基于原型理论和拓扑学的产品形态系列化设计研究

目的 解决产品系列化设计中存在的“流行风格缺乏”“形态主次模糊”“系列形态不连续”等问题,运用原型理论和拓扑学相关方法,从原型形态出发,基于拓扑性质和拓扑形变构建产品形态系列化设计方法。方法 首先运用语义差分法结合专家访谈获取具有流行风格意象的目标产品代表样本;其次通过拓扑定量分析法区分代表样本形态特征的主次;再次运用设计形态分析结合相似结果离散度分析提取形态原型;最后依据形态特征的主次,结合流行风格需求,运用不同的拓扑形变规则对产品形态原型进行系列化创新设计。结果 以拖拉机前脸作为验证对象,对该设计方法进行实例研究。结果表明,其能够使系列化设计方案既具有独特的流行风格又具备识别性、连续性的外观形态。结论 在产品形态系列化设计中,挖掘满足用户流行风格需求的形态原型,获取系列化产品的识别性特征,进而结合拓扑形变方法,解决了产品系列化设计的实际问题,为产品形态系列化提供普适有效的借鉴思路及设计方法。

Metabolic profiles and morphological characteristics of leaf tips among different sweet potato(Ipomoea batatas Lam.)varieties

Sweet potato leaf tips have high nutritional value,and exploring the differences in the metabolic profiles of leaf tips among different sweet potato varieties can provide information to improve their qualities.In this study,a UPLC-Q-Exactive Orbitrap/MS-based untargeted metabolomics method was used to evaluate the metabolites in leaf tips of 32 sweet potato varieties.Three varieties with distinct overall metabolic profiles(A01,A02,and A03),two varieties with distinct profiles of phenolic acids(A20 and A18),and three varieties with distinct profiles of flavonoids(A05,A12,and A16)were identified.In addition,a total of 163 and 29 differentially expressed metabolites correlated with the color and leaf shape of sweet potato leaf tips,respectively,were identified through morphological characterization.Group comparison analysis of the phenotypic traits and a metabolite-phenotypic trait correlation analysis indicated that the color differences of sweet potato leaf tips were markedly associated with flavonoids.Also,the level of polyphenols was correlated with the leaf shape of sweet potato leaf tips,with lobed leaf types having higher levels of polyphenols than the entire leaf types.The findings on the metabolic profiles and differentially expressed metabolites associated with the morphology of sweet potato leaf tips can provide useful information for breeding sweet potato varieties with higher nutritional value.

Profile of Amoebic vs. Pyogenic Liver Abscess and Comparison of Demographical, Clinical, Radiological, and Laboratory Profiles of These Patients from Three Secondary Care Centers in Senegal

Background: Liver abscess (LA) is a suppurated collection in the hepatic parenchyma. In Africa, liver abscesses are most often of amoebic origin, but more recently, the rate of pyogenic liver abscesses (PLA) has increased. Objective: to assess the epidemiological characteristics, clinical features, biological radiological findings, and outcomes of patients with PLA and with amebic liver abscess (ALA) in order to determine the potential factors that may help improve diagnosis and treatment for LA in the context of secondary care centers with limited medical supports. Methods: Retrospective review of LA diagnosed and treated at three secondary care centers in Thiès over 11 years. Results: 61 patients, were included, 52.45% had ALA and 47.54% had PLA. Males were predominant (79.31% in PLA vs 65.63% in ALA, p = 0.2). The median age was 38 years for the PLA group vs 39 years for the ALA group (p = 0.4). In both groups, the most common symptom was right upper abdominal pain (81.97%), hepatomegaly (81.97%). The PLA group had a higher prevalence of fever (79.31% vs 46.88%, p = 0,009), chills (51.72% vs 18.75%, p = 0.007), right basi-thoracic pain (55.17% vs 28.13%, p = 0.032), and jaundice (55.17% vs 28%, p = 0.032). There was no difference in radiological features between PLA and ALA. Patients with PLA had a higher level of White blood cell (20.600 vs 15.400, p = 0.014). The most common bacteria identified in PLA were Escherichia coli (58.8%). All patients had received antibiotic therapy, which was combined with aspiration puncture (37.3%), transcutaneous drainage (43.3%), and surgery (9.0%). Seven patients had received antibiotic therapy alone and all had amoebic abscesses. Elsewhere, the occurrence of complications was higher in PLA cases (75.86% vs 37.5%, p = 0.003). The overall hospital mortality rate was 13.11%, higher in cases of PLA (24.14% vs 3.13%, p = 0.022). Conclusion: Clinical and biological features were more severe in PLA. But radiological features cannot be used to distinguish between PLA and ALA.

