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COVID-19 exacerbates psoriasis progression through inducing IFN-αexpression 被引量:1
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作者 Mingjia Hu Lele Sun +4 位作者 Qing Zhao Yanyan Li Zhenzhen Wang Hong Liu Furen Zhang 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2024年第8期379-380,I0002,共3页
As a global public health issue that can cause systemic diseases,COVID-19 inflicts various harms on patients and impacts those with comorbidities.Psoriasis is primarily driven by a subset of T helper cells and the cyt... As a global public health issue that can cause systemic diseases,COVID-19 inflicts various harms on patients and impacts those with comorbidities.Psoriasis is primarily driven by a subset of T helper cells and the cytokines[1],and microbial infection is a predisposing factor in up to 45%of patients[2].Infection with SARS-CoV-2 may trigger the aggravation of psoriasis.Thus,we conducted a survey to explore the proportion of psoriasis patients who experienced exacerbation and relapse after SARS-CoV-2 infection and also performed a preliminary investigation into the mechanisms involved.One hundred and twenty-four psoriasis patients(79 males and 45 females)who contracted COVID-19 were followed up and provided detailed information. 展开更多
关键词 psoriasis INFECTION DISEASES
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Cytokine release syndrome triggered by programmed death 1 blockade(sintilimab)therapy in a psoriasis patient:A case report 被引量:2
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作者 Ming-Hui Zhou Min-Feng Ye +2 位作者 Zhen-Xing Zhang Feng Tao Yu Zhang 《World Journal of Clinical Cases》 SCIE 2024年第18期3555-3560,共6页
BACKGROUND In recent years,immune checkpoint inhibitors(ICIs)have demonstrated remarkable efficacy across diverse malignancies.Notably,in patients with advanced gastric cancer,the use of programmed death 1(PD-1)blocka... BACKGROUND In recent years,immune checkpoint inhibitors(ICIs)have demonstrated remarkable efficacy across diverse malignancies.Notably,in patients with advanced gastric cancer,the use of programmed death 1(PD-1)blockade has significantly prolonged overall survival,marking a pivotal advancement comparable to the impact of Herceptin over the past two decades.While the therapeutic benefits of ICIs are evident,the increasing use of immunotherapy has led to an increase in immune-related adverse events.CASE SUMMARY This article presents the case of a patient with advanced gastric cancer and chronic plaque psoriasis.Following sintilimab therapy,the patient developed severe rashes accompanied by cytokine release syndrome(CRS).Fortunately,effective management was achieved through the administration of glucocorticoid,tocilizumab,and acitretin,which resulted in favorable outcomes.CONCLUSION Glucocorticoid and tocilizumab therapy was effective in managing CRS after PD-1 blockade therapy for gastric cancer in a patient with chronic plaque psoriasis. 展开更多
关键词 Cytokine release syndrome Programmed death 1 blockade Sintilimab psoriasis Gastric cancer Case report
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Apigenin ameliorates imiquimod-induced psoriasis in C57BL/6J mice by inactivating STAT3 and NF-κB 被引量:2
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作者 Xianshe Meng Shihong Zheng +11 位作者 Zequn Yin Xuerui Wang Daigang Yang Tingfeng Zou Huaxin Li Yuanli Chen Chenzhong Liao Zhouling Xie Xiaodong Fan Jihong Han Yajun Duan Xiaoxiao Yang 《Food Science and Human Wellness》 SCIE CSCD 2024年第1期211-224,共14页
