Protein losing enteropathy(PLE), a very rare disease with hypoproteinemia and edema as its characteristics, is caused by various diseases resulting in protein depletion from the gut. The diagnosis is relatively diffic...Protein losing enteropathy(PLE), a very rare disease with hypoproteinemia and edema as its characteristics, is caused by various diseases resulting in protein depletion from the gut. The diagnosis is relatively difficult due to its complex pathogeneses.The present paper reported a case whose symptom started with acute diarrhea and hypoproteinemia.Gastrointestinal endoscopies showed digestive ulcersandcolonpolyp.Thetreatmentscontainedalbumin infusion, Chinese herbal decoction and other symptomatic therapies. The hypoproteinemia become even worse and edema occurred after 4 days' treatment.Alargerdoseofalbumininfusion(40-60g/d) and modified herbal decoctions were prescribed. A final diagnosis of eosinophilic gastroenteritis(EG) complicated with PLE was confirmed by histopathological examination of a repeated gastroscopy. After three weeks' treatment, the serum albumin level was raised and the edema subsided gradually. In conclusion, herbs may have an effect on PLE patients, but PLE resulting from EG is very complex and easy to misdiagnose, especially in atypical conditions. Further studies are required to find the exact mechanisms.展开更多
基金Supported by National Natural Science Foundation of China(No.81573806,81774066)National Science and technology support program for 12th Five-Year(No.2013BAI02B05)Beijing Key Laboratory of Functional Gastrointestinal Disorders Diagnosis and Treatment of Traditional Chinese Medicine(No.BZ0374)
文摘Protein losing enteropathy(PLE), a very rare disease with hypoproteinemia and edema as its characteristics, is caused by various diseases resulting in protein depletion from the gut. The diagnosis is relatively difficult due to its complex pathogeneses.The present paper reported a case whose symptom started with acute diarrhea and hypoproteinemia.Gastrointestinal endoscopies showed digestive ulcersandcolonpolyp.Thetreatmentscontainedalbumin infusion, Chinese herbal decoction and other symptomatic therapies. The hypoproteinemia become even worse and edema occurred after 4 days' treatment.Alargerdoseofalbumininfusion(40-60g/d) and modified herbal decoctions were prescribed. A final diagnosis of eosinophilic gastroenteritis(EG) complicated with PLE was confirmed by histopathological examination of a repeated gastroscopy. After three weeks' treatment, the serum albumin level was raised and the edema subsided gradually. In conclusion, herbs may have an effect on PLE patients, but PLE resulting from EG is very complex and easy to misdiagnose, especially in atypical conditions. Further studies are required to find the exact mechanisms.
