目的:观察中药消疕合剂对寻常型银屑病血热证的影响,比较银屑病皮损面积和严重性指数(Psoriasis Area and Severity Index,PASI)评分及血清血管内皮生长因子(Vascular Endothelial Growth Factor,VEGF)水平变化。方法:将90例入组患者随...目的:观察中药消疕合剂对寻常型银屑病血热证的影响,比较银屑病皮损面积和严重性指数(Psoriasis Area and Severity Index,PASI)评分及血清血管内皮生长因子(Vascular Endothelial Growth Factor,VEGF)水平变化。方法:将90例入组患者随机分成两组:治疗组50例口服消疕合剂,每次125 mL,每天2次;对照组40例口服消银颗粒,每次1包,每天3次,共观察8周。治疗组治疗前后检测外周血VEGF水平。结果:治疗组治疗后PASI评分明显低于对照组,差异有统计学意义(P<0.05),有效率优于对照组,差异有统计学意义(P<0.05);治疗组治疗后血清VEGF水平均较治疗前显著降低,差异有统计学意义(P<0.001)。结论:中药消疕合剂可显著降低寻常型银屑病血热证患者PASI指数,其机理可能与其降低患者血清VEGF水平有关。展开更多
目的分析皮损组织Cx26蛋白含量及信使RNA表达与寻常型银屑病(PV)患者皮损面积和严重程度指数(psoriasis area and severity index,PASI)评分的关联性。方法2018年7月-2019年7月选取本院PV患者60例作为研究组,另选同期健康体检者32例作...目的分析皮损组织Cx26蛋白含量及信使RNA表达与寻常型银屑病(PV)患者皮损面积和严重程度指数(psoriasis area and severity index,PASI)评分的关联性。方法2018年7月-2019年7月选取本院PV患者60例作为研究组,另选同期健康体检者32例作为对照组,分析皮损组织Cx26蛋白、信使RNA水平与PV患者PASI评分的关联性。结果研究组Cx26蛋白含量及信使RNA表达水平均高于对照组(P<0.05);研究组轻度患者Cx26蛋白含量及信使RNA表达水平低于中度,中度患者Cx26蛋白含量及信使RNA表达水平低于重度(P<0.05);经Spearman分析可知,PASI评分与Cx26蛋白含量(r=0.625)及信使RNA表达水平(r=0.541)存在明显正相关关系(P<0.05)。结论PV患者Cx26蛋白含量及信使RNA表达水平与PASI评分密切相关,可作为评判疾病进展、预后指标,为临床治疗提供指导依据。展开更多
Objective To investigate the effects of acitretin on T helper cell(Th)1/Th2 balance and Th17 cells in psoriasis vulgaris(PV)patients.Methods A total of 13 men and 17 women with PV were investigated.10 mg of acitretin ...Objective To investigate the effects of acitretin on T helper cell(Th)1/Th2 balance and Th17 cells in psoriasis vulgaris(PV)patients.Methods A total of 13 men and 17 women with PV were investigated.10 mg of acitretin was administered twice a day for 8 weeks for intervention therapy.Serum levels of interferon-gamma(IFN-γ),interleukin(IL)-4 and IL-17 were measured by enzyme-linked immunosorbent assay.T,Th1,Th2 and Th17 cells in skin biopsies were counted with double-labeled immunofluorescence.Psoriasis Area and Severity Index(PASI)score was calculated before and 8 weeks after treatment.Results Before treatment PV patients had higher serum levels of IFN-γ and IL-17,and increased T,Th1 and Th17 cells in skin biopsies.After treatment,both serum levels of IFN-γ and IL-17,and T,Th1 and Th17 cells infiltrating in PV skin decreased significantly.Th1/Th2 balance was restored to normal.However,their IL-4 and Th2 cells showed no significant change throughout the therapy.Conclusion Acitretin exerts influence on dermal Th1/Th2 balance and Th17 cell infiltration,so does it on production of systematic inflammatory cytokines IFN-γ and IL-17 in PV patients.However,Th2 cells and its derivative cytokine—IL-4 are not affected.展开更多
目的:观察卤米松乳膏联合卡泊三醇软膏治疗稳定期斑块状银屑病患者的效果。方法:回顾性分析2020年7月至2021年7月该院收治的108例稳定期斑块状银屑病患者的临床资料,按照治疗方法不同将其分为观察组和对照组各54例。对照组予以卡泊三醇...目的:观察卤米松乳膏联合卡泊三醇软膏治疗稳定期斑块状银屑病患者的效果。方法:回顾性分析2020年7月至2021年7月该院收治的108例稳定期斑块状银屑病患者的临床资料,按照治疗方法不同将其分为观察组和对照组各54例。对照组予以卡泊三醇软膏治疗,观察组予以卤米松乳膏联合卡泊三醇软膏治疗,两组均治疗6周。比较两组治疗前后银屑病面积和严重程度指数(Psoriasis Area and severity Index,PASI)评分、临床疗效、治疗前后炎性因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平和不良反应发生率。结果:治疗后,两组PASI评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组治疗总有效率为94.44%(51/54),高于对照组的75.93%(41/54),差异有统计学意义(P<0.05);治疗后,两组IL-6、TNF-α水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:卤米松乳膏联合卡泊三醇软膏治疗稳定期斑块状银屑病患者可提高治疗总有效率,降低PASI评分和炎性因子水平,效果优于单纯卡泊三醇软膏治疗。展开更多
