目的:探讨寻常型银屑病中医证型与血清miR-155、转化生长因子β1(TGF-β1)、银屑病皮损面积及严重程度指数(PASI)评分相关性研究。方法:回顾性选取2021年9月~2023年9月北京中医药大学东直门医院收治120例的寻常型银屑病患者为研究对象...目的:探讨寻常型银屑病中医证型与血清miR-155、转化生长因子β1(TGF-β1)、银屑病皮损面积及严重程度指数(PASI)评分相关性研究。方法:回顾性选取2021年9月~2023年9月北京中医药大学东直门医院收治120例的寻常型银屑病患者为研究对象。统计寻常型银屑病中医证型分布情况,比较不同中医证型患者血清miR-155、TGF-β1水平及PASI评分,分析寻常型银屑病中医证型与血清miR-155、TGF-β1水平与PASI评分的关系。结果:120例寻常型银屑病患者中血热证51例、血瘀证38例、血燥证31例;不同中医证型寻常型银屑病患者血清miR-155、TGF-β1水平及PASI评分为血热证>血瘀证>血燥证( P <0.05);寻常型银屑病患者血清miR-155、TGF-β1水平与PASI评分呈正相关(r=0.649、 P <0.05,r=0.676、 P <0.05)。结果:寻常型银屑病中医证型与血清miR-155、TGF-β1水平及PASI评分具有良好的相关性,可以为寻常型银屑病患者辨证施治提供指导。展开更多
目的:观察中药消疕合剂对寻常型银屑病血热证的影响,比较银屑病皮损面积和严重性指数(Psoriasis Area and Severity Index,PASI)评分及血清血管内皮生长因子(Vascular Endothelial Growth Factor,VEGF)水平变化。方法:将90例入组患者随...目的:观察中药消疕合剂对寻常型银屑病血热证的影响,比较银屑病皮损面积和严重性指数(Psoriasis Area and Severity Index,PASI)评分及血清血管内皮生长因子(Vascular Endothelial Growth Factor,VEGF)水平变化。方法:将90例入组患者随机分成两组:治疗组50例口服消疕合剂,每次125 mL,每天2次;对照组40例口服消银颗粒,每次1包,每天3次,共观察8周。治疗组治疗前后检测外周血VEGF水平。结果:治疗组治疗后PASI评分明显低于对照组,差异有统计学意义(P<0.05),有效率优于对照组,差异有统计学意义(P<0.05);治疗组治疗后血清VEGF水平均较治疗前显著降低,差异有统计学意义(P<0.001)。结论:中药消疕合剂可显著降低寻常型银屑病血热证患者PASI指数,其机理可能与其降低患者血清VEGF水平有关。展开更多
目的分析皮损组织Cx26蛋白含量及信使RNA表达与寻常型银屑病(PV)患者皮损面积和严重程度指数(psoriasis area and severity index,PASI)评分的关联性。方法2018年7月-2019年7月选取本院PV患者60例作为研究组,另选同期健康体检者32例作...目的分析皮损组织Cx26蛋白含量及信使RNA表达与寻常型银屑病(PV)患者皮损面积和严重程度指数(psoriasis area and severity index,PASI)评分的关联性。方法2018年7月-2019年7月选取本院PV患者60例作为研究组,另选同期健康体检者32例作为对照组,分析皮损组织Cx26蛋白、信使RNA水平与PV患者PASI评分的关联性。结果研究组Cx26蛋白含量及信使RNA表达水平均高于对照组(P<0.05);研究组轻度患者Cx26蛋白含量及信使RNA表达水平低于中度,中度患者Cx26蛋白含量及信使RNA表达水平低于重度(P<0.05);经Spearman分析可知,PASI评分与Cx26蛋白含量(r=0.625)及信使RNA表达水平(r=0.541)存在明显正相关关系(P<0.05)。结论PV患者Cx26蛋白含量及信使RNA表达水平与PASI评分密切相关,可作为评判疾病进展、预后指标,为临床治疗提供指导依据。展开更多
Objective To investigate the effects of acitretin on T helper cell(Th)1/Th2 balance and Th17 cells in psoriasis vulgaris(PV)patients.Methods A total of 13 men and 17 women with PV were investigated.10 mg of acitretin ...Objective To investigate the effects of acitretin on T helper cell(Th)1/Th2 balance and Th17 cells in psoriasis vulgaris(PV)patients.Methods A total of 13 men and 17 women with PV were investigated.10 mg of acitretin was administered twice a day for 8 weeks for intervention therapy.Serum levels of interferon-gamma(IFN-γ),interleukin(IL)-4 and IL-17 were measured by enzyme-linked immunosorbent assay.T,Th1,Th2 and Th17 cells in skin biopsies were counted with double-labeled immunofluorescence.Psoriasis Area and Severity Index(PASI)score was calculated before and 8 weeks after treatment.Results Before treatment PV patients had higher serum levels of IFN-γ and IL-17,and increased T,Th1 and Th17 cells in skin biopsies.After treatment,both serum levels of IFN-γ and IL-17,and T,Th1 and Th17 cells infiltrating in PV skin decreased significantly.Th1/Th2 balance was restored to normal.However,their IL-4 and Th2 cells showed no significant change throughout the therapy.Conclusion Acitretin exerts influence on dermal Th1/Th2 balance and Th17 cell infiltration,so does it on production of systematic inflammatory cytokines IFN-γ and IL-17 in PV patients.However,Th2 cells and its derivative cytokine—IL-4 are not affected.展开更多
