Systematic analysis and modeling of the FLASH sparing effect as a function of dose and dose rate

Ultrahigh-dose-rate radiotherapy(FLASH-RT)is a revolutionary radiotherapy technology that can spare normal tissues without compromising tumor control.Although qualitative experimental results have been reported,quantitative and systematic analysis of data is necessary.Particularly,the FLASH effect response model to the dose or dose rate is still unclear.This study investigated the relationships between the FLASH effect and experimental parameters,such as dose,dose rate,and other factors by analyzing published in vivo experimental data from animal models.The data were modeled based on logistic regression analysis using the sigmoid function.The model was evaluated using prediction accuracy,receiver operating characteristic(ROC)curve,and area under the ROC curve.Results showed that the FLASH effect was closely related to the dose,mean dose rate,tissue type,and corresponding biological endpoints.The dose rate corresponding to a 50% probability of triggering cognitive protection in the brain was 45 Gy s^(-1).The dose rate corresponding to a 50% probability of triggering intestinal crypt survival and regeneration was 140 Gy s^(-1).For the skin toxicity effect,the dose corresponding to a 50% probability of triggering the FLASH effect was 24 Gy.This study helps to characterize the conditions underlying the FLASH effect and provides important information for optimizing experiments.

Expanding the Use of Nipple-Sparing Mastectomies in Obese Patients Undergoing Staged Implant-Based Reconstruction

Background: Advantages of various mastectomy techniques include skin reduction and favorable aesthetics in Wise-pattern closures, and less visible scars in nipple-sparing mastectomies (NSM). This study compares postoperative complication profiles between Wise-pattern and nipple-sparing mastectomies in the obese population. Methods: A retrospective chart review of obese patients (BMI ≥ 30) who underwent staged breast reconstruction following Wise-pattern and nipple-sparing mastectomies at our institution between February 2016 and January 2020 was conducted. Complications between cohorts were analyzed using the independent samples t-test (2-sided) and the χ2 test. Results: A total of 232 breasts (163 Wise-pattern, 69 NSM) were re-constructed in 123 obese female patients (85 Wise-pattern, 38 NSM). Complication rates in both the Wise-pattern and NSM patient cohorts were similar following stage 1 (Wise-pattern: 30.7%, NSM: 39.1%, p = 0.212) and stage 2 (Wise-pattern: 16.6%, NSM: 15.9%, p = 0.907) of reconstruction. No statistically significant differences in rates of infection, dehiscence, seroma, hematoma or malposition of tissue expander (TE)/implant following stage 1 or stage 2 were found between cohorts. Conclusions: There were no significant differences in postoperative complication rates between the Wise-pattern and NSM cohorts of obese patients. NSM can be a viable surgical option in carefully selected obese patients and offer the advantage of concealed scarring.

Epigenetic combined with transcriptomic analysis of the m6A methylome after spared nerve injury-induced neuropathic pain in mice

Epigenetic changes in the spinal cord play a key role in the initiation and maintenance of nerve injury-induced neuro pathic pain.N6-methyladenosine(m6A)is one of the most abundant internal RNA modifications and plays an essential function in gene regulation in many diseases.However,the global m6A modification status of mRNA in the spinal cord at different stages after neuropathic pain is unknown.In this study,we established a neuropathic pain model in mice by preserving the complete sural nerve and only damaging the common peroneal nerve.High-throughput methylated RNA immunoprecipitation sequencing res ults showed that after spared nerve injury,there were 55 m6A methylated and diffe rentially expressed genes in the spinal cord.Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway results showed that m6A modification triggered inflammatory responses and apoptotic processes in the early stages after spared nerve injury.Over time,the diffe rential gene function at postoperative day 7 was enriched in "positive regulation of neurogenesis" and "positive regulation of neural precursor cell prolife ration." These functions suggested that altered synaptic morphological plasticity was a turning point in neuropathic pain formation and maintenance.Results at postoperative day 14 suggested that the persistence of neuropathic pain might be from lipid metabolic processes,such as "very-low-density lipoprotein particle clearance," "negative regulation of choleste rol transport" and "membrane lipid catabolic process." We detected the expression of m6A enzymes and found elevated mRNA expression of Ythdf2 and Ythdf3 after spared nerve injury modeling.We speculate that m6A reader enzymes also have an important role in neuropathic pain.These results provide a global landscape of mRNA m6A modifications in the spinal cord in the spared nerve injury model at diffe rent stages after injury.

