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沉默MPZL1调控β-catenin对A549/Tax细胞干性及耐药性的影响
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作者 臧超 戈巧 +6 位作者 李超 洪海宁 李伟 苏君 黎传奎 陈力维 王安生 《安徽医科大学学报》 CAS 北大核心 2024年第1期99-105,共7页
目的探讨髓磷脂蛋白零样蛋白1(MPZL1)沉默后是否通过调控β-catenin表达对A549/Tax耐药性和细胞干性产生影响。方法采用不同浓度阿霉素和紫杉醇处理A549和A549紫杉醇耐药性(A549/Tax)细胞,观察两种细胞的耐药性差异。实时荧光定量聚合... 目的探讨髓磷脂蛋白零样蛋白1(MPZL1)沉默后是否通过调控β-catenin表达对A549/Tax耐药性和细胞干性产生影响。方法采用不同浓度阿霉素和紫杉醇处理A549和A549紫杉醇耐药性(A549/Tax)细胞,观察两种细胞的耐药性差异。实时荧光定量聚合酶链式反应(qRT-PCR)和Western blot检测A549和A549/Tax细胞中MPZL1的表达量差异。对A549/Tax细胞沉默或者过表达MPZL1,进一步将细胞分为对照(control)组、短发卡RNA阴性对照(sh-NC)组、MPZL1沉默(sh-MPZL1)组、过表达阴性对照(OE-NC)组、MPZL1过表达(OE-MPZL1)组,运用细胞计数试剂盒8(CCK-8)和平板克隆实验分别检测MPZL1的表达变化对A549/Tax细胞增殖和克隆形成能力的影响。Western blot检测Wnt/β-catenin抑制剂XAV939和激活剂CHIR-99201处理细胞后,不同蛋白的表达变化。结果A549/Tax细胞对阿霉素和紫杉醇的半数抑制浓度(IC 50)较A549细胞明显增加(P<0.01)。MPZL1在A549/Tax中呈更高的表达趋势。MPZL1敲除后A549/Tax对阿霉素和紫杉醇的IC 50分别为2.731 mg/ml和4.939μg/ml,较阴性对照组的4.541 mg/ml和13.55μg/ml降低(P<0.01)。CCK-8和克隆形成实验结果显示,MPZL1敲除抑制肺癌A549/Tax细胞的增殖活力和克隆形成能力(P<0.05);Western blot结果显示,与阴性对照组相比,MPZL1、肿瘤干性相关蛋白(CD44和CD133)、多药耐药蛋白1(MDR1)、肺耐药相关蛋白(LRP)和β-catenin在sh-MPZL1中的表达水平明显减少(P<0.01)。此外,XAV939可抑制MPZL1、CD44、CD133、MDR1、LRP和β-catenin的表达。CHIR-99201处理细胞后部分逆转敲除MPZL1对上述蛋白的抑制作用。结论MPZL1在肺癌A549/Tax细胞中高表达。敲除MPZL1可抑制肿瘤干性和细胞增殖,增强肺癌A549/Tax细胞对阿霉素和紫杉醇的敏感性。 展开更多
关键词 MPZL1 肿瘤干性 A549/tax肺癌细胞 多药耐药 紫杉醇
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Taxing sugar-sweetened beverages in China:By volume or sugar content? A consumer welfare approach
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作者 Tianchang Zhai Jingjing Wang +1 位作者 Lei Li Wei Si 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第12期4237-4249,共13页
Using scanner data on the consumption of packaged liquid beverages by Chinese urban households,we estimated the price elasticity of various beverages and compared the effects of volume-based versus sugar-content-based... Using scanner data on the consumption of packaged liquid beverages by Chinese urban households,we estimated the price elasticity of various beverages and compared the effects of volume-based versus sugar-content-based taxation strategies on consumer welfare.Compared to the volume-based tax,the sugar-content-based beverage tax was predicted to cost less in compensating variation under the same amount of sugar reduced,indicating that taxation based on sugar content may be more efficient in preserving consumer welfare.Further comparison across different socioeconomic groups reveals that,given current beverage consumption status in China,the efficiency advantage of the sugar-content-based taxation strategy is more pronounced than that of the volume-based taxation.Our conclusions can provide insights for the food industry and the government to reduce the sugar content in beverages. 展开更多
关键词 sugar-sweetened beverages consumption tax welfare effect QUAIDS
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TAX1BP1 and FIP200 orchestrate non-canonical autophagy of p62 aggregates for mouse neural stem cell maintenance
