation in endoscopic dacryocystorhinostomy for nasolacrimal duct obstruction

AIM:To compare surgical outcomes between the conventional endoscopic dacryocystorhinostomy(DCR)and a modified endoscopic DCR for the treatment of nasolacrimal duct obstruction(NLDO),and evaluate factors associated with the surgical success rate.METHODS:Medical records of patients who underwent primary DCR surgery between January 2016 and July 2020 at the Otorhinolaryngology Department of Eye and Ear International Hospital,Lebanon were reviewed.RESULTS:The study group consisted of 50 consecutive modified endoscopic DCR and the control group consisted of 138 consecutive conventional endoscopic DCR.The success rates at 1y were 98.0%(49 out of 50)for modified DCR,significantly higher compared to 84.8%(117/138)for the conventional DCR;there was no significant difference in the success rate throughout the years in terms of both surgical techniques.The modified surgery vs traditional[adjusted odds ratio(aOR)=14.96]and having an adjunctive septoplasty surgery vs not(aOR=3.99)were significantly associated with higher odds of success.CONCLUSION:Mucosal flap preservation and apposition shows significant improvement in the surgical success rate.Moreover,there is no statistically significant difference found in terms of complication rate and mean operative time between the conventional and the modified techniques.

Curative effects of probing alone and probing combined with nasolacrimal injection of levofloxacin ophthalmic gel on congenital duct obstruction of children from 3–12 months of age

Background:To investigate the 1-time success rate of probing alone and nasolacrimal duct probing combined with nasolacrimal injection of levofloxacin ophthalmic gel on congenital nasolacrimal duct obstruction(CNLDO)in young children.Methods:A retrospective case series was performed on 494 cases(647 eyes)of 3–12 month-old children with CNLDO between July 2014 and July 2015.Material obtained from the lacrimal sac was cultured to isolate infectious agents.Susceptibility testing was done.Children from 3–12 months of age who were found to be sensitive to Levofloxacin(n=493 eyes)were separated into two groups:3–6 months of age(276 eyes)and 7–12 months of age(217 eyes).Each of the groups were then randomized into group A(138 eyes of3–6 months of age;102 eyes of 7–12 months of age)and group B(138 eyes of 3–6 months of age;115 eyes of7–12 months of age).Children in group A underwent nasolacrimal duct probing alone;those in group B underwent nasolacrimal duct probing plus nasolacrimal duct injection of levofloxacin and the efficacy of probing was evaluated.Results:The average detection rate of pathogenic bacteria in dacryocystitis was 75.1%,and Staphylococcus aureus was found to be the main pathogenic bacteria(42.59%,106 cases).Among children from 7–12 months of age,the 1-time success rate of nasolacrimal duct probing alone was 88.24%and the 1-time success rate of probing combined with nasolacrimal duct injection of levofloxacin ophthalmic gel was 96.52%(statistical significance,P=0.02<0.05).Conclusions:Most pathogenic bacteria(96.81%)were sensitive to levofloxacin.Nasolacrimal duct probing combined with nasolacrimal duct injection of levofloxacin may improve the success rate of probing in children older than 6 months of age.

Endoscopic dacryocystorhinostomy with bicanalicular silicone tube intubation for treating chronic dacryocystitis secondary to nasolacrimal duct stent incarceration

AIM:To investigate the feasibility of endoscopic dacryocystorhinostomy(En-DCR)with bicanalicular silicone tube intubation for treating chronic dacryocystitis secondary to nasolacrimal duct stent(NDS)incarceration.METHODS:En-DCRs were performed on 44 chronic dacryocystitis patients(46 eyes)secondary to NDS incarceration from April 2016 to October 2022.The granuloma and scar tissues were separated,and the removal of NDS incarceration was achieved during the surgery;the flap of the lacrimal sac was trimmed and anastomosed with nasal mucosal,a bicanalicular silicone tube was implanted,and lacrimal size and condition were assessed.The tube was removed 3mo after surgery.During the final follow-up of 12mo when the surgery was completed,the complications and the rates of surgical success were assessed.RESULTS:This study covered 40 patients(42 eyes).Intraoperatively,it was found that the lacrimal sac became small,and the sac wall had granulation and scar tissue attached to the incarcerated NDS in all eyes.At 12mo after surgery completed,the rates of the functional and anatomical success reached 80.95%(34/42)and 83.33%(35/42),respectively.Under the effect of intranasal ostial closure,seven eyes failed to achieve anatomical success.No serious complications(e.g.,visual impairment,sinusitis,and orbital fat prolapse)was observed.CONCLUSION:With the success rate over 80%and no serious complications,En-DCR with bicanalicular silicone tube implantation is effective in treating chronic dacryocystitis secondary to NDS incarceration.