Robot-Assisted Nephrotomy as a Nephron-Sparing Approach for Completely Intraparenchymal Renal Tumors

Introduction: The diagnosis of small renal masses and the endophytic tumor approach have become challenging. This study aims to describe exclusively robot-assisted surgery as an alternative nephron-sparing approach for renal intraparenchymal tumors. Patients and Methods: We retrospectively analyzed all patients with completely endophytic tumors undergoing robot-assisted partial nephrectomy, treated under the Da Vinci System®, aided by intraoperative ultrasound. The patients’ demographic characteristics, perioperative and oncological outcomes were assessed. Results: From a total of 13 partial nephrectomies performed between 06/2010 and 10/2021, all patients underwent nephrotomy. The patients’ mean age was 52 years and the tumor measured mean 2.6 cm. Warm ischemia time was 24 minutes and histopathological analysis revealed that 12 patients had renal cell carcinoma. In a mean 36-month follow-up, no significant renal function alterations were found and no local or systemic recurrences occurred. Conclusion: Robot-assisted access is a safe and effective option for the nephron-sparing technique in completely intraparenchymal renal tumors.

Organ sparing to cure stage IV rectal cancer: A case report and review of literature

BACKGROUND Rectal sparing is an option for some rectal cancers with complete or good response after chemoradiotherapy(CRT);however,it has never been evaluated in patients with metastases.We assessed long-term outcomes of a rectal-sparing approach in a liver-first strategy for patients with rectal cancer with resectable liver metastases.CASE SUMMARY We examined patients who underwent an organ-sparing approach for rectal cancer with synchronous liver metastases using a liver-first strategy during 2010-2015(n=8).Patients received primary chemotherapy and pelvic CRT.Liver surgery was performed during the interval between CRT completion and rectal tumor re-evaluation.Clinical and oncological characteristics and long-term outcomes were assessed.CASE SUMMARY All patients underwent liver metastatic resection with curative intent.The R0 rate was 100%.Six and two patients underwent local excision and a watch-and-wait(WW)approach,respectively.All patients had T3N1 tumors at diagnosis and had good clinical response after CRT.The median survival time was 60(range,14-127)mo.Three patients were disease free for 5,8,and 10 years after the procedure.Five patients developed metastatic recurrence in the liver(n=5)and/or lungs(n=2).Only one patient developed local recurrence concurrent with metastatic recurrence 24 mo after the WW approach.Two patients died during follow-up.CONCLUSION The results suggest good local control in patients undergoing organ-sparing strategies for rectal cancer with synchronous liver metastasis.Prospective trials are required to validate these data and identify good candidates for these strategies.

Dynamic Prediction Method for Valuable Spare Parts Demand in Weaponry Equipment Based on Data Perception

Missile is an important weapon system of the army.The spare parts of missile equipment are significant effect on military operations.In order to improve the mission completion rate of missile equipment in wartime,this paper introduces data sensing method to forecast the demand of valuable spare parts of missile equipment dynamically.Firstly,the information related to valuable spare parts of missile equipment was obtained by data sensing,and the sample size was determined by Bernoulli uniform sampling probability.Secondly,according to the data quality of multi-source and multi-modal,the data requirement for dynamic demand prediction of valuable spare parts of missile equipment was obtained.Finally,according to the characteristics of the spare parts,the life of the spare parts was predicted,realizing the dynamic prediction of the demand for valuable spare parts of missile equipment.The results show that the demand of valuable spare parts of missile equipment can be predicted dynamically by using this method,the accuracy is higher than 95%,and the real-time performance is more excellent.

