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Clinical Effect of Ilaprazole Enteric-Coated Tablets in Patients with Peptic Ulcer
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作者 Fanghui Chen 《Journal of Biosciences and Medicines》 2024年第9期155-160,共6页
Objective: To discuss the actual effect of ilaprazole enteric-coated tablets in the treatment of peptic ulcer patients. Methods: 200 peptic ulcer patients who received treatment from January to December 2023 were sele... Objective: To discuss the actual effect of ilaprazole enteric-coated tablets in the treatment of peptic ulcer patients. Methods: 200 peptic ulcer patients who received treatment from January to December 2023 were selected as the study sample, and all patients were randomly and evenly divided into the study group (n = 100) and the control group (n = 100), and the serum inflammatory factors and the disappearance time of symptoms were compared. Results: After treatment, the serum inflammatory factors in the observation group were better than those in the control group, and the time of belching and burning sensation in the observation group was shorter than that in the control group, all of which were statistically significant (P Conclusion: Ilaprazole enteric-coated tablets in the treatment of peptic ulcer have a good effect and can effectively improve the symptoms of patients with clinical signs, with reference significance. 展开更多
关键词 Ilaprazole enteric-coated tablets Peptic Ulcer SYMPTOMS
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Analysis of the Therapeutic Effect of Clopidogrel Bisulfate Tablets + Aspirin Enteric-Coated Tablets on Acute Myocardial Infarction
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作者 Yiru Chen 《Journal of Clinical and Nursing Research》 2024年第6期290-294,共5页
Objective:To investigate and analyze the clinical effect of clopidogrel bisulfate tablets combined with aspirin enteric-coated tablets on acute myocardial infarction(AMI)patients.Methods:The study period was from Janu... Objective:To investigate and analyze the clinical effect of clopidogrel bisulfate tablets combined with aspirin enteric-coated tablets on acute myocardial infarction(AMI)patients.Methods:The study period was from January 2020 to December 2023,the sample source was 82 AMI patients admitted to our hospital,grouped into an observation group(n=41)and a control group(n=41)by the numerical table method.The patients in the control group were treated with aspirin enteric-coated tablets,and the patients in the observation group were treated with aspirin enteric-coated tablets combined with clopidogrel bisulfate.The clinical efficacy,coagulation indexes,and the incidence of cardiovascular adverse events between the two groups were compared.Results:The clinical efficacy of the observation group was higher than that of the control group(P<0.05);the platelet aggregation rate(PAR)of the observation group was lower than that of the con-trol group after treatment(P<0.05),and there was no significant difference in the prothrombin time(PT)and activated partial thromboplastin time(APTT)between the two groups(P>0.05).The incidence of cardiovascular adverse events in the observation group was lower than that of the control group(P<0.05).Conclusion:The treatment effect of clopidogrel bisulfate tablets combined with aspirin enteric-coated tablets on AMI patients is remarkable.It reduces the PAR and the incidence of cardiovascular adverse events,so this treatment method should be popularized. 展开更多