Multi-circular formation control with reinforced transient profiles for nonholonomic vehicles:A path-following framework

This article investigates a multi-circular path-following formation control with reinforced transient profiles for nonholonomic vehicles connected by a digraph.A multi-circular formation controller endowed with the feature of spatial-temporal decoupling is devised for a group of vehicles guided by a virtual leader evolving along an implicit path,which allows for a circumnavigation on multiple circles with an anticipant angular spacing.In addition,notice that it typically imposes a stringent time constraint on time-sensitive enclosing scenarios,hence an improved prescribed performance control(IPPC)using novel tighter behavior boundaries is presented to enhance transient capabilities with an ensured appointed-time convergence free from any overshoots.The significant merits are that coordinated circumnavigation along different circles can be realized via executing geometric and dynamic assignments independently with modified transient profiles.Furthermore,all variables existing in the entire system are analyzed to be convergent.Simulation and experimental results are provided to validate the utility of suggested solution.

Radical Hysterectomy in Cervical Cancer: Patients’ Epidemiological and Clinical Profiles and Perioperative Outcome in Two Referral Hospitals in Cameroon

Background: Cervical cancer (CC) is one of the most frequent cancers and the leading cause of death from gynecological cancer in Low and middle income countries, Cameroon inclusive. Surgery is the primary treatment modality when the disease is diagnosed at early stage. Radical hysterectomy in cervical cancer has not been evaluated in recent years in Cameroon. The purpose of this study is thus to evaluate the epidemiological and clinical features and short term outcomes of patients who underwent surgery. Patients and methods: This retrospective study was conducted at the Douala Gynaeco-obstetric and Pediatric Hospital and the Douala General Hospital. Cervical cancer patients who underwent Radical hysterectomy between January 2015 and December 2020 were included. A pre-established data collection tool was used to record socio-demographic, clinical and outcomes information from patients’ files;additional outcome information was obtained from phone calls. Descriptive analysis was done using the SPSS version 26. Bivariate analysis was used to determine associations between disease and patients characteristics and occurrence of adverse postoperative outcome. P value of 0.05 was considered. Results: Sixty one patients were enrolled. Their ages ranged from 33 to 74 years with a mean age of 51.95 ± 10.29 years. Over 85% of women were married, 65.57% were unemployed and 86.88% were multiparous. Only 28% had never done cervical cancer screening. Most patients had stage IB1 to IB2 stage disease (57.1%). Less than 9% underwent radical hysterectomy and 8 of those (13.11%) suffered intraoperative complications. Twenty-five patients (40.98%) presented immediate and short term complications. There was no significant association between the disease or patients’ characteristics and adverse outcomes. Conclusion: Cervical cancer patients are relatively young in our settings and only 9% of them reach the hospital at early stage. Postoperative adverse outcomes rate is higher than that reported in the literature. Sensitization on screening and awareness of early symptoms can reverse the situation.

Profiles of the Headspace Volatile Organic and Essential Oil Compounds from the Tunisian Cardaria draba (L.) Desv. and Its Leaf and Stem Epidermal Micromorphology