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作者 Yi-Fu Zhu Rong-Hua Yu +15 位作者 Shuai Zhou Pei-Pei Tang Rui Zhang Yu-Xin Wu Ran Xu Jia-Ming Wei Ying-Ying Wang Jia-Li Zhang Meng-Ke Li Xiao-Jing Shi Yu-Wei Zhang Guang-Zhi Liu Rick FThorne Xu Dong Zhang Mian Wu Song Chen 《Zoological Research》 SCIE CSCD 2024年第4期937-950,共14页
Autophagy plays a pivotal role in diverse biological processes,including the maintenance and differentiation of neural stem cells(NSCs).Interestingly,while complete deletion of Fip200 severely impairs NSC maintenance ... Autophagy plays a pivotal role in diverse biological processes,including the maintenance and differentiation of neural stem cells(NSCs).Interestingly,while complete deletion of Fip200 severely impairs NSC maintenance and differentiation,inhibiting canonical autophagy via deletion of core genes,such as Atg5,Atg16l1,and Atg7,or blockade of canonical interactions between FIP200 and ATG13(designated as FIP200-4A mutant or FIP200 KI)does not produce comparable detrimental effects.This highlights the likely critical involvement of the non-canonical functions of FIP200,the mechanisms of which have remained elusive.Here,utilizing genetic mouse models,we demonstrated that FIP200 mediates non-canonical autophagic degradation of p62/sequestome1,primarily via TAX1BP1 in NSCs.Conditional deletion of Tax1bp1 in fip200hGFAP conditional knock-in(cKI)mice led to NSC deficiency,resembling the fip200hGFAP conditional knockout(cKO)mouse phenotype.Notably,reintroducing wild-type TAX1BP1 not only restored the maintenance of NSCs derived from tax1bp1-knockout fip200hGFAP cKI mice but also led to a marked reduction in p62 aggregate accumulation.Conversely,a TAX1BP1 mutant incapable of binding to FIP200 or NBR1/p62 failed to achieve this restoration.Furthermore,conditional deletion of Tax1bp1 in fip200hGFAP cKO mice exacerbated NSC deficiency and p62 aggregate accumulation compared to fip200hGFAP cKO mice.Collectively,these findings illustrate the essential role of the FIP200-TAX1BP1 axis in mediating the non-canonical autophagic degradation of p62 aggregates towards NSC maintenance and function,presenting novel therapeutic targets for neurodegenerative diseases. 展开更多
关键词 Non-canonical autophagy tax1BP1 FIP200 P62 AGGREGATES Neural stem cell
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Effect of Property Tax on Optimization and Upgrading of Industrial Structure
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作者 Zulong HUANG Zirun ZHANG Zhengjie ZHANG 《Asian Agricultural Research》 2024年第7期24-27,共4页
