Objective To investigate the effects of acitretin on T helper cell(Th)1/Th2 balance and Th17 cells in psoriasis vulgaris(PV)patients.Methods A total of 13 men and 17 women with PV were investigated.10 mg of acitretin ...Objective To investigate the effects of acitretin on T helper cell(Th)1/Th2 balance and Th17 cells in psoriasis vulgaris(PV)patients.Methods A total of 13 men and 17 women with PV were investigated.10 mg of acitretin was administered twice a day for 8 weeks for intervention therapy.Serum levels of interferon-gamma(IFN-γ),interleukin(IL)-4 and IL-17 were measured by enzyme-linked immunosorbent assay.T,Th1,Th2 and Th17 cells in skin biopsies were counted with double-labeled immunofluorescence.Psoriasis Area and Severity Index(PASI)score was calculated before and 8 weeks after treatment.Results Before treatment PV patients had higher serum levels of IFN-γ and IL-17,and increased T,Th1 and Th17 cells in skin biopsies.After treatment,both serum levels of IFN-γ and IL-17,and T,Th1 and Th17 cells infiltrating in PV skin decreased significantly.Th1/Th2 balance was restored to normal.However,their IL-4 and Th2 cells showed no significant change throughout the therapy.Conclusion Acitretin exerts influence on dermal Th1/Th2 balance and Th17 cell infiltration,so does it on production of systematic inflammatory cytokines IFN-γ and IL-17 in PV patients.However,Th2 cells and its derivative cytokine—IL-4 are not affected.展开更多
目的:研究口服氨甲环酸联合皮内注射氨甲环酸治疗黄褐斑的临床疗效。方法:选取2019年1月-2022年1月于笔者医院皮肤科就诊的黄褐斑患者168例,随机数字法分为对照组和实验组,每组84例;对照组采用口服氨甲环酸治疗,实验组采用口服氨甲环酸...目的:研究口服氨甲环酸联合皮内注射氨甲环酸治疗黄褐斑的临床疗效。方法:选取2019年1月-2022年1月于笔者医院皮肤科就诊的黄褐斑患者168例,随机数字法分为对照组和实验组,每组84例;对照组采用口服氨甲环酸治疗,实验组采用口服氨甲环酸联合皮内注射氨甲环酸治疗,比较两组治疗前后的临床疗效、皮肤颜色评分、皮损面积评分、症状总分、黄褐斑面积及严重程度(Melasma area severity index,MASI)评分,及治疗1个月、3个月后整体评价(Physician's global assessment,PGA)评分。结果:两组治疗后疗效等级比较差异有统计学意义(P<0.05),实验组的总有效率为97.62%高于对照组的总有效率84.52%(P<0.05);两组治疗后皮肤颜色评分、皮损面积评分及症状总分显著低于治疗前,且实验组治疗后皮肤颜色评分、皮损面积评分及症状总分显著低于对照组(P<0.05);两组治疗3个月后PGA评分较治疗1个月后PGA评分显著下降,且实验组PGA评分显著低于对照组(P<0.05);两组治疗后MASI评分较治疗前显著下降,且实验组MASI评分显著低于对照组(P<0.05);观察组不良反应发生率为2.38%,与对照组的1.19%比较无统计学意义(P>0.05)。结论:口服氨甲环酸联合皮内注射氨甲环酸治疗黄褐斑疗效显著。展开更多
目的:观察卤米松乳膏联合卡泊三醇软膏治疗稳定期斑块状银屑病患者的效果。方法:回顾性分析2020年7月至2021年7月该院收治的108例稳定期斑块状银屑病患者的临床资料,按照治疗方法不同将其分为观察组和对照组各54例。对照组予以卡泊三醇...目的:观察卤米松乳膏联合卡泊三醇软膏治疗稳定期斑块状银屑病患者的效果。方法:回顾性分析2020年7月至2021年7月该院收治的108例稳定期斑块状银屑病患者的临床资料,按照治疗方法不同将其分为观察组和对照组各54例。对照组予以卡泊三醇软膏治疗,观察组予以卤米松乳膏联合卡泊三醇软膏治疗,两组均治疗6周。比较两组治疗前后银屑病面积和严重程度指数(Psoriasis Area and severity Index,PASI)评分、临床疗效、治疗前后炎性因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平和不良反应发生率。结果:治疗后,两组PASI评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组治疗总有效率为94.44%(51/54),高于对照组的75.93%(41/54),差异有统计学意义(P<0.05);治疗后,两组IL-6、TNF-α水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:卤米松乳膏联合卡泊三醇软膏治疗稳定期斑块状银屑病患者可提高治疗总有效率,降低PASI评分和炎性因子水平,效果优于单纯卡泊三醇软膏治疗。展开更多