Psoriasis is a chronic autoimmune disease featured by patches on the skin.It is caused by malfunction of immune cells and keratinocytes with inflammation as one of its key features.Apigenin(API)is a natural flavonoid ... Psoriasis is a chronic autoimmune disease featured by patches on the skin.It is caused by malfunction of immune cells and keratinocytes with inflammation as one of its key features.Apigenin(API)is a natural flavonoid with anti-inflammatory and immunoregulatory properties.Therefore,we speculated that API can ameliorate psoriasis,and determined its effect on the development of psoriasis by using imiquimod(IMQ)-induced psoriasis mouse model.Our results showed that API attenuated IMQ-induced phenotypic changes,such as erythema,scaling and epidermal thickening,and improved splenic hyperplasia.Abnormal differentiation of immune cells was restored in API-treated mice.Mechanistically,we revealed that API is a key regulator of signal transducer activator of transcription 3(STAT3).API regulated immune responses by reducing interleukin-23(IL-23)/STAT3/IL-17A axis.Moreover,it suppressed IMQ-caused cell hyperproliferation by inactivating STAT3 through regulation of extracellular signal-regulated kinase 1/2 and nuclear factor-κB(NF-κB)pathway.Furthermore,API reduced expression of inflammatory cytokines through inactivation of NF-κB.Taken together,our study demonstrates that API can ameliorate psoriasis and may be considered as a strategy for psoriasis treatment. 展开更多
关键词 psoriasis APIGENIN IMIQUIMOD Inflammation Signal transducer activator of transcription 3 (STAT3) Nuclear factor-κB(NF-κB)
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Causal effect of psoriasis on aortic valve stenosis:a two-sample Mendelian randomization study
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作者 Ke-Xin JIANG Yan WANG +3 位作者 Yu-Tong LIU Yanjiani XU Fang-Yang HUANG Mao CHEN 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2024年第9期865-873,共9页
Background Epidemiological studies have suggested a potential connection between psoriasis and an increased risk of aortic valve stenosis(AS),though the impact of psoriasis on AS progression remains uncertain.The stud... Background Epidemiological studies have suggested a potential connection between psoriasis and an increased risk of aortic valve stenosis(AS),though the impact of psoriasis on AS progression remains uncertain.The study aims to investigate the causal relationship between psoriasis and AS using Mendelian randomization(MR)analysis,as well as to uncover potential mechanisms underlying this association.Methods A two-sample MR analysis was conducted using publicly available summary statistics from genome-wide association studies(GWAS)of psoriasis and AS.Cis-eQTL and significant genes were identified for each causal single-nucleotide polymorphisms(SNPs),followed by pathway enrichment and protein-protein interaction(PPI)analysis for functional evaluation.Hub genes were pinpointed by Cytospace.The transcriptional profile of AS population was acquired,and interconnected genes networks were clustered using Molecular Complex Detection(MCODE).Results Our results demonstrate a significant causal relationship between psoriasis and AS,with a genetic predisposition to psoriasis associated with a higher AS risk(odds ratio:1.46).Pathway and PPI analyses unveiled 15 hub genes,including HLA-C,HLA-B,ISG15,IFIT3,and MX2,along with immune-related pathways linking psoriasis and AS.Moreover,the transcriptional profiling of the AS database highlighted the significant involvement of adaptive immune cells in AS development.Notably,among the 15 hub genes,ISG15,MX2,OAS3,OASL,IFI6,and EPSTI1 exhibited higher expression in the AS population.Conclusion Our study provides compelling evidence supporting a causal relationship between psoriasis and AS.Furthermore,the identified hub genes and immune-related pathways may play an important role in the development of both diseases. 展开更多
关键词 psoriasis STENOSIS INVOLVEMENT
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Coleus forskohlii shows anti-psoriatic activity in imiquimod-induced psoriasis rats
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作者 Sagarika Majhi Iti Chauhan +3 位作者 Deepak Kumar Md.Niyaz Alam Md.Sarfaraj Hussain Muzaffar Iqbal 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2024年第9期382-390,I0002-I0007,共15页
