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Numerical investigation on properties of attack angle for an opposing jet thermal protection system 被引量:9
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作者 陆海波 刘伟强 《Chinese Physics B》 SCIE EI CAS CSCD 2012年第8期289-294,共6页
The three-dimensional Navier Stokes equation and the k-ε viscous model are used to simulate the attack angle characteristics of a hemisphere nose-tip with an opposing jet thermal protection system in supersonic flow ... The three-dimensional Navier Stokes equation and the k-ε viscous model are used to simulate the attack angle characteristics of a hemisphere nose-tip with an opposing jet thermal protection system in supersonic flow conditions. The numerical method is validated by the relevant experiment. The flow field parameters, aerodynamic forces, and surface heat flux distributions for attack angles of 0°, 2°, 5°, 7°, and 10° are obtained. The detailed numerical results show that the cruise attack angle has a great influence on the flow field parameters, aerodynamic force, and surface heat flux distribution of the supersonic vehicle nose-tip with an opposing jet thermal protection system. When the attack angle reaches 10°, the heat flux on the windward generatrix is close to the maximal heat flux on the wall surface of the nose-tip without thermal protection system, thus the thermal protection has failed. 展开更多
关键词 properties of attack angle opposing jet thermal protection system supersonic vehicle computer simulation
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Formation and ecological response of sand patches in the protection system of Shapotou section of the Baotou-Lanzhou railway,China
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作者 DUN Yaoquan QU Jianjun +4 位作者 KANG Wenyan LI Minlan LIU Bin WANG Tao SHAO Mei 《Journal of Arid Land》 SCIE CSCD 2024年第2期298-313,共16页
The development of bare patches typically signifies a process of ecosystem degradation.Within the protection system of Shapotou section of the Baotou-Lanzhou railway,the extensive emergence of bare sand patches poses ... The development of bare patches typically signifies a process of ecosystem degradation.Within the protection system of Shapotou section of the Baotou-Lanzhou railway,the extensive emergence of bare sand patches poses a threat to both stability and sustainability.However,there is limited knowledge regarding the morphology,dynamic changes,and ecological responses associated with these sand patches.Therefore,we analyzed the formation and development process of sand patches within the protection system and its effects on herbaceous vegetation growth and soil nutrients through field observation,survey,and indoor analysis methods.The results showed that sand patch development can be divided into three stages,i.e.,formation,expansion,and stabilization,which correspond to the initial,actively developing,and semi-fixed sand patches,respectively.The average dimensions of all sand patch erosional areas were found to be 7.72 m in length,3.91 m in width,and 0.32 m in depth.The actively developing sand patches were the largest,and the initial sand patches were the smallest.Throughout the stage of formation and expansion,the herbaceous community composition changed,and the plant density decreased by more than 50.95%.Moreover,the coverage and height of herbaceous plants decreased in the erosional area and slightly increased in the depositional lobe;and the fine particles and nutrients of soils in the erosional area and depositional lobe showed a decreasing trend.In the stabilization phases of sand patches,the area from the inlet to the bottom of sand patches becomes initially covered with crusts.Vegetation and 0-2 cm surface soil condition improved in the erosional area,but this improvement was not yet evident in the depositional lobe.Factors such as disturbance,climate change,and surface resistance to erosion exert notable influences on the formation and dynamics of sand patches.The results can provide evidence for the future treatment of sand patches and the management of the protection system of Shapotou section of the Baotou-Lanzhou railway. 展开更多
关键词 railway protection system sand patch MORPHOLOGY vegetation characteristic soil property
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Experimental Study on Engineering Behavior of Solidified Soil for Scour Repair and Protection
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作者 WU Xiao-ni LI Ru-yu +5 位作者 SHU Jian TANG Chao CHEN Jin-jian WANG Hui-li JIANG Hai-li WANG Xiao 《China Ocean Engineering》 SCIE EI CSCD 2024年第4期625-635,共11页
