Failure evaluation and control factor analysis of slope block instability along traffic corridor in Southeastern Tibet

The instability of slope blocks occurred frequently along traffic corridor in Southeastern Tibet(TCST),which was primarily controlled by the rock mass structures.A rapid method evaluating the control effects of rock mass structures was proposed through field statistics of the slopes and rock mass structures along TCST,which combined the stereographic projection method,modified M-JCS model,and limit equilibrium theory.The instabilities of slope blocks along TCST were then evaluated rapidly,and the different control factors of instability were analyzed.Results showed that the probabilities of toppling(5.31%),planar(16.15%),and wedge(35.37%)failure of slope blocks along TCST increased sequentially.These instability modes were respectively controlled by the anti-dip joint,the joint parallel to slope surface with a dip angle smaller than the slope angle(singlejoint),and two groups of joints inclined out of the slope(double-joints).Regarding the control effects on slope block instability,the stabilization ability of doublejoints(72.7%),anti-dip joint(67.4%),and single-joint(57.6%)decreased sequentially,resulting in different probabilities of slope block instability.Additionally,nearby regional faults significantly influenced the joints,leading to spatial heterogeneity and segmental clustering in the stabilization ability provided by joints to the slope blocks.Consequently,the stability of slope blocks gradually weakened as they approached the fault zones.This paper can provide guidance and assistance for investigating the development characteristics of rock mass structures and the stability of slope blocks.

PEGylated PLGA Nanoparticles as Tumor Ecrosis Factor-α Receptor Blocking Peptide Carriers:Preparation,Characterization and Release in vitro

To assess the merits of PEGylated poly （lactic-co-glycolic acid） （PEG-PLGA） nanoparticles as drug carriers for tumor necrosis factor-α receptor blocking peptide （TNFR-BP）, PEG-PLGA copolymer, which could be used to prepare the stealth nanoparticles, was synthesized with methoxypolyethyleneglycol, DL-lactide and glycolide. The structure of PEG-PLGA was confirmed with ^1H-NMR and FT-IR spectroscopy, and the molecular weight （MW） was determined by gel permeation chromatography. Fluorescent FITC-TNFR- BP was chosen as model protein and encapsulated within PEG-PLGA nanoparticles using the double emulsion method. Atomic force microscopy and photon correlation spectroscopy were employed to characterize the stealth nanoparticles fabricated for morphology, size with polydispersity index and zeta potential. Encapsulation efficiency （EE） and the release of FITC-TNFR-BP in nanopartieles in vitro were measured by the fluorescence measurement. The stealth nanoparticles were found to have the mean diameter less than 270 nm and zeta potential less than -20 mV. In all nanoparticle formulations, more than 45% of EE were obtained. FITC-TNFR-BP release from the PEG-PLGA nanoparticles exhibited a biphasic pattern, initial burst release and consequently sustained release. The experimental results show that PEG-PLGA nanoparticles possess the potential to develop as drug carriers for controlled release applications of TNFR-BP.

Algorithms for Finding the Inverses of Factor Block Circulant Matrices

In this paper,algorithms for finding the inverse of a factor block circulant matrix, a factor block retrocirculant matrix and partitioned matrix with factor block circulant blocks over the complex field are presented respectively.In addition,two algorithms for the inverse of a factor block circulant matrix over the quaternion division algebra are proposed.

BLU Factorization for Block Tridiagonal Matrices and Its Error Analysis

A block representation of the BLU factorization for block tridiagonal matrices is presented. Some properties on the factors obtained in the course of the factorization are studied. Simpler expressions for errors incurred at the process of the factorization for block tridiagonal matrices are considered.

BLOCK SPECTRUM CHARACTERISTICS AND FATIGUE CRACK RANDOM GROWTH

Two parameters,block spectrum intensity Seq and spectrum shape factor a,which describe the characteristics of the loading block spectrum are defined,and the relationship between the parameters and fatigue crack propagation behaviours is investigated.It is shown that the spectrum intensity is an 'average drive force' of fatigue crack propagation,and the variance of fatigue crack size at a given fatigue life is closely related to the spectrum shape factor α.

