A Study on Semantic Coherence in Discourse Translation from the Perspective of Thematic Progression Patterns

This paper discusses the semantic coherence in discourse translation from the perspective of thematic progression, and holds that in translating a discourse the translator should spare no effort to retain the original thematic progression pattern in the target text, but when the original thematic progression pattern cannot be directly retained, the translator should construct his own thematic structure and substitute progression pattern in the target text, thus to make it as readable as the original text without distorting the original information structure. This paper also attempts to explore the circumstances under which the original thematic progression pattern can be retained and the substitute should be reconstructed.

A Case Study of Commencement Speech from the Perspective of Thematic Progression Pattern

As a unique discourse genre,public speaking plays an important role in conveying the speaker’s position,gaining consensus of public opinion,even initiating a call and arousing the audience’s actions.Based on a commencement speech from the School of Medicine of Tsinghua university,this paper identifies four types of thematic progression pattern,their use and discourse features,the speech purpose and its gist,the distribution of different types of thematic progression pattern within the framework of the Theme-Rheme progression pattern of Systemic Functional Linguistics.By doing so,the speaker’s state position,alma mater position and her individual position are conveyed respectively and it is of significance to provide reference for the organization method of speech discourse during the special epidemic period.

The Study of Thematic Progression Patterns in TEM8 News Discourse

This paper studies thematic progression patterns of 20 news items in TEM8 based on the theories of theme and rheme.The use frequencies of three thematic progression patterns are calculated and analyzed to propose some implications on improving listening comprehension.

The Thematic Progression Patterns and Text Analysis of Necklace

This paper is an attempt to discuss the relationship between genre and the thematic progression. Through qualitative analysis of the short story Necklace of Maupassant, it is found that narrative texts always use the linear theme pattern and the constant theme pattern, and sometimes the derived theme pattern and other patterns are also used to facilitate the text coherence and the plot development. Thematic progression in various fields has been studied extensively, but the analysis aims to short story is less than text coherence and other aspects. And there are some implications to teaching, writing, reading, and translation.

Disease control and failure patterns of unresectable hepatocellular carcinoma following transarterial radioembolization with yttrium-90 microspheres and with/without sorafenib

BACKGROUND Impressive survival outcome of our previous study in unresectable hepatocellular carcinoma(HCC)patients undergoing yttrium-90 glass microspheres transarterial radioembolization(TARE)with/without sorafenib according to individuals’disease burden,i.e.,intrahepatic tumor load(IHT)and adverse disease features(ADFs)might partly be confounded by other treatments and underlying hepatic function.Therefore,a dedicated study focusing on treatment response and assessment of failure patterns might be a way to improve treatment outcome in addition to patient selection based on the disease burden.AIM To assess the tumor response,disease control and patterns of disease progression following TARE with/without sorafenib in unresectable HCC patients.METHODS This retrospective study was conducted in successful TARE procedures with available pre-and post-treatment imaging studies(n=169).Three treatment subgroups were(1)TARE only(TARE_alone)for IHT≤50%without ADFs,i.e.,macrovascular invasion,extrahepatic disease(EHD)and infiltrative/ill-defined HCC(n=63);(2)TARE with sorafenib(TARE_sorafenib)for IHT>50%and/or presence of ADFs(n=81);and(3)TARE only for patients who could not receive sorafenib due to contraindication or intolerance(TARE_no_sorafenib)(n=25).Objective response rate(ORR;consisted of complete response(CR)and partial response(PR)),disease control rate(DCR;consisted of CR,PR and stable disease)and failure patterns of treated,intrahepatic and extrahepatic sites were assessed using the modified response evaluation criteria in solid tumors.Time to progression(TTP)was calculated from TARE to the first radiologic progression at any site using Kaplan-Meier method.Identification of prognostic factors for TTP using the univariate Kaplan-Meier method and multivariate Cox proportional hazard model were performed in major population subgroups,TARE_alone and TARE_sorafenib.RESULTS The median radiologic follow-up time was 4.4 mo(range 0.5-48.8).In treated area,ORR was highest in TARE_sorafenib(53.1%),followed by TARE_alone(41.3%)and TARE_no_sorafenib(16%).In intrahepatic area,DCR remained highest in TARE_sorafenib(84%),followed by TARE_alone(79.4%)and TARE_no_sorafenib(44%).The overall DCR was highest in TARE_alone(79.4%),followed by TARE_sorafenib(71.6%)and TARE_no_sorafenib(40%).Dominant failure patterns were intrahepatic for both TARE_alone(44.5%)and TARE_sorafenib(38.4%).Extrahepatic progression was more common in TARE_sorafenib(32%)and TARE_no_sorafenib(40%)than in TARE_alone(12.7%).TTP was longest in TARE_alone(8.6 mo;95%CI:3.4-13.8),followed by TARE_sorafenib(5.1 mo;95%CI:4.0-6.2)and TARE_no_sorafenib(2.7 mo;95%CI:2.2-3.1).Pre-existing EHD(HR:0.37,95%CI:0.24-0.56,P<0.001)was a sole prognostic factor for TTP in TARE_sorafenib with no prognostic factor for TTP in TARE_alone.CONCLUSION TARE with/without sorafenib according to individuals’disease burden provided DCR approximately 70%with intrahepatic progression as dominant failure pattern.Extrahepatic progression was more common in procedures with initially high disease burden.