A comparison between monocanalicular and pushed monocanalicular silicone intubation in the treatment of congenital nasolacrimal duct obstruction

AIM: To compare the success rate of monocanalicular versus pushed monocanalicular silicone intubation(PMCI)of the nasolacrimal duct for congenital nasolacrimal duct obstruction(CNLDO).METHODS: In a prospective randomized clinical trial 53 eyes of 49 patients with CNLDO underwent either monocanalicular silicone intubation(MCI)(n =28 eyes) or PMCI(n =25 eyes). All procedures were performed by 1oculoplastic surgeon. Treatment success was defined as the complete resolution of epiphora at 3mo after tube removal.RESULTS: The surgical outcome was assessed in 20 eyes with MCI and 20 eyes with PMCI. The mean age of treatment was 26.25 ±10.08mo(range, 13-49mo) for MCI and 26.85±12.25mo(range, 16-68mo) for PMCI. Treatment success was achieved in 18 of 20 eyes(90.0%) in the MCI group compared with 10 of 20 eyes(50%) in the PMCI group(P =0.01). In the PMCI group, the tube loss(30%)was greater than the MCI group(5%), however the differences between the 2 groups proved to be not significant(P =0.91).CONCLUSION: Our results indicate that MCI has higher success rate in CNLDO treatment compared with PMCI in this small series of patients.

Laser-assisted dacryocystorhinostomy in nasolacrimal duct obstruction：5-year follow-up

AIM：To evaluate the long-term sucess rate of laserassisted dacryocystorhinostomy （L-DCR） in patients with nasolacrimal duct obstruction （NDO）.METHODS：Forty-one eyes of forty patients aged between 21-85y （mean 56.7y） who underwent L-DCR for the treatment of NDO were included in this retrospective,non-randomized study. The follow-up time was 72mo.Functional sucess was defined as the disappearance of epiphora under normal conditions and the presence of a patent ostium on lacrimal irrigation. Anatomical success was defined as a patent lacrimal passage on syringing besides continuing epiphora. Surgical failure was defined as persistent epiphora and closed ostium.RESULTS：Twenty-seven of 40 patients （67.5%） were female and 13 of 40 patients （32.5%） were male. The NDO was right-sided in 17 （42.5%） patients and left-sided in 22（55%） patients whereas 1 （2.5%） patient had undergone bilateral surgery. In 11 （27.5%） patients there were additional nasal abnormalities requiring simultaneous surgical approach. The average time for L-DCR was 26.50±4.9min（16-39min） and the average total amount of laser energy used was 287±27.9 J （239-367 J）. At the 5y follow-up, anatomical sucess rate was 75.0%（30 patients） and functional success rate was 65.0%（26 patients）, whereas surgical failure was seen in 25%（10 patients）. Revision of surgery was performed in 10 cases （25.0%）; failure of revision surgery was seen in 2 cases（5.0%）.CONCLUSION： Transcanalicular L-DCR is a reliable and fast procedure in the treatment of NDO. It can be alternative to external DCR which is accepted as the gold standard currently. The functional and anatomical success rate is higher in the first months and years, but still satisfactory at fifth year.

Measuring nasolacrimal duct volume using computed tomography images in nasolacrimal duct obstruction patients in Korean

AIM: To investigate nasolacrimal duct(NLD) volume in Korean patients and to examine the correlation between NLD volume and obstruction. METHODS: Of patients who underwent orbital computed tomography from March 2013 to January 2016, patients diagnosed with NLD obstruction were classified into the patient group and patients without obstruction were classified into the control group. The NLD volume was measured using the Image J program, which showed the NLD in axial,coronal, and sagittal images on computed tomography. RESULTS: The average value of men's NLD volume,265.33±90.57 mm3, was significantly larger than women's,211.87±68.61 mm3(P=0.009). In the patient group, the NLD volume of the obstructed eyes, 242.49±82.93 mm3,and the non-obstructed eyes, 225.20±73.20 mm3, were significantly higher than the control group, 217.61±82.04 mm3(P<0.001, P<0.001). CONCLUSION: The NLD volume is larger in men than in women in Korean adults. If there is NLD obstruction in women, the NLD volume is larger and it is judged that inflammatory reaction caused a chronic change in the bone around the NLD and affect the measurement of NLD volume.

