Epilepsy is a very complex disorder of the central nervous system. It is characterized by a sudden, disordered and excessive neuronal shock that causes different clinical evidences with specific related electroencepha...Epilepsy is a very complex disorder of the central nervous system. It is characterized by a sudden, disordered and excessive neuronal shock that causes different clinical evidences with specific related electroencephalogram (EEG). Psychogenic Non-Epileptic Seizures (PNES) can seriously complicate the diagnosis of epilepsy. The separoxysmal events have the same clinical evidences of epilepsy, such as an impairment of the self-control and a range of sensory, motor and mental manifestations, without the typical related electroencephalogram (EEG) because of the absence of an organic cause. The overwhelming majority of Psychogenic Non-Epileptic Seizures are related to psychological factors like dissociation. This is a defense mechanism used to cope stressful events or emotional conflicts. Psychological or psychiatric disorders, like Post Traumatic Stress Disorder (PTSD), are frequently associated to Psychogenic Non-Epileptic Seizures. In this article, we present a case report of epilepsy combined with Psychogenic Non-Epileptic Seizures. A joint intervention is of great significance in this occurrence. The subject received a psychological assessment including psychometric and projective tools. He stood MMPI-2, Wais-R, SCL-90, Rorschach test and graphic tests. A psychological disorder related to defense mechanisms was identified. The subject presents a tendency to convert his fears and emotive pains in rational and more socially acceptable problems, using his body to express his discomfort. Patient with epileptic seizures should receive a psychological assessment to exclude Psychogenic Non-Epileptic Seizures. Further studies should propose guidelines to integrate neurological, psychiatric and psychological intervention.展开更多
Distinguishing non-epileptic events,especially psychogenic non-epileptic seizures(PNES),from epileptic seizures(ES)constitutes a diagnostic challenge.Misdiagnoses are frequent,especially when video-EEG recording,the g...Distinguishing non-epileptic events,especially psychogenic non-epileptic seizures(PNES),from epileptic seizures(ES)constitutes a diagnostic challenge.Misdiagnoses are frequent,especially when video-EEG recording,the gold-standard for PNES confirmation,cannot be completed.The issue is further complicated in cases of combined PNES with ES.In emergency units,a misdiagnosis can lead to extreme antiepileptic drug escalade,unnecessary resuscitation measures(intubation,catheterization,etc.),as well as needless biologic and imaging investigations.Outside of the acute window,an incorrect diagnosis can lead to prolonged hospitalization or increase of unhelpful antiepileptic drug therapy.Early recognition is thus desirable to initiate adequate treatment and improve prognosis.Considering experience-based strategies and a thorough review of the literature,we aimed to present the main clinical clues for physicians facing PNES in non-specialized units,before management is transferred to epileptologists and neuropsychiatrists.In such conditions,patient recall or witness-report provide the first orientation for the diagnosis,recognizing that collected information may be inaccurate.Thorough analysis of an event(live or based on home-video)may lead to a clinical diagnosis of PNES with a high confidence level.Indeed,a fluctuating course,crying with gestures of frustration,pelvic thrusting,eye closure during the episode,and the absence of postictal confusion and/or amnesia are highly suggestive of PNES.Moreover,induction and/or inhibition tests of PNES have a good diagnostic value when positive.Prolactinemia may also be a useful biomarker to distinguish PNES from epileptic seizures,especially following bilateral tonic-clonic seizures.Finally,regardless the level of certainty in the diagnosis of the PNES,it is important to subsequently refer the patient for epileptological and neuropsychiatric follow-up.展开更多
From 1979 to 2012,the Chinese government implemented the one-child policy to control population growth.In 2013,families in which either parent was the only one child were allowed to apply for a second child.In 2016,Ch...From 1979 to 2012,the Chinese government implemented the one-child policy to control population growth.In 2013,families in which either parent was the only one child were allowed to apply for a second child.In 2016,China’s universal two-child policy was finally imposed.As such,many children who had always been the center of their family’s universe due to the unique family structure stemming from the one-child policy era became elder siblings during their adolescence.We report a case of a 9-year-old girl who developed seizures after the birth of her younger sister.The combination of clinical observation,laboratory examinations,and video-electroencephalography was not enough to make a confident diagnosis of epilepsy initially.Given her patient history and follow-up investigation,we speculated the two-child policy was related to her seizures.To our knowledge,this is the first report of seizures strongly related to the two-child policy.展开更多