In this work, we investigated aroma volatiles emanated by dry roots, stems, leaves, flowers, and fruits of Cardariadraba (L.) Desv. growing wild in Tunisia and its aerial part essential oils (EOs) composition. A total of 37 volatileorganic compounds (96.7%–98.9%) were identified;4 esters, 4 alcohols, 7 hydrocarbons, 12 aldehydes, 5 ketones,1 lactone, 1 organosulfur compound, 2 organonitrogen compounds, and 1 acid. The hydrocarbons form the maingroup, representing 49.5%–84.6% of the total detected volatiles. The main constituent was 2,2,4,6,6-pentamethylheptane(44.5%–76.2%) reaching the highest relative percentages. Forty-two compounds were determined in thetwo fractions of EOs, representing 98.8% and 97.2% of the total oil composition, respectively. The principal componentswere hexadecanoic acid (34.6%), 6-methyl-5-hepten-2-one (18.3%), decanal (15.0%), 6,10,14-trimethyl-2-pentadecanone (13.2%), and n-pentacosane (13%). Micromorphological details of the leaf and stem epidermisusing light microscopy revealed polygonal cells with sinuous walls in the adaxial and abaxial leaf surfaces andnearly rectangular and long ones with linear and thick walls for the stem epidermis. The stomata complexes wereanisocytic in the leaf epidermis and mainly anisocytic and rarely paracytic in the stem epidermis. Non-glandulartrichomes were unbranched and long with an acute apex or short with a convex apex. The glandular ones wereidentified for the first time in this species. They were short-stalked with a large secretory head. The highest stomatalindex (17.02%) was recorded in the abaxial leaf surface. The identification of headspace volatiles and essentialoil compounds can be used to characterize this species, and the various epidermis micromorphologicalfeatures are very useful for biosystematics taxonomic studies within Brassicaceae.

Co-inoculation of Debaryomyces hansenii and lactic acid bacteria: a strategy to improve the taste and odour profiles of dry sausages

The effects of the co-inoculation of Debaryomyces hansenii separately with 3 lactic acid bacteria(LAB),Lactobacillus sakei,Lactobacillus plantarum and Lactobacillus curvatus,on the taste and odour profi les of dry sausages were investigated.The co-inoculated sausages showed higher free amino acid and organic acid contents than the non-inoculated control and sausages inoculated with D.hansenii alone.Meanwhile,the sausages inoculated with D.hansenii+L.plantarum,D.hansenii+L.sakei and D.hansenii+L.curvatus had the highest contents of aldehydes,esters and alcohols,respectively.The results of electronic tongue,electronic nose and sensory evaluation demonstrated that compared with the sausage inoculated with D.hansenii,the sour taste and fl oral odour increased and the fatty odour decreased in the sausage inoculated with D.hansenii+L.sakei;this was more favourable for the development of a desirable fl avour in sausages.Moreover,the partial least squares regression analysis indicated that 10 taste and 33 odour compounds were mainly responsible for the differences in the flavour profiles among the sausages.Overall,these findings contributed to a more comprehensive understanding of the formation of sensory characteristics in dry sausages co-inoculated with yeast and LAB.

The Effect of Blood Lipid Profiles on Chronic Kidney Disease in a Prospective Cohort:Based on a Regression Discontinuity Design

Objective Previous studies on the association between lipid profiles and chronic kidney disease(CKD)have yielded inconsistent results and no defined thresholds for blood lipids.Methods A prospective cohort study including 32,351 subjects who completed baseline and follow-up surveys over 5 years was conducted.Restricted cubic splines and Cox models were used to examine the association between the lipid profiles and CKD.A regression discontinuity design was used to determine the cutoff value of lipid profiles that was significantly associated with increased the risk of CKD.Results Over a median follow-up time of 2.2(0.5,4.2)years,648(2.00%)subjects developed CKD.The lipid profiles that were significantly and linearly related to CKD included total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C),TC/HDL-C,and TG/HDL-C,whereas lowdensity lipoprotein cholesterol(LDL-C)and LDL-C/HDL-C were nonlinearly correlated with CKD.TC,TG,TC/HDL-C,and TG/HDL-C showed an upward jump at the cutoff value,increasing the risk of CKD by 0.90%,1.50%,2.30%,and 1.60%,respectively,whereas HDL-C showed a downward jump at the cutoff value,reducing this risk by 1.0%.Female and participants with dyslipidemia had a higher risk of CKD,while the cutoff values for the different characteristics of the population were different.Conclusion There was a significant association between lipid profiles and CKD in a prospective cohort from Northwest China,while TG,TC/HDL-C,and TG/HDL-C showed a stronger risk association.The specific cutoff values of lipid profiles may provide a clinical reference for screening or diagnosing CKD risk.