Mode of delivery, birth weight and the incidence of congenital nasolacrimal duct obstruction

AIM: To study any possible association of congenital nasolacrimal duct obstruction(CNLDO) with mode of delivery, birth weight and gestational age. METHODS: We retrospectively reviewed charts of all patients(n=2591) under the age of 3 y who were born between April 2015 and May 2017 and were examined at the Ophthalmology Clinic of Emsey Hospital Istanbul, Turkey. We identified patients(n=105) who were diagnosed as CNLDO. The mode of delivery, birth weight and gestational age along with any adverse event during or after delivery or any other health history were determined. Birth statistical data were obtained from the hospital’s medical records database. RESULTS: Gestational age of babies who were born via cesarean section(CS) was lower than gestational age of babies who were born via normal spontaneous vaginal delivery(NSVD;P=0.002). Babies who were born via CS were found to have 3.75 times higher risk of developing NLDO when compared to babies who were born via NSVD(OR=3.754). CONCLUSION: There is a possible association between CS and CNLDO.

Ocular Findings in Trisomy 13: Nasolacrimal Duct Stenosis Case Series

Trisomy 13, also known as Patau Syndrome, is a congenital malformation that leads to several ocular anomalies, of which cataracts are the most common, as well as iris and retinal colobomas, persistent hyperplastic primary vitreous, persistent tunica vasculosa lentis, and microphthalmos. While most do not survive beyond the neonatal period, those that do survive past one year of age have an 84% chance of making it to age 5. Therefore, treatments for ocular problems should be used to improve the quality of life if the child can withstand surgery. The literature on this topic has described histopathologic findings in postmortem eyes. This case series supports those observations and presents a new discovery of nasolacrimal duct obstructions or stenosis. Deciding on surgical intervention in cases with Trisomy 13 can be challenging, and a variety of factors must be taken into account before surgery is considered. Treatment of these cases can be difficult, necessitating deliberate consideration and determination on a case-by-case basis;however, this case series gives additional evidence to help guide these decisions. Traditionally, trisomy 13 was regarded as being lethal, multiple organ malformations and severe intellectual disability.

Pediatric nasolacrimal duct obstruction-benefit of a combined therapeutic approach

Background:Pediatric nasolacrimal duct obstruction (PNDO) requires therapeutic intervention after conservative procedures failed.As resilient treatment guidelines for the treatment are missing,the aim of this study was to evaluate the advantages of two different intervention techniques in children with PNDO.Methods:Between January,2006 and June,2014,233 children (0-208 months) were treated either with conventional probing by ophthalmologists only (Group I) or with endonasal endoscopic interdisciplinary approach (Group Ⅱ).The clinical outcome was analyzed.Results:The overall success rate of Group Ⅰ was 93.4% compared to 98.4% of Group Ⅱ (P<0.05).50% of all interventions (n=62) of Group Ⅱ required further surgical procedures in addition to probing/irrigation,particularly with regard to children <6 and >24 months.Conclusions:Endoscopic control in treatment of PNDO allows exact identification of the stenosis and appropriate surgical intervention with an improved clinical outcome.Endonasai endoscopic surgical techniques should be the standard PNDO treatment.

Comparison of scanning electron microscopy findings regarding biofilm colonization with microbiological results in nasolacrimal stents for external, endoscopic and transcanalicular dacryocystorhinostomy

AIM:To compare bacterial biofilm colonization in lacrimal stents following external dacryocystorhinostomy(EX-DCR),endoscopic dacryocystorhinostomy(EN-DCR),and transcanalicular dacryocystorhinostomy(TC-DCR)with multidiode laser.METHODS:This prospective study included 30consecutive patients with nasolacrimal duct obstruction who underwent EXT-,EN-,or TC-DCR.Thirty removed lacrimal stent fragments and conjunctival samples were cultured.The lacrimal stent biofilms were examined by scanning electron microscopy(SEM).RESULTS:Eleven(36.7%)of the 30 lacrimal stent cultures were positive for aerobic bacteria(most commonly Staphylococcus epidermidis and Pseudomonas aeruginosa).However anaerobic bacteria and fungi were not identified in the lacrimal stent cultures.Twenty-seven(90%)patients had biofilmpositive lacrimal stents.The conjunctival culture positivity after the DCR,biofilm positivity on stents,the grade of biofilm colonization,and the presence of mucus and coccoid and rod-shaped organisms did not significantly differ between any of the groups(P】0.05).However,a significant difference was found when the SEM results were compared to the results of the lacrimal stent and conjunctival cultures(P【0.001).CONCLUSION:Type of dacryocystorhinostomy(DCR)surgery did not affect the biofilm colonization of the lacrimal stents.SEM also appears to be more precise than microbiological culture for evaluating the presence of biofilms on lacrimal stents.