逆行松解神经血管束且保留Retzius间隙机器人辅助腹腔镜根治性前列腺切除术的技术要点(“大家泌尿网”观看手术视频)

保留耻骨后间隙的前列腺癌根治术(RS-RARP)可以显著提高术后即刻尿控且不增加切缘阳性率。然而该术式学习曲线长,目前能掌握的学者不到10%,尚未推广。基于对前列腺解剖结构及手术方式的认识,本中心对RS-RARP进行优化。我们首创了完全后入路逆行松解神经血管束的RARP,最大限度保留神经血管束,简化手术操作,仅使用一根缝线即可完成尿道吻合,无需使用Hem-o-lok,减少相关并发症。我们在本中心常规开展该术式,通过多维度分析认为这是一种“肿瘤控制可、尿控保护好、性功能恢复快、并发症少、可操作性强”的手术方式。本文详细介绍该术式的关键步骤及操作体会。

基于主成分分析-BP神经网络的风电备件需求预测

风电机组具有结构复杂,运维困难,且长期处于恶劣的工作环境的特点。风电备件的需求预测有助于为风电场配备最合适的备件数,以确保风电场的平稳、高效运行。构建主成分分析-反向传播(principal component analysis-back propagation,PCA-BP)模型,针对受多因素影响的复杂备件,先利用PCA将影响风电备件的要素进行筛选,再利用BP神经网络算法,得到最为精确的预测结果。比较自回归积分滑动平均(autoregressive integrated moving average,ARIMA)模型、BP神经网络预测和PCA-BP神经网络预测的结果。结果表明:PCA能显著降低神经网络预测误差,预测的精度为93.94%,高于BP神经网络预测的88.39%和ARIMA模型的85.31%,所以PCA-BP神经网络模型的预测精度准确且有可靠结果,能够适用于风机备件的需求预测。

显微镜下保留睾丸的睾丸良性肿瘤切除术临床疗效分析(附16例报道)

目的:探讨显微外科手术技术应用于保留睾丸的睾丸良性肿瘤切除术的安全性及临床疗效。方法:回顾性分析2020年10月至2023年2月青岛大学附属医院男科收治的16例睾丸肿瘤患者的病例资料。患者中位年龄23岁,睾丸肿瘤均为单侧,左侧7例,右侧9例,睾丸肿瘤最长径1.0~3.5 cm(中位数1.85 cm)。患者均在术前完善阴囊彩超(CDFI)、磁共振(MRI)、精液、血清睾酮、甲胎蛋白(AFP)、人绒毛膜促性腺激素(hCG)、乳酸脱氢酶(LDH)检查。16例患者均行显微镜下保留睾丸的睾丸肿瘤切除术(TSMS),术中运用显微外科技术,精准辨别睾丸内肿瘤与正常睾丸组织的边界,距离肿瘤边界约2 mm完整切除肿瘤及少部分邻近正常睾丸组织,使用显微双极电凝镊给予精确止血,最大限度保留正常睾丸组织。将完整切除的睾丸内肿瘤及邻近正常睾丸组织进行快速冰冻病理检查。术后定期复查CDFI、MRI、精液、血清睾酮等项目。结果:16例患者术前血清睾酮、AFP、hCG、LDH及精液检查指标均在正常参考值范围内。所有16例患者的术中快速冰冻病理依据2022年最新版WHO泌尿及男性生殖系统肿瘤分类标准,均诊断为睾丸良性肿瘤,并顺利完成TSMS治疗。16例患者术后康复顺利,术后1个月复查CDFI提示睾丸剩余组织血供良好,所有患者随访14~40个月,随访期内定期复查CDFI和MRI均未见睾丸内肿瘤残留、复发或转移征象,血清睾酮、AFP、hCG、LDH及精液检查较术前无显著变化,2例育龄期患者的配偶分别于术后16、18个月实现自然受孕。结论:睾丸内良性肿瘤可以通过CDFI、MRI检查进行术前鉴别诊断,最终定性诊断仍需组织病理检查。TSMS运用显微外科手术技术,可以在完整切除睾丸内肿瘤的前提下最大限度保留正常睾丸组织,从而有效保存男性生育力。TSMS疗效良好、安全性高,特别适用于有保留生育力需求的患者。

