Online pharmaceutical process analysis of Chinese medicine using a miniature mass spectrometer: Extraction of active ingredients as an example

The automation of traditional Chinese medicine(TCM)pharmaceuticals has driven the development of process analysis from offline to online.Most of common online process analytical technologies are based on spectroscopy,making the identification and quantification of specific ingredients still a challenge.Herein,we developed a quality control(QC)system for monitoring TCM pharmaceuticals based on paper spray ionization miniature mass spectrometry(mini-MS).It enabled real-time online qualitative and quantitative detection of target ingredients in herbal extracts using mini-MS without chromatographic separation for the first time.Dynamic changes of alkaloids in Aconiti Lateralis Radix Praeparata(Fuzi)during decoction were used as examples,and the scientific principle of Fuzi compatibility was also investigated.Finally,the system was verified to work stably at the hourly level for pilot-scale extraction.This mini-MS based online analytical system is expected to be further developed for QC applications in a wider range of pharmaceutical processes.

Highway Construction of Soft Soil Foundation Processing Analysis

Highway is an important channel to connect regional economic development,and is an indispensable part of modern transportation system.In view of the extensive nature of highway cover space and the existence of diversified construction environment,climate and geological influence in highway construction,soft soil foundation is one of the more typical geological forms.With wide distribution in our country,seen as a big difficulty,highway construction technology and directly affect the quality of highway construction,cost,if not properly handled,will cause the soft soil foundation highway engineering structure is not stable,prone to accidents in use.In this paper,we study the treatment of soft soil foundation in highway construction,and put forward some reasonable Suggestions.

Flexible Fixture Design for the Top and End Surface Processing of NP2_NP4 Cylinder Heads

This paper focuses on the design of fixtures for NP2 and NP4 cylinder heads on a horizontal machining center of flexible machining automatic lines.It began with an analysis of the diagrams of part processing and working procedure which formed the basis for the design of the processing technology scheme,a selection of suitable machine tools,and the setting of processing parameters.Fixtures tailored to the chosen machine tools were then designed to meet the processing requirements.Additional aspects of the project included the design of part drawings,calculation of working time quota,design of auxiliary guides,support clamping,and hydraulic circuits,all aimed at fulfilling practical production requirements.

基于PAT技术的动物细胞培养在线检测研究进展

动物细胞培养是一项重要的生物工程技术,在该过程中需要对一些重要的生物和生化指标进行监测。目前广泛采用的是取样离线分析手段,存在时间滞后性和潜在的染菌风险。利用过程分析技术(process analytical technology,PAT)在线实时检测动物细胞培养状况,进而实现培养过程的优化与控制,具有重要的学术意义和工业应用价值。本文介绍了两项应用前景最为广阔的细胞培养PAT技术,即原位显微镜成像与拉曼光谱技术,分别用于在线测量细胞培养过程的重要生物指标(细胞数目、尺寸、形状)与生化指标(营养物质、代谢物质、蛋白质产物的浓度)。作为这两项技术成功应用的关键,文中重点介绍了图像分析算法和拉曼光谱建模方法。此外,对近红外光谱、荧光光谱等技术的一些研究探索也做了简要概括性介绍。最后,结合PAT技术的发展,探讨了实现动物细胞培养过程自动化与智能化的未来发展方向。

动物细胞培养过程PAT和在线生物检测技术

利用动物细胞反应器大规模培养生产疫苗和抗体是现代生物医药产业的重要组成部分,这些产品在疾病管控、治疗重大疾病当中的作用是不可替代的。在过去的几十年中,动物细胞大规模培养技术已取得了长足的进步,相关产品的产量显著提高。现代生物制药对产品质量和一致性提出了更高的要求。越来越多的过程研究工作致力于提高产品质量和一致性。而一致的工艺性能和Qb D需要充分利用过程分析技术(process analytical technology,PAT)。对动物细胞培养过程的PAT应用、过程检测的类型、过程在线检测传感器和在线检测技术进行了较系统的介绍。