A new scour countermeasure using solidified slurry for offshore foundation has been proposed recently.Fluidized solidified slurry is pumped to seabed area around foundation for scour protection or pumped into the deve... A new scour countermeasure using solidified slurry for offshore foundation has been proposed recently.Fluidized solidified slurry is pumped to seabed area around foundation for scour protection or pumped into the developed scour holes for scour repair as the fluidized material solidifies gradually.In the pumping operation and solidification,the engineering behaviors of solidified slurry require to be considered synthetically for the reliable application in scour repair and protection of ocean engineering such as the pumpability related flow value,flow diffusion behavior related rheological property,anti-scour performance related retention rate in solidification and bearing capacity related strength property after solidification.In this study,a series of laboratory tests are conducted to investigate the effects of mix proportion(initial water content and binder content)on the flow value,rheological properties,density,retention rate of solidified slurry and unconfined compressive strength(UCS).The results reveal that the flow value increases with the water content and decreases with the binder amount.All the solidified slurry exhibits Bingham plastic behavior when the shear rate is larger than 5 s^(-1).The Bingham model has been employed to fit the rheology test results,and empirical formulas for obtaining the density,yield stress and viscosity are established,providing scientific support for the numerical assessment of flow and diffusion of solidified slurry.Retention rate of solidified slurry decreases with the water flow velocity and flow value,which means the pumpability of solidified slurry is contrary to anti-scour performance.The unconfined compressive strength after solidification reduces as the water content increases and binder content decreases.A design and application procedure of solidified soil for scour repair and protection is also proposed for engineering reference. 展开更多
关键词 scour repair and protection solidified soil PUMPABILITY STRENGTH flow properties anti-scour performance
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Intellectual Property Protection and High-quality Development of Cotton Industry in Xinjiang 被引量:7
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作者 Miaomiao XU Yueqiu HE +2 位作者 Wanzhen XIONG Chengshun SONG Zhiguo SUN 《Asian Agricultural Research》 2022年第6期4-11,共8页
This paper firstly introduces the general situation of cotton planting areas in China and cotton industry in Xinjiang,and the current situation of intellectual property protection of Xinjiang's cotton industry.The... This paper firstly introduces the general situation of cotton planting areas in China and cotton industry in Xinjiang,and the current situation of intellectual property protection of Xinjiang's cotton industry.Then,it analyzes the main problems in its intellectual property protection and high-quality development.On this basis,it comes up with the recommendations for high-quality development of cotton industry in Xinjiang under the strategy of strengthening the country with intellectual property.The recommendations include improving the level of creation of creative intellectual property rights,building an intellectual property rule system in the entire cotton industry chain in Xinjiang,building protected zones for production of major high quality agricultural product cotton,establishing a demonstration zone to undertake the transfer of the domestic cotton textile and garment industry,undertaking education on the sense of community for the Chinese nation in response to the Xinjiang cotton incident,and developing the"Belt and Road"blue market for Xinjiang cotton and its products. 展开更多
关键词 Xinjiang cotton incident protected zone for production of major high quality agricultural product cotton Sense of community for the Chinese nation Strategy of strengthening the country with intellectual property High-quality development
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Environmental properties of metallic minerals and their applications in environmental protection in China 被引量:3
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作者 王吉中 李胜荣 +2 位作者 江永宏 魏瑞华 牛花朋 《Chinese Journal Of Geochemistry》 EI CAS 2005年第3期221-227,共7页
In terms of environmental mineralogy, the environmental properties of metallic minerals, including chemical activation, adsorption, pore effect and nanometer effect, have been analyzed. On the basis of the analysis of... In terms of environmental mineralogy, the environmental properties of metallic minerals, including chemical activation, adsorption, pore effect and nanometer effect, have been analyzed. On the basis of the analysis of environmental properties of metallic minerals, the applications of iron-bearing sulfides, iron and manganese oxides in the purification of wastewaters containing heavy metal ions (Cr{6+}, Hg{2+}, Pb{2+}, etc.) have been summarized. Moreover, research on the application of metallic minerals in environmental protection has been anticipated. It should be a piece of dominating work for environmental mineralogic researchers in the future to lucubrate systematically the physical and chemical characteristics of the metallic mineral surfaces, further reveal the reciprocity process between metallic minerals and water surface, perfect the theory and model of the metallic minerals to remove contaminants, intensify study on the facilities and techniques of metallic minerals to remove contaminants, and entail well the extension and propagation of achievements. 展开更多
关键词 中国 环境保护 金属矿物 化学活化作用 环境管理
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China Strengthens the Protection of Intellectual Property
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作者 Xiao Yang, Ministec of Justice 《China's Foreign Trade》 1995年第1期5-6,共2页