Surgical Approaches in Primary Rhegmatogenous Retinal Detachment: A Systematic Review and Meta-Analysis Comparing Vitrectomy vs. Vitrectomy Combined with Scleral Buckling, Lens-Sparing vs. Phako Procedures

Aim: This study aimed to assess and compare the functional and anatomical results of pars plana vitrectomy (PPV) alone versus PPV combined with scleral buckling (SB), and lens-sparing versus phaco-procedures for treating rhegmatogenous retinal detachment. Methods: A comprehensive literature search was performed using the Web of Science, MEDLINE, EMBASE, and Cochrane Library databases to retrieve comparative studies. The main objective was to assess the BCVA, while reattachment rates and ocular adverse events were considered secondary measures. Rev Manager software was used for statistical analysis. Results: The literature search identified 10 articles comprising 1518 eyes, with 682 eyes in the PPV group, 193 eyes in the lens-sparing versus phaco-procedure group, and 643 eyes in the combined PPV and SB surgery group. Quality assessment revealed a low risk of bias in most domains. The meta-analysis results revealed a significant difference in postoperative BCVA between the PPV and PPV combined with SB groups (WMD = −0.17, 95% CI [0.27, 0.07], p = 0.001). The primary reattachment rates were 82.80% for PPV alone and 87.52% for PPV combined with SB (p = 0.34). The final reattachment rates did not differ significantly between PPV and PPV combined with SB (99% vs. 99.8%;RR = 1.00, 95% CI [1.01, 0.99], p = 0.96). PPV alone demonstrated a significantly reduced risk of macular edema compared to PPV combined with scleral buckling (9.9% vs. 23%;p = 0.006). The incidences of macular hole development (p = 0.46), recurrent retinal detachment (p = 0.27), proliferative vitreoretinopathy development (p = 0.48), epiretinal membrane proliferation (p = 0.77), and limited choroidal hemorrhage (p = 0.69) were not significantly different between the two groups. Conclusions: These findings suggest that PPV alone may be a more effective treatment option in terms of visual acuity (VA) improvement, lower risk of macular edema and cataract development. However, there was no significant difference in VA improvement or complication rates between the lens-sparing and phaco-procedure groups. .

宫颈癌保留神经手术后排尿功能评价

目的探讨宫颈癌保留神经的广泛性子宫切除术(nerve sparing radical hysterectomy,NSRH)治疗宫颈癌的效果及对排尿功能的影响。方法纳入2019年5月至2022年5月于首都医科大学附属北京妇产医院就诊并诊断为宫颈癌的患者55例,国际妇产科联盟分期分布在ⅠB至ⅡA2。其中28例患者接受了NSRH(NSRH组),27例患者接受了广泛性全子宫切除术(radical hysterectomy,RH)(RH组)。比较2组患者手术相关指标及术后排尿功能。结果NSRH组平均年龄为(51.0±7.9)岁,RH组平均年龄为(46.3±8.5)岁,年龄分布差异有统计学意义(P<0.05)。2组出血量差异无统计学意义(P>0.05)。2组患者手术切缘均为阴性。术后病理提示阴道长度、淋巴结转移、间质浸润深度、淋巴脉管浸润比较差异均无统计学意义(P>0.05)。在术后膀胱功能方面,NSRH组残余尿较RH组多(P<0.05),但NSRH组拔尿管的时间较RH组明显缩短(P<0.05)。结论NSRH能够在确保手术范围的同时,减轻对术后排尿功能的影响,缩短术后恢复时间。

