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Evolving spectrum of diabetic nephropathy 被引量:25
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作者 Jonathan Kopel Camilo Pena-Hernandez Kenneth Nugent 《World Journal of Diabetes》 SCIE CAS 2019年第5期269-279,共11页
Diabetes remains an important health issue as more patients with chronic and uncontrolled diabetes develop diabetic nephropathy(DN), which classically presents with proteinuria followed by a progressive decrease in re... Diabetes remains an important health issue as more patients with chronic and uncontrolled diabetes develop diabetic nephropathy(DN), which classically presents with proteinuria followed by a progressive decrease in renal function.However, an increasing proportion of DN patients have a decline in kidney function and vascular complications without proteinuria, known as nonproteinuric DN(NP-DN). Despite the increased incidence of NP-DN, few clinical or experimental studies have thoroughly investigated the pathophysiological mechanisms and targeted treatment for this form of DN. In this review, we will examine the differences between conventional DN and NP-DN and consider potential pathophysiological mechanisms, diagnostic markers, and treatment for both DN and NP-DN. The investigation of the pathophysiology of NP-DN should provide additional insight into the cardiovascular factors influencing renal function and disease and provide novel treatments for the vascular complications seen in diabetic patients. 展开更多
关键词 DIABETIC NEPHROPATHY Non-proteinuric DIABETIC NEPHROPATHY Diabetes KIDNEY VASCULAR COMPLICATIONS
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慢性肾脏病临床危险因素研究 被引量:14
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作者 李佳霖 王倩 +1 位作者 赵海玲 李平 《世界中医药》 CAS 2020年第17期2538-2543,共6页
归纳慢性肾脏病危险因素,应用于临床中可以对病情的发生发展进行评估。我们通过查阅近些年的国内外文献,对临床试验进行梳理,总结慢性肾脏病临床危险因素。研究发现,高血压、高血糖、蛋白尿、血脂异常等因素作为慢性肾脏病的危险因素,... 归纳慢性肾脏病危险因素,应用于临床中可以对病情的发生发展进行评估。我们通过查阅近些年的国内外文献,对临床试验进行梳理,总结慢性肾脏病临床危险因素。研究发现,高血压、高血糖、蛋白尿、血脂异常等因素作为慢性肾脏病的危险因素,与慢性肾脏病的发生发展具有一定的联系,一些临床生物标志物也可以应用于病情评估,这些发现为预测慢性肾脏病的发生发展提供了依据,并且有利于提高患者生命质量,减少不良事件发生。 展开更多
关键词 慢性肾脏病 危险因素 临床研究 高血压 高血糖 蛋白尿 血脂导异常
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A Cross-Sectional Study on Current Practice of the Management of Pregnancy Induced Hypertension and Its Maternal and Foetal Complications and Outcome in the Western Part of the State of Libya
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作者 Ahmed Elghoudi Abdulrahman Alsharef Asma Elghoudi 《Open Journal of Obstetrics and Gynecology》 2022年第3期222-241,共20页
Background: Maternal and perinatal mortality and morbidity are mainly affected by hypertension during pregnancy (pre-eclampsia). Haemorrhage and cerebral bleeding are the primary and significant complications of pre-e... Background: Maternal and perinatal mortality and morbidity are mainly affected by hypertension during pregnancy (pre-eclampsia). Haemorrhage and cerebral bleeding are the primary and significant complications of pre-eclampsia. Abruption of the placenta and renal failure are among the major complications caused by this disease. The perinatal complications include Intrauterine Growth Restriction (IUGR), Intrauterine Foetal Death (IUFD), neonatal death, and prematurity. Objective: The purpose of the present study was to examine the incidence of Pregnancy-Induced Hypertension (PIH), pre-eclampsia, the management of PIH, including the early diagnosis, the pharmacological drug management used, and the prevalence of maternal and perinatal complications. Methods and Patients: This cross-sectional study took place in Aljalaa maternity hospital, which represented the west of the state of Libya in the period from 1st January 2012 to 31st December 2012, with patients who were diagnosed, managed, and terminated according to protocol management of the hospital. Results: In the present study, from the total deliveries in Aljalaa Maternity hospital, the incidence of PIH is 8.4% and pre-eclampsia is 5.1%. No maternal mortality, CNS haemorrhaged, hepatic failure, or renal failure. The reported maternal complications included: Eclampsia, HELLP syndrome (Haemolysis, Elevated Liver enzymes and Low platelets), abruption placenta, and pulmonary oedema see in eighteen percent, six percent, nine percent, four percent and less than one percent, respectively. The foetal complications were preterm babies and Intrauterine Growth Restriction (IUGR) in nineteen percent, Low Birth Weight (LBW) in twenty-five percent, Intrauterine Foetal Death (IUFD) in five percent, neonatal death in two percent and, perinatal death in six percent. In the PIH patients, the presence of associated symptoms such as headache, blurred vision, irritability, and the presence of signs such as severe hypertension, generalized oedema, exaggerated reflexes, and abnormal investigations (protein urea, high uric acid, abnormal LFT, haemoconcentration, and low pits) increased the risk of maternal and foetal complications. Conclusion: To decrease mother and newborn mortality and morbidity in PIH patients, a rigorous management protocol is required to implement evidence-based guidelines. 展开更多
关键词 PREECLAMPSIA proteinuric Pregnancy Induced Hypertension
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