Seismic dynamic monitoring in CO_2 flooding based on characterization of frequency-dependent velocity factor

The phase velocity of seismic waves varies with the propagation frequency, and thus frequency-dependent phenomena appear when CO2 gas is injected into a reservoir. By dynamically considering these phenomena with reservoir conditions it is thus feasible to extract the frequency-dependent velocity factor with the aim of monitoring changes in the reservoir both before and after CO2 injection. In the paper, we derive a quantitative expression for the frequency-dependent factor based on the Robinson seismic convolution model. In addition, an inversion equation with a frequency-dependent velocity factor is constructed, and a procedure is implemented using the following four processing steps： decomposition of the spectrum by generalized S transform, wavelet extraction of cross-well seismic traces, spectrum equalization processing, and an extraction method for frequency-dependent velocity factor based on the damped least-square algorithm. An attenuation layered model is then established based on changes in the Q value of the viscoelastic medium, and spectra of migration profiles from forward modeling are obtained and analyzed. Frequency-dependent factors are extracted and compared, and the effectiveness of the method is then verified using a synthetic data. The frequency-dependent velocity factor is finally applied to target processing and oil displacement monitoring based on real seismic data obtained before and after CO2 injection in the G89 well block within Shengli oilfield. Profiles and slices of the frequency-dependent factor determine its ability to indicate differences in CO2 flooding, and the predicting results are highly consistent with those of practical investigations within the well block.

数字电视接收机中的Block-DFE算法研究

针对地面数字电视传输国家标准(DTMB),研究并提出一种新的数据块判决反馈均衡算法。该算法利用QR因式分解以解决最小二乘方探测问题。通过Matlab仿真对传统判决反馈均衡算法(DFE)、循环构造频域均衡算法(OLA-FDE)和数据块判决反馈均衡算法(Block-DFE)在不同信噪比下的性能作了比较,验证了Block-DFE算法的优越性。

膝骨关节炎疼痛领域热点与前沿的可视化分析

背景:疼痛是膝骨关节炎的主要症状,严重影响老年患者的生活质量。膝骨关节炎疼痛机制复杂,涉及多组织、多学科,需要可视化分析了解其主要内容与研究热点。目的:运用文献计量学可视化软件分析归纳膝骨关节炎疼痛领域的前沿内容和研究热点。方法:从Web of Science核心合集(Web of Science Core Collection,WoSCC)中检索2014-2024年膝骨关节炎疼痛领域的相关文献,运用Citespace、VOSviewer和Bibliometrix R-package三个可视化软件进行文献计量与可视化分析。结果与结论:①膝骨关节炎疼痛研究的发文量呈现逐年递增的趋势;②美国、中国、澳大利亚是该领域10年内发文量排名前三的国家;波士顿大学、悉尼大学、弗洛里达大学是发文量前三的科研机构;《OSTEOARTHRITIS AND CARTILAGE》是出版该领域文献最多的期刊,《PAIN》则是该领域被引次数最多的期刊;发文量最多的作者是Fillingim Roger B,该领域的核心作者之间已经建立了一些稳定的团队,但国际性合作尚有欠缺;③膝骨关节炎疼痛患者的日常管理(运动、心理、智能管理)、疼痛的炎症机制、蛋白组学、联合用药、中枢敏化和疼痛调节是膝骨关节炎疼痛研究的重点内容;人工智能辅助、体外冲击波疗法、射频消融术、神经冷冻术、关节腔内注射血液或细胞制剂可能是该领域的研究前沿。

3D Identification and Stability Analysis of Key Surface Blocks of Rock Slope

Complicated geological structures make it difficult to analyze the stability of rock slopes, such as faults, weak intercalated layers or joint fissures. Based on 3D geological modeling and surface block identifying methods, an integrated methodology framework was proposed and realized to analyze the stability of surface blocks in rock slopes. The surface blocks cut by geological structures, fissures or free faces could be identified subjected to the four principles of closure, completeness, uniqueness and validity. The factor of safety(FOS)of single key block was calculated by the limit equilibrium method. If there were two or more connected blocks, they were defined as a block-group. The FOS of a block-group was computed by the Sarma method. The proposed approach was applied to an actual rock slope of a hydropower project, and some possible instable blocks were demonstrated and analyzed visually. The obtained results on the key blocks or block-groups provide essential information for determining potential instable region of rock slopes and designing effective support scheme in advance.