Objective:To evaluate anti-psoriatic activity of Coleus forskohlii in rats with imiquimod-induced psoriasis.Methods:Imiquimod was used to induce psoriasis in rats.Body weight,skin thickness,erythema,scaling,spleen wei... Objective:To evaluate anti-psoriatic activity of Coleus forskohlii in rats with imiquimod-induced psoriasis.Methods:Imiquimod was used to induce psoriasis in rats.Body weight,skin thickness,erythema,scaling,spleen weight,and histological alternations were measured to assess the effect of Coleus forskohlii.Furthermore,an emulgel formulation containing Coleus forskohlii 10%was prepared and characterized along with its ex vivo permeation studies.Results:The emulgel formulation containing Coleus forskohlii 10%had a pH of 5.40±0.36,with optimum spreadability of(31.67±2.08)g/(cm·s)and viscosity of(15966.67±1274.10)cps,and enhanced both the rate and the extent of drug permeation through psoriatic skin.In an ex vivo study,the quantity of drug permeated(19.18%),deposited(52.38%),and drug remaining in the donor compartments(28.31%)was satisfactory.Coleus forskohlii significantly alleviated imiquimod-induced psoriasis by increasing glutathione and superoxide dismutase activity,decreasing malondialdehyde and nitric oxide levels,and alleviating histological alternations in rat skin.Conclusions:Coleus forskohlii can alleviate imiquimod-induced psoriasis,which may be used as a therapeutic candidate for the treatment of psoriasis. 展开更多
关键词 psoriasis Coleus forskohlii Emulgel Ex vivo IMIQUIMOD CARBOPOL
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The Application Progress of Skin Imaging Technology in Psoriasis
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作者 Qinyi Wang Jin Gong 《Advances in Bioscience and Biotechnology》 CAS 2024年第7期397-405,共9页
Skin imaging technologies such as dermoscopy, high-frequency ultrasound, reflective confocal microscopy and optical coherence tomography are developing rapidly in clinical application. Skin imaging technology can impr... Skin imaging technologies such as dermoscopy, high-frequency ultrasound, reflective confocal microscopy and optical coherence tomography are developing rapidly in clinical application. Skin imaging technology can improve clinical diagnosis rate, and its non-invasiveness and repeatability make it occupy an irreplaceable position in clinical diagnosis. With the “booming development” of medical technology, skin imaging technology can improve clinical diagnosis rate. Researchers have made significant advances in assisting clinical diagnosis, prediction, and treatment of disease. This article reviews the application and progress of skin imaging in the diagnosis of psoriasis. 展开更多
关键词 psoriasis Skin Imaging Technology High Frequency Ultrasound Optical Coherence Tomography
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Systemic Amyloidosis Secondary to Psoriasis: A Rare, Autoimmune and Genetically-Determined Disorder That Is Amenable to Treatment with Cyclosporin A—Cyclosporin A for Psoriasis-Induced Amyloidosis
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作者 Kamel El-Reshaid Shaima Al-Bader John Patrick Madda 《Open Journal of Nephrology》 2024年第2期226-232,共7页
Background: Systemic secondary amyloidosis (SSA) is associated with chronic inflammatory disorders and/or chronic infections. Patients and Methods: Over the past 10 years;a total of 21 patients, with long-term (17 mon... Background: Systemic secondary amyloidosis (SSA) is associated with chronic inflammatory disorders and/or chronic infections. Patients and Methods: Over the past 10 years;a total of 21 patients, with long-term (17 months) and extensive psoriasis (P) with psoriasis area severity index (PASI) >29, were evaluated. Results: Two patients had nephrotic syndrome (proteinuria 3.9 and 3.6 g/day) and decrease creatinine clearance (46 and 62 ml/minute). Their renal biopsy revealed Congo-red (+) nodular glomerulosclerosis that lacked immune-deposits and resisted wash with K-permanganate wash indicating SSA. Three months subsequent to Cyclosporin A (CyA) therapy with 100 mg twice daily;psoriasis improved in all patients with decrease in (PASI) from 29.5 to 3.5 1. In the 2 patients with SSA;proteinuria decreased to 2.1 and 1.8 g/day and creatinine clearance improved to 51 and 69 ml/minute. Such improvement persisted up to 2 years of follow up and up to 78 months in patients with SSA. Conclusion: psoriasis-induced SSA is an autoimmune disease, with genetic predisposition that is amenable to CyA therapy. 展开更多
关键词 AMYLOIDOSIS psoriasis Nephrotic Syndrome Cyclosporin A