子宫内膜不典型增生/早期子宫内膜癌患者保留生育功能治疗后IVF-ET妊娠结局及复发因素分析

目的分析子宫内膜不典型增生/早期子宫内膜癌(AH/EEC)患者保留生育功能治疗后接受体外受精-胚胎移植(IVF-ET)治疗的临床特点和预后,分析影响助孕妊娠结局和疾病复发的主要因素。方法回顾性分析2012年2月至2022年2月在北京协和医院接受AH/EEC生育保留治疗后进行IVF-ET治疗的78例患者的临床资料。总结分析纳入患者的临床特征、IVF-ET相关指标、妊娠结局和复发情况,以单因素和多因素分析临床妊娠率、活产率以及疾病复发的影响因素。结果78例患者中51例(65.38%)为AH患者,27例(34.62%)为EEC患者;开始IVF-ET周期的平均年龄为(34.17±3.70)岁。共有74例患者至少接受了1次移植,每移植周期的临床妊娠率和活产率分别为36.31%(65/179)和18.99%(34/179),累积妊娠率为72.97%(54/74)。多因素分析提示子宫内膜病变初次发病年龄是活产率的独立影响因素[OR=0.8794,95%CI(0.785,0.983),P=0.02]。纳入患者IVF-ET期间子宫内膜病变的总复发率为6.41%(5/78),多因素分析提示子宫内膜病变的病理类型和IVF-ET前复发史是疾病复发的危险因素(P<0.05)。结论AH/EEC患者保留生育功能治疗后的辅助生殖结局相对满意,在肿瘤治疗过程中,进行病变评估时应尽量保护内膜,减少损伤;在肿瘤治疗结束后,应尽快进行助孕治疗,以最大程度降低复发率。

基于模糊网络与TOPSIS的备件品种确定方法

舰船携行备件品种确定过程是一种典型的多属性决策问题,针对其属性评估时面临的复杂性与模糊性、评估过程透明性不足的问题,提出了一种集成模糊网络与熵权法来扩展TOPSIS的方法。该方法以语言值Z-numbers作为评估值表示形式,分别构造了效益和成本属性下的模糊网络子系统,将合并子系统规则的模糊隶属度函数作为聚合模糊隶属度函数,通过案例计算得到Spearman rho相关系数值。结果表明:模糊网络的应用提高了决策过程的透明性,熵权法的应用提高了属性权重确定过程中的客观性,证明了该方法较其他经典方法具有更高的准确性。

针刀疏筋解结术对类风湿关节炎家兔滑膜炎症的影响及作用机制研究

目的观察针刀疏筋解结术对类风湿关节炎(RA)模型家兔膝关节滑膜组织NF-κB/Bcl-2通路活性及肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-1β、IL-6、Bax、caspase-3表达的影响,探讨其抑制RA滑膜炎症的作用机制。方法24只新西兰白兔随机分为正常组、模型组、药物组和针刀组,每组6只,除正常组外,其余组采用卵蛋白+弗氏完全佐剂膝关节腔注射复制RA模型,分别予相应干预,连续18 d。测定家兔膝关节痛阈、膝关节周径,超声观察关节腔积液、滑膜厚度及内部血流信号,HE染色观察膝关节滑膜组织形态,TUNEL染色观察滑膜组织成纤维样滑膜细胞(FLS)凋亡情况,免疫组化检测滑膜组织TNF-α、IL-1β、IL-6表达,RT-PCR检测滑膜组织核因子(NF)-κBp65、Bcl-2mRNA表达,Westernblot检测滑膜组织NF-κBp65、p-NF-κBp65、Bcl-2、Bax、caspase-3蛋白表达。结果与正常组比较,模型组家兔膝关节痛阈降低、膝关节周径增加,超声评分和滑膜组织病理评分增加;滑膜组织FLS凋亡率降低,TNF-α、IL-1β、IL-6表达升高,NF-κBp65、Bcl-2 mRNA和蛋白及p-NF-κBp65蛋白表达升高,Bax、caspase-3蛋白表达降低,差异均有统计学意义(P<0.05)。与模型组比较,药物组和针刀组家兔膝关节痛阈增加、膝关节周径减小,超声评分和滑膜组织病理评分减少;滑膜组织FLS凋亡率升高,TNF-α、IL-1β、IL-6表达降低,NF-κBp65、Bcl-2m RNA和蛋白及p-NF-κBp65蛋白表达降低,Bax、caspase-3蛋白表达升高,差异均有统计学意义(P<0.05)。结论针刀疏筋解结术可能通过降低滑膜组织NF-κB/Bcl-2通路活性,促进FLS凋亡,减少TNF-α、IL-1β、IL-6产生,抑制RA滑膜炎症,减轻膝关节肿胀、提升痛阈。