Objective:Psoriasis is a chronic inflammatory systemic disease that severely impacts patients’ quality of life (QoL) and psychological health.While biologics have been shown to be effective in treating psoriatic lesi...Objective:Psoriasis is a chronic inflammatory systemic disease that severely impacts patients’ quality of life (QoL) and psychological health.While biologics have been shown to be effective in treating psoriatic lesions,thus improving QoL,real-life data regarding such effects remain scant.We administered a repeated cross-sectional survey to assess the effects of 8 weeks of biologics treatment on the QoL and mental health status of patients with moderate-to-severe plaque psoriasis.Methods:From March to May 2022,patients with moderate-to-severe plaque psoriasis were enrolled and treated with biologics in the outpatient clinic at the Dermatology Hospital of Southern Medical University.Assessments were performed before treatment and after 4 and 8 weeks of treatment with biologics.Psoriasis severity,QoL,and mental health status were evaluated using the Psoriasis Area and Severity Index (PASI),Dermatology Life Quality Index (DLQI),36-Item Short-form Health Survey (SF-36),and Hospital Anxiety and Depression Scale (HADS).A multivariate generalized estimating equations (GEE) analysis was used to account for repeated measures and to determine the effects of treatment duration and type of biological agent on relevant indicators.Results:Among the 78 enrolled patients,the ranges of pretreatment scores were 4.6 to 46.8 for the PASI,1 to 30 for the DLQI,31.5 to 100.0 for the physical component score (PCS) of the SF-36,16.6 to 100.0 for the mental component score (MCS) of the SF-36,0 to 15 for the HADS-A,and 0 to 17 for the HADS-D.After 8 weeks of biologics treatment,98.7% (77/78) of patients had obtained PASI 75.All assessed scores changed over time (GEE,P < 0.001).Moreover,there were group-by-time interaction effects for the DLQI score (GEE,P = 0.023) and PCS (GEE,P = 0.029).The HADS-A and HADS-D scores were both decreased at week 8 compared with pretreatment values.Correlation analyses revealed that higher DLQI scores were associated with lower levels of QoL and higher levels of anxiety or depression.Conclusion:Biologics are not only effective in the treatment of skin lesions but also exert beneficial effects upon the QoL and mental health of patients with psoriasis as determined in the short-term assessments conducted in this study.展开更多
目的探讨解毒凉血汤+中药药浴治疗对寻常型银屑病血燥证患者血清脂质运载蛋白-2(lipid carrier protein-2,lipocalin-2)水平等的影响。方法选取徐州市中医院2020年2月—2022年5月66例寻常型银屑病血燥证门诊患者作为研究对象。以投掷硬...目的探讨解毒凉血汤+中药药浴治疗对寻常型银屑病血燥证患者血清脂质运载蛋白-2(lipid carrier protein-2,lipocalin-2)水平等的影响。方法选取徐州市中医院2020年2月—2022年5月66例寻常型银屑病血燥证门诊患者作为研究对象。以投掷硬币法分为两组,其中参照组33例给予常规治疗,研究组33例给予解毒凉血汤+中药药浴治疗。对比两组血清相关因子水平、有效率和不良反应等。结果治疗后,研究组lipocalin-2水平、白细胞介素(interleukin,IL)-23、IL-17水平、治疗总有效率、银屑病面积与严重性指数(psoriasis area and severity index,PASI)评分优于参照组,差异有统计学意义(P<0.05);研究组不良反应总发生率同参照组比较,差异无统计学意义(P>0.05)。结论临床对寻常型银屑病血燥证患者采取解毒凉血汤+中药药浴方法展开治疗,可降低血清lipocalin-2水平并提高疗效,值得进一步大样本研究。展开更多