Stellate ganglion block reduces inflammation and improves neurological function in diabetic rats during ischemic stroke

Diabetes mellitus is an independent risk factor for ischemic stroke.Both diabetes mellitus and stroke are linked to systemic inflammation that aggravates patient outcomes.Stellate ganglion block can effectively regulate the inflammatory response.Therefore,it is hypothesized that stellate ganglion block could be a potential therapy for ischemic stroke in diabetic subjects.In this study,we induced diabetes mellitus in rats by feeding them a high-fat diet for 4 successive weeks.The left middle cerebral artery was occluded to establish models of ischemic stroke in diabetic rats.Subsequently,we performed left stellate ganglion block with 1%lidocaine using the percutaneous posterior approach 15 minutes before reperfusion and again 20 and 44 hours after reperfusion.Our results showed that stellate ganglion block did not decrease the blood glucose level in diabetic rats with diabetes mellitus but did reduce the cerebral infarct volume and the cerebral water content.It also improved the recovery of neurological function,increased 28-day survival rate,inhibited Toll like receptor 4/nuclear factor kappa B signaling pathway and reduced inflammatory response in the plasma of rats.However,injection of Toll like receptor 4 agonist lipopolysaccharide 5 minutes before stellate ganglion block inhibited the effect of stellate ganglion block,whereas injection of Toll like receptor 4 inhibitor TAK242 had no such effect.We also found that stellate ganglion block performed at night had no positive effect on diabetic ischemic stroke.These findings suggest that stellate ganglion block is a potential therapy for diabetic ischemic stroke and that it may be mediated through the Toll like receptor 4/nuclear factor kappa B signaling pathway.We also found that the therapeutic effect of stellate ganglion block is affected by circadian rhythm.

Application of malignant pleural effusion cell blocks in the diagnosis and personalized treatment of advanced non-small cell lung carcinoma

Objective The aim of the study was to investigate the efficacy of immunocytochemistry and related gene detection using cell block for the diagnosis and individualized treatment of advanced lung cancer.Methods Sixty-five malignant pleural effusion specimens were collected to make cell blocks, which were used for hematoxylin and eosin(H&E) staining, immunocytochemical studies, and gene sequencing of the tumors to guide the individualized diagnoses and treatment of the given tumors. Results The tumor cells in the cell block sections were abundant in number with high quality cellular structures, and the histological morphological characteristics were partially maintained. Immunocytochemical staining was helpful in identifying the cell origin and tumor classification, and amplification refractory mutation system(ARMS) was used to determine the mutation status of epidermal growth factor receptor(EGFR). Of the 65 samples, 50 had a diagnosis of adenocarcinoma, 7 were pulmonary squamous cells, 6 were small cell carcinoma of the lung, and 2 were mesothelioma. The morphological features of the tumors were as follows: acinar formation, papillary and single cells for adenocarcinoma;intercellular bridges for squamous cell carcinoma;and morphology of the small cells is similar to that of the smear. Correlating with the results of immunocytochemical staining and clinical data analysis, 40 cases were confirmed as pulmonary adenocarcinoma, with an additional 4 cases of breast cancer, 3 cases of ovarian adenocarcinoma, and 3 cases of colorectal adenocarcinoma. Of the 47 non-small cell lung carcinoma(NSCLC) patients, EGFR mutations were detected in 26 cases(55.3%) by ARMS, with four mutation types: exon 19 deletion(13 cases, 50.0%), exon 2l point mutations L858R(11 cases, 42.3%) and L861Q(1 case, 3.8%), and exon 18 point mutation G719X(1 case, 3.8%). Conclusion Malignant pleural effusion cell blocks combined with immunocytochemical markers and molecular pathology are helpful for the diagnosis of advanced tumors, the identification of tumor properties and histological tumor origin, and the selection of individualized treatment for advanced lung cancer.