Objective:Psoriasis is a chronic inflammatory systemic disease that severely impacts patients’ quality of life (QoL) and psychological health.While biologics have been shown to be effective in treating psoriatic lesi...Objective:Psoriasis is a chronic inflammatory systemic disease that severely impacts patients’ quality of life (QoL) and psychological health.While biologics have been shown to be effective in treating psoriatic lesions,thus improving QoL,real-life data regarding such effects remain scant.We administered a repeated cross-sectional survey to assess the effects of 8 weeks of biologics treatment on the QoL and mental health status of patients with moderate-to-severe plaque psoriasis.Methods:From March to May 2022,patients with moderate-to-severe plaque psoriasis were enrolled and treated with biologics in the outpatient clinic at the Dermatology Hospital of Southern Medical University.Assessments were performed before treatment and after 4 and 8 weeks of treatment with biologics.Psoriasis severity,QoL,and mental health status were evaluated using the Psoriasis Area and Severity Index (PASI),Dermatology Life Quality Index (DLQI),36-Item Short-form Health Survey (SF-36),and Hospital Anxiety and Depression Scale (HADS).A multivariate generalized estimating equations (GEE) analysis was used to account for repeated measures and to determine the effects of treatment duration and type of biological agent on relevant indicators.Results:Among the 78 enrolled patients,the ranges of pretreatment scores were 4.6 to 46.8 for the PASI,1 to 30 for the DLQI,31.5 to 100.0 for the physical component score (PCS) of the SF-36,16.6 to 100.0 for the mental component score (MCS) of the SF-36,0 to 15 for the HADS-A,and 0 to 17 for the HADS-D.After 8 weeks of biologics treatment,98.7% (77/78) of patients had obtained PASI 75.All assessed scores changed over time (GEE,P < 0.001).Moreover,there were group-by-time interaction effects for the DLQI score (GEE,P = 0.023) and PCS (GEE,P = 0.029).The HADS-A and HADS-D scores were both decreased at week 8 compared with pretreatment values.Correlation analyses revealed that higher DLQI scores were associated with lower levels of QoL and higher levels of anxiety or depression.Conclusion:Biologics are not only effective in the treatment of skin lesions but also exert beneficial effects upon the QoL and mental health of patients with psoriasis as determined in the short-term assessments conducted in this study.展开更多
文摘目的:观察中药消疕合剂对寻常型银屑病血热证的影响,比较银屑病皮损面积和严重性指数(Psoriasis Area and Severity Index,PASI)评分及血清血管内皮生长因子(Vascular Endothelial Growth Factor,VEGF)水平变化。方法:将90例入组患者随机分成两组:治疗组50例口服消疕合剂,每次125 mL,每天2次;对照组40例口服消银颗粒,每次1包,每天3次,共观察8周。治疗组治疗前后检测外周血VEGF水平。结果:治疗组治疗后PASI评分明显低于对照组,差异有统计学意义(P<0.05),有效率优于对照组,差异有统计学意义(P<0.05);治疗组治疗后血清VEGF水平均较治疗前显著降低,差异有统计学意义(P<0.001)。结论:中药消疕合剂可显著降低寻常型银屑病血热证患者PASI指数,其机理可能与其降低患者血清VEGF水平有关。
文摘目的分析皮损组织Cx26蛋白含量及信使RNA表达与寻常型银屑病(PV)患者皮损面积和严重程度指数(psoriasis area and severity index,PASI)评分的关联性。方法2018年7月-2019年7月选取本院PV患者60例作为研究组,另选同期健康体检者32例作为对照组,分析皮损组织Cx26蛋白、信使RNA水平与PV患者PASI评分的关联性。结果研究组Cx26蛋白含量及信使RNA表达水平均高于对照组(P<0.05);研究组轻度患者Cx26蛋白含量及信使RNA表达水平低于中度,中度患者Cx26蛋白含量及信使RNA表达水平低于重度(P<0.05);经Spearman分析可知,PASI评分与Cx26蛋白含量(r=0.625)及信使RNA表达水平(r=0.541)存在明显正相关关系(P<0.05)。结论PV患者Cx26蛋白含量及信使RNA表达水平与PASI评分密切相关,可作为评判疾病进展、预后指标,为临床治疗提供指导依据。
基金supported by the Science Technology Research and Development Program of Shaanxi Province of China.(No.2008K15-06(14))Research Fund for the Doctoral Programof Higher Education of China(No.20070698071)