China's economic growth and economic development has entered a new stage,and the optimization and upgrading of industrial structure is the core driving force for China to achieve high-quality economic development ... China's economic growth and economic development has entered a new stage,and the optimization and upgrading of industrial structure is the core driving force for China to achieve high-quality economic development during the"14 th Five-Year Plan"period.Property tax has a conductive effect on the upgrading of industrial structure.Therefore,from the perspective of property tax and industrial structure adjustment and the relationship between them,this study summarizes the relevant research of domestic and foreign scholars.On the basis of the research,the paper puts forward some relevant policy suggestions on improving China's property tax and promoting the optimization and upgrading of China's industrial structure. 展开更多
关键词 Property tax COLLECTION Industrial structure Optimization and upgrading
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Exploring Corporate Tax Compliance in the Era of Digital Tax Collection and Administration:Insights from the“Golden Tax Phase Four”Project
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作者 Kai Fan Yujin Xie +1 位作者 Wenjun Xu Haopeng Wei 《Proceedings of Business and Economic Studies》 2024年第2期151-156,共6页
This article primarily examines the current state of tax collection and management,alongside other associated issues.It integrates insights from China’s“14th Five-Year Plan”and anticipates the imminent implementati... This article primarily examines the current state of tax collection and management,alongside other associated issues.It integrates insights from China’s“14th Five-Year Plan”and anticipates the imminent implementation of the“Golden Tax Phase Four.”With this backdrop,the article offers recommendations for advancing the reform of the tax collection and management system,fostering the development of intelligent taxation,and accelerating the modernization of tax collection and management in China. 展开更多
关键词 Golden tax Phase Four Modernization of tax collection and administration tax compliance
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Research on Tax Risk Regulation and Strategic Management in the Context of Big Data
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作者 Shouzeng Gong 《Proceedings of Business and Economic Studies》 2024年第2期145-150,共6页
With the rapid development of big data,big data has been more and more applied in all walks of life.Under the big data environment,massive big data provides convenience for regional tax risk control and strategic deci... With the rapid development of big data,big data has been more and more applied in all walks of life.Under the big data environment,massive big data provides convenience for regional tax risk control and strategic decision-making but also increases the difficulty of data supervision and management.By analyzing the status quo of big data and tax risk management,this paper finds many problems and puts forward effective countermeasures for tax risk supervision and strategic management by using big data. 展开更多
关键词 Big data tax risk Strategic management
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Taxation Models and Improvement Proposals for Personal Income Tax in the Sharing Economy
