OBJECTIVE To investigate the effect of intermittent androgen blockade （IAB） on the quality of life （QOL） of patients with advanced prostatic carcinoma （APC）. METHODS Investigations on the QOL of 51 APC patients ...OBJECTIVE To investigate the effect of intermittent androgen blockade （IAB） on the quality of life （QOL） of patients with advanced prostatic carcinoma （APC）. METHODS Investigations on the QOL of 51 APC patients receiving lAB treatment, totaling 3 times, i.e. 6 months before and after, and 12 months after treatment, were perform using the EORTC QLQ-C30 measuring scale and QLQ-PR25 scale. RESULTS Although lAB became an economic burden for the families, it was lessened during the intermission （P〈0.05）. The overall health status significantly improved 6 months after lAB treatment （P〈0.01）, especially during the intermission （P〈0.05）, with a total or local easement of pain （P〈0.01） and an improvement of urinary function （P〈0.01）. Although there was impairment, to various degrees, in many functions of the patients on the 6th month of treatment, such as the physical function （P〈0.05）, role function （P〈0.05）, the emotional （P〈0.01） and the social functions （P〈0.01）, with an enhancement of fatigue （P〈0.01）, these functions gradually recovered by the 12th month as the intermission started. Treatment-related symptoms such as flushing and mammary swelling significantly emerged on the 6th treatment month （P〈0.01）, and lessened on the 12th （P〈0.01）. During the treatment period, there was an notable drop in sexual interest （P〈0.01）, with a deprivation of sex life, but revived to various degrees during the intermission （P〈0.01）. CONCLUSION Although lAB treatment of APC patients did impair the physiologic and psychologic status of patients to varying degrees, these were improved and restored during the intermission.展开更多
Background:Till date,the optimal treatment strategy for delivering adjuvant androgen deprivation therapy(ADT)in localized and locally advanced prostate cancer(PCa),as a lower stage in PCa progression compared with met...Background:Till date,the optimal treatment strategy for delivering adjuvant androgen deprivation therapy(ADT)in localized and locally advanced prostate cancer(PCa),as a lower stage in PCa progression compared with metastatic PCa,is still unclear.This study compares the efficacy of castration alone with complete androgen blockade(CAB)as adjuvant ADT in patients with localized and locally advanced PCa undergoing radical prostatectomy(RP).Methods:Patients diagnosed with PCa,without lymph node or distant metastasis,who received RP in West China Hospital between January 2009 and April 2019,were enrolled in this study.We performed survival,multivariable Cox proportional hazard regression,and subgroup analyses.Results:A total of 262 patients were enrolled,including 107 patients who received castration alone and 155 patients who received CAB.The survival analysis revealed that there was no significant difference between the two groups(hazard ratios[HR]=1.07,95%confidence intervals[95%CI]=0.60-1.90,P=0.8195).Moreover,the multivariable Cox model provided similarly negative results before and after adjustment for potential covariant.Similarly,there was no significant difference in the clinical recurrence between the two groups in both non-adjusted and adjusted models.Furthermore,our subgroup analysis showed that CAB achieved better biochemical recurrence(BCR)outcomes than medical castration alone as adjuvant ADT for locally advanced PCa(P for interaction=0.0247,HR=0.37,95%CI=0.14-1.00,P=0.0497).Conclusion:Combined androgen blockade achieved better BCR outcomes compared with medical castration alone as adjuvant ADT for locally advanced PCa without lymph node metastasis.展开更多
文摘OBJECTIVE To investigate the effect of intermittent androgen blockade （IAB） on the quality of life （QOL） of patients with advanced prostatic carcinoma （APC）. METHODS Investigations on the QOL of 51 APC patients receiving lAB treatment, totaling 3 times, i.e. 6 months before and after, and 12 months after treatment, were perform using the EORTC QLQ-C30 measuring scale and QLQ-PR25 scale. RESULTS Although lAB became an economic burden for the families, it was lessened during the intermission （P〈0.05）. The overall health status significantly improved 6 months after lAB treatment （P〈0.01）, especially during the intermission （P〈0.05）, with a total or local easement of pain （P〈0.01） and an improvement of urinary function （P〈0.01）. Although there was impairment, to various degrees, in many functions of the patients on the 6th month of treatment, such as the physical function （P〈0.05）, role function （P〈0.05）, the emotional （P〈0.01） and the social functions （P〈0.01）, with an enhancement of fatigue （P〈0.01）, these functions gradually recovered by the 12th month as the intermission started. Treatment-related symptoms such as flushing and mammary swelling significantly emerged on the 6th treatment month （P〈0.01）, and lessened on the 12th （P〈0.01）. During the treatment period, there was an notable drop in sexual interest （P〈0.01）, with a deprivation of sex life, but revived to various degrees during the intermission （P〈0.01）. CONCLUSION Although lAB treatment of APC patients did impair the physiologic and psychologic status of patients to varying degrees, these were improved and restored during the intermission.
基金National Natural Science Foundation of China(No.81902578)。
文摘Background:Till date,the optimal treatment strategy for delivering adjuvant androgen deprivation therapy(ADT)in localized and locally advanced prostate cancer(PCa),as a lower stage in PCa progression compared with metastatic PCa,is still unclear.This study compares the efficacy of castration alone with complete androgen blockade(CAB)as adjuvant ADT in patients with localized and locally advanced PCa undergoing radical prostatectomy(RP).Methods:Patients diagnosed with PCa,without lymph node or distant metastasis,who received RP in West China Hospital between January 2009 and April 2019,were enrolled in this study.We performed survival,multivariable Cox proportional hazard regression,and subgroup analyses.Results:A total of 262 patients were enrolled,including 107 patients who received castration alone and 155 patients who received CAB.The survival analysis revealed that there was no significant difference between the two groups(hazard ratios[HR]=1.07,95%confidence intervals[95%CI]=0.60-1.90,P=0.8195).Moreover,the multivariable Cox model provided similarly negative results before and after adjustment for potential covariant.Similarly,there was no significant difference in the clinical recurrence between the two groups in both non-adjusted and adjusted models.Furthermore,our subgroup analysis showed that CAB achieved better biochemical recurrence(BCR)outcomes than medical castration alone as adjuvant ADT for locally advanced PCa(P for interaction=0.0247,HR=0.37,95%CI=0.14-1.00,P=0.0497).Conclusion:Combined androgen blockade achieved better BCR outcomes compared with medical castration alone as adjuvant ADT for locally advanced PCa without lymph node metastasis.