Computed tomography imaging features for amyloid dacryolith in the nasolacrimal excretory system:A case report

BACKGROUND Nasolacrimal duct obstruction leading to epiphora is a common ophthalmologic complaint,and it may derive from amyloidosis in rare cases.There are a few reports about localized amyloidosis,and amyloidosis with involvement and obstruction of the nasolacrimal duct is exceedingly rare.CASE SUMMARY A 54-year-old male presented with a 2-year history of a lump overlying the left lacrimal sac that had grown rapidly for nearly half a year.Physical examination touched a firm lump in the left lacrimal sac.Nasal endoscopy discovered lesions in appearance of sediments with easy bleeding at the entry of the nasolacrimal duct of the left inferior nasal meatus.Computerized tomography scan revealed speckle high density in the left lacrimal sac and the dilated nasolacrimal duct.During an endoscopic exploration and excision,a large number of dacryoliths were exposed.Pathology indicated amorphous pink material and multinucleated giant cell reaction in the fibrous tissue.CONCLUSION This case showed amyloidosis in localized form mimicking dacryolith with nasolacrimal duct obstruction.In clinical practice,we should be aware of the possibility of localized amyloidosis in the nasolacrimal excretory system.

Endonasal Endoscopic Dacryocystorhinostomy with the Use of Radiofrequency (RF) Surgical Technique

Endonazal endoscopic dacryocystorhinostomy (DCR) with radiofrequency (RF) surgical technique is a procedure selected for nasolacrimal duct obstruction and chronic dacryostenosis in the setting of patent canaliculi and a functional lacrimal pump. Two major approaches are utilized: external, via a transcutaneous incision and endonasal endoscopically guided. The surgery has the high success rate via both approaches. We review the history, evolution, current techniques, complications and future directions of DCR radiofrequency RF operative technique. The modified endonasal RF-coagulation technique was performed in patients aged 18 - 85 (women-80, men-35) from 2017 to 2023. All patients suffered from chronic dacryocystitis. They had been administered the course of traditional conservative treatment and were provided with the ophthalmologist’s and otorhinolaryngology’s consultations prior to the surgery. In order to verify the diagnosis, the patients were conducted the CT-scan examination of nasal cavity and paranasal sinuses as well as the endoscopy of nasal cavity. Endonasal dacryocystorhinostomy with RF coagulator proved to be effective in 80% of patients;Over 3 - 4 years following the surgery, the recurrence was manifested in 8 patients after 6 months and in 12 patients, after a year. The above mentioned surgical treatment is administered by minimally invasive surgical method. At the same time, the long-term, for about 1 year, implantation of silicone drainage in the nasolacrimal ducts significantly reduces the risk of recurrence. At the present stage, the endoscopic Endo-DCR surgery is being improved, and the diverse treatment methods, including radiofrequency (RF) in endonasal endoscopic microsurgical techniques, are being studied and introduced into practice.

年龄因素对先天性鼻泪管阻塞泪道探通术治疗效果的影响

目的探讨年龄因素对先天性鼻泪管阻塞(CNLDO)泪道探通术治疗效果的影响。方法本研究为单中心回顾性病例研究,采用阶梯式治疗方案对保守治疗无效的患儿适时行泪道探通术,根据患儿年龄分为0~<6月、6~<12月、12~<24月和24~60月龄4组,对比分析各组的手术成功率及其与患儿年龄的相关性。结果共纳入269例患儿314只眼,4个年龄组一次泪道探通成功率分别为86.8%、91.7%、73.6%和37.8%,所有患儿泪道探通总成功率为84.7%(266/314)。12月龄以后探通总成功率下降与年龄增加呈显著相关(P=0.000),与患儿性别和眼别无显著相关性(P=0.255和0.708)。结论阶梯式方案治疗CNLDO安全有效,泪道探通术的成功率与年龄呈负相关,可作为2岁以下患儿保守治疗无效的首选手术方法。

