This paper examines the interface development between a single crystalline Ag matrix and core-shell AgnCom nanoclusters that have been deposited with energies varying between 0.25 eV and 1.5 eV per atom using computer...This paper examines the interface development between a single crystalline Ag matrix and core-shell AgnCom nanoclusters that have been deposited with energies varying between 0.25 eV and 1.5 eV per atom using computer modeling techniques. Clusters undergo deformation as a result of the slowing down;they may also become epitaxial with the substrate and maintain their core-shell structure. A detailed analysis of the effects of the cluster-surface interaction is conducted over a realistic size and energy range, and a model is created to show how clusters accumulate. It is discovered that both the silver shells and the cobalt cluster cores exhibit limited epitaxy with the substrate, and that the contact produced is only a few atomic layers thick. The effect is higher for Ag shells than for Co cores, and it is not very energy dependent.展开更多
目的:通过外源性注射趋化因子(C-X3-C基序)配体1(Fractalkine,CX3CL1)探索其对阿尔茨海默病(Alzheimer’sdisease,AD)小鼠神经元功能的影响及机制。方法:采用APP/PS1双转基因小鼠建立AD模型。将小鼠随机分为4组:对照组、AD模型组、AD+PB...目的:通过外源性注射趋化因子(C-X3-C基序)配体1(Fractalkine,CX3CL1)探索其对阿尔茨海默病(Alzheimer’sdisease,AD)小鼠神经元功能的影响及机制。方法:采用APP/PS1双转基因小鼠建立AD模型。将小鼠随机分为4组:对照组、AD模型组、AD+PBS溶剂组、AD+CX3CL1组。AD+CX3CL1组颅内给予CX3CL1。AD+PBS溶剂组注射等容积的PBS溶剂。采用旷场实验和Morris水迷宫测试小鼠认知行为,免疫荧光染色、TUNEL染色、尼氏染色、蛋白质印迹和RT-PCR技术对小鼠海马组织进行分析。结果:①AD小鼠接受CX3CL1注射后增加了移动距离,但没有显著差异(P=0.189);在水迷宫测试中,AD+CX3CL1组寻找水下平台的移动距离显著缩短(P=0.001);②AD模型组中GSDMD(Gasdermin D)蛋白和炎症相关蛋白表达显著升高(P<0.05),而CX3CL1注射能显著降低这些蛋白的表达水平(P<0.05);③AD模型组的尼氏体数量、突触相关蛋白25 kDa(synaptosomal-associated protein of 25 kDa,SNAP25)、突触后致密区蛋白95(post synaptic density protein 95,PSD95)和囊泡相关膜蛋白1(vesicle-associated membrane protein 1,VAMP1)表达水平显著降低,而CX3CL1组尼氏体数量(P=0.001)和SNAP25、PSD95、VAMP1蛋白的表达增加(P=0.043,P=0.026,P=0.003)。结论:外源性CX3CL1注射能够通过调节炎症因子和减少细胞焦亡来改善AD小鼠的神经元功能,保护神经元免受损伤。展开更多
锂-硒电池因其超高的体积能量密度和硒的高电导率而被认为是一种极具有发展前景的锂离子电池。然而,循环过程中电极严重的体积膨胀和多硒化物溶解,以及硒的低负载,阻碍了锂-硒电池应用的发展。解决这三个问题的一种行之有效的方法是将...锂-硒电池因其超高的体积能量密度和硒的高电导率而被认为是一种极具有发展前景的锂离子电池。然而,循环过程中电极严重的体积膨胀和多硒化物溶解,以及硒的低负载,阻碍了锂-硒电池应用的发展。解决这三个问题的一种行之有效的方法是将硒限制在具有丰富孔体积的碳基质中,并同时增强硒与碳的界面相互作用。通过将Se浸入酒石酸盐衍生的蜂窝状三维多孔炭中,合成出了一种具有Se―C键的蜂窝状三维多孔炭@硒(HPC@Se)的新型正极材料用于锂-Se电池。得到的蜂窝状三维多孔炭的孔体积可达1.794 cm^(3)g^(-1),能够均匀包封65%硒。此外,硒与碳之间的强化学键有利于稳定硒,从而进一步缓解其巨大的体积膨胀和多硒化物的溶解,还可促进循环过程中的电荷转移。该HPC@Se正极呈现出极好的循环性能和倍率性能。在0.2 C的电流密度下,经200次循环后,其比容量可保持在561 m Ahg^(-1)(为理论比容量的83%),每次循环的比容量衰减率仅为0.058%。此外,在5 C的高电流密度下,HPC@Se正极还可以达到472.8 m Ahg^(-1)的可观容量。展开更多
文摘This paper examines the interface development between a single crystalline Ag matrix and core-shell AgnCom nanoclusters that have been deposited with energies varying between 0.25 eV and 1.5 eV per atom using computer modeling techniques. Clusters undergo deformation as a result of the slowing down;they may also become epitaxial with the substrate and maintain their core-shell structure. A detailed analysis of the effects of the cluster-surface interaction is conducted over a realistic size and energy range, and a model is created to show how clusters accumulate. It is discovered that both the silver shells and the cobalt cluster cores exhibit limited epitaxy with the substrate, and that the contact produced is only a few atomic layers thick. The effect is higher for Ag shells than for Co cores, and it is not very energy dependent.