腹腔镜下保留盆腔自主神经广泛性子宫切除术在Ⅰa、Ⅰb1期宫颈癌患者中的应用

目的探究Ⅰa、Ⅰb1期宫颈癌患者行腹腔镜下保留盆腔自主神经广泛性子宫切除术(LNSRH)对其尿流动力学、性功能及并发症发生情况的影响。方法选取2019年5月至2022年5月在徐州市妇幼保健院接受治疗的早期宫颈癌患者80例为研究对象,采用随机数字表法分成对照组(n=40)和观察组(n=40)。对照组行腹腔镜下广泛性子宫切除术(LRH),观察组行LNSRH。比较两组患者的基本资料、围术期指标、肿瘤标志物水平、尿流动力学指标、性功能评分及并发症发生情况。结果两组患者的临床分期、年龄、体质量指数、病理类型比较均无显著性差异(P>0.05)。观察组手术时间显著长于对照组[(246.85±30.79)min vs.(227.41±28.43)min,P<0.05];两组出血量、清扫淋巴结数量、切除阴道长度、住院时间比较均无显著性差异(P>0.05)。两组患者术后的糖类抗原125(CA-125)、鳞状上皮细胞癌抗原(SCCA)水平均显著低于术前(P<0.05);两组间术后CA-125、SCCA水平比较无显著性差异(P>0.05)。两组患者术后最大尿流率(MFR)、最大逼尿肌收缩压(MDP)、膀胱顺应性水平均显著低于术前(P<0.05);观察组术后MFR、MDP及膀胱顺应性水平显著高于对照组(P<0.05)。两组患者术后女性性功能量表(FSFI)各维度评分均显著低于术前(P<0.05);观察组术后FSFI各维度评分显著高于对照组(P<0.05)。观察组术后并发症发生率显著低于对照组(12.50%vs.32.50%,P<0.05)。结论对Ⅰa、Ⅰb1期宫颈癌患者予以LNSRH和LRH治疗均有较好的疗效,可有效降低肿瘤标志物水平,且LNSRH对患者尿流动力学和性功能影响较小,术后并发症较少。

