Effects of procainamide on adenosine diphosphate-induced platelet aggregation and thromboxane B_2 production in rabbits in vitro

Turbidimetry and radioimmunoassay were used to study the effects of procainamide (PA ) onadenosine diphosphate (ADP)-induced rabbit platelet aggregation and thromboxane B2 (TXB2) production invitro. PA 8. 5--544. 0 μmol L-1 inhibited ADP-induced platelet aggregation and TXB2 production, and theinhibition rates were 26. 7% -- 66. 7 % and 21. 4 % -- 70. 1 %, respectively. There was positive correlation between PA concentration and its efficiency in inhibiting the platelet aggregation and TXB2 production, and alsobetween the inhibition rates of platelet aggregation and that of TXB2 production. The three linear equationsand main parameters were The results indicate that PA could significantly inhibit ADP--induced platelet aggregation and TXB2 production in rabbits.

复原活血汤对下颌下腺瓣修复软组织缺损患者血流动力学及血清6-酮-前列腺素F_(1α)、血栓素B_(2)水平的影响

目的:研究复原活血汤对下颌下腺瓣修复软组织缺损患者血流动力学及血清6-酮-前列腺素F_(1α)(6-keto prostaglandin F_(1α),6-keto-PGF_(1α))、血栓素B_(2)(Thromboxane B_(2),TXB_(2))水平的影响。方法:选取2014年6月-2019年6月在医院行下颌下腺瓣修复口咽部肿瘤切除术后口咽部缺损患者76例,按随机数字表法分为对照组(38例,采用术后常规治疗)和研究组(38例,在对照组的基础上给予复原活血汤)。比较两组临床疗效、血液动力学指标、血清6-keto-PGF_(1α)、TXB_(2)水平变化及术后并发症发生情况。结果:研究组临床总有效率为97.37%高于对照组78.95%,差异有统计学意义(P<0.05)。治疗后,两组创面血流灌注量相对值(Blood perfusion relative,BPR)、血流速度(Blood flow velocity,BFV)水平高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05)。治疗后,两组血清6-keto-PGF_(1α)水平高于治疗前,研究组高于对照组,差异有统计学意义(P<0.05)。两组血清TXB_(2)水平低于治疗前,研究组低于对照组,差异有统计学意义(P<0.05)。两组术后并发症总发生率比较,差异无统计学意义(P>0.05)。结论:复原活血汤能明显改善口咽部肿瘤切除术后行下颌下腺瓣修复缺损患者的血液动力学,改善血清6-keto-PGF_(1α)、TXB_(2)水平,临床疗效确切。