Effects of ultrasound-guided thoracic paravertebral block combined with general anesthesia on the secretion of pain-related mediators after modified radical mastectomy

Objective: To investigate the effects of ultrasound-guided thoracic paravertebral block combined with general anesthesia on the secretion of pain-related mediators after modified radical mastectomy. Methods: A total of 108 patients with breast cancer who were treated with modified radical mastectomy in this hospital between July 2015 and February 2017 were divided into the control group (n=54) and paravertebral block group (n=54) by random number table. Control group received routine general anesthesia, and paravertebral block group received ultrasound-guided thoracic paravertebral block combined with general anesthesia. The differences in serum levels of pain mediators, inflammatory factors and stress hormones were compared between the two groups of patients immediately after surgery (T0), 6h after surgery (T1), 12h after surgery (T2) and 24h after surgery (T3). Results: At T0, there was no statistically significant difference in serum levels of pain mediators, inflammatory factors and stress hormones between the two groups. At T1, T2 and T3, serum pain mediators NPY, PGE2 and 5-HT levels of paravertebral block group were lower than those of control group;serum inflammatory factors IL-1, IL-6, TNF-α and MCP-1 levels were lower than those of control group;serum stress hormones ACTH, Cor, AngⅠ and AngⅡ levels were lower than those of control group. Conclusion: ultrasound-guided thoracic paravertebral block combined with general anesthesia can effectively reduce the release of pain mediators and relieve the systemic inflammatory stress response after modified radical mastectomy.

断块油藏高含水井关井后剩余油再动用运移规律微观模拟

基于微观可视化光刻玻璃模型,从微观角度定性、定量研究了断块油藏高含水井关井后剩余油再动用运移规律,并开展了影响因素分析。结果表明:水驱后关井期间剩余油再动用类型主要为滴状、柱状和簇状。关井期间剩余油会沿模型倾斜方向向高部位运移聚集,有利于后续水驱阶段进一步提高驱油效率。地层倾角的增大、原油黏度的减小有利于剩余油再动用;关井时间的增加有利于剩余油向高部位采出端接近聚集;后续水驱阶段注入速度的增大会增加波及面积。

左侧星状神经节阻滞对心内直视术患者血流动力学及预后的影响

目的 探究左侧星状神经节阻滞对心内直视术患者血流动力学及预后的影响。方法 选取111例心内直视术患者作为研究对象,依据随机数字分配法分为观察组(56例)和对照组(55例)。对照组患者给予局部麻醉(局麻)后采集右侧颈内的血液标本并实行心内直视术,观察组患者在对照组基础上实行左侧星状神经节阻滞术。比较两组患者在逆行置管后(T0)、主动脉开放10 min(T1)、术后2 h(T2)、术后6 h(T3)、术后24 h(T4)时的血流动力学指标、血浆炎症因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)、白细胞介素-10(IL-10)]水平及血浆神经组织蛋白(S100β)、神经元特异性烯醇化酶(NSE)水平。结果 两组患者T0~T4时平均动脉压(MAP)、心率(HR)无明显差异(P>0.05)。两组患者T0时血浆炎症因子水平无明显差异(P>0.05);两组患者T1~T4时TNF-α、IL-8、IL-10均高于T0时,且观察组患者T1~T4时TNF-α、IL-8、IL-10均优于对照组(P<0.05)。两组患者TNF-α、IL-8、IL-10在T1~T4时随着时间变化先升高后降低,以T2时水平达到最高。T0~T4时,观察组患者S100β分别为(0.33±0.10)、(1.26±0.25)、(1.02±0.04)、(0.67±0.15)、(0.43±0.11)μg/L, NSE分别为(7.68±0.59)、(10.09±0.78)、(9.41±0.62)、(9.10±0.66)、(8.01±0.51)μg/L;对照组患者S100β分别为(0.31±0.08)、(1.52±0.35)、(1.18±0.12)、(1.05±0.33)、(0.52±0.25)μg/L, NSE分别为(7.56±0.65)、(11.35±1.33)、(10.66±1.01)、(10.56±1.02)、(8.98±0.68)μg/L。相比于T0时,两组患者的S100β、NSE水平在T1~T4时均有所上升(P<0.05);相比于对照组,观察组患者的S100β及NSE水平在T1~T4时均降低(P<0.05)。结论 左侧星状神经节阻滞对心内直视术患者血流动力学影响较小,且可减轻患者体内的炎症反应,改善神经因子。