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作者 Xinyao Ruan 《Proceedings of Business and Economic Studies》 2024年第3期220-226,共7页
As an innovative economic model,the sharing economy has seen rapid growth globally in recent years.It has not only brought a profound impact on traditional economies but also injected new vitality and momentum into th... As an innovative economic model,the sharing economy has seen rapid growth globally in recent years.It has not only brought a profound impact on traditional economies but also injected new vitality and momentum into the sustainable development of the social economy.However,for the sharing economy,the process of collecting personal income tax is facing several issues,such as the ambiguity of tax policies regarding personal income,challenges in identifying taxpayers,and difficulties in defining income.To achieve the fairness and efficiency of personal income tax collection in the sharing economy,this study proposes optimized regulatory mechanisms and conducts in-depth discussions on the adjustment of personal income tax policies,innovation in tax management technology,and improvement in the quality of personal income tax services. 展开更多
关键词 Sharing economy Personal income tax taxation models
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Analysis and Innovative Strategies of Tax Preferential Policies to Promote the Sustainable Development of Small-Scale Individual Businesses
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作者 Tiantian Wang Xinyu Yi +1 位作者 Ziyi Zhang Jingjing Xiang 《Proceedings of Business and Economic Studies》 2024年第3期120-125,共6页
This study conducted an in-depth analysis of the current tax preferential policies for small-scale individual businesses and compared them with similar policies both domestically and internationally,aiming to reveal t... This study conducted an in-depth analysis of the current tax preferential policies for small-scale individual businesses and compared them with similar policies both domestically and internationally,aiming to reveal the advantages and disadvantages of the current system.After examining the impact of these tax preferential policies on the economic status of individual business owners and the broader social economy,this article proposes a set of innovative tax preferential strategies based on theoretical foundations.By developing these innovative strategies and clarifying their implementation paths,the aim is to promote the sustainable and healthy development of small-scale individual businesses,thereby fostering comprehensive socio-economic progress.The conclusion of this study not only summarizes policy recommendations with practical significance but also provides theoretical support for the optimization and innovation of future related systems. 展开更多
关键词 Small-scale individual operation tax incentives Policy analysis Economic effects Innovation strategy