The intellectual property protection system was formed when civilization and the commodity economy were developing to a certain extent, and was a significant landmark for mankind in respecting talents and knowledge. N... The intellectual property protection system was formed when civilization and the commodity economy were developing to a certain extent, and was a significant landmark for mankind in respecting talents and knowledge. Now it is playing an important role in promoting scientific and technical progress, cultural prosperity and economic development. Such an important system ensures the smooth performance of the socialist economy, making up one of the basic premises for 展开更多
关键词 In China Strengthens the protection of Intellectual property
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Protection of Intellectual Property for Both Sides of the Straits
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作者 Jiang Shan 《China's Foreign Trade》 1995年第1期8-9,共2页
At the invitation of Pen-tsao Chang, Chairman of the Commercial Affairs Coordination Committee for the Two Sides of the Straits, a delegation composed of nine intellectual property experts and scholars, headed by Xie ... At the invitation of Pen-tsao Chang, Chairman of the Commercial Affairs Coordination Committee for the Two Sides of the Straits, a delegation composed of nine intellectual property experts and scholars, headed by Xie Jianqun, Vicechairman of the China Council for the Promotion of International Trade (CCPIT) and Chairman of the Economic and Trade Coordination Committee for the Two Sides of the Straits, recently paid a nineday visit to Taiwan. The visit caught the attention of Taiwan’s mass media as it was the first high-ranking economic 展开更多
关键词 In protection of Intellectual property for Both Sides of the Straits
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A procedural study of building up a performance evaluation indicator system of intellectual property protection
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作者 Luo Juan Xu Xingxiang 《International Journal of Technology Management》 2015年第10期113-116,共4页
The intellectual property protection, whether judicial or administrative, is evaluated through a performance evaluation indicator system. To building up such a system, we must follow certain working procedures which u... The intellectual property protection, whether judicial or administrative, is evaluated through a performance evaluation indicator system. To building up such a system, we must follow certain working procedures which usually consist of four steps: to determine the performance objectives, to design the structure of indicator system, to specify the indicators and to set up the weight of indicators. Each step plays a different role in performance evaluation indicator system and has its own impact on the realization of performance evaluation objectives respectively. So the scientifically building up a performance evaluation indicator system is the key to determine whether the intellectual property is protected well or not. 展开更多
关键词 lntellectual property protection performance evaluation indicator system performance objective evaluating indicators weights of indicators
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BEIJING'S JUDICIAL PROTECTION OF INTELLECTUAL PROPERTY
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作者 Zhang Guangliang 《China's Foreign Trade》 1996年第4期31-32,共2页
With legislation on intellectualproperty being perfectedcontinuously,"no law to follow"inChina’s intellectual property protectionhas become a phenomenon of thepast.Legislation is the prerequisitefor law enf... With legislation on intellectualproperty being perfectedcontinuously,"no law to follow"inChina’s intellectual property protectionhas become a phenomenon of thepast.Legislation is the prerequisitefor law enforcement,whereas thelatter is the aim of the former,and aguarantee for safeguarding people’slegitimate rights and interests.Thejudicial organs at various levels inBeijing have strictly implemented theintellectual property laws,safeguarded the legitimate rights andinterests of intellectual propertyproprietors,and enhanced the judicialprotection of intellectual property. 展开更多
关键词 BEIJING’S JUDICIAL protection OF INTELLECTUAL property
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Song Jian on China's Intellectual Property Protection
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作者 Jiang Min 《China's Foreign Trade》 1995年第11期6-7,共2页
On June 29 this year, Mr. Song Jian, State Councillor and Minister of the State Scientific and Technology Commission, was elected chairman at the 1995 Annual Meeting of the Chinese Group of the Association for the Int... On June 29 this year, Mr. Song Jian, State Councillor and Minister of the State Scientific and Technology Commission, was elected chairman at the 1995 Annual Meeting of the Chinese Group of the Association for the International Protection of Industrial Property (AIPPI). A leader in China’s scientific field and world-renowned expert, Mr. Song fully recognizes the positive role played by the Chinese Group of the AIPPI in promoting the establishment and development of China’s intellectual property system, expanding relations 展开更多