文摘目的:通过外源性注射趋化因子(C-X3-C基序)配体1(Fractalkine,CX3CL1)探索其对阿尔茨海默病(Alzheimer’sdisease,AD)小鼠神经元功能的影响及机制。方法:采用APP/PS1双转基因小鼠建立AD模型。将小鼠随机分为4组:对照组、AD模型组、AD+PBS溶剂组、AD+CX3CL1组。AD+CX3CL1组颅内给予CX3CL1。AD+PBS溶剂组注射等容积的PBS溶剂。采用旷场实验和Morris水迷宫测试小鼠认知行为,免疫荧光染色、TUNEL染色、尼氏染色、蛋白质印迹和RT-PCR技术对小鼠海马组织进行分析。结果:①AD小鼠接受CX3CL1注射后增加了移动距离,但没有显著差异(P=0.189);在水迷宫测试中,AD+CX3CL1组寻找水下平台的移动距离显著缩短(P=0.001);②AD模型组中GSDMD(Gasdermin D)蛋白和炎症相关蛋白表达显著升高(P<0.05),而CX3CL1注射能显著降低这些蛋白的表达水平(P<0.05);③AD模型组的尼氏体数量、突触相关蛋白25 kDa(synaptosomal-associated protein of 25 kDa,SNAP25)、突触后致密区蛋白95(post synaptic density protein 95,PSD95)和囊泡相关膜蛋白1(vesicle-associated membrane protein 1,VAMP1)表达水平显著降低,而CX3CL1组尼氏体数量(P=0.001)和SNAP25、PSD95、VAMP1蛋白的表达增加(P=0.043,P=0.026,P=0.003)。结论:外源性CX3CL1注射能够通过调节炎症因子和减少细胞焦亡来改善AD小鼠的神经元功能,保护神经元免受损伤。
文摘锂-硒电池因其超高的体积能量密度和硒的高电导率而被认为是一种极具有发展前景的锂离子电池。然而,循环过程中电极严重的体积膨胀和多硒化物溶解,以及硒的低负载,阻碍了锂-硒电池应用的发展。解决这三个问题的一种行之有效的方法是将硒限制在具有丰富孔体积的碳基质中,并同时增强硒与碳的界面相互作用。通过将Se浸入酒石酸盐衍生的蜂窝状三维多孔炭中,合成出了一种具有Se―C键的蜂窝状三维多孔炭@硒(HPC@Se)的新型正极材料用于锂-Se电池。得到的蜂窝状三维多孔炭的孔体积可达1.794 cm^(3)g^(-1),能够均匀包封65%硒。此外,硒与碳之间的强化学键有利于稳定硒,从而进一步缓解其巨大的体积膨胀和多硒化物的溶解,还可促进循环过程中的电荷转移。该HPC@Se正极呈现出极好的循环性能和倍率性能。在0.2 C的电流密度下,经200次循环后,其比容量可保持在561 m Ahg^(-1)(为理论比容量的83%),每次循环的比容量衰减率仅为0.058%。此外,在5 C的高电流密度下,HPC@Se正极还可以达到472.8 m Ahg^(-1)的可观容量。