伐昔洛韦联合神经阻滞对急性期带状疱疹性神经痛临床疗效的影响

目的:探讨伐昔洛韦联合神经阻滞对急性期带状疱疹性神经痛患者睡眠质量及血清疼痛介质指标、炎症因子表达的影响。方法:前瞻性选取2020年5月—2023年5月广州医科大学附属第六医院收治的60例急性期带状疱疹性神经痛患者作为本次研究对象,按照随机数字表法分为治疗A组和治疗B组,各30例。治疗A组予以伐昔洛韦治疗,治疗B组则在治疗A组基础上加用神经阻滞治疗。评估两组临床疗效、匹兹堡睡眠质量指数(PSQI)评分、血清疼痛介质指标、炎症因子表达水平及不良反应发生情况。结果:治疗B组临床治疗总有效率为93.33%,显著高于治疗A组的63.33%,差异有统计学意义(P<0.05)。干预后,两组PSQI评分较干预前均显著改善,且治疗B组PSQI评分显著优于治疗A组,差异均有统计学意义(P<0.05)。干预后,治疗B组血清疼痛介质指标较干预前均明显改善,且治疗B组β-内啡肽(β-EP)指标明显高于治疗A组,血浆P物质(SP)及一氧化氮(NO)指标则明显低于治疗A组,差异均有统计学意义(P<0.05)。干预后,治疗B组炎症因子表达水平较干预前均明显改善,且治疗B组γ干扰素(IFN-γ)水平明显高于治疗A组,而白细胞介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)水平则明显低于治疗A组,差异均有统计学意义(P<0.05)。治疗B组发生的头晕、胃肠不适及皮肤瘙痒总发生率显著低于治疗A组,差异有统计学意义(P<0.05)。结论:伐昔洛韦联合神经阻滞治疗急性期带状疱疹性神经痛患者,其临床疗效更为显著,可有效改善患者的睡眠质量、血清疼痛介质指标及炎症因子表达水平,减少不良反应的发生率。

星状神经节阻滞对大鼠炎症反应的作用及其机制研究

目的:观察星状神经节阻滞(SGB)对急性腹膜炎大鼠血清炎症因子的影响和α7nAChR蛋白表达情况,旨在深入探讨SGB对大鼠急性腹膜炎炎症反应的作用机制。方法:40只SPF级雄性大鼠随机分为4组:对照组(Control)、急性腹膜炎组(AP)、急性腹膜炎+星状神经节阻滞组(AP+SGB)、急性腹膜炎+星状神经节阻滞+α7nAChR抑制剂甲基牛扁亭碱组(AP+SGB+MLA),每组10只。将2%乙酸1 ml/100 g分别注入AP组、AP+SGB组和AP+SGB+MLA组大鼠腹腔内建立急性腹膜炎模型。ELISA法检测血清中IL-18和TNF-α的浓度。Western Blot法检测腹膜组织中α7nAChR蛋白水平,RT-qPCR法检测腹膜组织中α7nAChR mRNA的表达情况。结果:与Control组对比,其余3组血清IL-18和TNF-α水平增高(P<0.05);与AP组对比,AP+SGB组血清IL-18和TNF-α水平降低(P<0.05);与AP+SGB组对比,AP+SGB+MLA组血清IL-18和TNF-α水平增高(P<0.05)。腹膜组织α7nAChR蛋白和α7nAChR mRNA表达水平的比较:与Control组对比,其余3组α7nAChR蛋白和α7nAChR mRNA表达水平均增高(P<0.05);与AP组对比,AP+SGB组α7nAChR蛋白和α7nAChR mRNA表达水平增高(P<0.05);与AP+SGB组相比,AP+SGB+MLA组α7nAChR蛋白和α7nAChR mRNA表达水平降低(P<0.05)。结论:星状神经节阻滞治疗可以减少大鼠炎症因子的产生,抑制急性腹膜炎的炎症反应,其抗炎机制可能与α7nAChR介导的胆碱能抗炎通路(CAP)有关。

街区建成环境对空气质量影响的研究进展

街区作为建成环境的有机组成部分,是构建绿色生态城市的基本单元,也是推动健康城市建设的有效切入点,研究街区建成环境对空气质量的影响能够为街区尺度环境改善提供理论和实践参考。文章梳理了从中国知网数据库筛选的381篇相关文献,在分析研究视角、历程、热点的基础上,总结了街区建成环境对空气质量的影响因素、街区空气污染物时空数据获取技术,以及提升街区建成环境空气质量的策略,从指标调控组合、管控指标制定、建成环境更新、健康街区打造等方面展望了未来发展趋势,以期为街区规划建设、污染治理、调控施策和法规制定提供参考。