文摘目的:探讨寻常型银屑病中医证型与血清miR-155、转化生长因子β1(TGF-β1)、银屑病皮损面积及严重程度指数(PASI)评分相关性研究。方法:回顾性选取2021年9月~2023年9月北京中医药大学东直门医院收治120例的寻常型银屑病患者为研究对象。统计寻常型银屑病中医证型分布情况,比较不同中医证型患者血清miR-155、TGF-β1水平及PASI评分,分析寻常型银屑病中医证型与血清miR-155、TGF-β1水平与PASI评分的关系。结果:120例寻常型银屑病患者中血热证51例、血瘀证38例、血燥证31例;不同中医证型寻常型银屑病患者血清miR-155、TGF-β1水平及PASI评分为血热证>血瘀证>血燥证( P <0.05);寻常型银屑病患者血清miR-155、TGF-β1水平与PASI评分呈正相关(r=0.649、 P <0.05,r=0.676、 P <0.05)。结果:寻常型银屑病中医证型与血清miR-155、TGF-β1水平及PASI评分具有良好的相关性,可以为寻常型银屑病患者辨证施治提供指导。
文摘目的:观察中药消疕合剂对寻常型银屑病血热证的影响,比较银屑病皮损面积和严重性指数(Psoriasis Area and Severity Index,PASI)评分及血清血管内皮生长因子(Vascular Endothelial Growth Factor,VEGF)水平变化。方法:将90例入组患者随机分成两组:治疗组50例口服消疕合剂,每次125 mL,每天2次;对照组40例口服消银颗粒,每次1包,每天3次,共观察8周。治疗组治疗前后检测外周血VEGF水平。结果:治疗组治疗后PASI评分明显低于对照组,差异有统计学意义(P<0.05),有效率优于对照组,差异有统计学意义(P<0.05);治疗组治疗后血清VEGF水平均较治疗前显著降低,差异有统计学意义(P<0.001)。结论:中药消疕合剂可显著降低寻常型银屑病血热证患者PASI指数,其机理可能与其降低患者血清VEGF水平有关。
文摘目的分析皮损组织Cx26蛋白含量及信使RNA表达与寻常型银屑病(PV)患者皮损面积和严重程度指数(psoriasis area and severity index,PASI)评分的关联性。方法2018年7月-2019年7月选取本院PV患者60例作为研究组,另选同期健康体检者32例作为对照组,分析皮损组织Cx26蛋白、信使RNA水平与PV患者PASI评分的关联性。结果研究组Cx26蛋白含量及信使RNA表达水平均高于对照组(P<0.05);研究组轻度患者Cx26蛋白含量及信使RNA表达水平低于中度,中度患者Cx26蛋白含量及信使RNA表达水平低于重度(P<0.05);经Spearman分析可知,PASI评分与Cx26蛋白含量(r=0.625)及信使RNA表达水平(r=0.541)存在明显正相关关系(P<0.05)。结论PV患者Cx26蛋白含量及信使RNA表达水平与PASI评分密切相关,可作为评判疾病进展、预后指标,为临床治疗提供指导依据。
基金supported by the Science Technology Research and Development Program of Shaanxi Province of China.(No.2008K15-06(14))Research Fund for the Doctoral Programof Higher Education of China(No.20070698071)
文摘Objective To investigate the effects of acitretin on T helper cell(Th)1/Th2 balance and Th17 cells in psoriasis vulgaris(PV)patients.Methods A total of 13 men and 17 women with PV were investigated.10 mg of acitretin was administered twice a day for 8 weeks for intervention therapy.Serum levels of interferon-gamma(IFN-γ),interleukin(IL)-4 and IL-17 were measured by enzyme-linked immunosorbent assay.T,Th1,Th2 and Th17 cells in skin biopsies were counted with double-labeled immunofluorescence.Psoriasis Area and Severity Index(PASI)score was calculated before and 8 weeks after treatment.Results Before treatment PV patients had higher serum levels of IFN-γ and IL-17,and increased T,Th1 and Th17 cells in skin biopsies.After treatment,both serum levels of IFN-γ and IL-17,and T,Th1 and Th17 cells infiltrating in PV skin decreased significantly.Th1/Th2 balance was restored to normal.However,their IL-4 and Th2 cells showed no significant change throughout the therapy.Conclusion Acitretin exerts influence on dermal Th1/Th2 balance and Th17 cell infiltration,so does it on production of systematic inflammatory cytokines IFN-γ and IL-17 in PV patients.However,Th2 cells and its derivative cytokine—IL-4 are not affected.