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Moyamoya syndrome may result from psoriasis: Four case reports
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作者 Zhi-Ying Chen Xiao-Qin Yu +2 位作者 Yuan-Yuan Xiang Ling-Hua Liu Xiao-Ping Yin 《World Journal of Clinical Cases》 SCIE 2024年第10期1830-1836,共7页
BACKGROUND Moyamoya syndrome(MMS)is a group of diseases that involves more than one underlying disease and is accompanied by moyamoya vascular phenomena.Psoriasis is a chronic immune skin disease closely linked to hig... BACKGROUND Moyamoya syndrome(MMS)is a group of diseases that involves more than one underlying disease and is accompanied by moyamoya vascular phenomena.Psoriasis is a chronic immune skin disease closely linked to high blood pressure and heart disease.However,psoriasis-related MMS has not been reported.CASE SUMMARY We collected data on patients with stroke due to MMS between January 2017 and December 2019 and identified four cases of psoriasis.Case histories,imaging,and hematological data were collected.The average age of the initial stroke onset was 58.25±11.52 years;three cases of hemorrhagic and one case of ischemic stroke were included.The average duration from psoriasis confirmation to the initial MMS-mediated stroke onset was 17±3.56 years.All MMS-related stenoses involved the bilateral cerebral arteries:Suzuki grade III in one case,grade IV in two cases,and grade V in one case.Abnormally elevated plasma interleukin-6 levels were observed in four patients.Two patients had abnormally elevated immunoglobulin E levels,and two had thrombocytosis.All four patients received medication instead of surgery.With an average follow-up time of 2 years,two causing transient ischemic attacks occurred in two patients,and no hemorrhagic events occurred.CONCLUSION Psoriasis may be a potential risk factor for MMS.Patients with psoriasis should be screened for MMS when they present with neurological symptoms. 展开更多
关键词 Moyamoya syndrome psoriasis Stroke INTERLEUKIN-6 IMMUNE HYPERTENSION Case report
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Toll-like receptors 2 polymorphism is associated with psoriasis: A case-control study in the northern Chinese population
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作者 Siyu Hao Yu Zhang +4 位作者 Anqi Yin Ying Lyu Nannan Tong Jiangtian Tian Yuzhen Li 《Frigid Zone Medicine》 2024年第2期96-101,共6页
Background:Psoriasis is a disease caused by genetics and immune system dysfunction,affecting the skin and joints.Toll-like receptors(TLRs)play an important role in triggering the innate immune response and controlling... Background:Psoriasis is a disease caused by genetics and immune system dysfunction,affecting the skin and joints.Toll-like receptors(TLRs)play an important role in triggering the innate immune response and controlling adaptive immunity.The role of TLR2 in the progression of psoriasis is not well understood.Methods:A case-control study was conducted on a northern Chinese Han population,consisting of psoriasis patients and healthy control subjects.Genotyping was performed using the tetra-primer amplification refractory mutation system-polymerase chain reaction(ARMS-PCR),and allele and genotype frequencies of four SNPs in TLR2 were analyzed in 270 psoriasis patients and 246 healthy controls.Results:Four TLR2 SNPs(rs11938228,rs4696480,rs3804099,rs5743699)were genotyped and found to be in linkage disequilibrium.The genotype distributions of rs11938228 and rs4696480 in two groups were in Hardy-Weinberg equilibrium and statistically significant except for the overdominance model.The haplotypes ATTC and ATCC were found to be protective against psoriasis.Conclusion:Our study found a correlation between TLR2 genetic variations and the likelihood of psoriasis in northern China. 展开更多
关键词 Toll-like receptors 2 psoriasis POLYMORPHISM SUSCEPTIBILITY
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Secoemestrin C Ameliorates Psoriasis-like Skin Inflammation in Mice by Suppressing the TNF-α/NF-κB Signaling Pathway
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作者 Zhi-bin ZHU Meng-jie LIU +2 位作者 Jing WANG Zhou SHU Jie CAO 《Current Medical Science》 SCIE CAS 2024年第1期232-240,共9页