小儿上肢骨折手术采用臂丛神经阻滞复合全身麻醉的应激反应分析

目的探讨小儿上肢骨折手术采用臂丛神经阻滞复合全身麻醉的应激反应。方法回顾性选取滕州市中心人民医院于2020年3月—2023年3月诊治的120例上肢骨折患儿的临床资料,按照不同麻醉方法将患儿分为参考组(n=60)和研究组(n=60)。参考组实施全身麻醉,研究组予以臂丛神经阻滞复合全身麻醉,比较两组血流动力学指标、应激反应和炎症因子水平。结果参考组与研究组T0(麻醉前)心率以及平均动脉压对比,差异无统计学意义(P均>0.05);T1(置入喉罩时)、T2(拔除喉罩时)时研究组心率以及平均动脉压低于参照组,差异有统计学意义(P均<0.05)。参考组与研究组术前5 min应激反应指标对比,差异无统计学意义(P>0.05);术后6h,研究组皮质醇、肾上腺素和去甲肾上腺素水平低于参考组,差异有统计学意义(P均<0.05)。术前参考组与研究组炎症因子水平对比,差异无统计学意义(P>0.05);术后3 d,研究组的肿瘤坏死因子-α(26.01±5.34)ng/L、C反应蛋白(8.71±1.25)mg/L和白介素-1β(2.03±0.34)ng/L低于参考组,差异有统计学意义(t=12.865、11.849、18.676,P均<0.05)。结论臂丛神经阻滞复合全身麻醉可以降低患儿的应激反应,炎症反应较小,同时血流动力学水平波动较小。

巫山坎区块嘉二1亚段储层控制因素研究

川东巫山坎区块下三叠统嘉二1亚段云岩油气资源潜力大。对嘉二1亚段沉积、储层特征及控制因素的研究表明,巫山坎区块位于局限台地的台内点滩上,受较强水动力影响,具备储层形成和演化的基础。嘉二1亚段储集岩以泥-细粉晶云岩、粗粉晶云岩为主,镜下溶孔、裂缝发育。由于该区的获气井位于构造顶部,后期溶蚀作用较强,在云岩中产生了一定的溶蚀孔,而构造作用改造形成的裂缝是储层中油气渗流的主要通道。因此,在巫山坎区块嘉二1亚段储层的形成与演化过程中,台内点滩是储层发育的有利沉积环境;白云岩化及溶蚀作用控制着储层孔隙的发育程度;构造作用改善了储层的渗透能力,储层有沿构造高点和轴线分布的趋势。

鄂尔多斯盆地神府区块深部煤层气体积压裂实践与认识

鄂尔多斯盆地东缘神府深煤层大气田探明地质储量超千亿方,实现该地区深部煤层气高效开发对保障国家能源供应具有重要意义。但是,由于深煤层地质环境复杂,具有高地应力、中高温度、特低渗透、强非均质性、割理/裂隙发育等特点,导致现有中浅煤层压裂改造技术难以完全适用于深煤层,其施工规模与参数仍处于探索阶段。为了探究与深煤层地质条件相适应的增产改造技术,以鄂尔多斯盆地神府区块为地质背景,以深煤层大规模体积压裂为工程实践,围绕“极限动用+均衡扩展+有效支撑”的设计理念,提出“少段多簇适度密切割+等孔径深穿透限流射孔+复合液造缝(高黏液体破岩+低黏液体造复杂缝)+大排量高强度加砂+前置酸液降低破裂压力+多粒径组合支撑剂”为核心的体积压裂技术,并引入地质−工程−智能一体化压后评估方法,通过压裂−产能双重智能拟合校正,精细刻画了储层改造体积(SRV)和气体泄流体积(DRV),预测了不同压裂规模及井型条件下的最终可采储量EUR。最后,通过统计神府区块深煤层压裂井地质、工程和产量特征数据,采用随机森林算法量化分析了影响深部煤层气产能的主控因素。实践结果表明:采用上述大规模体积压裂技术,已投产的直/定向井最高日产气量超过1×10^(4) m^(3),水平井最高日产气量超过2×10^(4 )m^(3),说明深煤层可压性良好、开发潜力巨大;深部煤层气峰值产气量的主要影响因素为:煤层含气量、煤层厚度和加砂强度;累积产气量的主要影响因素为:煤层含气量、加砂强度和总砂量。