关键词 Clopidogrel bisulfate Aspirin enteric-coated tablets Acute myocardial infarction
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Gradient high performance liquid chromatography method for simultaneous determination of ilaprazole and its related impurities in commercial tablets 被引量:2
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作者 Shang Wang Dong Zhang +3 位作者 Yingli Wang Xiaohong Liu Yan Liu Lu Xu 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS 2015年第2期146-151,共6页
A methodology(HPLC)proposed in this paper for simultaneously quantitative determination of ilaprazole and its related impurities in commercial tablets was developed and validated.The chromatographic separation was car... A methodology(HPLC)proposed in this paper for simultaneously quantitative determination of ilaprazole and its related impurities in commercial tablets was developed and validated.The chromatographic separation was carried out by gradient elution using an Agilent C8 column(4.6 mm×250 mm,5 mm)which was maintained at 25℃.The mobile phase composed of solvent A(methanol)and solvent B(solution consisting 0.02 mmol/l monopotassium phosphate and 0.025 mmol/l sodium hydroxide)was at a flow rate of 1.0 ml/min.The samples were detected and quantified at 237 nm using an ultraviolet absorbance detector.Calibration curves of all analytes from 0.5 to 3.5 mg/ml were good linearity(r≥0.9990)and recovery was greater than 99.5% for each analyte.The lower limit of detection(LLOD)and quantification(LOQ)of this analytical method were 10 ng/ml and 25 ng/ml for all impurities,respectively.The stress studies indicated that the degradation products could not interfere with the detection of ilaprazole and its related impurities and the assay can thus be considered stability-indicating.The method precisions were in the range of 0.41-1.21 while the instrument precisions were in the range of 0.38-0.95 in terms of peak area RSD% for all impurities,respectively.This method is considered stabilityindicating and is applicable for accurate and simultaneous measuring of the ilaprazole and its related impurities in commercial enteric-coated tablets. 展开更多
关键词 Ilaprazole enteric-coated tablets Related impurities HPLC Validation
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Delayed-release oral mesalamine tablet mimicking a small jejunal gastrointestinal stromal tumor:A case report
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作者 Fabio Frosio Emanuele Rausa +2 位作者 Paolo Marra Marie-Christine Boutron-Ruault Alessandro Lucianetti 《World Journal of Clinical Cases》 SCIE 2022年第19期6710-6715,共6页
BACKGROUND Enteric-coated medications are supposed to pass intact through the gastric environment and to release the drug content into the small intestine or the colon.Before dissolution of the enteric coating,they ma... BACKGROUND Enteric-coated medications are supposed to pass intact through the gastric environment and to release the drug content into the small intestine or the colon.Before dissolution of the enteric coating,they may appear hyperdense on computed tomography(CT).Unfortunately,few reports have been published on this topic so far.In this case report,the hyperdense appearance on contrastenhanced CT of an enteric-coated mesalamine tablet was initially misinterpreted as a jejunal gastrointestinal stromal tumor(GIST).CASE SUMMARY An asymptomatic 81-year-old male patient,who had undergone laparoscopic right nephrectomy four years earlier