Objective Secoemestrin C(SC),an epitetrathiodioxopiperazine isolated from Aspergillus nidulans,has been previously reported to have immunomodulatory and hepatoprotective effects against acute autoimmune hepatitis.Howe... Objective Secoemestrin C(SC),an epitetrathiodioxopiperazine isolated from Aspergillus nidulans,has been previously reported to have immunomodulatory and hepatoprotective effects against acute autoimmune hepatitis.However,the effect of SC on regulating the inflammation and its underlying mechanisms in the pathogenesis of psoriasis remain unclear.This study aimed to evaluate the effects of SC on inflammatory dermatosis both in vitro and in vivo.Methods In vitro,HaCaT cells were induced with tumor necrosis factor-alpha(TNF-α,10 ng/mL)to establish an inflammatory injury model,and the expression of nuclear transcription factor-κB(NF-κB)pathway components was measured using qRT-PCR and Western blotting.An in vivo mouse model of imiquimod(IMQ)-induced psoriasis-like skin inflammation was used to evaluate the effectiveness of SC in alleviating psoriasis.Results SC significantly blocked the activation of NF-κB signaling in TNF-α-stimulated HaCaT cells.In addition,systemic and local administration of SC improved psoriatic dermatitis in the IMQ-induced mouse model.SC reduced skin scale and significantly inhibited the secretion of inflammatory factors in skin lesions.Conclusion The protective effect of SC against psoriatic-associated inflammation reveals its potential therapeutic value for treating psoriasis. 展开更多
关键词 secoemestrin C(SC) psoriasis tumor necrosis factor-alpha(TNF-α) nuclear transcription factor-kB(NF-kB) inflammation
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Protective effects of Bifi dobacterium breve on imiquimod-induced psoriasis in mice through secondary bile acid production and FXR-TLR4/NF-κB pathway
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作者 Xinqi Chen Yang Chen +4 位作者 Catherine Stanton RPaul Ross Jianxin Zhao Bo Yang Wei Chen 《Food Science and Human Wellness》 SCIE CAS CSCD 2024年第6期3447-3460,共14页
This study aimed to evaluate the effects of Bifi dobacterium breve CCFM683 on psoriasis and to investigate the underlying mechanisms.B.breve CCFM683 significantly ameliorated psoriasis in mice as well as elevated the ... This study aimed to evaluate the effects of Bifi dobacterium breve CCFM683 on psoriasis and to investigate the underlying mechanisms.B.breve CCFM683 significantly ameliorated psoriasis in mice as well as elevated the deoxycholic acid(DCA)and lithocholic acid(LCA)in the colon compared with those of the imiquimod(IMQ)-treated mice.Meanwhile,B.breve CCFM683 increased the relative abundance of DCA-producing Lachnoclostridium and diminished the harmful Desulfovibrio and Prevotellaceae UCG001.Additionally,the farnesoid X receptor(FXR)in the skin was activated and the expression of the Toll-like receptor 4(TLR4)/nuclear factor kappa-B(NF-κB)pathway was inhibited,and the downstream interleukin(IL)-17 and tumor necrosis factor(TNF)-αwere downregulated whereas IL-10 was up-regulated.Moreover,the subsequent hyperproliferation of keratinocytes and the dysfunction of the epidermal barrier were improved.In conclusion,CCFM683 administration ameliorated IMQ-induced psoriasis via modulating gut microbiota,promoting the DCA production,regulating the FXR-TLR4/NF-κB pathway,diminishing proinflammatory cytokines,and regulating keratinocytes and epidermal barrier.These findings may be conducive to elucidating the mechanism for probiotics to ameliorate psoriasis and to promote its clinical trials in skin disease. 展开更多
关键词 psoriasis Bifi dobacterium breve Gut microbiota Secondary bile acids FXR-TLR4/NF-κB pathway
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Medical dilemma:Programmed death 1 blockade(sintilimab)therapy in patients suffering from tumours combined with psoriasis
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作者 Di Jin Yu-Wei Wang +2 位作者 Zhi-Min Lin Chen Li Ming Li 《World Journal of Cardiology》 2024年第9期546-549,共4页