文摘Epilepsy is a very complex disorder of the central nervous system. It is characterized by a sudden, disordered and excessive neuronal shock that causes different clinical evidences with specific related electroencephalogram (EEG). Psychogenic Non-Epileptic Seizures (PNES) can seriously complicate the diagnosis of epilepsy. The separoxysmal events have the same clinical evidences of epilepsy, such as an impairment of the self-control and a range of sensory, motor and mental manifestations, without the typical related electroencephalogram (EEG) because of the absence of an organic cause. The overwhelming majority of Psychogenic Non-Epileptic Seizures are related to psychological factors like dissociation. This is a defense mechanism used to cope stressful events or emotional conflicts. Psychological or psychiatric disorders, like Post Traumatic Stress Disorder (PTSD), are frequently associated to Psychogenic Non-Epileptic Seizures. In this article, we present a case report of epilepsy combined with Psychogenic Non-Epileptic Seizures. A joint intervention is of great significance in this occurrence. The subject received a psychological assessment including psychometric and projective tools. He stood MMPI-2, Wais-R, SCL-90, Rorschach test and graphic tests. A psychological disorder related to defense mechanisms was identified. The subject presents a tendency to convert his fears and emotive pains in rational and more socially acceptable problems, using his body to express his discomfort. Patient with epileptic seizures should receive a psychological assessment to exclude Psychogenic Non-Epileptic Seizures. Further studies should propose guidelines to integrate neurological, psychiatric and psychological intervention.
文摘Distinguishing non-epileptic events,especially psychogenic non-epileptic seizures(PNES),from epileptic seizures(ES)constitutes a diagnostic challenge.Misdiagnoses are frequent,especially when video-EEG recording,the gold-standard for PNES confirmation,cannot be completed.The issue is further complicated in cases of combined PNES with ES.In emergency units,a misdiagnosis can lead to extreme antiepileptic drug escalade,unnecessary resuscitation measures(intubation,catheterization,etc.),as well as needless biologic and imaging investigations.Outside of the acute window,an incorrect diagnosis can lead to prolonged hospitalization or increase of unhelpful antiepileptic drug therapy.Early recognition is thus desirable to initiate adequate treatment and improve prognosis.Considering experience-based strategies and a thorough review of the literature,we aimed to present the main clinical clues for physicians facing PNES in non-specialized units,before management is transferred to epileptologists and neuropsychiatrists.In such conditions,patient recall or witness-report provide the first orientation for the diagnosis,recognizing that collected information may be inaccurate.Thorough analysis of an event(live or based on home-video)may lead to a clinical diagnosis of PNES with a high confidence level.Indeed,a fluctuating course,crying with gestures of frustration,pelvic thrusting,eye closure during the episode,and the absence of postictal confusion and/or amnesia are highly suggestive of PNES.Moreover,induction and/or inhibition tests of PNES have a good diagnostic value when positive.Prolactinemia may also be a useful biomarker to distinguish PNES from epileptic seizures,especially following bilateral tonic-clonic seizures.Finally,regardless the level of certainty in the diagnosis of the PNES,it is important to subsequently refer the patient for epileptological and neuropsychiatric follow-up.
文摘From 1979 to 2012,the Chinese government implemented the one-child policy to control population growth.In 2013,families in which either parent was the only one child were allowed to apply for a second child.In 2016,China’s universal two-child policy was finally imposed.As such,many children who had always been the center of their family’s universe due to the unique family structure stemming from the one-child policy era became elder siblings during their adolescence.We report a case of a 9-year-old girl who developed seizures after the birth of her younger sister.The combination of clinical observation,laboratory examinations,and video-electroencephalography was not enough to make a confident diagnosis of epilepsy initially.Given her patient history and follow-up investigation,we speculated the two-child policy was related to her seizures.To our knowledge,this is the first report of seizures strongly related to the two-child policy.