关键词 Song Jian on China’s Intellectual property protection
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Game Analysis for Intellectual Property Protection(IPP) of Multinational Corporations in the Context of R&D Internationalization
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作者 贺团涛 曾德明 《Journal of Donghua University(English Edition)》 EI CAS 2011年第1期109-114,共6页
In order to explore the impact relationship between intellectual property protection(IPP) system and technological innovation,a game model was constructed.The system of IPP is a set of game rules to protect the innova... In order to explore the impact relationship between intellectual property protection(IPP) system and technological innovation,a game model was constructed.The system of IPP is a set of game rules to protect the innovation under the background of R&D internationalization.Only when the main parties abide by the system of intellectual property,can the self-interest and collective interest of the two sides be maximized.The government must strengthen the penalties for intellectual property right(IPR) violations,reduce the cost of IPP declaration,reduce the cost of the innovator's own rights protection,and increase the cost of imitate behavior of IPR. 展开更多
关键词 R&D internationalization transnational corporations(TNCs) intellectual property protection(IPP) game1
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On the Perfection of Legislation on Property Rights Protection of Criminal Suspects in Investigation Process
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作者 林铁军 《The Journal of Human Rights》 2016年第1期30-37,共8页
The property rights of a criminal suspect are an important component of human rights,but,unfortunately,may be restrained by factors in the investigation process like judicial stereotypes,legal regulations,and a lack o... The property rights of a criminal suspect are an important component of human rights,but,unfortunately,may be restrained by factors in the investigation process like judicial stereotypes,legal regulations,and a lack of initiative on the part of the rights holder,which,from time to time,may result in infringements of such rights.Thus it is necessary for us to probe into the reasons why such infringements occur and sort out the contents about enhancing property rights protection of criminal suspects in the amendment to Criminal Procedure Law.To counter the existing disregard for property rights protection of criminal suspects and its legislative deficiency,judicial reform must be carried out as to three aspects:procedural improvement,institutional establishment,and judicial transformation property rights ideas in criminal proceedings. 展开更多
关键词 criminal suspects human rights property rights protection investigation measures
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Status of Intellectual Property Protection, Exploitation and Utilization of Germplasm Resources in Henan Province
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作者 WEI Wen-xing HU Lin Hui-yong ZHANG Lei CHENG Ze-qiang 《河南农业科学》 CSCD 北大核心 2009年第9期26-30,共5页
关键词 河南 农业 种质资源 生态研究
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Provide Equal Protection to Property Under All Ownerships
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作者 STAFF REPORTER ZHAO HAINING 《The Journal of Human Rights》 2005年第6期21-23,共3页
Editor's note: On July 10,2005, a draft of Real Rights Law of the People's Republic of China was made public for opinions and suggestions from peo- ple of all walks of life. Following is a transcript of an int... Editor's note: On July 10,2005, a draft of Real Rights Law of the People's Republic of China was made public for opinions and suggestions from peo- ple of all walks of life. Following is a transcript of an interview by our reporter with Professor Wang Liming of the Renmin University of China, a noted expert of law, who is involved in the drafting of the law: 展开更多
关键词 Provide Equal protection to property Under All Ownerships REAL CODE NPC
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Innovative Design and Additive Manufacturing of Regenerative Cooling Thermal Protection System Based on the Triply Periodic Minimal Surface Porous Structure 被引量:3
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作者 Xinglong Wang Cheng Wang +3 位作者 Xin Zhou Mingkang Zhang Peiyu Zhang Lei Wang 《Computer Modeling in Engineering & Sciences》 SCIE EI 2020年第5期495-508,共14页
The new regenerative cooling thermal protection system exhibits the multifunctional characteristics of load-carrying and heat exchange cooling,which are fundamental for the lightweight design and thermal protection of... The new regenerative cooling thermal protection system exhibits the multifunctional characteristics of load-carrying and heat exchange cooling,which are fundamental for the lightweight design and thermal protection of hypersonic vehicles.Triply periodic minimal surface(TPMS)is especially suitable for the structural design of the internal cavity of regenerative cooling structures owing to its excellent structural characteristics.In this study,test pieces were manufactured using Ti6Al4V lightweight material.We designed three types of porous test pieces,and the interior was filled with a TPMS