Financial Poverty Alleviation in Rural Areas of Hubei Province

In order to find out the various restrictions and difficulties of financial poverty alleviation in rural areas,taking Hubei Province as an example,this paper firstly introduced current situations of financial poverty alleviation in rural areas of Hubei Province. Then,it analyzed problems confronted by financial poverty alleviation in rural areas of Hubei Province:( i) subjects of financial poverty alleviation not mature and poverty alleviation risks increased,( ii) backward agricultural insurance system,( iii) rural credit system not perfect,and( iv) weak guiding policies of financial poverty alleviation. Finally,it came up with pertinent recommendations: improving rural financial environment,actively developing the innovation mode of financial poverty alleviation,and strengthening relevant supervision efforts.

Increased expression of Notch1 in temporal lobe epilepsy: animal models and clinical evidence

Temporal lobe epilepsy is associated with astrogliosis. Notchl signaling can induce astrogliosis in glioma. However, it remains unknown whether Notchl signaling is involved in the pathogenesis of epilepsy. This study investigated the presence of Notchl, hairy and enhancer of split-l, and glial fibrillary acidic protein in the temporal neocortex and hippocampus of lithium-pilocar- pine-treated rats. The presence of Notchl and hairy and enhancer of split-1 was also explored in brain tissues of patients with intractable temporal lobe epilepsy. Quantitative electroencephalo- gram analysis and behavioral observations were used as auxiliary measures. Results revealed that the presence of Notchl, hairy and enhancer of split-l, and glial fibriUary acidic protein were en- hanced in status epilepticus and vehicle-treated spontaneous recurrent seizures rats, but remain unchanged in the following groups： control, absence of either status epilepticus or spontaneous recurrent seizures, and zileuton-treated spontaneous recurrent seizures. Compared with patient control cases, the presences of Notch1 and hairy and enhancer of split- 1 were upregulated in the temporal neocortex of patients with intractable temporal lobe epilepsy. Therefore, these results suggest that Notchl signaling may play an important role in the onset of temporal lobe epilepsy via astrogliosis. Furthermore, zileuton may be a potential therapeutic strategy for temporal lobe epilepsy by blocking Notchl signaling.