【目的】探讨戈舍瑞林联合比卡鲁胺间歇性治疗对前列腺癌（PC）患者前列腺抗原及免疫功能的影响。【方法185例晚期PC患者根据入院时间先后顺序分为观察组43例和对照组42例，观察组患者接受戈舍瑞林联合比卡鲁胺间歇性治疗，对照组接受...【目的】探讨戈舍瑞林联合比卡鲁胺间歇性治疗对前列腺癌（PC）患者前列腺抗原及免疫功能的影响。【方法185例晚期PC患者根据入院时间先后顺序分为观察组43例和对照组42例，观察组患者接受戈舍瑞林联合比卡鲁胺间歇性治疗，对照组接受戈舍瑞林联合比卡鲁胺连续性治疗。比较治疗前及治疗后3、6、9、12个月时两组前列腺抗原、血管内皮生长因子（VEGF）、免疫功能变化及不良反应。【结果】治疗后3、6、9、12个月时，两组患者血清前列腺特异性抗原（PSA）、游离前列腺特异抗原（F-PSA）含量均明显低于治疗前（P〈0．05），VEGF含量显著低于治疗前（P〈0．05），外周血中CD3＋、CD4＋、CD4／CD8淋巴细胞的含量明显高于治疗前，CD8＋淋巴细胞亚群的含量明显低于治疗前（P〈0．05），但两组间上述各指标比较差异无显著性（P〉0．05）；两组不良反应发生率比较差异无显著性（6．98％ vs 11．90％）（P〉0．05）。【结论】戈舍瑞林联合比卡鲁胺间歇性治疗的疗效与连续性治疗相当，均能有效降低PSA含量并调节患者免疫功能。展开更多
Objective To introduce an operation procedure and evaluate the continence diversion results of the modified ureterosigmoidostomy after radical cystectomy. Methods Fourteen cases of bladder cancer or prostate carcin...Objective To introduce an operation procedure and evaluate the continence diversion results of the modified ureterosigmoidostomy after radical cystectomy. Methods Fourteen cases of bladder cancer or prostate carcinoma were operated on with modified Sigma pouch from Feb, 1998 to Dec, 1999. A longitudinal incision about 25 cm on the sigmoid wall was done to form a low pressure pouch. The vertex of the new pouch was fixed to sacrum. Both ends of ureters were anastomosed side to side and to form a big nipple and inserted into the top of pouch for 2 to 3 centimeters.Results It took about sixty five minutes to create a new low pressure pouch after radical cystectomy. Early complication of was found in two cases postoperatively, and cured with temporary colonostomy. Hydronephrosis and hypokalemia in one patient were cured by percutaneous anterograde ureter dilatation with balloon and oral replacement of potassium salt. All patients displayed urinary continence. No symptomatic renal infection or hypercholoraemic acidosis occurred. Conclusion Modified ureterosigmoidostomy is a safe procedure of urinary diversion and provides a big volume, low intravesical pressure pouch. The patients are free from the troublesome urine bag, intermittert catheterization, and upper urinary tracts are protected effectively. The quality of life is satisfied.展开更多
文摘【目的】探讨戈舍瑞林联合比卡鲁胺间歇性治疗对前列腺癌（PC）患者前列腺抗原及免疫功能的影响。【方法185例晚期PC患者根据入院时间先后顺序分为观察组43例和对照组42例，观察组患者接受戈舍瑞林联合比卡鲁胺间歇性治疗，对照组接受戈舍瑞林联合比卡鲁胺连续性治疗。比较治疗前及治疗后3、6、9、12个月时两组前列腺抗原、血管内皮生长因子（VEGF）、免疫功能变化及不良反应。【结果】治疗后3、6、9、12个月时，两组患者血清前列腺特异性抗原（PSA）、游离前列腺特异抗原（F-PSA）含量均明显低于治疗前（P〈0．05），VEGF含量显著低于治疗前（P〈0．05），外周血中CD3＋、CD4＋、CD4／CD8淋巴细胞的含量明显高于治疗前，CD8＋淋巴细胞亚群的含量明显低于治疗前（P〈0．05），但两组间上述各指标比较差异无显著性（P〉0．05）；两组不良反应发生率比较差异无显著性（6．98％ vs 11．90％）（P〉0．05）。【结论】戈舍瑞林联合比卡鲁胺间歇性治疗的疗效与连续性治疗相当，均能有效降低PSA含量并调节患者免疫功能。
文摘Objective To introduce an operation procedure and evaluate the continence diversion results of the modified ureterosigmoidostomy after radical cystectomy. Methods Fourteen cases of bladder cancer or prostate carcinoma were operated on with modified Sigma pouch from Feb, 1998 to Dec, 1999. A longitudinal incision about 25 cm on the sigmoid wall was done to form a low pressure pouch. The vertex of the new pouch was fixed to sacrum. Both ends of ureters were anastomosed side to side and to form a big nipple and inserted into the top of pouch for 2 to 3 centimeters.Results It took about sixty five minutes to create a new low pressure pouch after radical cystectomy. Early complication of was found in two cases postoperatively, and cured with temporary colonostomy. Hydronephrosis and hypokalemia in one patient were cured by percutaneous anterograde ureter dilatation with balloon and oral replacement of potassium salt. All patients displayed urinary continence. No symptomatic renal infection or hypercholoraemic acidosis occurred. Conclusion Modified ureterosigmoidostomy is a safe procedure of urinary diversion and provides a big volume, low intravesical pressure pouch. The patients are free from the troublesome urine bag, intermittert catheterization, and upper urinary tracts are protected effectively. The quality of life is satisfied.