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Consideration of the Application and Risk Prevention of VAT Tax Rebate Policy for Construction Enterprises at the End of the Period
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作者 Liangliang Wu 《Proceedings of Business and Economic Studies》 2024年第5期138-144,共7页
The“Announcement on Deepening the Value-Added Tax Reform”clearly outlines the preferential policy regarding incremental retention tax rebates.With the advancement of value-added tax(VAT)reform and the improvement of... The“Announcement on Deepening the Value-Added Tax Reform”clearly outlines the preferential policy regarding incremental retention tax rebates.With the advancement of value-added tax(VAT)reform and the improvement of VAT legislation in China,VAT tax planning for construction enterprises,particularly related to retained tax credits,has become routine.This paper,focusing on the characteristics of construction enterprises,analyzes VAT retained tax credits at the end of the period,the status of tax refunds,practical issues,and related processes,and offers suggestions for policy application and risk prevention. 展开更多
关键词 Construction enterprises VAT retained tax credit refunds Planning Risk prevention
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SYBRGreen荧光定量PCR检测HTLV-I前病毒tax基因方法的建立 被引量:5
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作者 伍晓菲 王华 +3 位作者 王迅 梁辉 刘晓颖 贾尧 《现代检验医学杂志》 CAS 2008年第3期21-23,共3页
目的建立HTLV—I前病毒tax基因的荧光定量PCR检测方法。方法根据HTLV—Itax基因序列设计引物,将PCR克隆的tax片段链接入质粒载体,经筛选鉴定后,以含有目的片断的质粒为阳性模板建立实时荧光定量检测方法。结果扩增体系的敏感度可达1... 目的建立HTLV—I前病毒tax基因的荧光定量PCR检测方法。方法根据HTLV—Itax基因序列设计引物,将PCR克隆的tax片段链接入质粒载体,经筛选鉴定后,以含有目的片断的质粒为阳性模板建立实时荧光定量检测方法。结果扩增体系的敏感度可达10拷贝/反应。模板浓度在10^5~10^1拷贝/反应时,模板浓度与循环闽值(Q)之间相关性良好,相关系数r=-0,9987,且模板浓度相同的反应管之间具有良好的重复性和稳定性。结论SYBRGreen荧光定量PCR检测HTLV—I前病毒tax基因方法具有简便、快速和灵敏度高等优点,可能在疾病诊断、监测以及血液筛查中具有一定的应用前景。 展开更多
关键词 HTLV—I tax基因 荧光定量PCR
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Tax基因表达细胞系的建立及其生物学活性的初步研究 被引量:12
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作者 夏云 石瑛 +3 位作者 高琰 郭继强 宋向凤 王辉 《中国实验血液学杂志》 CAS CSCD 2008年第6期1425-1429,共5页
本研究旨在建立成人T细胞白血病病毒-1(HTLV-1)的tax基因表达细胞系,并对其生物学特性进行初步研究。利用脂质体将真核表达载体pCMV-tax和空载体pCMV-neo-Bam转入T淋巴细胞系(JurkatE 6-1)细胞,用G418筛选出稳定表达tax基因的T细胞系Tax... 本研究旨在建立成人T细胞白血病病毒-1(HTLV-1)的tax基因表达细胞系,并对其生物学特性进行初步研究。利用脂质体将真核表达载体pCMV-tax和空载体pCMV-neo-Bam转入T淋巴细胞系(JurkatE 6-1)细胞,用G418筛选出稳定表达tax基因的T细胞系TaxP和表达tax阴性细胞系TaxN。用RT-PCR检测LAT、SLP-76、ZAP-70和NF-κB(p65)mRNA的表达。将pNF-κB-Luc报告基因质粒分别转染入TAX蛋白阳性和空载细胞后,检测细胞内NF-κB的活性。用流式细胞仪检测CD25,CD69分子的表达。结果表明:用G418筛选出稳定转染tax基因的Jurkat细胞株,经检测RNA转录水平获得了tax稳定表达的转染细胞;RT-PCR显示,与TaxN细胞LAT相比TaxP细胞的ZAP-70,SLP-76和NF-κB表达增高(p<0.05);pNF-κB-Luc报告基因检测显示,TaxP细胞中NF-κB的活化程度明显提高(p<0.01);流式细胞仪检测显示,TAX能够促进T细胞表面CD69,CD25分子的表达。结论:建立了tax基因表达细胞系,TAX蛋白能够促进T细胞的活化和激活NF-κB通路。 展开更多
关键词 T细胞白血病 成人T细胞白血病病毒-1 tax蛋白 NF—κB通路 Jurkat细胞系
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人类T细胞白血病病毒的tax基因研究进展 被引量:1
