Dr.Yi-Han Chen is an excellent cardiologist and a medical scientist.Through more than two decades of clinical and biomedical research work,he has made remarkable achievements in regards to treatment and pathogenesis o...Dr.Yi-Han Chen is an excellent cardiologist and a medical scientist.Through more than two decades of clinical and biomedical research work,he has made remarkable achievements in regards to treatment and pathogenesis of cardiac arrhythmias and heart failure,and was elected as a member of the Chinese Academy of Sciences in 2015 because of his outstanding contributions.展开更多
On the basis of a self-similar solution as well as of the assumption of the 'Transserse Motion',a general linear theory on hypersonic flow over a general slender body is set up in this paper By means of this t...On the basis of a self-similar solution as well as of the assumption of the 'Transserse Motion',a general linear theory on hypersonic flow over a general slender body is set up in this paper By means of this theory, the problem concerned can he put into a universal system of O.D Eqs .which can be integrated manerically in adyance展开更多
Dr. Chen received her bachelor-equivelent medical education at School of Medicine Shandong University (previously the Shandong Medical College), and got her MD–Ph D in1989 majoring in Obstetrics and Gynecology. As th...Dr. Chen received her bachelor-equivelent medical education at School of Medicine Shandong University (previously the Shandong Medical College), and got her MD–Ph D in1989 majoring in Obstetrics and Gynecology. As the youngest professor in the school’s history, Dr. Chen joined the faculty of School of Medicine Shandong University.展开更多
Cellular functions, either under the normal or pathological conditions or under different stresses, are the results of the coordinated action of multiple proteins interacting in macromolecular complexes or assemblies....Cellular functions, either under the normal or pathological conditions or under different stresses, are the results of the coordinated action of multiple proteins interacting in macromolecular complexes or assemblies. The precise determination of the specific composition of protein complexes, especially using scalable and high-throughput methods, represents a systematic approach toward revealing particular cellular biological functions. In this regard, the direct profiling protein-protein interactions (PPIs) represent an efficient way to dissect functional pathways for revealing novel protein functions. In this review, we illustrate the technological evolution for the large-scale and precise identification of PPIs toward higher physiologically relevant accuracy. These techniques aim at improving the efficiency of complex pull-down, the signal specificity and accuracy in distinguishing specific PPIs, and the accuracy of identifying physiological relevant PPIs. A newly developed streamline proteomic approach for mapping the binary relationship of PPIs in a protein complex is introduced.展开更多
Dr. Yizhuang Xu was born at Beijing, China in 1967. He received his bachelor and master degree in 1991 and 1994 at Department of Chemistry, Peking University. Then he got his PhD of physical chemistry at College Chemi...Dr. Yizhuang Xu was born at Beijing, China in 1967. He received his bachelor and master degree in 1991 and 1994 at Department of Chemistry, Peking University. Then he got his PhD of physical chemistry at College Chemistry and Molecular Engineering, Peking University in 1997.展开更多
文摘Dr.Yi-Han Chen is an excellent cardiologist and a medical scientist.Through more than two decades of clinical and biomedical research work,he has made remarkable achievements in regards to treatment and pathogenesis of cardiac arrhythmias and heart failure,and was elected as a member of the Chinese Academy of Sciences in 2015 because of his outstanding contributions.
文摘On the basis of a self-similar solution as well as of the assumption of the 'Transserse Motion',a general linear theory on hypersonic flow over a general slender body is set up in this paper By means of this theory, the problem concerned can he put into a universal system of O.D Eqs .which can be integrated manerically in adyance
文摘Dr. Chen received her bachelor-equivelent medical education at School of Medicine Shandong University (previously the Shandong Medical College), and got her MD–Ph D in1989 majoring in Obstetrics and Gynecology. As the youngest professor in the school’s history, Dr. Chen joined the faculty of School of Medicine Shandong University.
基金support from the Shanghai Science and Technology Development Program (Grant Nos. 03DZ14024 & 07ZR14010)the 863 High Technology Foundation of China (Grant No. 2006AA02A310)+1 种基金US NIH 1R01AI064806-01A2, 5R21DK082706U.S. Department of Energy, the Office of Science (BER) (Grant No. DE-FG02- 07ER64422)
文摘Cellular functions, either under the normal or pathological conditions or under different stresses, are the results of the coordinated action of multiple proteins interacting in macromolecular complexes or assemblies. The precise determination of the specific composition of protein complexes, especially using scalable and high-throughput methods, represents a systematic approach toward revealing particular cellular biological functions. In this regard, the direct profiling protein-protein interactions (PPIs) represent an efficient way to dissect functional pathways for revealing novel protein functions. In this review, we illustrate the technological evolution for the large-scale and precise identification of PPIs toward higher physiologically relevant accuracy. These techniques aim at improving the efficiency of complex pull-down, the signal specificity and accuracy in distinguishing specific PPIs, and the accuracy of identifying physiological relevant PPIs. A newly developed streamline proteomic approach for mapping the binary relationship of PPIs in a protein complex is introduced.
文摘Dr. Yizhuang Xu was born at Beijing, China in 1967. He received his bachelor and master degree in 1991 and 1994 at Department of Chemistry, Peking University. Then he got his PhD of physical chemistry at College Chemistry and Molecular Engineering, Peking University in 1997.