Correlation of basic indicators with stages of keratoconus assessed by Pentacam tomography

AIM: To evaluate the diagnostic efficiency of basic indicators and find characteristic indicators for keratoconus (KC) at adjacent stages, and to assess the progression pattern of KC. METHODS: One hundred and eight (41 subclinical, 40 moderate, and 27 severe) keratoconic patients (108 eyes) and 105 myopic patients (105 eyes) as controls were recruited in this prospective, comparative case series study. Pentacam topography was performed. Receiver operating -characteristic curves were used to get the characteristic indicators. RESULTS: The most efficient distinguishing index between the subclinical KC and the controls was posterior elevation value (PEV, AUC =0.882), with the highest specificity being 93.8%. Corneal thickness (AUC=0.852) and posterior inferior-superior value (I-S) ranked second and third (AUC=0.776). When KC became moderate, PEV remained to be of the highest diagnostic efficiency (AUC=0.988), followed by the anterior elevation value (AUC=0.986) and other parameters of anterior surface. The diagnostic value increased significantly in the anterior curvature indices (all AUC >0.900) and appeared in the anterior best fitting sphere radius (AUC= 0.919) when KC developed into the severe stage. CONCLUSION: In the subclinical stage of KC, PEV, thickness, and posterior I-S had important diagnostic values, and elevation values remained most efficient when KC developed to the moderate stage. The anterior curvature indices were most characteristic when KC became severe. KC first appeared in the inferior cornea of posterior surface, but the feature of protrusion formed at the moderate stage.

Application of Theme-Rheme Theory to News Translation

News,as an important way of communication is playing a crucial role in the comprehensive development of our country ranging from fast economic expansion,giant leap in science and technology,and progress in every aspects of social life.There is no doubt that News translation,in its specific and special way serves as an effective tool in spreading all sorts of information to a larger base of readers as rapid as possible.The function of the News is the transmission of information covering great events happening both at home and abroad in a timely and accurate manner.The information structure and the main ThemeRheme structure functions belong to the language of discourse.As we know,English pays emphasis on hypotactic relations while Chinese pay more attention to paratactic relations.What is more,English is the subject-predominant language with subject-predicate pattern easy to identify while Chinese is the topic-predominant language with topic-comment patterns as its prototype.The paper selects a large number of news items covering a wide range of subjects from CCTV news channel website and the Xinhua net as the paper’s corpus,Through the comparative study of both English and Chinese at the level of sentence then to text,the paper is trying to analyze the similarities and dissimilarities of source language and target language in their conversion process.Meanwhile,this paper draws a new conclusion that Theme-Rheme structures help us find the semantic connections between source language and target language.The novel point is that this is a two-way communication,namely,not only is the target language in accordance with source language,but also the source language conforms to the habitual usage of target language,realizing the stylistic equivalence between two texts.In a sense,the study of Theme-Rheme structure provides a great boost to the News Translation.

Favorable clinical outcomes of checkpoint inhibitorbased combinations after progression with immunotherapy in advanced non-small cell lung cancer

Aim:Immune checkpoint inhibitors(ICIs)have dramatically changed the treatment paradigm in patients with non-small-cell lung cancer(NSCLC).However,progression patterns with immunotherapy are currently unclear and therapeutic options beyond resistance remain challenging.Methods:We reviewed advanced NSCLC patients between January 2016 and December 2019 who were treated with anti-PD-1/PD-L1 inhibitors in our center and identified those who developed disease progression.Later-line treatment strategies were collected and objective response rate,progression-free survival(PFS),and overall survival(OS)were assessed.Results:Of the 118 patients,46(39.0%)showed oligoprogression and 72(61.0%)showed systemic progression.No difference in progression patterns was observed between monotherapy and combination therapy.Systemic progression was strongly associated with never-smokers(51.4%vs.21.7%,P=0.001)and ECOG PS=2(13.9%vs.2.2%,P=0.048)at baseline.The distribution of progression sites was roughly similar between oligoprogression and systemic progression,and the most commonly affected anatomic site was lung(66.9%),followed by bone(12.7%)and lymph nodes(11.0%).For patients beyond first disease progression,checkpoint inhibitor-based combinations could lead to a significantly longer PFS2 compared with ICIs monotherapy(9.63 months vs.4.23 months,P=0.004,HR=0.394,95%CI:0.174-0.893)and other therapy(9.63 months vs.4.07 months,P=0.046,HR=0.565,95%CI:0.326-0.980).Median OS of the ICIs combination group was not reached but was significantly longer than other therapy group(NR vs.14.37 months,P=0.010,HR=0.332,95%CI:0.167-0.661).Conclusion:Systemic progression occurs more frequently among NSCLC patients receiving ICIs.Checkpoint inhibitor-based combinations show favorable outcomes as subsequent treatment strategies after the failure of previous ICIs treatment.