鼻内镜下泪囊鼻腔造口术与泪道逆行置管术治疗鼻泪管阻塞的临床对比研究

目的 对比鼻内镜下泪囊鼻腔造口术与泪道逆行置管术治疗鼻泪管阻塞(NLDO)的临床效果。方法 50例鼻泪管阻塞患者,按就诊天数的单双号分为A组(单号日期, 25例)、B组(双号日期,25例)。A组实施鼻内镜下泪道逆行置管术, B组实施鼻内镜下泪囊鼻腔造口术。对比两组手术相关指标、并发症发生率、复发率。结果 A组手术时间(29.25±3.18)min、在院时间(0.85±0.23)d明显短于B组的(51.74±3.26)min、(4.47±1.26)d,出血量(5.03±1.06)ml少于B组的(46.45±11.12)ml(P<0.05)。A组并发症发生率(4.00%)低于B组(24.00%),但术后1年复发率(28.00%)高于B组(4.00%)(P<0.05)。结论 鼻内镜下泪道逆行置管术治疗鼻泪管阻塞较泪囊鼻腔造口术具有手术时间短、操作较容易、出血量少等优势,而鼻内镜下泪囊鼻腔造口术较泪道逆行置管术则更有利于预防术后复发。

鼻泪管支架植入术改善预后的研究进展

原发性鼻泪管阻塞通常表现为顽固性泪溢,可继发角膜炎、急慢性泪囊炎等影响眼部健康。鼻泪管支架植入为治疗该疾病的重要辅助方式,有效降低泪道探通、激光泪道成形、泪囊鼻腔吻合等术后膜性泪道再阻塞率。但术中机械损伤、术后持续的慢性炎症及瘢痕组织增生等问题仍会引起术后鼻泪管狭窄及再阻塞。文章就鼻泪管支架植入术再发性阻塞的发病机制及相应改善措施的前沿进展进行综述,为临床诊疗提供新思路。

鱼腥草滴眼液联合泪道探通术治疗泪道阻塞合并慢性泪囊炎患儿的效果

目的评估鱼腥草滴眼液联合泪道探通术对泪道阻塞合并慢性泪囊炎患儿的治疗效果。方法选择河北省保定市妇幼保健院2021年8月至2022年8月收治的196例泪道阻塞合并慢性泪囊炎患儿为研究对象,采用随机数字表法将患儿分为对照组和观察组,每组98例。对照组给予泪道探通术,观察组采用泪道探通术联合鱼腥草滴眼液冲洗。记录两组患儿的临床疗效,比较两组患儿治疗前和治疗3个月后的炎症因子水平、泪液分泌量、泪膜破裂时间、泪河高度、角膜荧光素染色(FLS)评分、睑板腺分泌状态,比较两组患儿出血、组织水肿、眼膜划伤等并发症发生率和家属满意度。结果观察组患儿的临床疗效优于对照组,差异有统计学意义(P<0.05)。治疗前,两组患儿炎症水平和眼部症状比较,差异无统计学意义(P>0.05)。治疗后,两组患儿炎症因子水平、FLS评分、眼睑板状态评分、泪液分泌量、泪河高度低于治疗前,且观察组低于对照组;两组患儿泪膜破裂时间长于治疗前,且观察组长于对照组,差异有统计学意义(P<0.05)。观察组患儿术后并发症发生率低于对照组,家属满意度优于对照组,差异有统计学意义(P<0.05)。结论泪道探通术联合鱼腥草滴眼液冲洗,能够降低患儿术后炎症因子水平、改善眼部症状,从而提高治疗效果。