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作者 阮光萍 安梅 +1 位作者 邓淑芬 杨晓顺 《医学综述》 2004年第3期140-141,共2页
关键词 白血病 淋巴瘤 HTLV病毒 tax基因 P40tax蛋白
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人T细胞白血病1型病毒Tax蛋白、高迁移率组蛋白1及自噬 被引量:2
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作者 韩静贤 牛志国 王辉 《新乡医学院学报》 CAS 2015年第6期487-490,共4页
人T细胞白血病1型病毒(HTLV-1)是引起成人T细胞白血病的病原体,癌蛋白Tax在HTLV-1病毒复制及疾病转归过程中发挥重要的促进作用;自噬是细胞质内一种溶酶体降解途径,可以发挥细胞防御作用,参与病原体的清除。高迁移率组蛋白作为细胞应激... 人T细胞白血病1型病毒(HTLV-1)是引起成人T细胞白血病的病原体,癌蛋白Tax在HTLV-1病毒复制及疾病转归过程中发挥重要的促进作用;自噬是细胞质内一种溶酶体降解途径,可以发挥细胞防御作用,参与病原体的清除。高迁移率组蛋白作为细胞应激的产物,在多种疾病中出现高表达,在细胞自噬、DNA损伤修复、炎症因子释放等生理或病理过程中发挥重要作用,与病原体感染关系密切。本文就Tax、高迁移率组蛋白1及细胞自噬三者之间的相互关系做一综述。 展开更多
关键词 高迁移率组蛋白1 HTLV-1病毒 tax蛋白 细胞自噬
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RNA干扰Tax基因表达及其对HTLV-Ⅰ在TLC中转录的影响 被引量:1
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作者 肖颖秀 张俏忻 庄伟端 《广东医学》 CAS CSCD 北大核心 2009年第6期885-887,共3页
目的探讨RNA干扰Tax基因表达对人嗜T淋巴细胞病毒Ⅰ型(HTLV-Ⅰ)在T淋巴细胞(TLC)中表达的影响。方法运用RNAi技术特异性干扰Tax基因的表达,流式细胞技术和western blot法鉴定Tax蛋白的表达情况,并通过p27特异性蛋白的检测反映HTLV-Ⅰ在... 目的探讨RNA干扰Tax基因表达对人嗜T淋巴细胞病毒Ⅰ型(HTLV-Ⅰ)在T淋巴细胞(TLC)中表达的影响。方法运用RNAi技术特异性干扰Tax基因的表达,流式细胞技术和western blot法鉴定Tax蛋白的表达情况,并通过p27特异性蛋白的检测反映HTLV-Ⅰ在TLC中表达。结果重组质粒psiTax/U6转染T细胞组Tax蛋白的表达(9.84±3.32)%较未处理组(47.45±14.52)%和pSilencer1.0/U6转染组(45.98±10.66)%明显降低;western blot法显示重组质粒psiTax/U6转染TLC后。Tax以及p27蛋白表达较pSilencer1.0/U6转染组明显降低。结论运用RNA技术干扰Tax基因表达可以有效的阻止HTLV-Ⅰ在TLC中的转录。 展开更多
关键词 人嗜T淋巴细胞病毒Ⅰ型 RNAI tax P27
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通路抑制剂对Tax诱导的Bcl-3的影响及其在NF-κB激活中作用的研究
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作者 黄艳梅 张莉莉 +3 位作者 王金恒 吕壮伟 张新宁 王辉 《中国免疫学杂志》 CAS CSCD 北大核心 2012年第4期291-294,共4页
目的:通过研究不同通路的抑制剂在TaxP细胞(稳定表达Tax的Jurkat亚细胞系)中对Bcl-3(Human B-cellleukemia protein 3)表达的影响和shRNA Bcl-3对NF-κB转录激活作用的影响,探讨Tax阳性细胞中调控Bcl-3的通路及Bcl-3在NF-κB通路中的作... 目的:通过研究不同通路的抑制剂在TaxP细胞(稳定表达Tax的Jurkat亚细胞系)中对Bcl-3(Human B-cellleukemia protein 3)表达的影响和shRNA Bcl-3对NF-κB转录激活作用的影响,探讨Tax阳性细胞中调控Bcl-3的通路及Bcl-3在NF-κB通路中的作用。方法:将TaxP细胞分别用NF-κB(Nuclear factor-κB)抑制剂、GSK(Glycogen synthase kinase)抑制剂和蛋白酶抑制剂处理后,Western blot检测Bcl-3蛋白的表达情况;将Bcl-3的shRNA质粒转入TaxP细胞中,RT-PCR检测Bcl-3mRNA的表达抑制情况;共转染Bcl-3的shRNA和pNF-κB-luc质粒至Jurkat和TaxP细胞中,检测抑制Bcl-3表达后对NF-κB转录活性的影响。结果:Bcl-3的表达不受GSK抑制剂的影响,但在蛋白酶抑制后有明显的升高;RT-PCR的结果表明,在转染Bcl-3 shRNA质粒后,Bcl-3的mRNA表达有明显的下降,荧光素酶活性结果显示Bcl-3在Jurkat和TaxP细胞中被抑制后NF-κB的转录活性明显下降(P<0.05)。结论:Tax诱导的Bcl-3表达不依赖于GSK通路,而NF-κB通路参与了Bcl-3的调控,说明Bcl-3在NF-κB的激活中发挥着促进作用。 展开更多
关键词 tax Bcl-3 NF-κB转录活性 抑制剂
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体外HTLV-Ⅰ Tax蛋白在Müller细胞中的靶蛋白分析
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作者 罗琳 邓江云 +1 位作者 黄强 吴开力 《眼科研究》 CSCD 北大核心 2008年第9期689-692,共4页
目的观察体外人类嗜T淋巴细胞病毒(HTLV-Ⅰ)Tax蛋白与Mller细胞蛋白结合及其靶蛋白组成成分。方法用含Tax蛋白cDNA的原核表达载体PGEX-3X-GST-Tax转化大肠杆菌,诱导表达并提取纯化GST-Tax融合蛋白;细胞外GST-Tax融合蛋白与Mller细... 目的观察体外人类嗜T淋巴细胞病毒(HTLV-Ⅰ)Tax蛋白与Mller细胞蛋白结合及其靶蛋白组成成分。方法用含Tax蛋白cDNA的原核表达载体PGEX-3X-GST-Tax转化大肠杆菌,诱导表达并提取纯化GST-Tax融合蛋白;细胞外GST-Tax融合蛋白与Mller细胞蛋白结合,GS4B下拉(pull-down)与GST-Tax结合的蛋白;应用二维凝胶电泳、质谱分析(MALDI-Tof-MS)和免疫印迹分析等方法分析鉴定结合的蛋白。结果通过与对照组比较,在二维凝胶电泳上观察到多个差异蛋白质斑点,经质谱分析鉴定出10个差异蛋白质为Tax的候选靶蛋白,经免疫印迹,初步证实Tax蛋白能与ENO1相结合。结论初步分离鉴定出Mller细胞中的ENO1等蛋白质可能为Tax蛋白的靶蛋白分子。 展开更多