目的观察百癣夏塔热胶囊联合阿维A胶囊、复方氟米松软膏治疗斑块状银屑病的临床疗效。方法将162例斑块状银屑病患者分为试验组(82例)和对照组(80例),试验组采用百癣夏塔热胶囊联合阿维A胶囊、复方氟米松软膏治疗,对照组采用阿维A胶囊联...目的观察百癣夏塔热胶囊联合阿维A胶囊、复方氟米松软膏治疗斑块状银屑病的临床疗效。方法将162例斑块状银屑病患者分为试验组(82例)和对照组(80例),试验组采用百癣夏塔热胶囊联合阿维A胶囊、复方氟米松软膏治疗,对照组采用阿维A胶囊联合复方氟米松软膏治疗,持续8周,治疗前、治疗4周和治疗8周后分别进行银屑病面积与严重指数(psoriasis area and severity index,PASI)测评,观察并比较两组临床疗效。结果治疗4周和8周后,两组PASI均较治疗前显著降低(P<0.01),且试验组PASI降低程度均显著大于对照组(P<0.01);治疗4周和8周后,试验组临床疗效均显著优于对照组(P<0.05)。结论在阿维A胶囊、复方氟米松软膏联合治疗的基础上再联用百癣夏塔热胶囊可明显提高斑块状银屑病的临床疗效。展开更多
基金supported by the Science Technology Research and Development Program of Shaanxi Province of China.(No.2008K15-06(14))Research Fund for the Doctoral Programof Higher Education of China(No.20070698071)
文摘Objective To investigate the effects of acitretin on T helper cell(Th)1/Th2 balance and Th17 cells in psoriasis vulgaris(PV)patients.Methods A total of 13 men and 17 women with PV were investigated.10 mg of acitretin was administered twice a day for 8 weeks for intervention therapy.Serum levels of interferon-gamma(IFN-γ),interleukin(IL)-4 and IL-17 were measured by enzyme-linked immunosorbent assay.T,Th1,Th2 and Th17 cells in skin biopsies were counted with double-labeled immunofluorescence.Psoriasis Area and Severity Index(PASI)score was calculated before and 8 weeks after treatment.Results Before treatment PV patients had higher serum levels of IFN-γ and IL-17,and increased T,Th1 and Th17 cells in skin biopsies.After treatment,both serum levels of IFN-γ and IL-17,and T,Th1 and Th17 cells infiltrating in PV skin decreased significantly.Th1/Th2 balance was restored to normal.However,their IL-4 and Th2 cells showed no significant change throughout the therapy.Conclusion Acitretin exerts influence on dermal Th1/Th2 balance and Th17 cell infiltration,so does it on production of systematic inflammatory cytokines IFN-γ and IL-17 in PV patients.However,Th2 cells and its derivative cytokine—IL-4 are not affected.
文摘目的:研究口服氨甲环酸联合皮内注射氨甲环酸治疗黄褐斑的临床疗效。方法:选取2019年1月-2022年1月于笔者医院皮肤科就诊的黄褐斑患者168例,随机数字法分为对照组和实验组,每组84例;对照组采用口服氨甲环酸治疗,实验组采用口服氨甲环酸联合皮内注射氨甲环酸治疗,比较两组治疗前后的临床疗效、皮肤颜色评分、皮损面积评分、症状总分、黄褐斑面积及严重程度(Melasma area severity index,MASI)评分,及治疗1个月、3个月后整体评价(Physician's global assessment,PGA)评分。结果:两组治疗后疗效等级比较差异有统计学意义(P<0.05),实验组的总有效率为97.62%高于对照组的总有效率84.52%(P<0.05);两组治疗后皮肤颜色评分、皮损面积评分及症状总分显著低于治疗前,且实验组治疗后皮肤颜色评分、皮损面积评分及症状总分显著低于对照组(P<0.05);两组治疗3个月后PGA评分较治疗1个月后PGA评分显著下降,且实验组PGA评分显著低于对照组(P<0.05);两组治疗后MASI评分较治疗前显著下降,且实验组MASI评分显著低于对照组(P<0.05);观察组不良反应发生率为2.38%,与对照组的1.19%比较无统计学意义(P>0.05)。结论:口服氨甲环酸联合皮内注射氨甲环酸治疗黄褐斑疗效显著。
文摘目的:观察卤米松乳膏联合卡泊三醇软膏治疗稳定期斑块状银屑病患者的效果。方法:回顾性分析2020年7月至2021年7月该院收治的108例稳定期斑块状银屑病患者的临床资料,按照治疗方法不同将其分为观察组和对照组各54例。对照组予以卡泊三醇软膏治疗,观察组予以卤米松乳膏联合卡泊三醇软膏治疗,两组均治疗6周。比较两组治疗前后银屑病面积和严重程度指数(Psoriasis Area and severity Index,PASI)评分、临床疗效、治疗前后炎性因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平和不良反应发生率。结果:治疗后,两组PASI评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组治疗总有效率为94.44%(51/54),高于对照组的75.93%(41/54),差异有统计学意义(P<0.05);治疗后,两组IL-6、TNF-α水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:卤米松乳膏联合卡泊三醇软膏治疗稳定期斑块状银屑病患者可提高治疗总有效率,降低PASI评分和炎性因子水平,效果优于单纯卡泊三醇软膏治疗。