lattice(Gyroid,Primitive,I-WP)with a porosity of 30%.All porous test pieces were manufactured via selective laser melting technology.A combination of experiments and finite element simulations were performed to study the selection of the internal cavity structure of the regenerative cooling thermal protection system.Hence,the relationship between the geometry and mechanical properties of a unit cell is established,and the deformation mechanism of the porous unit cell is clarified.Among the three types of porous test pieces,the weight of the test piece filled with the Gyroid unit cell was reduced by 8.21%,the average tensile strength was reduced by 17.7%compared to the solid test piece,while the average tensile strength of the Primitive and I-WP porous test pieces were decreased by 30.5%and 33.3%,respectively.Compared with the other two types of unit cells,Gyroid exhibited better mechanical conductivity characteristics.Its deformation process was characterised by stretching,shearing,and twisting,while the Primitive and I-WP unit cells underwent tensile deformation and tensile and shear deformation,respectively.The finite element predictions in the study agree well with the experimental results.The results can provide a basis for the design of regenerative cooling thermal protection system. 展开更多
关键词 Triply periodic minimal surface(TPMS) regenerative cooling thermal protection system selective laser melting mechanical properties fracture analysis
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Microstructural characteristics and mechanical properties of bronze/steel bimetallic laminated composite prepared by protective atmosphere casting process 被引量:1
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作者 Bin Liu Da-shan Sui +5 位作者 Zhi-min Guo Yuan-long Wang Xiao-lin Yang Guang-hong Hu Ji-xian Zhang Chang-zeng Luo 《China Foundry》 SCIE CAS 2021年第5期497-504,共8页
The bonding quality of bronze/steel bimetallic laminated composite is the key factor to whether it can be used in poor working conditions.In this study,bimetallic billets were prepared by the protective atmosphere cas... The bonding quality of bronze/steel bimetallic laminated composite is the key factor to whether it can be used in poor working conditions.In this study,bimetallic billets were prepared by the protective atmosphere casting process.The microstructural characteristics,mechanical properties and interface bonding mechanism of the bronze/steel bimetallic composites were analyzed comprehensively through a series of microstructure analysis(inicluding OM,SEM,and EDS)and mechanical properties tests.The experimental results demonstrate that the vaporization of lead(Pb)element in the bronze is only 0.4%in weight,and alloy elements are diffused into both sides at the interface.Moreover,the hardness in the bronze region exceeds 100.0 HV which indicates excellent wear resistance.Tensile and shear tests indicate that the fractures mainly occur on the bronze side with the interaction of the brittle fracture of Pb particles and the ductile fracture of Cu-Sn solid solution.The maximum tensile strength and shear strength reach 204.0 MPa and 211.0 MPa,respectively.These results demonstrate that the protective atmosphere casting process is applicable for the preparation of bronze/steel bimetallic laminated composite with high quality. 展开更多
关键词 protective atmosphere casting process lead bronze bimetallic composite microstructure mechanical properties
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Conductive Mortar as Anode Material for Cathodic Protection of Steel in Concrete
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作者 徐晶 姚武 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2010年第5期883-888,共6页
The behavior of a new type of secondary anode material made of carbon fiber reinforced cement used for cathodic protection of steel in concrete was studied. The mechanical, electrical and electrochemical properties of... The behavior of a new type of secondary anode material made of carbon fiber reinforced cement used for cathodic protection of steel in concrete was studied. The mechanical, electrical and electrochemical properties of this conductive mortar were investigated. Results indicate that the addition of carbon fiber enhances the strength and ductility of the mortar, as well as the electrical property. The anodic polarization behavior was tested on specimens immersed in aqueous solutions of saturated Ca(OH)2 in the presence or absence of 3% NaCl. Based on impedance measurements the electrochemical parameters of conductive mortar were calculated. It is shown that the investigated conductive mortar can be used in cathodic protection of reinforced concrete. The study also shows that the optimum fiber content in mortar should be in the range from 0.5 vol% to 0.7 vol%. 展开更多
关键词 reinforced concrete cathodic protection EIS electrochemical property
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Protective Properties of High Temperature Oxide Films on Ni-based Superalloys in 3.5% NaCl Solution
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作者 Huiping BAI Fuhui WANG 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2007年第4期541-546,共6页