for stage 1 renal carcinoma,was diagnosed with a jejunal GIST at the 4-year follow-up thoraco-abdominal CT scan.He was referred to our hub hospital for gastroenterological evaluation,and subsequently underwent 18-fluorodeoxyglucose positron emission tomography,abdominal magnetic resonance imaging,and video capsule endoscopy.None of these examinations detected any lesion of the small intestine.After reviewing all the CT images in a multidisciplinary setting,the panel estimated that the hyperdense jejunal image was consistent with a tablet rather than a GIST.The tablet was an 800 mg delayed-release enteric-coated oral mesalamine tablet(Asacol®),which had been prescribed for non-specific colitis,while not informing the hospital physicians.CONCLUSION Delayed-release oral mesalamine(Asacol®),like other enteric-coated medications,can appear as a hyperdense image on a CT scan,mimicking a small intestinal GIST.Therefore,adetailed knowledge of the patients’medications and a multidisciplinary review of the images areessential. 展开更多
关键词 MESALAMINE enteric-coating Asacol tablet Gastrointestinal stromal tumor Case report
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HPLC法测定丙硫异烟胺肠溶片的释放度
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作者 许晖 林夏楠 《海峡药学》 2010年第9期44-46,共3页
目的建立高效液相色谱法测定丙硫异烟胺肠溶片释放度。方法色谱柱为Phenomenex Gemi mi C18柱,以0.2mol.L-1磷酸二氢钠溶液(用磷酸调节pH值至3.0)-乙腈(80∶20)为流动相,流速为1.0mL.min-1,检测波长为282nm。结果丙硫异烟胺在20.14μg.m... 目的建立高效液相色谱法测定丙硫异烟胺肠溶片释放度。方法色谱柱为Phenomenex Gemi mi C18柱,以0.2mol.L-1磷酸二氢钠溶液(用磷酸调节pH值至3.0)-乙腈(80∶20)为流动相,流速为1.0mL.min-1,检测波长为282nm。结果丙硫异烟胺在20.14μg.mL-1~201.35μg.mL-1浓度范围内与峰面积呈良好线性关系,线性方程:A=44861C+29511,r=0.99999,n=7。结论本法专属性与准确性较高,可用于丙硫异烟胺肠溶片释放度测定。 展开更多
关键词 丙硫异烟胺肠溶片 释放度 高效液相色谱法
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HPLC法测定丙硫异烟胺肠溶片的含量 被引量:3
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作者 范荣 石俊跃 杨俊杰 《中国药品标准》 CAS 2008年第1期55-57,共3页
目的:建立HPLC法测定丙硫异烟胺肠溶片的含量。方法:用KromasilC18(4.6mm×200mm,5μm),以甲醇-水(65:35)为流动相,检测波长290nm,柱温30℃,流速1mL·min^-1,进样量为20μL。结果:丙硫异烟胺在10~200mg·L... 目的:建立HPLC法测定丙硫异烟胺肠溶片的含量。方法:用KromasilC18(4.6mm×200mm,5μm),以甲醇-水(65:35)为流动相,检测波长290nm,柱温30℃,流速1mL·min^-1,进样量为20μL。结果:丙硫异烟胺在10~200mg·L^-1浓度范围内与峰面积呈良好线性关系,r=0.9999,回归方程为:A=28591C+64794。平均回收率为99.79%,RSD为1、07%。结论:方法简便、快速、准确、可靠。 展开更多
关键词 HPLC法 丙硫异烟胺 丙硫异烟胺肠溶片 含量测定
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利奈唑胺联合常规化疗治疗广泛耐药肺结核的疗效观察 被引量:37
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作者 王爱民 王小军 董雪松 《现代药物与临床》 CAS 2016年第10期1652-1656,共5页
目的探讨利奈唑胺联合常规化疗治疗广泛耐药肺结核的临床效果及安全性。方法选取2010年1月—2014年1月唐山市第四医院收治的广泛耐药结核病患者94例,按治疗方案不同分为对照组(40例)和治疗组(54例)。对照组口服丙硫异烟胺肠溶片,0.2... 目的探讨利奈唑胺联合常规化疗治疗广泛耐药肺结核的临床效果及安全性。方法选取2010年1月—2014年1月唐山市第四医院收治的广泛耐药结核病患者94例,按治疗方案不同分为对照组(40例)和治疗组(54例)。对照组口服丙硫异烟胺肠溶片,0.25 g/次,2-3次/d;口服盐酸左氧氟沙星胶囊,0.2 g/次,2次/d;口服盐酸乙胺丁醇片,0.75 g/次,1次/d;口服吡嗪酰胺片,0.75 g/次,2次/d;静脉静滴硫酸阿米卡星注射液,0.2 g/次,2次/d。治疗组在对照组基础上,初始静脉滴注利奈唑胺注射液,600 mg/次,2次/d;治疗1-2个月后,根据患者耐受度和不良反应情况改为600 mg,1次/d,或者口服利奈唑胺片,600 mg/次,1次/d。两组患者均治疗4-10个月,平均时间(8.5±0.6)个月。观察两组的临床疗效,比较两组的症状改善时间、SF-36量表评分、复发和转归的情况。结果治疗后,对照组和治疗组的总有效率分别为45.00%、85.19%,两组比较差异有统计学意义(P〈0.05)。治疗后,治疗组空洞缩小时间、空洞闭合时间、痰涂片转阴时间、痰培养转阴时间和痰定量PCR阴转时间均短于对照组,两组比较差异有统计学意义(P〈0.05)。随访6、12、18个月后,两组SF-36量表评分均上升,同组治疗前后比较差异有统计学意义(P〈0.05);且治疗组SF-36量表评分的升高程度明显优于对照组,两组比较差异具有统计学意义(P〈0.05)。对照组和治疗组的复发率分别为35.00%、7.41%,转归率分别为30.00%、59.26%,两组比较差异有统计学意义(P〈0.05)。结论利奈唑胺联合常规化疗治疗广泛耐药结核病具有较好的临床疗效,可改善临床症状,缩短痰菌阴转时间,改善生活质量,具有一定的临床推广应用价值。 展开更多
关键词 丙硫异烟胺肠溶片 盐酸左氧氟沙星胶囊 盐酸乙胺丁醇片 吡嗪酰胺片 硫酸阿米卡星注射液 利奈唑胺注射液 利奈唑胺片 广泛耐药肺结核
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