Tumour immunotherapy represented by immune checkpoint inhibitors(ICIs)has greatly improved the overall prognosis of patients with malignant tumours,and is regarded as an important breakthrough in the field of medicine... Tumour immunotherapy represented by immune checkpoint inhibitors(ICIs)has greatly improved the overall prognosis of patients with malignant tumours,and is regarded as an important breakthrough in the field of medicine in recent years.ICIs have gradually become the core of tumour therapy and are increasingly used in the clinic.In order to achieve early clinical prediction and management of immune-related adverse events(irAEs),it is still necessary to perform further research on the mechanisms,risk factors,and predictors of irAE occurrence in the future.Zhou et al describe the consultation of a patient with advanced gastric cancer combined with chronic plaque psoriasis.This case provides an important reference for the use of programmed cell death protein-1(PD-1)inhibitors in patients of tumours combined with chronic plaque psoriasis.This case also highlights that screening of high-risk groups for irAEs is critical before applying PD-1 inhibitors to patients with chronic psoriasis combined with tumours.PD-1 inhibitors are new and potent antineoplastic agents that can cause serious immunerelated adverse events such as toxic epidermal necrolysis release and psoriasis.Glucocorticosteroids are the first-line agents for irAEs.The incidence of rheumatic irAEs may be higher in reality,which will inevitably become a new challenge for rheumatologists and dermatologists. 展开更多
关键词 Immune checkpoint inhibitors Tumor immunotherapy Immune-related adverse events Cytokine release syndrome psoriasis
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Mechanism of traditional Chinese medicine in the treatment of psoriasis with depression:A review
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作者 ZHANG Ning YANG Su-qing YUAN Rui 《Journal of Hainan Medical University》 CAS 2024年第1期76-82,共7页
Psoriasis is a kind of immune-mediated, chronic, inflammatory skin disease, which is often associated with different degrees of psychological disorders. Specifically, there is a significant correlation between psorias... Psoriasis is a kind of immune-mediated, chronic, inflammatory skin disease, which is often associated with different degrees of psychological disorders. Specifically, there is a significant correlation between psoriasis and depression, and they show the relationships of reciprocal causation and mutual promotion. Psoriasis with depression is more harmful than simple psoriasis, and its prognosis is worse, which brings a huge burden to the family and society and is worthy of clinical attention. Based on the pathogenic factors of western medicine and pathogenesis of traditional Chinese medicine in psoriasis with depression, the paper summarized and elaborated the research progress on the mechanism of traditional Chinese medicine in the treatment of psoriasis with depression, in order to provide new ideas for clinical treatment. 展开更多
关键词 psoriasis DEPRESSION Mechanism of action Chinese medicinal compound Characteristic therapy of traditional Chinese medicine
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Cytokine release syndrome induced by anti-programmed death-1 treatment in a psoriasis patient:A dark side of immune checkpoint inhibitors
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作者 JoséLuis Maldonado-García Ana Fragozo Lenin Pavón 《World Journal of Clinical Cases》 SCIE 2024年第35期6782-6790,共9页
In recent years,cancer immunotherapy has introduced novel treatments,such as monoclonal antibodies,which have facilitated targeted therapies against tumor cells.Programmed death-1(PD-1)is an immune checkpoint expresse... In recent years,cancer immunotherapy has introduced novel treatments,such as monoclonal antibodies,which have facilitated targeted therapies against tumor cells.Programmed death-1(PD-1)is an immune checkpoint expressed in T cells that regulates the immune system’s activity to prevent over-activation and tissue damage caused by inflammation.However,PD-1 is also expressed in tumor cells and functions as an immune evasion mechanism,making it a therapeutic target to enhance the immune response and