BACKGROUND A prostatic stromal tumor is deemed to be a rare oncology condition.Based on the retrospective analysis of clinical data and scientific literature review,a case of prostatic stromal tumor was reported in th...BACKGROUND A prostatic stromal tumor is deemed to be a rare oncology condition.Based on the retrospective analysis of clinical data and scientific literature review,a case of prostatic stromal tumor was reported in this article to explore the diagnosis,treatment and prognosis of this rare disease.CASE SUMMARY The present case involved an older male patient who was admitted to our department for a medical consultation of dysuria.Serum prostate-specific antigen was 8.30 ng/mL,Ultrasound and magnetic resonance imaging suggested evident enlargement of the prostate and multiple cystic developments internally.Considering that the patient was an elderly male with a poor health status,transurethral resection of the prostate was performed to improve the symptoms of urinary tract obstruction.Furthermore,based on histopathologic examination and immunohistochemical staining,the patient was pathologically diagnosed with prostatic stromal tumor.The patient did not receive any further adjuvant therapy following surgery leading to a clinical recommendation that the patient should be followed up on a long-term basis.However,during the recent follow-up assessment,the patient demonstrated recurrence of lower urinary tract symptoms and gross hematuria.CONCLUSION Referring to scientific literature review,we believe that the management of these lesions requires a thorough assessment of the patient.Furthermore,the treatment of prostate stromal tumors should be based on the imaging examination andpathological classification. Active surgical treatment is of great significance to theprognosis of patients, and subsequent surveillance after the treatment iswarranted.展开更多
BACKGROUND Prostatic stromal sarcoma presenting with rhabdoid features is extremely rare,and only four cases have been reported in the English-language literature to date.Accordingly, there is no absolute definition o...BACKGROUND Prostatic stromal sarcoma presenting with rhabdoid features is extremely rare,and only four cases have been reported in the English-language literature to date.Accordingly, there is no absolute definition of this group of tumors as yet, and our overall understanding of its morphological features, therapeutic regimen and prognosis is limited.CASE SUMMARY A 34-year-old male patient was referred to our hospital to address a 2-mo history of hematuria and progressive dysuria. Pelvic computed tomography scan revealed a 6.0 cm × 5.2 cm × 7.2 cm mass in the prostate, with bladder invasion.The patient underwent transurethral prostatectomy as upfront therapy. He refused further treatment and died of uncontrollable tumor growth 3 mo after surgery. Pathology analysis revealed the stroma to be pleomorphic, with a huge number of atypical spindle cells. Rhabdomyoblastic cells, with abundant eosinophilic cytoplasm, were detected. The spindle cells were positive for vimentin, INI1 and β-catenin, and the rhabdomyoblastic cells were positive for MyoD1, myogenin and INI1. The spindle cells and epithelial cells were sporadically positive for P53.CONCLUSION The prostatic stromal sarcoma tumor was immunoreactive for β-catenin,suggesting a role for the Wnt/β-catenin pathway in this tumor type.展开更多
文摘BACKGROUND A prostatic stromal tumor is deemed to be a rare oncology condition.Based on the retrospective analysis of clinical data and scientific literature review,a case of prostatic stromal tumor was reported in this article to explore the diagnosis,treatment and prognosis of this rare disease.CASE SUMMARY The present case involved an older male patient who was admitted to our department for a medical consultation of dysuria.Serum prostate-specific antigen was 8.30 ng/mL,Ultrasound and magnetic resonance imaging suggested evident enlargement of the prostate and multiple cystic developments internally.Considering that the patient was an elderly male with a poor health status,transurethral resection of the prostate was performed to improve the symptoms of urinary tract obstruction.Furthermore,based on histopathologic examination and immunohistochemical staining,the patient was pathologically diagnosed with prostatic stromal tumor.The patient did not receive any further adjuvant therapy following surgery leading to a clinical recommendation that the patient should be followed up on a long-term basis.However,during the recent follow-up assessment,the patient demonstrated recurrence of lower urinary tract symptoms and gross hematuria.CONCLUSION Referring to scientific literature review,we believe that the management of these lesions requires a thorough assessment of the patient.Furthermore,the treatment of prostate stromal tumors should be based on the imaging examination andpathological classification. Active surgical treatment is of great significance to theprognosis of patients, and subsequent surveillance after the treatment iswarranted.
文摘BACKGROUND Prostatic stromal sarcoma presenting with rhabdoid features is extremely rare,and only four cases have been reported in the English-language literature to date.Accordingly, there is no absolute definition of this group of tumors as yet, and our overall understanding of its morphological features, therapeutic regimen and prognosis is limited.CASE SUMMARY A 34-year-old male patient was referred to our hospital to address a 2-mo history of hematuria and progressive dysuria. Pelvic computed tomography scan revealed a 6.0 cm × 5.2 cm × 7.2 cm mass in the prostate, with bladder invasion.The patient underwent transurethral prostatectomy as upfront therapy. He refused further treatment and died of uncontrollable tumor growth 3 mo after surgery. Pathology analysis revealed the stroma to be pleomorphic, with a huge number of atypical spindle cells. Rhabdomyoblastic cells, with abundant eosinophilic cytoplasm, were detected. The spindle cells were positive for vimentin, INI1 and β-catenin, and the rhabdomyoblastic cells were positive for MyoD1, myogenin and INI1. The spindle cells and epithelial cells were sporadically positive for P53.CONCLUSION The prostatic stromal sarcoma tumor was immunoreactive for β-catenin,suggesting a role for the Wnt/β-catenin pathway in this tumor type.