基于QBD理念和PAT技术的仪器分析实验教学研究与实践

仪器分析是中药学专业学生的主干课程之一,对拓宽学生知识视野、加强基本实验技能、提高创新思维和科研素养具有重要的作用。将QBD理念和PAT技术融入到仪器分析实验教学体系中,将会不断提高教学水平和学生综合素质,从而助力中医药双创人才培养。

过程分析技术(PAT)在原料药生产中的应用

该文通过采用近红外光谱分析技术对原料药(API)的浓度调节过程进行实时监控,介绍了在良好生产规范条件下过程分析技术(PAT)的实施过程。利用偏最小二乘算法开发出两个校正模型分别用以监控原料药和水分含量,并通过模型校正均方根误差(RMSEC)、交叉检验均方根误差(RMSECV)和预测均方根误差(RMSEP)以及对应的决定系数(R2)来评估模型的性能。为保证模型性能,按照分析方法验证要求对模型的线性和范围、准确性、精密度(重复性)、专属性以及稳健性指标进行验证。最后通过系统性能测试确认检测系统满足商业化运行的要求。结果显示,采用过程分析技术控制浓度调节过程,可以大幅度缩短浓度调节时间,节约蒸汽能耗和检测费用,减少生产过程中的偏差,提升产品工艺水平和批次间一致性。

Study progression in application of process analytical technologies on film coating

Film coating is an important unit operation to produce solid dosage forms,thereby,the monitoring of this process is helpful to find problems in time and improve the quality of coated products.Traditional methods adopted to monitor this process include measurement of coating weight gain,performance of disintegration and dissolution test,etc.However,not only do these methods cause destruction to the samples,but also consume time and energy.There have recently emerged the applications of process analytical technologies(PAT)on film coating,especially some novel spectroscopic and imaging technologies,which have the potential to real-time track the progress in film coating and optimize production efficiency.This article gives an overview on the application of such technologies for film coating,with the goal to provide a reference for the further researches.

Polyphenols, Carotenoids, Vitamin C Content in Tropical Fruits and Vegetables and Impact of Processing Methods

Thirty-five fruits and seventeen vegetables from Martinique were evaluated for total phenol content (TPC), Vitamin C and carotenoid content. TPC, Vitamin C and carotenoid contents ranged from 11.7 to 978.6 mg/100g, 0.1 to 2853.8 mg/100g and 9.7 to 9269.7 μg/100g respectively. Fruits and vegetables from Martinique have equivalent or higher TPC, Vitamin C and carotenoid contents than fruits and vegetables from temperate climates. Cashew apple had high values for all three parameters (55.8 mg/100g of Vitamin C, 603 mg/100g of TPC and 924 μg/100g of carotenoids). Bassignac mango and mamey apple had the highest carotenoid contents, with 3800.3 and 3199.7 μg/100g respectively. Acerola had the highest Vitamin C and polyphenol contents with 2853.8 μg/100g and 727.4 mg/100g respectively. Pigeon peas had high values for all three parameters (569.2 mg/100g of Vitamin C, 978.6 mg/100g of TPC and 364.3 μg/100g of carotenoids). Pumpkin and watercress had the highest carotenoid content, with 9269.7 and 4339 μg/100g respectively. TPC, Vitamin C and carotenoid content were significantly impacted by processing techniques. TPC, Vitamin C and carotenoid contents decreased by up to 75.78%, 100% and 70.18% respectively, depending on the processing technique used.

The Symbiotic Relationship Unraveling the Interplay between Technology and Artificial Intelligence(An Intelligent Dynamic Relationship)

This article investigates the dynamic relationship between technology and AI(artificial intelligence)and the role that societal requirements play in pushing AI research and adoption.Technology has advanced dramatically throughout the years,providing the groundwork for the rise of AI.AI systems have achieved incredible feats in various disciplines thanks to advancements in computer power,data availability,and complex algorithms.On the other hand,society’s needs for efficiency,enhanced healthcare,environmental sustainability,and personalized experiences have worked as powerful accelerators for AI’s progress.This article digs into how technology empowers AI and how societal needs dictate its progress,emphasizing their symbiotic relationship.The findings underline the significance of responsible AI research,which considers both technological prowess and ethical issues,to ensure that AI continues to serve the greater good.