eliminate tumor cells.Consequently,immune checkpoint inhibitors(ICIs)have emerged as an option for certain tumor types.Nevertheless,blocking immune checkpoints can lead to immune-related adverse events(irAEs),such as psoriasis and cytokine release syndrome(CRS),as exemp-lified in the clinical case presented by Zhou et al involving a patient with adva-nced gastric cancer who received sintilimab,a monoclonal antibody targeting PD-1.Subsequently,the patient experienced exacerbation of psoriasis and CRS.The objective of this editorial article is to elucidate potential immunologic mechanisms that may contribute to the development of CRS and psoriasis in patients receiving ICIs.It is crucial to acknowledge that while ICIs offer superior safety and efficacy compared to conventional therapies,they can also manifest irAEs affecting the skin,gastrointestinal tract,or respiratory system.In severe cases,these irAEs can lead to life-threatening complications such as circulatory shock or multiorgan failure.Consequently,it is recommended that patients receiving ICIs undergo regular monitoring to identify and manage these adverse events effectively. 展开更多
关键词 Immune checkpoints inhibitors Programmed death-1 Cancer immunotherapy psoriasis Cytokine release syndrome Immune-related adverse events
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ZJ116型卷接机组吸丝带转向带轮机构的改进
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作者 韩永 赵斌 +1 位作者 周岩 潘恒乐 《中国烟草学报》 CAS CSCD 北大核心 2024年第5期50-55,共6页
为解决ZJ116型卷接机组吸丝带转向带轮拆装不方便,轴承更换作业时间长的问题,对转向带轮机构进行了改进。设计了一种三段组合式偏心轴代替原来的一体式偏心轴,使得转向带轮拆装方便、快捷,从而减少了转向带轮轴承更换作业时间。以济南... 为解决ZJ116型卷接机组吸丝带转向带轮拆装不方便,轴承更换作业时间长的问题,对转向带轮机构进行了改进。设计了一种三段组合式偏心轴代替原来的一体式偏心轴,使得转向带轮拆装方便、快捷,从而减少了转向带轮轴承更换作业时间。以济南卷烟厂的ZJ116型卷接机组为对象进行测试,结果表明:改进后的吸丝带转向带轮轴承更换作业时间缩短了约66.6%,且对转向带轮轴承使用寿命无显著负面影响。该方法可为提高设备维修效率、降低维修人员劳动强度提供技术支持。 展开更多
关键词 zj116型卷接机组 吸丝带 转向带轮 偏心轴 轴承
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ZJ116卷接机组可快速更换接装纸规格的胶前导纸块设计 被引量:1
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作者 何鹏程 朱岩 +1 位作者 刘志崇 王东翔 《中国烟草学报》 CAS CSCD 北大核心 2024年第3期69-74,共6页
【目的】提高ZJ116卷接机组更换接装纸规格时的作业效率。【方法】通过对胶前导纸块的结构原理进行分析,采用仿真方法对胶前导纸块进行了重新设计。【结果】以3台ZJ116卷接机组为对象进行测试,结果表明,新研制的胶前导纸块可实现一次性... 【目的】提高ZJ116卷接机组更换接装纸规格时的作业效率。【方法】通过对胶前导纸块的结构原理进行分析,采用仿真方法对胶前导纸块进行了重新设计。【结果】以3台ZJ116卷接机组为对象进行测试,结果表明,新研制的胶前导纸块可实现一次性成功更换接装纸规格,接装纸导纸块的更换调整时间从59.67min减少到2.15min。【结论】该胶前导纸块的设计,支持更多接装纸规格,实现了更换接装纸规格无需更换导纸块,提高了效率,为国产卷接机组烟支牌号、规格的快速更换提供了新的思路。 展开更多
关键词 zj116 卷接机组 接装纸 导纸块
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Chemerin Exacerbates Psoriasis by Stimulating Keratinocyte Proliferation and Cytokine Production
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作者 Shu-min KONG Xiao-yan SUN +1 位作者 Wen-ya CUI Yu-chun CAO 《Current Medical Science》 SCIE CAS 2023年第2期399-408,共10页
Objective Psoriasis is often combined with metabolic abnormalities,such as obesity and diabetes.The upregulation of chemerin,which is an essential protein produced primarily from white fat,is strongly correlated to th... Objective Psoriasis is often combined with metabolic abnormalities,such as obesity and diabetes.The upregulation of chemerin,which is an essential protein produced primarily from white fat,is strongly correlated to the development of psoriasis.However,there is no clarification on its exact function and mechanism in disease pathogenesis.The present study aims to determine its function and mechanism in disease pathogenesis.Methods The present study used a psoriasislike inflammatory cell model and imiquimod(IMQ)-induced mouse model to confirm whether chemerin is upregulated in psoriasis patients.Results Chemerin enhanced the keratinocyte proliferation,inflammatory cytokine secretion,and activation of the MAPK signaling pathway.Crucially,the intraperitoneal injection of neutralizing anti-chemerin antibody(ChAb)diminished the epidermal proliferation and inflammation in the IMQ-induced mouse model.Conclusion The present results indicate that chemerin promotes keratinocyte proliferation,and enhances the production of inflammatory cytokines,thereby aggravating the psoriasis.Thus,chemerin can be a prospective target for the treatment of psoriasis. 展开更多
关键词 psoriasis KERATINOCYTE CHEMERIN PROLIFERATION INFLAMMATION