文摘Objective To investigate the effects of acitretin on T helper cell(Th)1/Th2 balance and Th17 cells in psoriasis vulgaris(PV)patients.Methods A total of 13 men and 17 women with PV were investigated.10 mg of acitretin was administered twice a day for 8 weeks for intervention therapy.Serum levels of interferon-gamma(IFN-γ),interleukin(IL)-4 and IL-17 were measured by enzyme-linked immunosorbent assay.T,Th1,Th2 and Th17 cells in skin biopsies were counted with double-labeled immunofluorescence.Psoriasis Area and Severity Index(PASI)score was calculated before and 8 weeks after treatment.Results Before treatment PV patients had higher serum levels of IFN-γ and IL-17,and increased T,Th1 and Th17 cells in skin biopsies.After treatment,both serum levels of IFN-γ and IL-17,and T,Th1 and Th17 cells infiltrating in PV skin decreased significantly.Th1/Th2 balance was restored to normal.However,their IL-4 and Th2 cells showed no significant change throughout the therapy.Conclusion Acitretin exerts influence on dermal Th1/Th2 balance and Th17 cell infiltration,so does it on production of systematic inflammatory cytokines IFN-γ and IL-17 in PV patients.However,Th2 cells and its derivative cytokine—IL-4 are not affected.
文摘目的:观察卤米松乳膏联合卡泊三醇软膏治疗稳定期斑块状银屑病患者的效果。方法:回顾性分析2020年7月至2021年7月该院收治的108例稳定期斑块状银屑病患者的临床资料,按照治疗方法不同将其分为观察组和对照组各54例。对照组予以卡泊三醇软膏治疗,观察组予以卤米松乳膏联合卡泊三醇软膏治疗,两组均治疗6周。比较两组治疗前后银屑病面积和严重程度指数(Psoriasis Area and severity Index,PASI)评分、临床疗效、治疗前后炎性因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平和不良反应发生率。结果:治疗后,两组PASI评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组治疗总有效率为94.44%(51/54),高于对照组的75.93%(41/54),差异有统计学意义(P<0.05);治疗后,两组IL-6、TNF-α水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:卤米松乳膏联合卡泊三醇软膏治疗稳定期斑块状银屑病患者可提高治疗总有效率,降低PASI评分和炎性因子水平,效果优于单纯卡泊三醇软膏治疗。
文摘Objective:Psoriasis is a chronic inflammatory systemic disease that severely impacts patients’ quality of life (QoL) and psychological health.While biologics have been shown to be effective in treating psoriatic lesions,thus improving QoL,real-life data regarding such effects remain scant.We administered a repeated cross-sectional survey to assess the effects of 8 weeks of biologics treatment on the QoL and mental health status of patients with moderate-to-severe plaque psoriasis.Methods:From March to May 2022,patients with moderate-to-severe plaque psoriasis were enrolled and treated with biologics in the outpatient clinic at the Dermatology Hospital of Southern Medical University.Assessments were performed before treatment and after 4 and 8 weeks of treatment with biologics.Psoriasis severity,QoL,and mental health status were evaluated using the Psoriasis Area and Severity Index (PASI),Dermatology Life Quality Index (DLQI),36-Item Short-form Health Survey (SF-36),and Hospital Anxiety and Depression Scale (HADS).A multivariate generalized estimating equations (GEE) analysis was used to account for repeated measures and to determine the effects of treatment duration and type of biological agent on relevant indicators.Results:Among the 78 enrolled patients,the ranges of pretreatment scores were 4.6 to 46.8 for the PASI,1 to 30 for the DLQI,31.5 to 100.0 for the physical component score (PCS) of the SF-36,16.6 to 100.0 for the mental component score (MCS) of the SF-36,0 to 15 for the HADS-A,and 0 to 17 for the HADS-D.After 8 weeks of biologics treatment,98.7% (77/78) of patients had obtained PASI 75.All assessed scores changed over time (GEE,P < 0.001).Moreover,there were group-by-time interaction effects for the DLQI score (GEE,P = 0.023) and PCS (GEE,P = 0.029).The HADS-A and HADS-D scores were both decreased at week 8 compared with pretreatment values.Correlation analyses revealed that higher DLQI scores were associated with lower levels of QoL and higher levels of anxiety or depression.Conclusion:Biologics are not only effective in the treatment of skin lesions but also exert beneficial effects upon the QoL and mental health of patients with psoriasis as determined in the short-term assessments conducted in this study.