COVID-19 infection and inactivated vaccination:Impacts on clinical and immunological profiles in Chinese children with type 1 diabetes

BACKGROUND The coronavirus disease 2019(COVID-19)pandemic has been linked to an increased incidence of diabetes and diabetic ketoacidosis(DKA).However,the relationship between COVID-19 infection and progression to type 1 diabetes(T1D)in children has not been well defined.AIM To evaluate the influence of COVID-19 infection and inactivated vaccine adminis-tration on the progression of T1D among Chinese children.METHODS A total of 197 newly diagnosed patients with T1D were retrospectively enrolled from Children's Hospital of Fudan University between September 2020 and December 2023.The patients were divided into three groups based on their history of COVID-19 infection and vaccination:the infection group,the vacci-nation-only group,and the non-infection/non-vaccination group.Comprehensive clinical assessments and detailed immunological evaluations were performed to delineate the characteristics and immune responses of these groups.RESULTS The incidence of DKA was significantly higher in the COVID-19 infection group(70.2%)compared to the non-infection/non-vaccination group(62.5%)and vac-scination-only group(45.6%;P=0.015).Prior COVID-19 infection was correlated with increased DKA risk(OR:1.981,95%CI:1.026-3.825,P=0.042),while vacci-nation was associated with a reduced risk(OR:0.558,95%CI:0.312-0.998,P=0.049).COVID-19 infection mildly altered immune profiles,with modest dif-ferences in autoantibody positivity,lymphocyte distribution,and immunoglobulin levels.Notably,HLA-DR3 po-sitive children with a history of COVID-19 infection had an earlier T1D onset and lower fasting C-peptide levels than the HLA-DR3 negative children with a history of infection(both P<0.05).CONCLUSION COVID-19 infection predisposes children to severe T1D,characterized by enhanced DKA risk.Inactivated vaccination significantly lowers DKA incidence at T1D onset.These findings are valuable for guiding future vaccination and T1D risk surveillance strategies in epidemic scenarios in the general pediatric population.

Comparative study of cancer profiles between 2020 and 2022 using global cancer statistics(GLOBOCAN)

Background:The International Agency for Research on Cancer(IARC)released the latest estimates of the global burden of cancer.We present a comparison of cancer profiles between 2020 and 2022,leveraging data from the Global Cancer Statistics(GLOBOCAN).Methods:Cancer incidence and mortality data were sourced from two different years,2020 and 2022,in the GLOBOCAN database.We tracked changes in age-standardized incidence and mortality rates,as well as estimated numbers of new cancer cases and deaths of the 15 most common cancer types globally and in China between 2020 and 2022.Additionally,we conducted comparisons to assess alterations in the cancer burden and variations in mortality-to-incidence ratio(MIR)across different regions and countries for both 2020 and 2022.Results:Lung cancer remained the most common cancer and the leading cause of cancer death worldwide.The new cases of thyroid cancer witnessed a sharp increase in 2022.Conversely,the numbers of new cancer cases and deaths from stomach and esophageal cancer decreased significantly in 2022.The geographic distribution of cancer incidence and mortality across six continents in 2022 largely mirrored that of 2020.Higher Human Development Index(HDI)levels in countries corresponded with elevated rates of cancer incidence and mortality,consistent with the previous year.Among 185 countries or territories,China’s age-standardized incidence rate(ASIR)ranked 64th and its age-standardized mortality rate(ASMR)ranked 68th,aligning with global averages.Lung cancer continued to impose the greatest burden of incidence and mortality.Stomach,breast,and esophageal cancers showed declines in both case counts and ASIR.Noteworthy reductions in both ASMR and absolute mortality numbers were observed in liver,stomach,and esophageal cancers.The global MIR decreased from 0.516 in 2020 to 0.488 in 2022.MIR trends indicated an upward trajectory with decreasing HDI levels in both 2022 and 2020.While Canada,Germany,India,Italy,Japan,and the United Kingdom demonstrated increasing MIRs,China exhibited the most significant decrease,followed by Russia and the United States.Conclusions:The global landscape of cancer incidence and mortality in 2022 reflects ongoing trends observed in 2020.Cancer burdens vary notably across countries with differing socioeconomic statuses.Decreases in stomach,liver,and esophageal cancer cases and deaths signify progress in cancer control efforts.The decrease in the global MIRs highlights potential improvements in cancer management.