The electrochemical behaviors of high temperature oxide film formed on the sputtered microcrystalline coating of M38 alloy (mc-M38) were investigated by potentiodynamic and electrochemical impedance spectroscopy (... The electrochemical behaviors of high temperature oxide film formed on the sputtered microcrystalline coating of M38 alloy (mc-M38) were investigated by potentiodynamic and electrochemical impedance spectroscopy (EIS) techniques in 3.5% NaCl solution. Mott-Schottky analysis was used to study the semi-conductive properties of the surface oxide. The results of the capacitance measurements showed that the oxide films on both the coating and the cast alloy were p-type semiconducting characteristics. Both the carrier density (Na)and the flat band potential (Efb) were obviously frequency-dependent, and the optimal frequency range was from 1000 to 1500 Hz. The oxidized coating exhibited higher protectivity than the oxidized cast alloy due to the lower carrier density compared with that of the oxidized cast alloy. The EIS data of the long-term immersing tests suggested that the oxide film served as an inner-barrier layer against chloride ions. The penetration of the aggressive ions into the surface oxide resulted in the decreased polarization resistance as a function of the immersion time. 展开更多
关键词 High temperature oxide film protective properties EIS Mott-Schottky analysis
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Assessment of Hydraulic Parameters and Protection Zones of Catchment Aquifers for Water Supply Network in NdéDivision, West-Cameroon (Central Africa)
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作者 Roger Feumba Kemgang Dongmo Tchouta +3 位作者 Jean Ghislain Tabué Youmbi Valentin Yvan Emmanuel Mvondo Depesquidoux I. Tchaptchet Tchato Benjamin Ngounou Ngatcha 《Journal of Water Resource and Protection》 2021年第7期478-497,共20页
Ndé Division in West-Cameroon is facing with water supply although many attempts of restoring existing SCANWATER facilities by Bangangté Municipality. In order to address the issue, we assess the exploitable... Ndé Division in West-Cameroon is facing with water supply although many attempts of restoring existing SCANWATER facilities by Bangangté Municipality. In order to address the issue, we assess the exploitable pumping flow rate of catchment aquifers and its hydraulic properties by using Jacob and Theis method, and define protection zones with Hoffman and Lillich method. It emerges that the hydraulic conductivity of aquifer is in the order of 10<sup>-4</sup> m/sec, transmissivity varies from 10<sup>-4</sup> to 10<sup>-6</sup> m<sup>2</sup>/sec. Aquifer pumping flow rate (Q) varies between 1.5 and 10.5 m<sup>3</sup>/h. In volcanic rocks, aquifer is more productive (4.5 ≤ Q ≤ 10.5 m<sup>3</sup>/h). Transfer time of pollutants to aquifer varies from 3 to 56 days depending on rock-types and groundwater slope (0.03 - 0.13 m/m). Furthermore, 113,624 m and 1123 m are radius to be implemented for a better protection of groundwater against any form of pollutant. 展开更多
关键词 Pumping Tests Aquifer Properties Groundwater protection Ndé Division West-Cameroon (Central Africa)
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Immunogenic and Protective Properties of the First Kazakhstan Vaccine against Pandemic Influenza А(Н1N1) pdm09 in Ferrets
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作者 Kaissar Tabynov Zhailaubai Kydyrbayev +5 位作者 Abylai Sansyzbay Berik Khairullin Sholpan Ryskeldinova Nurika Assanzhanova Yerken Kozhamkulov Dulat Inkarbekov 《Virologica Sinica》 SCIE CAS CSCD 2012年第6期345-352,共8页
This paper presents the results of a pre-clinical study of the immunogenicity and efficacy of an egg-derived, inactivated, whole-virion adjuvanted vaccine (Refluvac) on ferret models. For this purpose, groups of eig... This paper presents the results of a pre-clinical study of the immunogenicity and efficacy of an egg-derived, inactivated, whole-virion adjuvanted vaccine (Refluvac) on ferret models. For this purpose, groups of eight ferrets (6 to 7 months old) were injected with 0.5 mL of vaccine specimens containing 3.75, 7.5 or 15.0 μg of virus hemagglutinin. Administration was intramuscular and given either as a single dose or as two doses 14 days apart. All vaccine specimens manifested immunogenicity in ferrets for single (HI titer, from 51 ± 7 to 160 ± 23) and double (HI titer, from 697± 120 to 829 ± 117) administrations. To assess the protective effects of the vaccine, ferrets from the vaccinated and control groups were infected intranasally with pandemic virus A/California/7/09 (H1N1) pdm09 at a dose of 106 106/0.5 mL. Fourteen days post-infection, the ferrets inoculated with single or double vaccines containing 3.75, 7.5 or 15.0 ~g of hemagglutinin per dose showed no signs of influenza infection, weight loss, or body temperature rise, and no premature deaths occurred. The number of vaccinated ferrets shedding the virus via the upper airway, as well as the amount of virus shed after infection, was significantly reduced in comparison with animals from the control group. Based on our results, we suggest that a single vaccination at a dose of 3.75 or 7.5 μg hemagglutinin be used for Phase I clinical trials. 展开更多
关键词 VACCINE Pandemic Influenza A (H1N1) pdm09 Immunogenic and protective Properties FERRETS
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