Present Situation and Developing Trend on Laser Processing Industry in China

Developing trend and present situation on laser processing industry in China are mainly reviewed.The market analysis on laser processing systems are given,some new and rapidly developed laser processing systems are introduced.Finally,the paper also introduces some new kinds of laser systems and equipment.

视频侦查技术关键及其发展展望

视频侦查技术的核心是通过视频图像的提取、查看、分析和研判来获取侦查线索、固定涉案证据。多年来经过在实战应用中不断地发展创新,视频侦查技术形成了自己独特的关键技术体系:视频信息分析解读技术是侦查应用和证据固定的基础和核心;视频证据固定保全技术的规范是审判中心主义的客观要求,可以获取视频侦查记录报告、视频检验鉴定报告或视频数据关联报告;低质量视频图像的增强恢复技术专业性强,应用范围窄,技术成熟度高,然而它不断面临新的挑战。目前,视频数据的智能应用在大数据背景下变得越来越重要,仍需进一步突破视频自动识别技术的应用范畴,建立完善多层次的视频数据综合应用体系,打造适应不同业务需要的视频数据实战应用模型。

川西藏区牦牛酸醡肉在番茄汤锅中的应用及风味特征分析

为探究牦牛酸醡肉在番茄汤锅中的应用及风味特征分析,以感官评分、质构、色差、烹饪损失率和热量分析为评价指标,以牦牛酸醡肉的发酵温度、发酵时间、肉块厚度、煮制时间为考察因素,通过熵权法对综合得分进行评价,得出最佳应用工艺;以新鲜牦牛肉为对照,通过电子舌和GC-IMS分析牦牛酸醡肉在番茄汤锅中的风味特征。结果表明,最佳应用工艺条件为发酵温度25℃、发酵时间24 h、肉块厚度2.0 cm、煮制时间5 min,在此条件下制备的牦牛酸醡肉风味浓厚、大小适宜、口感佳。相比于新鲜牦牛肉,牦牛酸醡肉的酸味值、甜味值、咸味值更高,使得滋味更加浓郁,香气成分增加了酮类、醇类、醛类和酯类等21种物质,风味差异较明显,使得牦牛酸醡肉在番茄汤锅中的风味更加丰富,为牦牛酸醡肉在餐饮业中的应用提供了一定的参考。

专利视角下蒙古文信息处理技术发展动态研究

以专利数据为基础,绘制蒙古文信息处理技术的发展图谱,分析该技术发展现状和趋势,为技术研发提供数据支撑。利用innojoy和incopat专利检索分析平台对中国蒙古文信息处理技术专利进行统计和对比分析。从不同维度,对蒙古文信息处理技术的专利数量、申请量、活跃度、区域分布、专利技术构成等方面进行了分析和讨论。经过几十年的技术储备、应用尝试等,蒙古文信息处理技术处于大幅增长的态势。在区域分布上,内蒙古具有天然的优势,其中内蒙古工业大学相对于其他创新主体表现突出。然而,有权专利数量和占比均表现不佳。蒙古文信息处理技术通常注重在研发阶段以合作开发的方式开展研究以及应用工作,而在专利权取得后,以转让方式进行专利价值释放或者落地实施的方式并不明显。苏依拉和仁庆道尔吉研发力优势突出,即专利申请总量以及活跃度均表现较好。从蒙古文信息处理专利技术构成看,自然语言处理技术专利最多,其次为信息检索技术,最后是识别模式的方法和装置。