精准膜解剖下保留盆腔自主神经宫颈癌根治术疗效观察

目的观察精准膜解剖下保留盆腔自主神经宫颈癌根治术的疗效。方法选取2020年12月至2022年12月我院收治的60例宫颈癌患者,按照随机数字表法分为对照组和观察组,每组30例。对照组患者采用传统根治性子宫切除术治疗,观察组患者采用精准膜解剖下保留盆腔自主神经宫颈癌根治术治疗。比较2组患者手术指标、术后恢复情况、并发症发生情况及术后6个月生存情况。术前及术后6个月检测2组患者的残余尿量(RUV)、最大尿流率(MFR)、平均尿流率(AFR)、最大尿意膀胱容量(BVMS)、初始尿意膀胱容量(BVFS)及最大逼尿肌压力等尿动力学指标。结果与对照组相比,观察组患者手术时间更长,宫旁和阴道切除长度更短,术中出血量、术后切缘阳性率更少/低,淋巴结清扫数更多,差异均有统计学意义(P<0.05)。与对照组相比,观察组患者术后留置尿管时间、术后肛门排气和排便时间更短,术后膀胱功能障碍发生率更低,差异均有统计学意义(P<0.05)。2组患者术后6个月RUV、BVMS、BVFS明显增加(P<0.05),但观察组患者术后6个月RUV、BVMS、BVFS低于对照组(P<0.05);2组患者术后6个月MFR、AFR、最大逼尿肌压力均明显降低(P<0.05),但观察组术后6个月MFR、AFR、最大逼尿肌压力高于对照组(P<0.05)。观察组患者并发症总发生率(6.67%)低于对照组(36.67%),差异有统计学意义(P<0.05)。术后随访6个月,2组生存率、复发率和转移率比较,差异无统计学意义(P>0.05)。结论精准膜解剖下保留盆腔自主神经宫颈癌根治术治疗宫颈癌,能够显著改善手术指标、尿动力学指标,促进术后恢复,降低并发症发生率。

基于改进Croston方法的多需求模式零备件预测

维修备件管理是提高产线可靠性、实现降本增效的关键。针对具备间歇性与随机性特征的维修备件需求预测问题,提出了基于改进Croston方法的备件需求预测模型。依据Syntetos准则基于间断性与波动性特征将备件需求划分为4类。针对含有波动性特征的需求,基于Croston方法主要思想将备件需求预测分解为需求发生状态预测和需求量预测两类问题,设计了集合经验模态分解(ensemble empirical mode decomposition,EEMD)-长短期记忆网络集成(long short-term memory,LSTM)预测模型。EEMD方法将剧烈波动序列分解为若干相对平稳的分量,进而采用LSTM方法对各分量进行预测。针对含有间断性特征的需求,引入信号处理技术中的信号调制技术,将需求发生状态0-1二值序列进行连续化处理。所提方法解决了备件需求波动性强、间断性大的难题,已应用于湖北中烟武汉卷烟厂,证明了方法的优越性与可行性。

子宫内膜癌保育治疗后复发的影响因素分析

目的 分析子宫内膜癌(EC)保育治疗后复发的影响因素。方法 选取2019年1月至2021年1月于湖北医药学院附属十堰市太和医院妇科进行治疗的102例EC患者作为研究对象,根据患者复发情况分为复发组(n=30)和未复发组(n=72),采用单因素及多因素logistic回归分析影响EC保育治疗后复发的因素。结果 两组体重指数(BMI)≥24kg/m^(2)、病灶大小≥2cm比较,差异有统计学意义(P<0.05);两组POLE超突变型、CN-H型比较,差异有统计学意义(P<0.05);多因素logistic回归分析结果显示,BMI≥24 kg/m^(2)、病灶大小≥2 cm、CN-H型是EC保育治疗后复发的危险因素(P <0.05)。结论 BMI≥24 kg/m^(2)、病灶大小≥2 cm和CN-H型是EC患者保育治疗后复发的影响因素,临床应根据实际情况,及时调整治疗方案,保障患者预后。

基于质量问题统计数据的某型车辆备件配置研究

基于交付用户使用后的某型特种车辆质量问题统计数据,对发生的质量问题进行了分类和分析,梳理出车辆易损件备件清单。最后对该产品备件配置存在的问题进行了探讨并提出了建议,以期对其他产品备件配置提供一定的借鉴。

MBSE在直升机航材支持场景建模中的应用

介绍了基于Rhapsody的直升机航材支持场景建模与开发的流程与方法;通过模型的方式建立用例图、活动图、顺序图和可用于执行验证的状态机来描述航材支持场景;指导直升机航材支持方案设计过程中的需求分析、功能分析和设计综合;探索MBSE方法在直升机运营保障领域的指导作用,为直升机用户航材支持提供初始建议。