Near-infrared (NIR) spectroscopy was applied to reagent-free quantitative analysis of polysaccharide of a brand product of proprietary Chinese medicine (PCM) oral solution samples. A novel method, called absorbance up...Near-infrared (NIR) spectroscopy was applied to reagent-free quantitative analysis of polysaccharide of a brand product of proprietary Chinese medicine (PCM) oral solution samples. A novel method, called absorbance upper optimization partial least squares (AUO-PLS), was proposed and successfully applied to the wavelength selection. Based on varied partitioning of the calibration and prediction sample sets, the parameter optimization was performed to achieve stability. On the basis of the AUO-PLS method, the selected upper bound of appropriate absorbance was 1.53 and the corresponding wavebands combination was 400 - 1880 & 2088 - 2346 nm. With the use of random validation samples excluded from the modeling process, the root-mean-square error and correlation coefficient of prediction for polysaccharide were 27.09 mg·L<sup>-</sup><sup>1</sup> and 0.888, respectively. The results indicate that the NIR prediction values are close to those of the measured values. NIR spectroscopy combined with AUO-PLS method provided a promising tool for quantification of the polysaccharide for PCM oral solution and this technique is rapid and simple when compared with conventional methods.展开更多
In a placebo-controlled, double-blind, randomized clinical trial, the tolerability of a proprietary larch arabinogalactan preparation (ResistAidTM) was investigated. METHODS: 199 healthy participants were randomly ass...In a placebo-controlled, double-blind, randomized clinical trial, the tolerability of a proprietary larch arabinogalactan preparation (ResistAidTM) was investigated. METHODS: 199 healthy participants were randomly assigned to receive either placebo (n = 98) or an arabinogalactan preparation (n = 101) over a period of 12 weeks. As safety parameters the total number of adverse events, changes in various biochemical and laboratory parameters as well as the global evaluation of tolerability by investigator and subjects compared to placebo were evaluated. RESULTS: In total 16 adverse events were observed in 16 subjects, with no difference between the arabinogalactan and the placebo group (p = 0.935). There were no differences in the mean changes of the measured biochemical and laboratory parameters. The tolerability of the arabinogalactan extract was rated as “very good” or “good” by the investigators for 99% of the subjects and by 98% subjects in self-assessment with no statistical differences to placebo. CONCLUSION: The measured parameters as well as the evaluation of the tolerability by the investigators and the subjects demonstrate a very good tolerance profile of the proprietary arabinogalactan extract with no differences to placebo when taken for 12 weeks.展开更多
A novel catalytic cracking process named the MIP process was developed by the Research Institute of Petroleum Processing(RIPP),SINOPEC,to manufacture clean gasoline with lower olefin contents. The MIP pro-cess feature...A novel catalytic cracking process named the MIP process was developed by the Research Institute of Petroleum Processing(RIPP),SINOPEC,to manufacture clean gasoline with lower olefin contents. The MIP pro-cess features a unique riser consisting of two sequential reaction zones with different radii,in which different kinds of chemical reactions are intensified respectively to achieve better product slates and product properties. In order to fully implement the MIP potentials,a proprietary catalyst RMI tailored to the needs of the MIP process was devel-oped by adopting an AIRY zeolite having improved accessibility to active sites,which could result in better heavy oil cracking,coke selectivity and olefin reduction performance compared with the conventional REUSY zeolite. Its commercial application showed that the RMI catalyst could further reduce the olefin content in gasoline and raise the gasoline octane number while increasing the total liquid yield. On the basis of the MIP process,the MIP-CGP process was also developed to significantly reduce the olefin content in FCC naphtha and to enhance the propylene yield simultaneously. As far as the MIP-CGP process itself is concerned,both the MIP-CGP process and the MIP process have the similar reactor configuration but with different reactor size and operating parameters. The proprietary catalyst CGP-1 is also proposed to tailor for the MIP-CGP process. The specific features of the CGP-1 catalyst cover the new matrix,which possesses excellent capability to accommodate coke formation in the first reaction zone;the modified Y zeolite,which exhibits high hydrogen transfer activity in the second reaction zone;and the MFI zeolite,which has good gasoline olefin cracking activity. The commercial test results of MIP-CGP process applied along with the CGP-1 catalyst showed that the olefin content of gasoline was less than 18 v% and the propylene yield was more than 8 m%. Furthermore,as compared with the conventional FCC process,the gasoline properties were improved greatly and a higher total liquid yield was obtained. The advantages and characteristics of the MIP-CGP process were fully exploited by using the CGP-1 catalyst.展开更多