稻壳在化工领域应用的专利技术研究动向

【目的】为各创新主体如何在国家政策指向下实现粮食副产物资源最大化利用提供专利方面的技术支持。【方法】从专利视角分析了稻壳在化工领域应用的专利申请,重点分析了国内外申请趋势、主要创新主体的状况及相关技术等内容。【结果】稻壳资源在化工领域应用的专利技术主要涉及电池、电容器、石墨烯,且以国内专利申请为主。创新主体主要为科研院所和企业,科研院所具有较为先进的研发团队,企业在政策导向下也加大研发力度,呈现良好的发展态势,但专利转化率较低。【结论】稻壳资源在电池、电容器、石墨烯等化工领域具有较好的应用前景,可作为大力发展的方向之一。基于科研院所较强的研发实力,地方政府及企业可加强与之的合作,在降低成本的同时实现粮食资源的最大化利用。

不同工艺梅占绿茶香气与主成分分析

为探明不同工艺梅占绿茶香气成分差异,对5份不同工艺梅占绿茶茶样香气组分含量及香气特征进行分析。结果表明,5份不同工艺梅占绿茶共检测出主要香气成分38种,包括碳氢类8种、醇类12种、醛酮类11种、酯类3种、含氮化合物类2种及含硫化合物和杂氧类化合物各1种。其中醇类含量明显高于其他香气成分含量;醇类在梅占绿茶(饼形)中含量显著高于传统炒青绿茶;醛酮类在传统炒青绿茶中含量高于梅占绿茶(饼形)。β-芳樟醇具百合花或玉兰花香气,在梅占绿茶(饼形)中含量丰富,增加摇青工艺的梅占绿茶(饼形)香气主要表现清鲜、有花香或果香,香高持久;传统炒青绿茶花香不显。通过PCA进一步分析得到4个主成分,第一主成分的初始特征值为29.06,贡献率为76.472%;第二主成分的初始特征值为4.197,贡献率为11.046%;前4个主成分累计贡献率达100%,完全能够解释原有香气成分所包含的全部信息。表明摊青过程中加入摇青工艺加工出来的茶样具有高香优质绿茶品质特征,其中4号茶样(摇青15 s,揉捻12 min)感观审评分最高,香气清香持久,带栗香、兰花香。

化学计量学指导原则在我国制药行业中的需求分析

目的:了解和把握我国制药行业的现状和实际需求,为《中国药典》通则“化学计量学指导原则”的建立提供依据。方法:以网络问卷的形式对制药行业从业人员化学计量学相关背景和需求进行调研。结果:我国制药行业从业人员对化学计量学指导原则具有一定期望和需求,但人才储备情况不容乐观。结论:《中国药典》通则“化学计量学指导原则”的制订极为迫切,其作为法定依据指导分析实践活动中的数据质量控制、分析方法的建立及分析方法的验证,以保障多变量分析方法的科学性和分析结果的可靠性,这将有利于推动我国制药水平的提高。

基于SurfMill软件的骨科接骨板加工的研究与实践

通过对L字形骨科接骨板进行工艺分析,采用SurfMill软件进行软件编程,进行了虚拟仿真加工和实际加工,验证了加工工艺和SurfMill软件的相应模块,证明了工艺方案的可行性和国产SurfMill软件的可靠性,为骨科接骨板加工制造提供一种新方案。

箱盖加工工艺与钻孔专夹设计

根据钻箱盖零件6-Φ13.5通孔的特点及工厂的实际状况,该文设计了一种带分度装置、定位芯轴、能快速装拆工件的专用夹具。此夹具改变了以往采用传统分度装置或偏摆分度装置的装夹方式,可按照箱盖零件要求对其进行机械加工工艺设计,使其从铸造件成为合格的产品。其中,设计了第十道工艺步骤钻6-Φ13.5通孔,采用一圆一面定位,限制五个自由度,并利用弹簧压板、偏心手柄夹紧,然后利用弹簧对顶杆进行分度定位后进行加工。对比以往常用的此类夹具,该夹具能使钻孔所用的麻花钻刀长度有效减少,操作简单方便,节约了时间,提高了生产效率,可行性极高。