According to the 22nd edition of "The American Illustrated Medical Dictionary",dialysis[dia=through,apart,across or between;lysis=to loose]is defined as the process of separating crystalloids and colloid... According to the 22nd edition of "The American Illustrated Medical Dictionary",dialysis[dia=through,apart,across or between;lysis=to loose]is defined as the process of separating crystalloids and colloids in solution by the differences in their rates of diffusion through a semipermeable membrane:crystalloids pass through readily,colloids very slowly or not at all(1).……展开更多
Improving material biocompatibility has been a continu-ous effort and remains a major goal of dialysis therapy. In this respect, vitamin E-modified copolymers have been used to produce a generation of biomaterials tha...Improving material biocompatibility has been a continu-ous effort and remains a major goal of dialysis therapy. In this respect, vitamin E-modified copolymers have been used to produce a generation of biomaterials that has offered new clinical challenges and the chance of further improving the quality of synthetic hemodialyser membranes. This mini review article describes the evo-lution of these copolymers that only recently have been adopted to develop new vitamin E-modifed polysulfone hemodialysers. Biomaterial characteristics and clinical aspects of these membranes are discussed, starting from the most recent contributions that have appeared in the literature that are of interest for the community of nephrology and dialysis specialists, as well as bioma-terial scientists.展开更多
Comparative optical study of biofluids(serum,urine,hemodialyste)by concentration change ofendogenous visible fluorescence substance(VFS)has been carried out.Biofluids were collectedfrom chronic kidney diseases(CKD)pat...Comparative optical study of biofluids(serum,urine,hemodialyste)by concentration change ofendogenous visible fluorescence substance(VFS)has been carried out.Biofluids were collectedfrom chronic kidney diseases(CKD)patients(Pts)_as well as from healthy controls(HCs).Exeitation/emission spectra are similar for all samples of biofluids differing only in intensity,which is higher for CKD Pts.Strong similarity enables the study of given biofluids from a unitedphysical platform,proposed earlier,i.e.,as nanoparticles approach.Specific spectral redistribu-tion of visible fluorescence(VF)intensity as a result of dilution is revealed.The concentrationchange of VFS by dilution of samples manifests in nonlinear dependences in the scales"VFintensity-concentration"for serum and urine and in perfect linearity for hemodialysate(HD).The latter fact can be used in monitoring of hemodialysis procedure.展开更多
We describe an application of carrier protein-free strategy in constructing a fully synthetic methamphetamine(METH)vaccine that contains three components:Toll-like receptor 2 ligand,Th2 epitope,and METH hapten.The imm...We describe an application of carrier protein-free strategy in constructing a fully synthetic methamphetamine(METH)vaccine that contains three components:Toll-like receptor 2 ligand,Th2 epitope,and METH hapten.The immunological evaluation in mice revealed high titers of METH-specific antibodies induced by the construct and the activation of humoral immunity that would be beneficial for neutralization and clearance of the METH molecule.Behavio ral experiments indicated that the synthetic vaccine attenuated the acquisition of METH-induced conditioned place preference and inhibited the initiation and expression of METH-induced locomotor sensitization.These results demonstrate that the lipopeptide-based vaccine has invo ked an immune response and showed the potential of preventing the rewarding and psychoactive effects of METH.展开更多
文摘 According to the 22nd edition of "The American Illustrated Medical Dictionary",dialysis[dia=through,apart,across or between;lysis=to loose]is defined as the process of separating crystalloids and colloids in solution by the differences in their rates of diffusion through a semipermeable membrane:crystalloids pass through readily,colloids very slowly or not at all(1).……
文摘Improving material biocompatibility has been a continu-ous effort and remains a major goal of dialysis therapy. In this respect, vitamin E-modified copolymers have been used to produce a generation of biomaterials that has offered new clinical challenges and the chance of further improving the quality of synthetic hemodialyser membranes. This mini review article describes the evo-lution of these copolymers that only recently have been adopted to develop new vitamin E-modifed polysulfone hemodialysers. Biomaterial characteristics and clinical aspects of these membranes are discussed, starting from the most recent contributions that have appeared in the literature that are of interest for the community of nephrology and dialysis specialists, as well as bioma-terial scientists.
基金support for this work by the Archimedes project 3.2.1101.12-0011.
文摘Comparative optical study of biofluids(serum,urine,hemodialyste)by concentration change ofendogenous visible fluorescence substance(VFS)has been carried out.Biofluids were collectedfrom chronic kidney diseases(CKD)patients(Pts)_as well as from healthy controls(HCs).Exeitation/emission spectra are similar for all samples of biofluids differing only in intensity,which is higher for CKD Pts.Strong similarity enables the study of given biofluids from a unitedphysical platform,proposed earlier,i.e.,as nanoparticles approach.Specific spectral redistribu-tion of visible fluorescence(VF)intensity as a result of dilution is revealed.The concentrationchange of VFS by dilution of samples manifests in nonlinear dependences in the scales"VFintensity-concentration"for serum and urine and in perfect linearity for hemodialysate(HD).The latter fact can be used in monitoring of hemodialysis procedure.
基金supported in part by the National Natural Science Foundation of China(Nos.81821092 and 81701312)Beijing Municipal Science and Technology Commission(Nos.Z181100001518005 and JQ.18024)National Key Research and Development Program of China(Nos.2017YFC0803608 and 2019YFC0118604)。
文摘We describe an application of carrier protein-free strategy in constructing a fully synthetic methamphetamine(METH)vaccine that contains three components:Toll-like receptor 2 ligand,Th2 epitope,and METH hapten.The immunological evaluation in mice revealed high titers of METH-specific antibodies induced by the construct and the activation of humoral immunity that would be beneficial for neutralization and clearance of the METH molecule.Behavio ral experiments indicated that the synthetic vaccine attenuated the acquisition of METH-induced conditioned place preference and inhibited the initiation and expression of METH-induced locomotor sensitization.These results demonstrate that the lipopeptide-based vaccine has invo ked an immune response and showed the potential of preventing the rewarding and psychoactive effects of METH.