芒市华浙优系列水稻品种比较试验

芒市水稻品种多而杂,为筛选出适合芒市推广种植的优质高产高效水稻新品种,德宏州农业技术推广中心通过国家水稻产业技术体系从中国水稻研究所引进华浙优261、华浙优210、华浙优2005、华浙优717、华浙优新占、华浙优831、华浙优8088共7个华浙优系列水稻新品种,以芒市稻农种植较多、面积较大的杂交稻泰优390为对照,在德宏州农业技术推广中心试验田开展比较试验。结果表明:华浙优261全生育期132 d,长势繁茂,株型紧束,植株整齐,株高120.3 cm,分蘖力强,结实率89.23%,千粒重22.48 g,抗性强,实收产量8533.33kg/hm^(2),比对照品种增产520.00kg/hm^(2),是最适宜芒市种植的华浙优水稻品种。

Psycho-gastroenterological profile of an Italian population of children with disorders of gut-brain interaction:A case-control study

BACKGROUND Disorders of gut-brain interaction(DGBI)are common,but knowledge about their physiopathology is still poor,nor valid tools have been used to evaluate them in childhood.AIM To develop a psycho-gastroenterological questionnaire(PGQ)to assess the psycho-gastroenterological profile and social characteristics of a pediatric population with and without DGBI.METHODS One hundred and nineteen Italian children(age 11-18)were included:28 outpatient patients with DGBI(Rome IV criteria)and 91 healthy controls.They filled the PGQ,faces pain scale revised(FPS-R),Bristol stool chart,ga-strointestinal symptoms rating scale,state-trait anxiety inventory,Toronto alexithymia scale 20,perceived self-efficacy in the management of negative emotions and expression of positive emotions(APEN-G,APEP-G),irritable bowel syndrome-quality of life questionnaire,school performances,tobacco use,early life events,degree of digital-ization.RESULTS Compared to controls,patients had more medical examinations(35%of them went to the doctor more than five times),a higher school performance(23%vs 13%,P<0.05),didn’t use tobacco(never vs 16%,P<0.05),had early life events(28%vs 1%P<0.05)and a higher percentage of pain classified as 4 in the FPS-R during the examination(14%vs 7%,P<0.05).CONCLUSION Pediatric outpatients with DGBI had a higher prevalence of early life events,a lower quality of life,more medical examinations rising health care costs,lower anxiety levels.

Causal relationship between lipid profile and muscle atrophy:A bi-directional Mendelian randomization study

Background:The aim of this study was to analyze the bi-directional causal relation-ship between lipid profile and characteristics related to muscle atrophy by using a bi-directional Mendelian randomization(MR)analysis.Methods:The appendicular lean mass(ALM),whole body fat-free mass(WBFFM)and trunk fat-free mass(TFFM)were used as genome-wide association study(GWAS)data for evaluating muscle mass;the usual walking pace(UWP)and low grip strength(LGS)were used as GWAS data for evaluating muscle strength;and the triglycerides(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL),low density lipo-protein cholesterol(LDL),apolipoprotein A-1(Apo A-1),and apolipoprotein B(Apo B)were used as GWAS data for evaluating lipid profile.For specific investigations,we mainly employed inverse variance weighting for causal estimation and MR-Egger for pleiotropy analysis.Results:MR results showed that the lipid profile predicted by genetic variants was negatively correlated with muscle mass,positively correlated with UWP,and was not causally correlated with LGS.On the other hand,the muscle mass predicted by genetic variants was negatively correlated with lipid profile,the UWP predicted by genetic variants was mainly positively correlated with lipid profile,while the LGS pre-dicted by genetic variants had no relevant causal relationship with lipid profile.Conclusions:Findings of this MR analysis suggest that hyperlipidemia may affect muscle mass and lead to muscle atrophy,but has no significant effect on muscle strength.On the other hand,increased muscle mass may reduce the incidence of dyslipidemia.