文摘Objective:Psoriasis is a chronic inflammatory systemic disease that severely impacts patients’ quality of life (QoL) and psychological health.While biologics have been shown to be effective in treating psoriatic lesions,thus improving QoL,real-life data regarding such effects remain scant.We administered a repeated cross-sectional survey to assess the effects of 8 weeks of biologics treatment on the QoL and mental health status of patients with moderate-to-severe plaque psoriasis.Methods:From March to May 2022,patients with moderate-to-severe plaque psoriasis were enrolled and treated with biologics in the outpatient clinic at the Dermatology Hospital of Southern Medical University.Assessments were performed before treatment and after 4 and 8 weeks of treatment with biologics.Psoriasis severity,QoL,and mental health status were evaluated using the Psoriasis Area and Severity Index (PASI),Dermatology Life Quality Index (DLQI),36-Item Short-form Health Survey (SF-36),and Hospital Anxiety and Depression Scale (HADS).A multivariate generalized estimating equations (GEE) analysis was used to account for repeated measures and to determine the effects of treatment duration and type of biological agent on relevant indicators.Results:Among the 78 enrolled patients,the ranges of pretreatment scores were 4.6 to 46.8 for the PASI,1 to 30 for the DLQI,31.5 to 100.0 for the physical component score (PCS) of the SF-36,16.6 to 100.0 for the mental component score (MCS) of the SF-36,0 to 15 for the HADS-A,and 0 to 17 for the HADS-D.After 8 weeks of biologics treatment,98.7% (77/78) of patients had obtained PASI 75.All assessed scores changed over time (GEE,P < 0.001).Moreover,there were group-by-time interaction effects for the DLQI score (GEE,P = 0.023) and PCS (GEE,P = 0.029).The HADS-A and HADS-D scores were both decreased at week 8 compared with pretreatment values.Correlation analyses revealed that higher DLQI scores were associated with lower levels of QoL and higher levels of anxiety or depression.Conclusion:Biologics are not only effective in the treatment of skin lesions but also exert beneficial effects upon the QoL and mental health of patients with psoriasis as determined in the short-term assessments conducted in this study.
文摘目的探讨解毒凉血汤+中药药浴治疗对寻常型银屑病血燥证患者血清脂质运载蛋白-2(lipid carrier protein-2,lipocalin-2)水平等的影响。方法选取徐州市中医院2020年2月—2022年5月66例寻常型银屑病血燥证门诊患者作为研究对象。以投掷硬币法分为两组,其中参照组33例给予常规治疗,研究组33例给予解毒凉血汤+中药药浴治疗。对比两组血清相关因子水平、有效率和不良反应等。结果治疗后,研究组lipocalin-2水平、白细胞介素(interleukin,IL)-23、IL-17水平、治疗总有效率、银屑病面积与严重性指数(psoriasis area and severity index,PASI)评分优于参照组,差异有统计学意义(P<0.05);研究组不良反应总发生率同参照组比较,差异无统计学意义(P>0.05)。结论临床对寻常型银屑病血燥证患者采取解毒凉血汤+中药药浴方法展开治疗,可降低血清lipocalin-2水平并提高疗效,值得进一步大样本研究。
文摘目的观察百癣夏塔热胶囊联合阿维A胶囊、复方氟米松软膏治疗斑块状银屑病的临床疗效。方法将162例斑块状银屑病患者分为试验组(82例)和对照组(80例),试验组采用百癣夏塔热胶囊联合阿维A胶囊、复方氟米松软膏治疗,对照组采用阿维A胶囊联合复方氟米松软膏治疗,持续8周,治疗前、治疗4周和治疗8周后分别进行银屑病面积与严重指数(psoriasis area and severity index,PASI)测评,观察并比较两组临床疗效。结果治疗4周和8周后,两组PASI均较治疗前显著降低(P<0.01),且试验组PASI降低程度均显著大于对照组(P<0.01);治疗4周和8周后,试验组临床疗效均显著优于对照组(P<0.05)。结论在阿维A胶囊、复方氟米松软膏联合治疗的基础上再联用百癣夏塔热胶囊可明显提高斑块状银屑病的临床疗效。