泪道X线造影、鱼腥草滴眼液冲洗联合泪道探通术在治疗婴幼儿泪囊炎中的应用

目的探究泪道X线造影、鱼腥草滴眼液冲洗联合泪道探通术治疗婴幼儿泪囊炎的临床疗效。方法将2021年8月至2022年8月在保定市妇幼保健院接受治疗的200例患有泪囊炎的2个月~2岁婴幼儿纳入本次研究。按照随机数字表法将其分为观察组(n=100)和对照组(n=100)。对照组患儿接受泪道X线造影+泪道探通术治疗,观察组患儿接受X线造影+鱼腥草滴眼液冲洗+泪道探通术治疗。比较2组的临床疗效、1次探通成功率、治疗前后血清炎症因子[白细胞介素6(IL-6)、肿瘤坏死因子-α(TNF-α)和高敏C反应蛋白(hs-CRP)]水平、并发症发生情况及术后复发情况。结果观察组患儿的总有效率为92.00%,显著高于对照组(81.00%),差异有统计学意义(P<0.05)。观察组的1次探通成功率为94.00%,显著高于对照组(85.00%),差异有统计学意义(P<0.05)。治疗后,2组的血清IL-6、TNF-α和hs-CRP水平均较治疗前显著下降,且观察组治疗后的血清IL-6、TNF-α和hs-CRP水平分别为(2.49±0.77)pg/mL、(5.13±1.60)pg/mL、(10.63±2.39)mg/L,均显著低于对照组[(3.65±0.89)pg/mL、(6.01±1.75)pg/mL、(13.17±2.71)mg/L],差异均有统计学意义(P<0.05)。2组的总并发症发生率和复发率比较,差异均无统计学意义(P>0.05)。结论泪道X线造影+鱼腥草滴眼液冲洗+泪道探通术治疗婴幼儿泪囊炎的临床疗效良好,可显著提高1次探通成功率,降低炎症反应,且安全性良好,术后不易复发。

单眼内窥镜下鼻腔泪囊吻合术后双眼眼表指标的变化

目的:探讨单眼内窥镜下鼻腔泪囊吻合术对双眼眼表指标的影响。方法:纳入于2022-12-01/2023-07-31诊断为单眼原发性获得性鼻泪管阻塞(PANDO),并成功实施内窥镜下鼻腔泪囊吻合术的患者45例。收集术前,术后0.5、1、3 mo的眼表指标,包括平均非侵入性泪膜破裂时间(NIBUT)、干燥综合征国际合作临床联盟眼部染色评分(SICCA OSS)、眼睑刷Korb评分、非表面麻醉泪液分泌试验(Schirmer test)。对比手术前后术眼与健眼在各个时间点上的各项指标。结果:术眼和健眼NIBUT、SICCA OSS、Korb评分、Schirmer test无明显的组间差异(均P>0.05)。术眼术后0.5、1、3 mo的Korb评分明显低于术前(P=0.034、0.044、0.027)。术眼术后1 mo的Schirmer test明显低于手术前(P=0.0461)。结论:内窥镜下鼻腔泪囊吻合术后泪液引流恢复正常,眼表损伤加重,这些变化通常在术后约1 mo达到峰值,然后逐渐恢复。

两种不同治疗方法治疗婴幼儿泪囊炎的疗效对比分析

目的比较泪道探通术+鱼腥草滴眼液与泪道探通术+妥布霉素滴眼液冲洗治疗婴幼儿泪囊炎的疗效。方法将2021年8月至2022年8月在保定市妇幼保健院接受治疗的200例患有泪囊炎的2个月~2岁婴幼儿纳入本次前瞻性研究。按照随机数字表法将其分为鱼腥草组(n=100)和妥布霉素组(n=100)。鱼腥草组患儿接受泪道X线造影+鱼腥草滴眼液冲洗+泪道探通术治疗;妥布霉素组患儿接受泪道X线造影+妥布霉素滴眼液冲洗+泪道探通术治疗。比较两组的临床疗效、1次探通成功率、治疗前后血清炎症因子[白细胞介素6(IL-6)、肿瘤坏死因子-α(TNF-α)和高敏C反应蛋白(hs-CRP)]水平、并发症发生情况及术后复发情况。结果鱼腥草组和妥布霉素组的总有效率比较(90.00%vs.95.00%),差异无统计学意义(P>0.05)。鱼腥草组与妥布霉素组的1次探通成功率比较(91.00%vs.96.00%),差异无统计学意义(P>0.05)。治疗后,两组的血清IL-6、TNF-α和hs-CRP水平均较治疗前显著下降,差异均有统计学意义(P<0.05);鱼腥草组与妥布霉素组治疗后的血清IL-6、TNF-α和hs-CRP水平比较[(2.52±0.71)pg/mL vs.(2.39±0.65)pg/mL,(5.18±1.61)pg/mL vs.(5.05±1.57)pg/mL,(10.57±2.46)mg/L vs.(10.10±2.27)mg/L],差异均无统计学意义(P>0.05)。鱼腥草组与妥布霉素组的并发症发生率(7.00%vs.4.00%)和术后复发率(0 vs.0)比较,差异均无统计学意义(P>0.05)。结论鱼腥草滴眼液冲洗+泪道探通术治疗婴幼儿泪囊炎的临床疗效与妥布霉素滴眼液冲洗+泪道探通术相当,且安全性高,术后不易复发。