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Water-responsive gel extends drug retention and facilitates skin penetration for curcumin topical delivery against psoriasis
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作者 Qing Yao Yuanyuan Zhai +11 位作者 Zhimin He Qian Wang Lining Sun Tuyue Sun Leyao Lv Yingtao Li Jiyong Yang Donghui Lv Ruijie Chen Hailin Zhang Xiang Luo Longfa Kou 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS 2023年第2期61-75,共15页
Psoriasis is a chronic inflammatory skin disease characterized by erythema,scaling,and skin thickening.Topical drug application is recommended as the first-line treatment.Many formulation strategies have been develope... Psoriasis is a chronic inflammatory skin disease characterized by erythema,scaling,and skin thickening.Topical drug application is recommended as the first-line treatment.Many formulation strategies have been developed and explored for enhanced topical psoriasis treatment.However,these preparations usually have low viscosity and limited retention on the skin surface,resulting in low drug delivery efficiency and poor patient satisfaction.In this study,we developed the first water-responsive gel(WRG),which has a distinct water-triggered liquid-to-gel phase transition property.Specifically,WRG was kept in a solution state in the absence of water,and the addition of water induced an immediate phase transition and resulted in a high viscosity gel.Curcumin was used as a model drug to investigate the potential of WRG in topical drug delivery against psoriasis.In vitro and in vivo data showed that WRG formulation could not only extend skin retention but also facilitate the drug permeating across the skin.In a mouse model of psoriasis,curcumin loaded WRG(CUR-WRG)effectively ameliorated the symptoms of psoriasis and exerted a potent anti-psoriasis effect by extending drug retention and facilitating drug penetration.Further mechanism study demonstrated that the anti-hyperplasia,anti-inflammation,anti-angiogenesis,anti-oxidation,and immunomodulation properties of curcumin were amplified by enhanced topical drug delivery efficiency.Notably,neglectable local or systemic toxicity was observed for CUR-WRG application.This study suggests that WRG is a promising formulation for topically psoriasis treatment. 展开更多
关键词 psoriasis Sol-gel transition Water-responsive CURCUMIN Topical drug delivery
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Advancements in Psoriasis Research: Skin Microcirculation and Its Prognostic Significance
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作者 Wenxi Han Faqing Huang 《Journal of Biosciences and Medicines》 2023年第12期1-11,共11页
Psoriasis, a chronic and recurring inflammatory skin disorder, is distinguished by the excessive proliferation of keratinocytes, immune cell infiltration, and angiogenesis. Ever since the observation of microvascular ... Psoriasis, a chronic and recurring inflammatory skin disorder, is distinguished by the excessive proliferation of keratinocytes, immune cell infiltration, and angiogenesis. Ever since the observation of microvascular hyperplasia in psoriatic lesions, there has been a growing focus on exploring the intricate relationship between microcirculation and psoriasis. Furthermore, the potential utility of microcirculatory changes as prognostic indicators for psoriasis has garnered significant attention. This paper provides a comprehensive review of the role of skin microcirculation in psoriasis pathogenesis and its potential application as a clinical prognostic indicator. 展开更多
关键词 psoriasis MICROCIRCULATION ANGIOGENESIS PROGNOSIS
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细支ZJ17机组烟丝成型关键部件改进
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作者 张艮水 兰志超 +3 位作者 鄢红章 郭子国 胡祥胜 李诚 《自动化技术与应用》 2024年第7期62-65,共4页
针对细支烟烟丝结构特性,对ZJ17机组烟丝成型关键部位进行研究。通过对抛丝辊、吸丝带导轨、平准器及劈刀盘材质等核心部件进行创新性改进,提高烟丝供料松散度、均匀性,降低烟丝运行的阻力和造碎等,为大幅提高细支ZJ17机组生产效率和质... 针对细支烟烟丝结构特性,对ZJ17机组烟丝成型关键部位进行研究。通过对抛丝辊、吸丝带导轨、平准器及劈刀盘材质等核心部件进行创新性改进,提高烟丝供料松散度、均匀性,降低烟丝运行的阻力和造碎等,为大幅提高细支ZJ17机组生产效率和质量水平提供技术方案。 展开更多
关键词 zj17卷烟机 部件改进 抛丝辊 吸丝带导轨 平准器 劈刀盘
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