关键词 HTLV—Ⅰ tax MÜLLER细胞 蛋白质组学
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大鼠肝再生相关基因Tax1bp1与绿色荧光蛋白融合表达的研究
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作者 范念斯 杨献光 +1 位作者 潘兆倩 渠畅 《新乡医学院学报》 CAS 2011年第3期285-287,290,共4页
目的构建大鼠肝再生相关基因Tax1bp1的真核表达载体,融合绿色荧光蛋白并在再生肝中高效表达,观察目的蛋白的表达情况。方法利用反转录聚合酶链式反应(RT-PCR)技术以大鼠再生肝为材料克隆Tax1bp1基因的开放阅读框(ORF),然后亚克隆到表达... 目的构建大鼠肝再生相关基因Tax1bp1的真核表达载体,融合绿色荧光蛋白并在再生肝中高效表达,观察目的蛋白的表达情况。方法利用反转录聚合酶链式反应(RT-PCR)技术以大鼠再生肝为材料克隆Tax1bp1基因的开放阅读框(ORF),然后亚克隆到表达载体上构建重组表达载体pEGFP-N1-Tax1bp1,再用尾静脉液压法转入大鼠再生肝中进行绿色荧光蛋白融合表达。结果 Tax1bp1ORF克隆正确,融合绿色荧光蛋白重组表达载体pEGFP-N1-Tax1bp1构建成功;部分肝切除转基因6、12、24、48 h后均有荧光表达,Tax1bp1融合蛋白在上述时间点绿色荧光融合蛋白细胞转染率分别为8.7%、11.2%、14.5%和1.2%,转染率趋势同空载体绿色荧光蛋白表达情况一致。结论重组表达载体pEGFP-N1-Tax1bp1构建成功,并实现了绿色荧光融合蛋白的高效表达,为进一步研究肝再生相关Tax1bp1基因功能奠定了基础。 展开更多
关键词 大鼠 tax1bp1 CDNA克隆 融合表达
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TAX、CBDCA与VP16联合治疗小细胞肺癌30例临床疗效观察
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作者 张宏伟 《河北医学》 CAS 2002年第4期313-315,共3页
目的 :研究化学抗癌药物联合治疗小细胞肺癌的效果。方法 :应用TAX、CBDCA与VP16联合治疗 30例晚期小细胞肺癌。结果 :CR  2例 ,PR  19例 ,总有效率达 70 % (2 1/ 30 ) ,且毒副反应较轻 ,无Ⅲ、Ⅳ级发生。结论 :TAX。
关键词 小细胞肺癌 tax CBDCA VPl6 疗效
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HTLV-1 Tax蛋白与T细胞的细胞周期调变
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作者 周绪斌 朱学良 《细胞生物学杂志》 CSCD 北大核心 2002年第2期93-95,共3页
人1型T细胞白血病病毒(HTLV-1)能引发成人急性T细胞白血病(ATL)以及一种慢性渐进性的中枢神经系统疾病--热性痉挛性下身截瘫/白血病病毒相关脊髓病(TSP/HAM).成人T细胞白血病(ATL)表现为成熟T淋巴细胞恶性增生.由于HTLV-1 Tax蛋白与T细... 人1型T细胞白血病病毒(HTLV-1)能引发成人急性T细胞白血病(ATL)以及一种慢性渐进性的中枢神经系统疾病--热性痉挛性下身截瘫/白血病病毒相关脊髓病(TSP/HAM).成人T细胞白血病(ATL)表现为成熟T淋巴细胞恶性增生.由于HTLV-1 Tax蛋白与T细胞增殖调控有重要关系,本文将主要综述HTLV-1 Tax蛋白如何参与调变T细胞细胞周期从而探讨Tax在T淋巴细胞转化中的作用. 展开更多
关键词 调控 T细胞白血病 HTLV-1 tax蛋白 T细胞 细胞周期 调变
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Eco-taxes and Sustainable Utilization of Grassland Resources 被引量:1
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作者 鲍文 《Animal Husbandry and Feed Science》 CAS 2009年第3期44-48,共5页
The sustainable development of grassland resources objectively requires that the social, economic and ecological costs of grassland resources should be brought into economic activities in order to internalize the exte... The sustainable development of grassland resources objectively requires that the social, economic and ecological costs of grassland resources should be brought into economic activities in order to internalize the external costs of grassland resources. Eco-tax is a very effective means to internalize the externality of grassland resources. Its main advantage is to bdng the cost of ecological environment into economic life, which can amend market pdce, improve the effectiveness of government policies, perform the eco-saboteurs-pays principle, and thus perfect the ecological compensation system. 展开更多
关键词 Eco-tax Grassland resources Sustainable utilization
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