文摘Near-infrared (NIR) spectroscopy was applied to reagent-free quantitative analysis of polysaccharide of a brand product of proprietary Chinese medicine (PCM) oral solution samples. A novel method, called absorbance upper optimization partial least squares (AUO-PLS), was proposed and successfully applied to the wavelength selection. Based on varied partitioning of the calibration and prediction sample sets, the parameter optimization was performed to achieve stability. On the basis of the AUO-PLS method, the selected upper bound of appropriate absorbance was 1.53 and the corresponding wavebands combination was 400 - 1880 & 2088 - 2346 nm. With the use of random validation samples excluded from the modeling process, the root-mean-square error and correlation coefficient of prediction for polysaccharide were 27.09 mg·L<sup>-</sup><sup>1</sup> and 0.888, respectively. The results indicate that the NIR prediction values are close to those of the measured values. NIR spectroscopy combined with AUO-PLS method provided a promising tool for quantification of the polysaccharide for PCM oral solution and this technique is rapid and simple when compared with conventional methods.
文摘In a placebo-controlled, double-blind, randomized clinical trial, the tolerability of a proprietary larch arabinogalactan preparation (ResistAidTM) was investigated. METHODS: 199 healthy participants were randomly assigned to receive either placebo (n = 98) or an arabinogalactan preparation (n = 101) over a period of 12 weeks. As safety parameters the total number of adverse events, changes in various biochemical and laboratory parameters as well as the global evaluation of tolerability by investigator and subjects compared to placebo were evaluated. RESULTS: In total 16 adverse events were observed in 16 subjects, with no difference between the arabinogalactan and the placebo group (p = 0.935). There were no differences in the mean changes of the measured biochemical and laboratory parameters. The tolerability of the arabinogalactan extract was rated as “very good” or “good” by the investigators for 99% of the subjects and by 98% subjects in self-assessment with no statistical differences to placebo. CONCLUSION: The measured parameters as well as the evaluation of the tolerability by the investigators and the subjects demonstrate a very good tolerance profile of the proprietary arabinogalactan extract with no differences to placebo when taken for 12 weeks.
文摘A novel catalytic cracking process named the MIP process was developed by the Research Institute of Petroleum Processing(RIPP),SINOPEC,to manufacture clean gasoline with lower olefin contents. The MIP pro-cess features a unique riser consisting of two sequential reaction zones with different radii,in which different kinds of chemical reactions are intensified respectively to achieve better product slates and product properties. In order to fully implement the MIP potentials,a proprietary catalyst RMI tailored to the needs of the MIP process was devel-oped by adopting an AIRY zeolite having improved accessibility to active sites,which could result in better heavy oil cracking,coke selectivity and olefin reduction performance compared with the conventional REUSY zeolite. Its commercial application showed that the RMI catalyst could further reduce the olefin content in gasoline and raise the gasoline octane number while increasing the total liquid yield. On the basis of the MIP process,the MIP-CGP process was also developed to significantly reduce the olefin content in FCC naphtha and to enhance the propylene yield simultaneously. As far as the MIP-CGP process itself is concerned,both the MIP-CGP process and the MIP process have the similar reactor configuration but with different reactor size and operating parameters. The proprietary catalyst CGP-1 is also proposed to tailor for the MIP-CGP process. The specific features of the CGP-1 catalyst cover the new matrix,which possesses excellent capability to accommodate coke formation in the first reaction zone;the modified Y zeolite,which exhibits high hydrogen transfer activity in the second reaction zone;and the MFI zeolite,which has good gasoline olefin cracking activity. The commercial test results of MIP-CGP process applied along with the CGP-1 catalyst showed that the olefin content of gasoline was less than 18 v% and the propylene yield was more than 8 m%. Furthermore,as compared with the conventional FCC process,the gasoline properties were improved greatly and a higher total liquid yield was obtained. The advantages and characteristics of the MIP-CGP process were fully exploited by using the CGP-1 catalyst.