不同采高综采工作面液压支架封闭控尘装置系列化研究

为了解决不同采高综采面液压支架降柱移架粉尘污染问题,开展了液压支架封闭控尘装置系列化研究。基于降柱移架产尘特点和液压支架结构,研发了适用于4 m以下、4~6 m、6 m、6 m以上采高综采面的架间喷雾引射抽尘净化装置和拉簧式、扭簧式、滑移式液压支架防尘装置,在源头降低支架产尘90%以上。该系列装置在国能集团、陕煤集团下属多个矿井推广应用,受到矿方一致好评。

周春芽“园林”系列作品研究

周春芽的“园林”系列作品主要以上海豫园、扬州与苏州的园林为题材,他以西方油画的表现形式呈现了精巧与别致的中国古典园林设计,以流畅、块状的笔触表现出他的情感与所思所想,画面效果呈现出鲜明的文人画特征。周春芽“园林”系列作品的文人画特点体现在周春芽的文人情怀、“园林”系列作品的题材选择、绘画语言、艺术追求四个方面。其在作品中展现了不求形似的美学理念与返璞归真的精神境界,创新了文人画的表现面貌。

汽车EMC法规/标准系列会议线上召开

2025年1月9-10日,负责修订UN R10法规的IWG-EMC工作组与负责修订CISPR 12中动态工况整车辐射发射测试的特别工作组(STF)分别以线上形式召开了工作组会议。此次UN R10会议对UN R10第八版修订提案进行了探讨,明确了未来IWG-EMC工作组提案/投票形式。动态工况STF小组受IWG-EMC委托,对车辆不同加载状态下的摸底数据进行了讨论。

中华优秀传统文化的符码转译与意义构建——以河南卫视“中国节日”系列节目为例

河南卫视“中国节日”系列节目以中华优秀传统文化为内核、综艺晚会为载体,倾注共通情感与审美意趣,搭建了全新的中华古典美学视听场域;对中华优秀传统文化符码进行现代阐释与微观叙事,在化古通今的巧妙腾挪中,实现现代具体语境中的意义增容与生机重焕;时间与空间记忆的注入,给予观众深度参与对话的可能性,激活受众深蕴于心的文化基因与民族身份认同。梳理其中的符码转译、叙事逻辑与意义建构策略,有助于为后续文化节目创新提供范式指引,推动中华优秀传统文化的创造性转化与创新性发展。

重生系列微短剧视频特征与传播热度影响因素探究

近年来,微短剧市场蓬勃发展,重生系列破圈而出。本文针对抖音平台重生系列微短剧用户参与度差异,创新引入传播热度这一概念,作为衡量重生系列微短剧用户参与度的指标,并运用熵权法量化分析。研究发现,重生系列微短剧的主要特征是:传播主体主要是自媒体博主;呈现形式多为竖屏,视频时长通常为2~4分钟;在传播内容上,题材突出快感和爽感,运用恰当的背景音乐增强故事的表现力,标题运用表意清晰明确的陈述句。进一步证明了重生系列微短剧的台词使用网络热词次数、背景音乐使用次数与传播热度为正相关关系,而且背景音乐的使用次数对传播热度有显著的正向影响。最后,提出了提高微短剧传播热度的建议,为发展精品化微短剧提供借鉴。

系列化精细控压钻井设备研究

现阶段,经济市场不断发展,油气资源日益紧张,为切实强化油气勘探开发质量,解决在复杂地层背景下钻井工作的实际风险以及问题,应加强对精细控压钻井设备的分析。通过对其进行合理应用,掌握实际应用原理,切实避免井漏以及卡钻等多种现象,降低钻井成本的同时,在一定程度上弱化钻井工作的复杂程度。对此,本文针对系列化精细控压钻井设备展开研究,并着重推广相应控井钻压技术,有效提高钻井时效,切实推动油田行业实现可持续、稳定发展。

“互联网+教育”模式在Web系列课程中的创新与探究

文章针对现有“互联网+教育”模式在Web系列课程应用中存在的线上、线下资源缺乏、教学资源单一、教学资源没有针对性等问题进行了改进,提出了对应的解决方案并在实践教育教学过程中进行了试验。实验结果表明,文章提出的“互联网+教育”模式的创新方法在Web系列课程教学中起到了积极性作用,提高了学生Web系列课程的成绩、降低了相关课程挂科率。在软件开发过程中,提高了学生发现错误、解决错误的能力,同时,还提高了学生的创新思维能力。